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Volumn 13, Issue 1, 2006, Pages 8-15

p16 expression in the female genital tract and its value in diagnosis

Author keywords

Diagnosis; Gynecologic neoplasms; Immunohistochemistry; p16

Indexed keywords

PROTEIN P16; PROTEIN P16INK4A; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

EID: 33644939223     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/01.pap.0000201828.92719.f3     Document Type: Review
Times cited : (208)

References (65)
  • 1
    • 0038819652 scopus 로고    scopus 로고
    • The INK 4a/ARF locus and melanoma
    • Sharpless NE, Chin L. The INK 4a/ARF locus and melanoma. Oncogene. 2003;22:3092-3098.
    • (2003) Oncogene , vol.22 , pp. 3092-3098
    • Sharpless, N.E.1    Chin, L.2
  • 2
    • 0035675513 scopus 로고    scopus 로고
    • The INK4a-ARF locus: Role in the genetic predisposition to familial melanoma and in skin carcinogenesis
    • Soufir N, Basset-Seguin N. The INK4a-ARF locus: role in the genetic predisposition to familial melanoma and in skin carcinogenesis. Bull Cancer. 2001;88:1061-1067.
    • (2001) Bull Cancer , vol.88 , pp. 1061-1067
    • Soufir, N.1    Basset-Seguin, N.2
  • 3
    • 0032589744 scopus 로고    scopus 로고
    • Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma
    • Xing EP, Nie Y, Song Y, et al. Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res. 1999;5:2704-2713.
    • (1999) Clin Cancer Res , vol.5 , pp. 2704-2713
    • Xing, E.P.1    Nie, Y.2    Song, Y.3
  • 4
    • 22144489899 scopus 로고    scopus 로고
    • INK4a/ARF: A multifunctional tumor suppressor locus
    • Sharpless NE. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res. 2005;576:22-38.
    • (2005) Mutat Res , vol.576 , pp. 22-38
    • Sharpless, N.E.1
  • 5
    • 0031716133 scopus 로고    scopus 로고
    • Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia
    • Sano T, Oyama T, Kashiwabara K, et al. Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia. Pathol Int. 1998;48:580-585.
    • (1998) Pathol Int , vol.48 , pp. 580-585
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3
  • 6
    • 0032589106 scopus 로고    scopus 로고
    • Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues
    • Nielsen GP, Stemmer-Rachamimov AO, Shaw J, et al. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab Invest. 1999;79:1137-1143.
    • (1999) Lab Invest , vol.79 , pp. 1137-1143
    • Nielsen, G.P.1    Stemmer-Rachamimov, A.O.2    Shaw, J.3
  • 7
    • 0035835818 scopus 로고    scopus 로고
    • p16 (MTS-1/CDKN2/INK4a) in cancer progression
    • Rocco JW, Sidransky D. p16 (MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res. 2001;264:42-55.
    • (2001) Exp Cell Res , vol.264 , pp. 42-55
    • Rocco, J.W.1    Sidransky, D.2
  • 8
    • 0030824829 scopus 로고    scopus 로고
    • Loss of Rb and MTS1/CDKN2 (P16) expression in human sarcomas
    • Cohen JA, Geradts J. Loss of Rb and MTS1/CDKN2 (P16) expression in human sarcomas. Hum Pathol. 1997;28:893-898.
    • (1997) Hum Pathol , vol.28 , pp. 893-898
    • Cohen, J.A.1    Geradts, J.2
  • 9
    • 0036916624 scopus 로고    scopus 로고
    • CDKN2A promoter methylation in gastric adenocarcinomas: Clinical variables
    • Vo QN, Geradts J, Boudreau DA, et al. CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables. Hum Pathol. 2002;33:1200-1204.
    • (2002) Hum Pathol , vol.33 , pp. 1200-1204
    • Vo, Q.N.1    Geradts, J.2    Boudreau, D.A.3
  • 10
    • 0032589956 scopus 로고    scopus 로고
    • P16-INK4A is regularly expressed in Hodgkin's disease: Comparison with retinoblastoma, p53 and MDM2 protein status and the presence of EBV
    • Guenova M, Rassidakis GZ, Gorgoulis VG, et al. P16-INK4A is regularly expressed in Hodgkin's disease: comparison with retinoblastoma, p53 and MDM2 protein status and the presence of EBV. Mod Pathol. 1999;12:1062-1071.
    • (1999) Mod Pathol , vol.12 , pp. 1062-1071
    • Guenova, M.1    Rassidakis, G.Z.2    Gorgoulis, V.G.3
  • 11
    • 0035163837 scopus 로고    scopus 로고
    • Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas
    • Bai M, Vlachoniklois J, Agnantis, et al. Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas. Mod Pathol. 2001;14:1105-1113.
    • (2001) Mod Pathol , vol.14 , pp. 1105-1113
    • Bai, M.1    Vlachoniklois, J.2    Agnantis3
  • 12
    • 0037330728 scopus 로고    scopus 로고
    • The p16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung
    • Beasley MB, Lantuejoul S, Abbondanzo S, et al. The p16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum Pathol. 2003;34:136-142.
    • (2003) Hum Pathol , vol.34 , pp. 136-142
    • Beasley, M.B.1    Lantuejoul, S.2    Abbondanzo, S.3
  • 13
    • 0042023334 scopus 로고    scopus 로고
    • Expression of p53, pRB, and p16 in lung tumours: A validation study on tissue microarrays
    • Levrsha MA, Fielding P, Watson S, et al. Expression of p53, pRB, and p16 in lung tumours: a validation study on tissue microarrays. J Pathol. 2003;200:610-619.
    • (2003) J Pathol , vol.200 , pp. 610-619
    • Levrsha, M.A.1    Fielding, P.2    Watson, S.3
  • 14
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol. 1998;153:1741-1748.
    • (1998) Am J Pathol , vol.153 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3
  • 15
    • 0035871985 scopus 로고    scopus 로고
    • Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    • Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001;92:276-284.
    • (2001) Int J Cancer , vol.92 , pp. 276-284
    • Klaes, R.1    Friedrich, T.2    Spitkovsky, D.3
  • 16
    • 0034962509 scopus 로고    scopus 로고
    • Ki-67, cyclin E and p16 are complimentary surrogate biomarkers for human papillomavirus-related cervical neoplasia
    • Keating JT, Cviko A, Reithdorf S, et al. Ki-67, cyclin E and p16 are complimentary surrogate biomarkers for human papillomavirus-related cervical neoplasia. Am J Surg Pathol. 2001;25:894-991.
    • (2001) Am J Surg Pathol , vol.25 , pp. 894-991
    • Keating, J.T.1    Cviko, A.2    Reithdorf, S.3
  • 17
    • 0344990170 scopus 로고    scopus 로고
    • Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus
    • Klussmann JP, Gultekin E, Weissenborn SJ, et al. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol. 2003;162:747-753.
    • (2003) Am J Pathol , vol.162 , pp. 747-753
    • Klussmann, J.P.1    Gultekin, E.2    Weissenborn, S.J.3
  • 18
    • 0038107598 scopus 로고    scopus 로고
    • Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA
    • Lu DW, El-Mofty S, Wang HL. Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNA. Mod Pathol. 2003;16:692-699.
    • (2003) Mod Pathol , vol.16 , pp. 692-699
    • Lu, D.W.1    El-Mofty, S.2    Wang, H.L.3
  • 19
    • 0034927426 scopus 로고    scopus 로고
    • Expression of cyclin-dependent kinase inhibitors p16, p21 and p27 in HPV-positive and HPV-negative cervical adenocarcinomas
    • Milde-Langosch K, Reithdorf S, Kraws-Poppinghaus A. Expression of cyclin-dependent kinase inhibitors p16, p21 and p27 in HPV-positive and HPV-negative cervical adenocarcinomas. Virchows Arch. 2001;439:55-61.
    • (2001) Virchows Arch , vol.439 , pp. 55-61
    • Milde-Langosch, K.1    Reithdorf, S.2    Kraws-Poppinghaus, A.3
  • 20
    • 17744387725 scopus 로고    scopus 로고
    • p16 INK4A immunoexpression and HPV in situ hybridization signal patterns: Potential markers of high-grade cervical intraepithelial neoplasia
    • Kalof AN, Evans MF, Simmons-Arnold L, et al. p16 INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia. Am J Surg Pathol. 2005;29:674-679.
    • (2005) Am J Surg Pathol , vol.29 , pp. 674-679
    • Kalof, A.N.1    Evans, M.F.2    Simmons-Arnold, L.3
  • 21
    • 13244262654 scopus 로고    scopus 로고
    • Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents
    • Hu L, Guo M, He Z, et al. Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol. 2005;18:267-273.
    • (2005) Mod Pathol , vol.18 , pp. 267-273
    • Hu, L.1    Guo, M.2    He, Z.3
  • 22
    • 3042851635 scopus 로고    scopus 로고
    • Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia
    • Tringler B, Gup CJ, Singh M, et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol. 2004;35:689-696.
    • (2004) Hum Pathol , vol.35 , pp. 689-696
    • Tringler, B.1    Gup, C.J.2    Singh, M.3
  • 23
    • 17844387136 scopus 로고    scopus 로고
    • p16 (INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies
    • Dray M, Russell P, Dulrymple C, et al. p16 (INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology. 2005;37:112-124.
    • (2005) Pathology , vol.37 , pp. 112-124
    • Dray, M.1    Russell, P.2    Dulrymple, C.3
  • 24
    • 0037770031 scopus 로고    scopus 로고
    • p16 (INK4a) expression correlates with degree of cervical neoplasia: A comparison with Ki67 expression and detection of high-risk HPV types
    • Agoff SN, Lin P, Morihara J, et al. p16 (INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki67 expression and detection of high-risk HPV types. Mod Pathol. 2003;16:665-673.
    • (2003) Mod Pathol , vol.16 , pp. 665-673
    • Agoff, S.N.1    Lin, P.2    Morihara, J.3
  • 25
    • 12144254382 scopus 로고    scopus 로고
    • p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri
    • Negri G, Vittadello F, Romano F, et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch. 2004;445:616-620.
    • (2004) Virchows Arch , vol.445 , pp. 616-620
    • Negri, G.1    Vittadello, F.2    Romano, F.3
  • 26
    • 16244395459 scopus 로고    scopus 로고
    • Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions
    • Guimaraes MC, Goncalves MA, Soares P, et al. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem. 2005;53:509-516.
    • (2005) J Histochem Cytochem , vol.53 , pp. 509-516
    • Guimaraes, M.C.1    Goncalves, M.A.2    Soares, P.3
  • 27
    • 17844374351 scopus 로고    scopus 로고
    • Histologic and immunohistochemical characteristics of neoplastic and nonneoplastic subgroups of atypical squamous lesions of the uterine cervix
    • Aoyama C, Liu P, Ostrzega N, et al. Histologic and immunohistochemical characteristics of neoplastic and nonneoplastic subgroups of atypical squamous lesions of the uterine cervix. Am J Clin Pathol. 2005;123:699-705.
    • (2005) Am J Clin Pathol , vol.123 , pp. 699-705
    • Aoyama, C.1    Liu, P.2    Ostrzega, N.3
  • 28
    • 0029817160 scopus 로고    scopus 로고
    • Interobserver variation in the reporting of cervical colposcopic biopsy specimens: Comparison of grading systems
    • McCluggage WG, Bharucha H, Caughley LM, et al. Interobserver variation in the reporting of cervical colposcopic biopsy specimens: comparison of grading systems. J Clin Pathol. 1996;49:833-835.
    • (1996) J Clin Pathol , vol.49 , pp. 833-835
    • McCluggage, W.G.1    Bharucha, H.2    Caughley, L.M.3
  • 29
    • 0036826860 scopus 로고    scopus 로고
    • p16 INK 4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
    • Klaes R, Benner A, Friedrich T, et al. p16 INK 4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002;26:1389-1399.
    • (2002) Am J Surg Pathol , vol.26 , pp. 1389-1399
    • Klaes, R.1    Benner, A.2    Friedrich, T.3
  • 30
    • 16244415576 scopus 로고    scopus 로고
    • Differentiating high-grade cervical intraepithelial lesion from atrophy in postmenopausalwomen using Ki-67, cyclin e and p16 immunohistochemical analysis
    • Qiao X, Bhuiya TA, Spitzer M. Differentiating high-grade cervical intraepithelial lesion from atrophy in postmenopausalwomen using Ki-67, cyclin E and p16 immunohistochemical analysis. J Low Genit Tract Dis. 2005;9:100-107.
    • (2005) J Low Genit Tract Dis , vol.9 , pp. 100-107
    • Qiao, X.1    Bhuiya, T.A.2    Spitzer, M.3
  • 31
    • 0036411845 scopus 로고    scopus 로고
    • Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia
    • Cameron RI, Maxwell P, Jenkins D, et al. Immunohistochemical staining with MIB1, bcl2 and p16 assists in the distinction of cervical glandular intraepithelial neoplasia from tubo-endometrial metaplasia, endometriosis and microglandular hyperplasia. Histopathology. 2002;41:313-321.
    • (2002) Histopathology , vol.41 , pp. 313-321
    • Cameron, R.I.1    Maxwell, P.2    Jenkins, D.3
  • 32
    • 0037531418 scopus 로고    scopus 로고
    • Immunohistochemical staining with p16 may assist in the distinction between endometrial and endocervical adenocarcinoma
    • McCluggage WG, Jenkins D. Immunohistochemical staining with p16 may assist in the distinction between endometrial and endocervical adenocarcinoma. Int J Gynecol Pathol. 2003;22:231-235.
    • (2003) Int J Gynecol Pathol , vol.22 , pp. 231-235
    • McCluggage, W.G.1    Jenkins, D.2
  • 33
    • 10744223520 scopus 로고    scopus 로고
    • The presence of high-risk HPV combined with specific p53 and p16 INK 4 a expression patterns points to high-risk HPV as the main causative agent for adenocarcinoma in situ and adenocarcinoma of the cervix
    • Zielinski GD, Snijders PJ, Rozendaal L, et al. The presence of high-risk HPV combined with specific p53 and p16 INK 4 A expression patterns points to high-risk HPV as the main causative agent for adenocarcinoma in situ and adenocarcinoma of the cervix. J Pathol. 2003;201:535-543.
    • (2003) J Pathol , vol.201 , pp. 535-543
    • Zielinski, G.D.1    Snijders, P.J.2    Rozendaal, L.3
  • 34
    • 0033054328 scopus 로고    scopus 로고
    • Infrequent occurrence of high-risk human papillomavirus and of p53 mutation in minimal deviation adenocarcinoma of the cervix
    • Toki T, Zhai YL, Park JS, et al. Infrequent occurrence of high-risk human papillomavirus and of p53 mutation in minimal deviation adenocarcinoma of the cervix. Int J Gynecol Pathol. 2002;18:215-219.
    • (2002) Int J Gynecol Pathol , vol.18 , pp. 215-219
    • Toki, T.1    Zhai, Y.L.2    Park, J.S.3
  • 35
    • 3342927802 scopus 로고    scopus 로고
    • Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: A possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'
    • Mikami Y, Kikoyawa T, Hata S, et al. Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum.' Mod Pathol. 2004;17:962-972.
    • (2004) Mod Pathol , vol.17 , pp. 962-972
    • Mikami, Y.1    Kikoyawa, T.2    Hata, S.3
  • 36
    • 13444259742 scopus 로고    scopus 로고
    • Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: Clinicopathologic features, human papillomavirus DNA detection and p16 expression
    • Parwani AV, Smith Sehdev AE, Kurman RJ, et al. Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection and p16 expression. Hum Pathol. 2005;36:82-90.
    • (2005) Hum Pathol , vol.36 , pp. 82-90
    • Parwani, A.V.1    Smith Sehdev, A.E.2    Kurman, R.J.3
  • 37
    • 0033775524 scopus 로고    scopus 로고
    • Stratified mucin-producing intraepithelial lesions of the cervix: Adenosquamous or columnar cell neoplasia?
    • Park JJ, Sun D, Quade BJ, et al. Stratified mucin-producing intraepithelial lesions of the cervix: adenosquamous or columnar cell neoplasia? Am J Surg Pathol. 2000;24:1414-1419.
    • (2000) Am J Surg Pathol , vol.24 , pp. 1414-1419
    • Park, J.J.1    Sun, D.2    Quade, B.J.3
  • 38
    • 0037289732 scopus 로고    scopus 로고
    • p16 INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: An immunohistochemical study with immunocytochemical correlations
    • Negri G, Egarter-Vigl E, Kasal A, et al. p16 INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol. 2003;27:187-193.
    • (2003) Am J Surg Pathol , vol.27 , pp. 187-193
    • Negri, G.1    Egarter-Vigl, E.2    Kasal, A.3
  • 39
    • 12144251609 scopus 로고    scopus 로고
    • p16INK4a positivity in benign, premalignant and malignant cervical glandular lesions: A potential diagnostic problem
    • Murphy N, Heffron CC, Ling B, et al. p16INK4a positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem. Virchow Arch. 2004;445:610-615.
    • (2004) Virchow Arch , vol.445 , pp. 610-615
    • Murphy, N.1    Heffron, C.C.2    Ling, B.3
  • 40
    • 0036742794 scopus 로고    scopus 로고
    • Human papillomaviruses, expression of p16 and early endocervical glandular neoplasia
    • Riethdorf L, Riethdorf S, Lee KR, et al. Human papillomaviruses, expression of p16 and early endocervical glandular neoplasia. Hum Pathol. 2002;33:899-904.
    • (2002) Hum Pathol , vol.33 , pp. 899-904
    • Riethdorf, L.1    Riethdorf, S.2    Lee, K.R.3
  • 41
    • 0036134086 scopus 로고    scopus 로고
    • The fruits of our labors: Distinguishing endometrial from endocervical adenocarcinoma
    • Zaino RJ. The fruits of our labors: distinguishing endometrial from endocervical adenocarcinoma. Int J Gynecol Pathol. 2002;21:1-3.
    • (2002) Int J Gynecol Pathol , vol.21 , pp. 1-3
    • Zaino, R.J.1
  • 42
    • 1642494668 scopus 로고    scopus 로고
    • Distinction of endocervical and endometrial adenocarcinomas: Immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection
    • Ansari-Lari MA, Staebler A, Zaino RJ, et al. Distinction of endocervical and endometrial adenocarcinomas: immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol. 2004;28:160-167.
    • (2004) Am J Surg Pathol , vol.28 , pp. 160-167
    • Ansari-Lari, M.A.1    Staebler, A.2    Zaino, R.J.3
  • 43
    • 0036134073 scopus 로고    scopus 로고
    • A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin and estrogen receptor aids the distinction between primary endometrial and endocervical adenocarcinomas
    • McCluggage WG, Sumathi VP, McBride HA, et al. A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin and estrogen receptor aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol. 2002;21:11-15.
    • (2002) Int J Gynecol Pathol , vol.21 , pp. 11-15
    • McCluggage, W.G.1    Sumathi, V.P.2    McBride, H.A.3
  • 44
    • 0036134090 scopus 로고    scopus 로고
    • Distinction between endometrial and endocervical adenocarcinoma: An immunohistochemical study
    • Castillon DH, Lee KR, Nucci MR, et al. Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study. Int J Gynecol Pathol. 2002;21:4-10.
    • (2002) Int J Gynecol Pathol , vol.21 , pp. 4-10
    • Castillon, D.H.1    Lee, K.R.2    Nucci, M.R.3
  • 45
    • 3042719735 scopus 로고    scopus 로고
    • Detection of human papillomavirus DNA and expression of p16, Rb and p53 proteins in small cell carcinomas of the uterine cervix
    • Wang HL, Lu DW. Detection of human papillomavirus DNA and expression of p16, Rb and p53 proteins in small cell carcinomas of the uterine cervix. Am J Surg Pathol. 2004;28:901-908.
    • (2004) Am J Surg Pathol , vol.28 , pp. 901-908
    • Wang, H.L.1    Lu, D.W.2
  • 46
    • 0141705411 scopus 로고    scopus 로고
    • p16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix
    • Masumoto N, Fuji T, Ishikawa M, et al. p16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. Hum Pathol. 2003;34:778-783.
    • (2003) Hum Pathol , vol.34 , pp. 778-783
    • Masumoto, N.1    Fuji, T.2    Ishikawa, M.3
  • 47
    • 11144284047 scopus 로고    scopus 로고
    • p16(INK4A) is a surrogate biomarker for a subset of human papilloma virus associated dysplasias of the uterine cervix as determined on the Pap smear
    • Bose S, Evans H, Lantzy L, et al. p16(INK4A) is a surrogate biomarker for a subset of human papilloma virus associated dysplasias of the uterine cervix as determined on the Pap smear. Diagn Cytopathol. 2005;32:21-24.
    • (2005) Diagn Cytopathol , vol.32 , pp. 21-24
    • Bose, S.1    Evans, H.2    Lantzy, L.3
  • 48
    • 15544371798 scopus 로고    scopus 로고
    • Is p16(INK4A) expression more useful than human papilloma virus test to determine the outcome of atypical squamous cells of uncertain significance-categorised Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies
    • Nieh S, Chen SF, Chu TY, et al. Is p16(INK4A) expression more useful than human papilloma virus test to determine the outcome of atypical squamous cells of uncertain significance-categorised Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol. 2005;97:35-40.
    • (2005) Gynecol Oncol , vol.97 , pp. 35-40
    • Nieh, S.1    Chen, S.F.2    Chu, T.Y.3
  • 49
    • 1842853122 scopus 로고    scopus 로고
    • Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing: A comparative study using simultaneously sampled histology materials
    • Yoshida T, Fukuda T, Sano T, et al. Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing: a comparative study using simultaneously sampled histology materials. Cancer. 2004;102:100-108.
    • (2004) Cancer , vol.102 , pp. 100-108
    • Yoshida, T.1    Fukuda, T.2    Sano, T.3
  • 50
    • 1342263744 scopus 로고    scopus 로고
    • P16INK4a as an adjunct marker in liquid-based cervical cytology
    • Sahebali S, Depudyt CE, Segers K, et al. P16INK4a as an adjunct marker in liquid-based cervical cytology. Int J Cancer. 2004;108:871-876.
    • (2004) Int J Cancer , vol.108 , pp. 871-876
    • Sahebali, S.1    Depudyt, C.E.2    Segers, K.3
  • 51
    • 25444450573 scopus 로고    scopus 로고
    • Abnormalities of the Rb1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16 (INK4a) protein
    • Armes JE, Lourie R, de Silva M, et al. Abnormalities of the Rb1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16 (INK4a) protein. Int J Gynecol Pathol. 2005;24:363-368.
    • (2005) Int J Gynecol Pathol , vol.24 , pp. 363-368
    • Armes, J.E.1    Lourie, R.2    De Silva, M.3
  • 52
    • 0032762958 scopus 로고    scopus 로고
    • Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma
    • Zhai YL, Nikaido T, Orii A, et al. Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma. Gynecol Oncol. 1999;75:453-459.
    • (1999) Gynecol Oncol , vol.75 , pp. 453-459
    • Zhai, Y.L.1    Nikaido, T.2    Orii, A.3
  • 53
    • 10044225693 scopus 로고    scopus 로고
    • Expression of p16 protein in patients with uterine smooth muscle tumors: An immunohistochemical analysis
    • Bodner-Adler B, Bodner K, Czerwenka K, et al. Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis. Gynecol Oncol. 2005;96:62-66.
    • (2005) Gynecol Oncol , vol.96 , pp. 62-66
    • Bodner-Adler, B.1    Bodner, K.2    Czerwenka, K.3
  • 54
    • 3042821926 scopus 로고    scopus 로고
    • Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva
    • Santos M, Montagut C, Mellado B, et al. Immunohistochemical staining for p16 and p53 in premalignant and malignant epithelial lesions of the vulva. Int J Gynecol Pathol. 2004;23:206-214.
    • (2004) Int J Gynecol Pathol , vol.23 , pp. 206-214
    • Santos, M.1    Montagut, C.2    Mellado, B.3
  • 55
    • 10944224979 scopus 로고    scopus 로고
    • p16 INK4A expression as biomarker for HPV16-related vulvar neoplasias
    • Riethdorf S, Neffen EF, Cviko A, et al. p16 INK4A expression as biomarker for HPV16-related vulvar neoplasias. Hum Pathol. 2004;35:1477-1483.
    • (2004) Hum Pathol , vol.35 , pp. 1477-1483
    • Riethdorf, S.1    Neffen, E.F.2    Cviko, A.3
  • 56
    • 0034089176 scopus 로고    scopus 로고
    • Vulvar intraepithelial neoplasia of the simplex (differentiated) type: A clinicopathological study including analysis of HPV and p53 expression
    • Yang B, Hart WR. Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathological study including analysis of HPV and p53 expression. Am J Surg Pathol. 2000;24:429-441.
    • (2000) Am J Surg Pathol , vol.24 , pp. 429-441
    • Yang, B.1    Hart, W.R.2
  • 57
    • 0028868250 scopus 로고
    • Vulvar intraepithelial neoplasia. Morphological phenotype, papillomavirus DNA and coexisting invasive carcinoma
    • Kaefner HK, Tate JE, Mc Lachlin CM, et al. Vulvar intraepithelial neoplasia. Morphological phenotype, papillomavirus DNA and coexisting invasive carcinoma. Hum Pathol. 1995;26:147-154.
    • (1995) Hum Pathol , vol.26 , pp. 147-154
    • Kaefner, H.K.1    Tate, J.E.2    Mc Lachlin, C.M.3
  • 58
    • 20644455963 scopus 로고    scopus 로고
    • Simplex (differentiated) type VIN: Absence of p16 INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers
    • Ruhul Quddus M, Xu C, Steinhoff MM, et al. Simplex (differentiated) type VIN: absence of p16 INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. Histopathology. 2005;46:718-720.
    • (2005) Histopathology , vol.46 , pp. 718-720
    • Ruhul Quddus, M.1    Xu, C.2    Steinhoff, M.M.3
  • 59
    • 0030955478 scopus 로고    scopus 로고
    • Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis
    • Dong Y, Walsh MD, McGuckin MA, et al. Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Int J Cancer. 1997;74:57-63.
    • (1997) Int J Cancer , vol.74 , pp. 57-63
    • Dong, Y.1    Walsh, M.D.2    McGuckin, M.A.3
  • 60
    • 14644442941 scopus 로고    scopus 로고
    • Synchronous and metachronous endocervical and ovarian neoplasms: Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms
    • Elishaev E, Gilks CB, Miller D, et al. Synchronous and metachronous endocervical and ovarian neoplasms: evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol. 2005;29:281-294.
    • (2005) Am J Surg Pathol , vol.29 , pp. 281-294
    • Elishaev, E.1    Gilks, C.B.2    Miller, D.3
  • 61
    • 22944486725 scopus 로고    scopus 로고
    • An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas. Significantly higher expression of p53, MIB1, BCL2, HER-2/neu and C-KIT in high-grade neoplasms
    • O'Neill CJ, Deavers MT, Malpica A, et al. An immunohistochemical comparison between low-grade and high-grade ovarian serous carcinomas. Significantly higher expression of p53, MIB1, BCL2, HER-2/neu and C-KIT in high-grade neoplasms. Am J Surg Pathol. 2005;29:1034-1041.
    • (2005) Am J Surg Pathol , vol.29 , pp. 1034-1041
    • O'Neill, C.J.1    Deavers, M.T.2    Malpica, A.3
  • 62
    • 2642583203 scopus 로고    scopus 로고
    • A multistep model for ovarian tumorigenesis: The value of mutation analysis in the KRAS and BRAF genes
    • Russell HE, McCluggage WG. A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes. J Pathol. 2004;203:617-619.
    • (2004) J Pathol , vol.203 , pp. 617-619
    • Russell, H.E.1    McCluggage, W.G.2
  • 63
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shih IM, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol. 2004;164:1511-1518.
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shih, I.M.1    Kurman, R.J.2
  • 64
    • 0037216291 scopus 로고    scopus 로고
    • Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: Invasive MPSC (low-grade tumor) and conventional serous carcinoma
    • Singer G, Shih IM, Truskinovsky A, et al. Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma. Int J Gynecol Pathol. 2003;22:37-41.
    • (2003) Int J Gynecol Pathol , vol.22 , pp. 37-41
    • Singer, G.1    Shih, I.M.2    Truskinovsky, A.3
  • 65
    • 12844251290 scopus 로고    scopus 로고
    • Patterns of p53 mutations separate ovarian serous borderline tumors and low and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: A mutational analysis with immunohistochemical correlation
    • Singer G, Stohr R, Cope L, et al. Patterns of p53 mutations separate ovarian serous borderline tumors and low and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. Am J Surg Pathol. 2005;29:218-224.
    • (2005) Am J Surg Pathol , vol.29 , pp. 218-224
    • Singer, G.1    Stohr, R.2    Cope, L.3


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