AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules

AIDS Research and Human Retroviruses

Volumn 12, Issue 10, 1996, Pages 893-899

  Dudhane, Anita ^a   Wang, Zhi Qin ^a   Orlikowsky, Thorsten ^a   Gupta, Asha ^a   Wormser, Gary P ^a   Horowitz, Harold ^a   Kufer, Peter ^b   Hoffmann, Michael K ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; PRIORITY JOURNAL; PROGNOSIS; T LYMPHOCYTE SUBPOPULATION;

EID: 0029900829     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1996.12.893     Document Type: Article

References (26)

1. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, and Axel R: The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986;47:333.
2. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, and Fauci AS: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature (London) 1993;362:355.
3. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, and Haase AT: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature (London) 1993;362:359.
4. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, et al.: Viral dynamics in human immunodeficiency virus type 1 infection. Nature (London) 1995;373:117.
5. Ho DD, Neumann AU, Perlson AS, Chen W, Leonard JM, and Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (London) 1995;373:123.
6. Dudhane A, Conti B, Orlikowsky T, Wang ZQ, Mangla N, Gupta A, Wormser GP, and Hoffmann MK: Monocytes in HIV type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity. AIDS Res Hum Retroviruses 1996;12:885-892.
7. Blum MD, Wong GT, Higgins KM, Sunshine MJ, and Lacy E: Reconstruction of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of trangenic mice: Identification of a human CD4 enhancer. J Exp Med 1993;177:1343.
8. Dannecker G, Mecheri S, Staiano-Coico L, and Hoffmann MK: A characteristic Mls-1a response precedes Mls-1a anergy in vivo. J Immunol 1991;146:2083.
9. Chapman B, Thayer RM, Vincent KA, and Haigwood N: Effect of intron A from human cytomegalovirus immediate-early gene on heterologous expression in mammalian cells. Nucleic Acids Res 1991;19:3979.
10. Scandella CJ, Kilpatrick J, Lidster W, Parker C, Moore JP, Moore GK, Mann KA, Brown P, Coates S, Chapman B, et al.: Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development. AIDS Res Hum Retroviruses 1993;9:1233.
11. Krauss S, Kufer P, Federle C, Tabaszewski P, Weiss E, Rieber EP, and Riethmuller G: Recombinant CD4 IgE, a novel hybrid molecule inducing basophils to respond to human immunodeficiency virus and HIV-infected target cells. Eur J Immunol 1995;25:192.
12. Riethmuller G, Rieber RB, Kiefersauer S, Prinz J, van der Lubbe B, Meiser B, Breedvelt F, Eisenburg J, Kruger K, Deusch K, Sanders M, and Reiter C: From antilymphocyte serum to therapeutic monoclonal antibodies: First experiences with a chimeric CD4 antibody in the treatment of autoimmune disease. Immunol Rev 1992;129:81-104.
13. Van de Winkel JG and Capel PJ: Human Fc receptor heterogeneity: Molecular aspects and clinical implications. Immunol Today 1993;14:215.
14. Nathan C, Murray H, and Cahn ZA: The macrophage as an effector cell. N Engl J Med 1980;303:622.
15. Wang ZQ, Orlikowsky T, Dudhane A, Mittler R, Blum M, Lacy E, Riethmuller G, and Hoffmann MK: Deletion of T lymphocytes in human CD4 transgenic mice induced by HIV-gp120 and gp120-specific antibodies from AIDS patients. Eur J Immunol 1994;24:1553.
16. Wang ZQ, Dudhane A, Orlikowsky T, Clarke K, Li X, Darzynkiewicz Z, and Hoffmann MK: CD4 engagement induces Fas Ag dependent apoptosis of T cells in vivo. Eur J Immunol 1994;24:1549.
17. + cell function down-regulation in AIDS patients. J Immunol 1992;148:2709.
18. Daniel V, Susal C, Weimer R, Zimmerman R, Huth-Kuhne A, and Opelz G: Association of T cell and macrophage dysfunction with surface gp120-immunoglobulin-complement complexes in HIV-1-infected patients. Clin Exp Immunol 1993;93:152.
19. Van de Winkel JG and Capel PJ: Human FcR heterogeneity; molecular aspects and clinical implications. Immunol Today 1993; 14:215.
20. Mittler RS and Hoffmann MK: Synergism between gp120 and gp120-specific antibody in the suppression of CD4-positive T cells. Science 1989;245:1380.
21. Banda NK, Bernier J, Kurahara DK, Kurrle R, Haigwood N, Sekaly NP, and Finkel TH. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 1992;176:1099.
22. Oyaizu N, McCloskey TW, Corondesi M, Chirmule N, and Pahwa S: Accelerated apoptosis in peripheral blood mononuclear cells from HIV infected patients and CD4 crosslinked PBMC from normal individuals. Blood 1993;82:3392.
23. + T cells from HIV-infected asymptomatic individuals. J Exp Med 1992; 175:331-340.
24. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RP, and Miedema F: Programmed death of T cells in HIV-1 infection. Science 1992;257:217-219.
25. Li DC, Friedman DJ, Wang C, Metcher V, and Pardee AD: Induction of apoptosis in uninfected lymphocytes by HIV Tat protein. Science 1995;268:429.
26. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin K, and Krammer PH: Sensitization of cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (London) 1995;375:497.