Verapamil exerts biphasic modulation on phenobarbital transport across the blood-brain barrier: Evidence from an in vivo and in vitro study

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 383, Issue 4, 2011, Pages 393-402

  Yao, Dan ^a   Yang, Zhi Hong ^b   Liu, Li ^a   Li, Jia ^a   Yu, Yun Li ^a   Zhang, Lu Lu ^a   Pan, Xian ^a   Liu, Xiao Dong ^a   Xie, Lin ^a   Wang, Guang Ji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Biphasic modulation; Blood brain barrier; P glycoprotein; Phenobarbital; Rhodamine 123; Verapamil

Indexed keywords

CARBAMAZEPINE; GLYCOPROTEIN P; PHENOBARBITAL; RHODAMINE 123; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIPHASIC MODULATION; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULATURE; MOUSE; NEUROMODULATION; NEWBORN; NONHUMAN; PROTEIN FUNCTION; RAT; RIGHTING REFLEX;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; MALE; MICE; MICE, INBRED ICR; MICROVESSELS; P-GLYCOPROTEIN; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VASODILATOR AGENTS; VERAPAMIL;

EID: 79954623568     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-011-0609-y     Document Type: Article

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