Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals

Cytometry Part B - Clinical Cytometry

Volumn 86, Issue 2, 2014, Pages 121-134

  Hudig, Dorothy ^a   Hunter, Kenneth W ^a   Diamond, W John ^a   Redelman, Doug ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

CD14; CD16; CD163; CD33; CD91; HLA DQ; HLA DR; monocytes

Indexed keywords

ANTIGEN; B7 ANTIGEN; CD11B ANTIGEN; CD14 ANTIGEN; CD244 ANTIGEN; CD33 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; TIA 1 ANTIGEN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; CD244 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LEUKOCYTE ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CELL POLARITY; FEMALE; FLOW CYTOMETRY; HEMATOLOGY ANALYZER; HUMAN; IMMUNOPATHOLOGY; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTE; NEUTROPHIL COUNT; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; YOUNG ADULT; BLOOD; CYTOLOGY; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL;

ADULT; ANTIGENS, CD; ANTIGENS, CD4; FEMALE; FLOW CYTOMETRY; HEALTHY VOLUNTEERS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; MALE; RECEPTORS, IMMUNOLOGIC;

EID: 84896718384     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.21141     Document Type: Article

References (115)

1. Kennedy DW, Abkowitz JL,. Mature monocytic cells enter tissues and engraft. Proc Natl Acad Sci U S A 1998; 95: 14944-9149.
2. Hume DA, Ross IL, Himes SR, Sasmono RT, Wells CA, Ravasi T,. The mononuclear phagocyte system revisited. J Leukoc Biol 2002; 72: 621-627. (Pubitemid 36277831)
3. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K,. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 2003; 9: 61-67. (Pubitemid 36098261)
4. Schnizlein-Bick CT, Sherman MR, Boggs DL, Leemhuis TB, Fife KH,. Incidence of HIV infection in monocyte subpopulations characterized by CD4 and HLA-DR surface density. Aids 1992; 6: 151-156.
5. Dudhane A, Wang ZQ, Orlikowsky T, Gupta A, Wormser GP, Horowitz H, Kufer P, Hoffmann MK,. AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules. AIDS Res Hum Retroviruses 1996; 12: 893-899. (Pubitemid 26230786)
6. Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS,. Unique monocyte subset in patients with AIDS dementia. Lancet 1997; 349: 692-695. (Pubitemid 27107748)
7. Zembala M, Bach S, Szczepanek A, Mancino G, Colizzi V,. Phenotypic changes of monocytes induced by HIV-1 gp120 molecule and its fragments. Immunobiology 1997; 197: 110-121. (Pubitemid 27355084)
8. Abel PM, McSharry C, Galloway E, Ross C, Severn A, Toner G, Gruer L, Wilkinson PC,. Heterogeneity of peripheral blood monocyte populations in human immunodeficiency virus-1 seropositive patients. FEMS Microbiol Immunol 1992; 5: 317-323.
9. Schlueter AJ, Glasgow JK,. Phenotypic comparison of multiple monocyte-related populations in murine peripheral blood and bone marrow. Cytometry Part A 2006; 69A: 281-290.
10. Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ,. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest 2007; 117: 195-205. (Pubitemid 46048466)
11. Tacke F, Alvarez D, Kaplan TJ, Jakubzick C, Spanbroek R, Llodra J, Garin A, Liu J, Mack M, van Rooijen N, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 2007; 117: 185-194. (Pubitemid 46048465)
12. Philbrick WM, Palfree RG, Maher SE, Bridgett MM, Sirlin S, Bothwell AL,. The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur J Immunol 1990; 20: 87-92. (Pubitemid 20087032)
13. Passlick B, Flieger D, Ziegler-Heitbrock HW,. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989; 74: 2527-2534. (Pubitemid 19286475)
14. +) monocytes and regular monocytes in human blood. Pathobiology 1991; 59: 127-130.
15. Qureshi SS, Lewis SM, Gant VA, Treacher D, Davis BH, Brown KA,. Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS). Clin Exp Immunol 2001; 125: 258-265. (Pubitemid 32758437)
16. Li Y, Lee PY, Kellner ES, Paulus M, Switanek J, Xu Y, Zhuang H, Sobel ES, Segal MS, Satoh M, et al. Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus. Arthritis Res Ther 2010; 12: R90.
17. Redelman D, Hudig D, Berner MD, Castell LM, Roberts DE, Ensign WY,. Determining quantitative immunophenotypes and evaluating their implications. Proc Int Soc Opt Eng 2002; 4622: 218-227.
18. Hudig D, Hunter KW, Diamond WJ, Redelman D,. Properties of Human Blood Monocytes. I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression. Cytometry Part B. 2014; 86B: 111-120.
19. Coder DM, Redelman D, Vogt RF,. Computing the central location of immunofluorescence distributions: Logarithmic data transformations are not always appropriate. Cytometry 1994; 18: 75-78. (Pubitemid 24219288)
20. Overton WR,. Modified histogram subtraction technique for analysis of flow cytometry data. Cytometry 1988; 9: 619-626. (Pubitemid 18264743)
21. Bagwell B,. A journey through flow cytometric immunofluorescence analyses-Finding accurate and robust algorithms that estimate positive fraction distributions. Clin Immunol Newsletter 1996; 16: 33-37.
22. + cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 16: 83-92.
23. Iyer SB, Hultin LE, Zawadzki JA, Davis KA, Giorgi JV,. Quantitation of CD38 expression using QuantiBRITE beads. Cytometry 1998; 33: 206-212. (Pubitemid 28447145)
24. Coetzee LM, Tay SS, Lawrie D, Janossy G, Glencross DK,. From research tool to routine test: CD38 monitoring in HIV patients. Cytometry Part B Clin Cytom 2009; 76B: 375-384.
25. Musso T, Deaglio S, Franco L, Calosso L, Badolato R, Garbarino G, Dianzani U, Malavasi F,. CD38 expression and functional activities are up-regulated by IFN-gamma on human monocytes and monocytic cell lines. J Leukoc Biol 2001; 69: 605-612. (Pubitemid 32294846)
26. Villanueva JL, Solana R, Alonso MC, Pena J,. Changes in the expression of HLA-class II antigens on peripheral blood monocytes from aged humans. Dis Markers 1990; 8: 85-91. (Pubitemid 20204862)
27. Colbaugh P, Stastny P,. Antigens in human monocytes. III. Use of monocytes in typing for HLA-D related (DR) antigens. Transplant Proc 1978; 10: 871-874. (Pubitemid 9093789)
28. Chuang SS, Kumaresan PR, Mathew PA,. 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol 2001; 167: 6210-6216. (Pubitemid 33081549)
29. Bai Y, Fu S, Honig S, Wang Y, Qin L, Chen D, Bromberg JS,. CD2 is a dominant target for allogeneic responses. Am J Transplant 2002; 2: 618-626. (Pubitemid 36306853)
30. Romero X, Benitez D, March S, Vilella R, Miralpeix M, Engel P,. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 2004; 64: 132-144. (Pubitemid 38969577)
31. Mathew SO, Vaidya SV, Kim JR, Mathew PA,. Human natural killer cell receptor 2B4 (CD244) down-regulates its own expression by reduced promoter activity at an Ets element. Biochem Biophys Res Commun 2007; 355: 483-487. (Pubitemid 46282654)
32. Medley QG, Kedersha N, O'Brien S, Tian Q, Schlossman SF, Streuli M, Anderson P,. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. Proc Natl Acad Sci U S A 1996; 93: 685-689. (Pubitemid 26048553)
33. Meehan SM, McCluskey RT, Pascual M, Preffer FI, Anderson P, Schlossman SF, Colvin RB,. Cytotoxicity and apoptosis in human renal allografts: Identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA. Lab Invest 1997; 76: 639-649.
34. Orlikowsky T, Dannecker GE, Wang Z, Horowitz H, Niethammer D, Hoffmann MK,. Activation or destruction of T cells via macrophages. Pathobiology 1999; 67: 298-301. (Pubitemid 30135928)
35. Rae F, Woods K, Sasmono T, Campanale N, Taylor D, Ovchinnikov DA, Grimmond SM, Hume DA, Ricardo SD, Little MH,. Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev Biol 2007; 308: 232-246. (Pubitemid 47087792)
36. Gronlund J, Vitved L, Lausen M, Skjodt K, Holmskov U,. Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages. J Immunol 2000; 165: 6406-6415.
37. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK,. Identification of the haemoglobin scavenger receptor. Nature 2001; 409 (6817): 198-201. (Pubitemid 32144285)
38. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A,. Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-555. (Pubitemid 35223554)
39. Biswas A, Banerjee P, Mukherjee G, Biswas T,. Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response. Mol Immunol 2007; 44: 812-820. (Pubitemid 44429977)
40. Henning LN, Azad AK, Parsa KV, Crowther JE, Tridandapani S, Schlesinger LS,. Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol 2008; 180: 7847-7858.
41. - human monocyte subsets. J Immunol 1984; 133: 1293-1299. (Pubitemid 14060080)
42. Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K,. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 2000; 165: 6635-6643.
43. Kristensen T, Moestrup SK, Gliemann J, Bendtsen L, Sand O, Sottrup-Jensen L,. Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett 1990; 276: 151-155.
44. Strickland DK, Ashcom JD, Williams S, Burgess WH, Migliorini M, Argraves WS,. Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem 1990; 265: 17401-17404.
45. Binder RJ, Han DK, Srivastava PK,. CD91: A receptor for heat shock protein gp96. Nat Immunol 2000; 1: 151-155.
46. Basu S, Binder RJ, Ramalingam T, Srivastava PK,. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 2001; 14: 303-313. (Pubitemid 32289294)
47. Duus K, Hansen EW, Tacnet P, Frachet P, Arlaud GJ, Thielens NM, Houen G,. Direct interaction between CD91 and C1q. Febs J 2010; 277: 3526-3537.
48. Duus K, Thielens NM, Lacroix M, Tacnet P, Frachet P, Holmskov U, Houen G,. CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site. Febs J 2010; 277: 4956-4964.
49. Riera N, Galassi N, Felippo M, Ruibal-Ares B, Perez Bianco R, de Bracco M,. Increased CD4-positive monocytes in HIV-infected haemophilic patients. Haemophilia 1998; 4: 725-730. (Pubitemid 28442428)
50. Tuttle DL, Harrison JK, Anders C, Sleasman JW, Goodenow MM,. Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1. J Virol 1998; 72: 4962-4969. (Pubitemid 28215676)
51. + T lymphocytes as a biological calibrator. Cytometry 1998; 33: 123-132. (Pubitemid 28447136)
52. Davis KA, Abrams B, Iyer SB, Hoffman RA, Bishop JE,. Determination of CD4 antigen density on cells: Role of antibody valency, avidity, clones, and conjugation. Cytometry 1998; 33: 197-205. (Pubitemid 28447144)
53. Brown MH, Boles K, van der Merwe PA, Kumar V, Mathew PA, Barclay AN,. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med 1998; 188: 2083-2090. (Pubitemid 28562525)
54. Latchman Y, McKay PF, Reiser H,. Identification of the 2B4 molecule as a counter-receptor for CD48. J Immunol 1998; 161: 5809-8512.
55. Valiante NM, Trinchieri G,. Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J Exp Med 1993; 178: 1397-1406. (Pubitemid 23277371)
56. Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH,. Cutting edge: Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol 1999; 162: 6981-6985. (Pubitemid 29277663)
57. Nakajima H, Cella M, Langen H, Friedlein A, Colonna M,. Activating interactions in human NK cell recognition: The role of 2B4-CD48. Eur J Immunol 1999; 29: 1676-1683. (Pubitemid 29224473)
58. Dong Z, Davidson D, Perez-Quintero LA, Kurosaki T, Swat W, Veillette A,. The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. Immunity 2012; 36: 974-985.
59. Lund FE, Cockayne DA, Randall TD, Solvason N, Schuber F, Howard MC,. CD38: A new paradigm in lymphocyte activation and signal transduction. Immunol Rev 1998; 161: 79-93.
60. Funaro A, Malavasi F,. Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker. J Biol Regul Homeost Agents 1999; 13: 54-61.
61. Deaglio S, Morra M, Mallone R, Ausiello CM, Prager E, Garbarino G, Dianzani U, Stockinger H, Malavasi F,. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol 1998; 160: 395-402. (Pubitemid 28116754)
62. Fernandez JE, Deaglio S, Donati D, Beusan IS, Corno F, Aranega A, Forni M, Falini B, Malavasi F,. Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues. J Biol Regul Homeost Agents 1998; 12: 81-91. (Pubitemid 28470074)
63. Lande R, Urbani F, Di Carlo B, Sconocchia G, Deaglio S, Funaro A, Malavasi F, Ausiello CM,. CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes. Cell Immunol 2002; 220: 30-38. (Pubitemid 36444497)
64. Aksoy P, White TA, Thompson M, Chini EN,. Regulation of intracellular levels of NAD: A novel role for CD38. Biochem Biophys Res Commun 2006; 345: 1386-1392. (Pubitemid 43817885)
65. Arnaout MA, Todd RF 3rd, Dana N, Melamed J, Schlossman SF, Colten HR,. Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest 1983; 72: 171-179. (Pubitemid 13026640)
66. Brown EJ,. Complement receptors and phagocytosis. Curr Opin Immunol 1991; 3: 76-82.
67. Brunialti MK, Martins PS, Barbosa de Carvalho H, Machado FR, Barbosa LM, Salomao R,. TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock. Shock 2006; 25: 351-357.
68. Cifarelli V, Libman IM, Deluca A, Becker D, Trucco M, Luppi P,. Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children. Rev Diabet Stud 2007; 4: 112-117.
69. Aydin M, Onuk T, Dogan SM, Yildirim N, Demirci E, Kalaycioglu E, Madak H, Aktop Z, Ali Cetiner M, Sayin MR, et al. [The effect of statin treatment on inflammation in patients with metabolic syndrome]. Turk Kardiyol Dern Ars 2009; 37: 26-34.
70. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999; 274: 33419-33425. (Pubitemid 129511647)
71. Akira S,. Toll-like receptors: Lessons from knockout mice. Biochem Soc Trans 2000; 28: 551-556.
72. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A,. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 2000; 97: 13766-13771.
73. Flo TH, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, Sundan A, Espevik T,. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol 2001; 69: 474-481. (Pubitemid 32221453)
74. Kornbluth RS, Edgington TS,. Tumor necrosis factor production by human monocytes is a regulated event: Induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin. J Immunol 1986; 137: 2585-2591. (Pubitemid 17176616)
75. Beutler B,. Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity. Curr Opin Microbiol 2000; 3: 23-28. (Pubitemid 30094259)
76. Means TK, Lien E, Yoshimura A, Wang S, Golenbock DT, Fenton MJ,. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J Immunol 1999; 163: 6748-6755.
77. Kuwahata S, Fujita S, Orihara K, Hamasaki S, Oba R, Hirai H, Nagata K, Ishida S, Kataoka T, Oketani N, et al. High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease. Atherosclerosis 2010; 209: 248-254.
78. Orihara K, Nagata K, Hamasaki S, Oba R, Hirai H, Ishida S, Kataoka T, Oketani N, Ogawa M, Mizoguchi E, et al. Time-course of Toll-like receptor 2 expression, as a predictor of recurrence in patients with bacterial infectious diseases. Clin Exp Immunol 2007; 148: 260-270. (Pubitemid 46587596)
79. Kajiya T, Orihara K, Hamasaki S, Oba R, Hirai H, Nagata K, Kumagai T, Ishida S, Oketani N, Ichiki H, et al. Toll-like receptor 2 expression level on monocytes in patients with viral infections: Monitoring infection severity. J Infect 2008; 57: 249-259.
80. McDaniel DO, Zhou X, Moore CK, Aru G,. Cardiac allograft rejection correlates with increased expressions of Toll-like receptors 2 and 4 and allograft inflammatory factor 1. Transplant Proc 2010; 42: 4235-4237.
81. Haziot A, Chen S, Ferrero E, Low MG, Silber R, Goyert SM,. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol 1988; 141: 547-552.
82. Bazil V, Baudys M, Hilgert I, Stefanova I, Low MG, Zbrozek J, Horejsi V,. Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14. Mol Immunol 1989; 26: 657-662. (Pubitemid 19188482)
83. Bazil V, Strominger JL,. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J Immunol 1991; 147: 1567-1574.
84. Kruger C, Schutt C, Obertacke U, Joka T, Muller FE, Knoller J, Koller M, Konig W, Schonfeld W,. Serum CD14 levels in polytraumatized and severely burned patients. Clin Exp Immunol 1991; 85: 297-301.
85. Wuthrich B, Kagi MK, Joller-Jemelka H,. Soluble CD14 but not interleukin-6 is a new marker for clinical activity in atopic dermatitis. Arch Dermatol Res 1992; 284: 339-342.
86. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC,. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249 (4975): 1431-1433.
87. Ulevitch RJ, Tobias PS,. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995; 13: 437-457.
88. Schutt C, Schilling T, Kruger C,. sCD14 prevents endotoxin inducible oxidative burst response of human monocytes. Allerg Immunol (Leipz) 1991; 37 (3-0000): 159-164.
89. + T lymphocytes. J Immunol 1990; 144: 574-582. (Pubitemid 20036086)
90. Kedersha N, Anderson P,. Stress granules: Sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans 2002; 30 (Pt 6): 963-969. (Pubitemid 36002389)
91. Piecyk M, Wax S, Beck AR, Kedersha N, Gupta M, Maritim B, Chen S, Gueydan C, Kruys V, Streuli M, et al. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. Embo J 2000; 19: 4154-4163. (Pubitemid 30608553)
92. Dixon DA, Balch GC, Kedersha N, Anderson P, Zimmerman GA, Beauchamp RD, Prescott SM,. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med 2003; 198: 475-481. (Pubitemid 36976058)
93. Lopez de Silanes I, Galban S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M,. Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol 2005; 25: 9520-9531. (Pubitemid 41507852)
94. Carballo E, Lai WS, Blackshear PJ,. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 1998; 281 (5379): 1001-1005. (Pubitemid 28399252)
95. Anderson P, Phillips K, Stoecklin G, Kedersha N,. Post-transcriptional regulation of proinflammatory proteins. J Leukoc Biol 2004; 76: 42-47. (Pubitemid 38857170)
96. Phillips K, Kedersha N, Shen L, Blackshear PJ, Anderson P,. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc Natl Acad Sci U S A 2004; 101: 2011-2016. (Pubitemid 38229006)
97. Carreno BM, Collins M,. The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002; 20: 29-53. (Pubitemid 34293419)
98. Terstappen LW, Hollander Z, Meiners H, Loken MR,. Quantitative comparison of myeloid antigens on five lineages of mature peripheral blood cells. J Leukoc Biol 1990; 48: 138-148. (Pubitemid 20227109)
99. Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML,. The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol 1999; 29: 3440-3449. (Pubitemid 29527791)
100. Mingari MC, Vitale C, Romagnani C, Falco M, Moretta L,. p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells. Immunol Rev 2001; 181: 260-268. (Pubitemid 32703413)
101. Hernandez-Caselles T, Martinez-Esparza M, Perez-Oliva AB, Quintanilla-Cecconi AM, Garcia-Alonso A, Alvarez-Lopez DM, Garcia-Penarrubia P,. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: Two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol 2006; 79: 46-58. (Pubitemid 43054249)
102. Perez-Oliva AB, Martinez-Esparza M, Vicente-Fernandez JJ, Corral-San Miguel R, Garcia-Penarrubia P, Hernandez-Caselles T,. Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells. Glycobiology 2011; 21: 757-770.
103. Zhou H, Su HS, Zhang X, Douhan J 3rd, Glimcher LH,. CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. J Immunol 1997; 158: 4741-4749. (Pubitemid 127483794)
104. de Preval C, Lisowska-Grospierre B, Loche M, Griscelli C, Mach B,. A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes. Nature 1985; 318 (6043): 291-293. (Pubitemid 16206732)
105. Steimle V, Otten LA, Zufferey M, Mach B,. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 1993; 75: 135-146. (Pubitemid 23306027)
106. Fontes JD, Kanazawa S, Nekrep N, Peterlin BM,. The class II transactivator CIITA is a transcriptional integrator. Microbes Infect 1999; 1: 863-869.
107. Schnappauf F, Hake SB, Camacho Carvajal MM, Bontron S, Lisowska-Grospierre B, Steimle V,. N-terminal destruction signals lead to rapid degradation of the major histocompatibility complex class II transactivator CIITA. Eur J Immunol 2003; 33: 2337-2347. (Pubitemid 37010051)
108. Rigaud G, De Lerma Barbaro A, Nicolis M, Cestari T, Ramarli D, Riviera AP, Accolla RS,. Induction of CIITA and modification of in vivo HLA-DR promoter occupancy in normal thymic epithelial cells treated with IFN-gamma: Similarities and distinctions with respect to HLA-DR-constitutive B cells. J Immunol 1996; 156: 4254-4258.
109. Piskurich JF, Wang Y, Linhoff MW, White LC, Ting JP,. Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene. J Immunol 1998; 160: 233-240. (Pubitemid 28116734)
110. Ziegler-Heitbrock HW,. Definition of human blood monocytes. J Leukoc Biol 2000; 67: 603-606.
111. Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM,. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 2000; 164: 6166-6173. (Pubitemid 30408793)
112. Stein M, Keshav S, Harris N, Gordon S,. Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation. J Exp Med 1992; 176: 287-292.
113. Goerdt S, Orfanos CE,. Other functions, other genes: Alternative activation of antigen-presenting cells. Immunity 1999; 10: 137-142. (Pubitemid 29115619)
114. Park SY, Jung MY, Lee SJ, Kang KB, Gratchev A, Riabov V, Kzhyshkowska J, Kim IS,. Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J Cell Sci 2009; 122: 3365-3373.
115. + cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993; 150: 3070-3079. (Pubitemid 23127556)