Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 12, 2007, Pages 1649-1655

  Fang, Weirong ^a   Li, Yunman ^a   Cai, Ying ^a   Kang, Kai ^a   Yan, Fang ^a   Liu, Guoqing ^a   Huang, Wenlong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; B 3; DOXORUBICIN; GLYCOPROTEIN P; RHODAMINE 123; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG SUBSTITUTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; RAT; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOTHELIAL CELLS; HUMANS; ISOQUINOLINES; K562 CELLS; LEUKEMIA, EXPERIMENTAL; MICE; MICE, NUDE; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; TETRAHYDROISOQUINOLINES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 36849089533     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.12.0006     Document Type: Article

References (34)

1. Abbott, N. J., Hughes, C. C., Revest, P. A., Greenwood, J. (1992) Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J. Cell Sci. 103 (Pt 1): 23-37
2. Berger, D., Citarella, R., Dutia, M., Greenberger, L., Hallett, W., Paul, R., Powell, D. (1999) Novel multidrug resistance reversal agents. J. Med. Chem. 42: 2145-2161
3. Biedler, J. L., Riehm, H. (1970) Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res. 30: 1174-1184
4. Biscardi, M., Teodori, E., Caporale, R., Budriesi, R., Balestri, F., Scappini, B., Gavazzi, S., Grossi, A. (2006) Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity. Leukemia Res. 30: 1-8
5. Borst, P., Schinkel, A. H. (1996) What have we learnt thus far from mice with disrupted P-glycoprotein genes? Eur. J. Cancer 32A: 985-990
6. Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D., Mitchell, J. B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47: 936-942
7. Chen, L. M., Liang, Y. J., Ruan, J. W., Ding, Y., Wang, X. W., Shi, Z., Gu, L. Q., Yang, X. P., Fu, L. W. (2004) Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318. J. Pharm. Pharmacol. 56: 1061-1066
8. Dimmock, J. R., Das, U., Gul, H. I., Kawase, M., Sakagami, H., Barath, Z., Ocsovsky, I., Molnar, J. (2005) 3-Arylidene-1-(4-nitrophenylmethylene)-3,4- dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells. Bioorg. Med. Chem. Lett. 15: 1633-1636
9. Fontaine, M., Elmquist, W. F., Miller, D. W. (1996) Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life Sci. 59: 1521-1531
10. Fu, L., Liang, Y., Deng, L., Ding, Y., Chen, L., Ye, Y., Yang, X., Pan, Q. (2004) Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Chemother. Pharmacol. 53: 349-356
11. Gao, L., Chen, L., Fei, X. H., Qiu, H. Y., Zhou, H., Wang, J. M. (2006) STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model. Chin. Med. J. (Engl.) 119: 911-918
12. Germann, U. A. (1996) P-glycoprotein-a mediator of multidrug resistance in tumour cells. Eur. J. Cancer 32A: 927-944
13. Hegmann, E. J., Bauer, H. C., Kerbel, R. S. (1992) Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Res. 52: 6969-6975
14. Ji, B. S., He, L., Li, X. Q., Liu, G. Q. (2006) CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells. Acta Pharmacol. Sin. 27: 414-418
15. Juliano, R. L., Ling, V. (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta Biomembranes 455: 152-162
16. Lambert, E., Rees, J. K., Twentyman, P. R. (1992) Resistance circumvention strategies tested in clinical leukaemia specimens using the MTT colorimetric assay. Leukemia 6: 1063-1071
17. Lella, J. W. (2001) Constructing history in biography: a symposium on William Osler: a life in medicine. Bliss's Osler. Bull. Hist. Med. 75: 760-766
18. Liu, Z. L., Hirano, T., Tanaka, S., Onda, K., Oka, K. (2003) Persistent reversal of P-glycoprotein-mediated daunorubicin resistance by tetrandrine in multidrug-resistant human T lymphoblastoid leukemia MOLT-4 cells. J. Pharm. Pharmacol. 55: 1531-1537
19. Ludescher, C., Thaler, J., Drach, D., Drach, J., Spitaler, M., Gattringer, C., Huber, H., Hofmann, J. (1992) Detection of activity of P-glycoprotein in human tumour samples using rhodamine 123. Br. J. Haematol. 82: 161-168
20. Mi, Q., Cui, B., Silva, G. L., Lantvit, D., Lim, E., Chai, H., You, M., Hollingshead, M. G., Mayo, J. G., Kinghorn, A. D., Pezzuto, J. M. (2001) Pervilleine A, a novel tropane alkaloid mat reverses the multidrug-resistance phenotype. Cancer Res. 61: 4030-4037
21. Mihalyi, A., Gaspar, R., Zalan, Z., Lazar, L., Fulop, F., de, W. P. (2004) Synthesis and multidrug resistance reversal activity of 1,2-disubstituted tetrahydroisoquinoline derivatives. Anticancer Res. 24: 1631-1636
22. Naito, M., Matsuba, Y., Sato, S., Hirata, H., Tsuruo, T. (2002) MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin. Cancer Res. 8: 582-588
23. Nakajima, T., Takayama, T., Miyanishi, K., Nobuoka, A., Hayashi, T., Abe, T., Kate, J., Sakon, K., Naniwa, Y., Tanabe, H., Niitsu, Y. (2003) Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S- benzylcysteinyl-D-phenylglycine ethylester. J. Pharmacol. Exp. Ther. 306: 861-869
24. Qi, J., Wang, S., Liu, G., Peng, H., Wang, J., Zhu, Z., Yang, C. (2004) Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. Biochem. Biophys. Res. Commun. 319: 1124-1131
25. Raderer, M., Scheithauer, W. (1993) Clinical trials of agents that reverse multidrug resistance. A literature review. Cancer 72: 3553-3563
26. Regina, A., Koman, A., Piciotti, M., El, H. B., Center, M. S., Bergmann, R., Couraud, P. O., Roux, F. (1998) Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J. Neurochem. 71: 705-715
27. Shiraishi, N., Akiyama, S., Nakagawa, M., Kobayashi, M., Kuwano, M. (1987) Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells. Cancer Res. 47: 2413-2416
28. Suzuki, T., Fukazawa, N., San-nohe, K., Sato, W., Yano, O., Tsuruo, T. (1997) Structure-activity relationship of newly synthesized quinoline derivatives for reversal of multidrug resistance in cancer. J. Med. Chem. 40: 2047-2052
29. Takakura, Y., Audus, K. L., Borchardt, R. T. (1992) Cultured brain microvessel endothelial cells as in vitro models of the blood-brain barrier. NIDA Res. Monogr. 120: 138-152
30. Teodori, E., Dei, S., Scapecchi, S., Gualtieri, F. (2002) The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Farmaco 57: 385-415
31. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., Willingham, M. C. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. U S A 84: 7735-7738
32. Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, Y., Tamai, I., Yamashima, T., Moritani, S., Tsuruo, T., Yamashita, J. (1992) P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51: 1427-1437
33. Wang, Q., Yang, H., Miller, D. W., Elmquist, W. F. (1995) Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats. Biochem. Biophys. Res. Commun. 211: 719-726
34. Zhu, H. J., Wang, J. S., Guo, Q. L., Jiang, Y., Liu, G. Q. (2005) Reversal of P-glycoprotein mediated multidrug resistance in K562 cell line by a novel synthetic calmodulin inhibitor, E6. Biol. Pharm. Bull. 28: 1974-1978