CD38: A new paradigm in lymphocyte activation and signal transduction

Immunological Reviews

Volumn 161, Issue , 1998, Pages 79-93

  Lund, Frances E ^a   Cockayne, Debra A ^b   Randall, Troy D ^a   Solvason, Nanette ^c   Schuber, Francis ^d   Howard, Maureen C ^e  

^a TRUDEAU INSTITUTE   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d CNRS   (France)

^e GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD38 ANTIGEN; GLYCOPROTEIN;

B LYMPHOCYTE; CALCIUM TRANSPORT; HEMATOPOIETIC CELL; HUMORAL IMMUNITY; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADP-RIBOSYL CYCLASE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; NAD+ NUCLEOSIDASE; SIGNAL TRANSDUCTION;

EID: 0031910151     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01573.x     Document Type: Review

References (82)

1. Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF. Discrete stages of intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of the T lineage. Proc Natl Acad Sci USA 1980;77:1588-1592.
2. Brohee D, Cauchie P, Kennes B, Neve P, Vanhaeverbeek M. CD38 expression and CD38 CD10 coexpression by bone marrow lymphocytes in various diseases. Med Sci Res 1995;23:783-785.
3. Funaro A, et al. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J Immunol 1990;145:2390-2396.
4. Santos-Argumedo L, Teixeira C, Preece G, Kirkham PA, Parkhouse RME. A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels. J Immunol 1993;151:3119-3130.
5. Zupo S, Rugari E, Dono M, Taborelli G, Malavasi F, Ferrarini M. CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells. Eur J Immunol 1994;24:1218-1222.
6. Yamashita Y, Miyake K, Kikuchi Y, Takatsu K, Noda S, Kosugi A. A monoclonal antibody against a murine CD38 homologue delivers a signal to B cells for prolongation of survival and protection against apoptosis in vitro: unresponsiveness of X-linked immunodeficient B cells. Immunology 1995;85:248-255.
7. Kumagai M, et al. Ligation of CD38 suppresses human B lymphopoiesis. J Exp Med 1995;181:1101-1110.
8. Ausiello CM, Urbani F, la Sala F, Funaro A, Malavasi F. CD38 Ligation induces discrete cytokine mRNA expression in human cultured lymphocytes. Eur J Immunol 1995;25:1477-1480.
9. Lund FE, Yu N, Kim K-M, Reth M, Howard MC. Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression. J Immunol 1996;157:1455-1467.
10. Jackson DG, Bell JI. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol 1990;144:2811-2815.
11. Harada N, et al. Expression cloning of a cDNA encoding a novel murine B cell activation marker. J Immunol 1993;151:3111-3118.
12. Alessio M, et al. CD38 molecule: Structural and biochemical analysis on human T lymphocytes, thymocytes, and plasma cells. J Immunol 1990;145:878-884.
13. Deaglio S, et al. Human CD38 ligand: A 120-KDA protein predominantly expressed on endothelial cells. J Immunol 1996;156:727-734.
14. Howard M, et al. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 1993;262:1056-1059.
15. Takasawa S. et al. Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J Biol Chem 1993;268:26052-26054.
16. Summerhill RJ, Jackson DG, Galione A. Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP-ribose. FEBS Lett 1993;335:231-233.
17. + glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribosyl hydrolase activities at the outer surface of human erythrocytes. Biochem Biophys Res Commun 1993;196: 1459-1465.
18. Thompson LF, Ruedi JM, Glass A, Low MG, Lucas AH. Antibodies to 5′-nucleotidase (CD73), a glycosyl-phosphatidylinositol-anchored protein, cause human peripheral blood T cells to proliferate. J Immunol 1989;143:1815-1821.
19. Misumi Y, Ogata S, Ohkubo K, Hirose S. Ikehara Y. Primary structure of human placental 5′-nucleotidase and identification of the glycolipid anchor in the mature form. Eur J Biochem 1990;191:563-569.
20. Klemens MR, Sherman WR, Holmberg NJ, Ruedi JM, Low MG, Thompson LF. Characterization of soluble vs. membrane bound human placental 5′-nucleotidise. Biochem Biophys Res Commun 1990;172: 1371-1377.
21. Massaia M, et al. Synergy between CD73 (ecto-5′-nucleotidase) and signals delivered through CD3 and CD2 molecules. J Immunol 1990;145:1664-1674.
22. Wonigeit K, Schwinzer R. Polydonal activation of rat T lymphocytes by RT6 alloantisera. Transplant Proc 1987;19:296-299.
23. Takada T, Iida K, Moss J. Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2. J Biol Chem 1994;269:9420-9423.
24. Koch-Nolte F, et al. Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl) transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins. J Biol Chem 1996;271:7686-7693.
25. Lee HC, Graeff RM, Walseth TF. ADP-ribosyl cydase and CD38. Adv Exp Med Biol 1997;419:411-419.
26. Clapper DL, Walseth TF, Dargie PJ, Lee HC. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol triphosphate. J Biol Chem 1987;262:9561-9568.
27. Dirgie PJ, Agee MC, Lee HC. Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol triphosphate. Cell Regul 1990;1:279-280.
28. 2+release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science 1991;253:1143-1146.
29. Koguma T, et al. Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of langerhans. Biochim Biophys Acta 1994;1224:160-162.
30. Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout DC. Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectoenzyme CD38. Nat Struct Biol 1996;3:957-964.
31. - thymocytes. Int Immunol 1995;7:213-221.
32. Oliver AM, Martin F, Kearney JF. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol 1997;158:1108-1115.
33. Solvason N, et al. Distribution and function of CD38 on mouse hematopoietic cells. (Submitted)
34. Mehta K, Shahid U, Malavasi F. Human CD38, a cell-surface protein with multiple functions. FASEB J 1996;10:1408-1417.
35. Randall TD, Lund FE, Howard MC, Weissman IL. Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood 1996;87:4057-4067.
36. Terstappen LWMM, Huang S, Safford M, Landsorp PM, Loken MR. Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+ CD38- progenitor cells. Blood 1991;77:1218-1227.
37. Arpin C, et al. Generation of memory B cells and plasma cells in vitro. Science 1995;268:720-722.
38. Lund FE, et al. Signaling through murine CD38 is impaired in antigen receptor unresponsive B cells. Eur J Immunol 1995;25:1338-1345.
39. Thomas JD, Sideras P, Smith CIE, Vorechovsky I, Chapman V, Paul WE. Colocalization of X-linked agammaglobulinemia and X linked immunodeficiency genes. Science 1993;216:355-358.
40. Rawlings DJ, et al. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 1993;261:358-361.
41. Santos-Argumedo L, et al. CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction. Int Immunol 1994;7:163-170.
42. Goodnow CC, et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1988;334:676-682.
43. Cooke MP, et al. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med 1994;179:425-438.
44. Healy JI, et al. Different Nuclear Signals are activated by the B cell receptor during positive versus negative signaling. Immunity 1997;6:419-428.
45. Taira S, Matsui M, Hayakawa K, Yokoyama T, Nariuchi H. Interleukin 2 secretion by B cell lines and splenic B cells stimulated with calcium ionophore and phorbol ester. J Immunol 1987;139:2957-2964.
46. Justement LB, Kreiger J, Cambier JC. Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol 1989;143:881-889.
47. Kakiuchi T, Tamura T, Gyotoku Y, Nariuchi H. IL-2 production by B cells stimulated with a specific antigen. Cell Immunol 1991;138:207-215.
48. Gold MR, Crowley MT, Martin GA, McCormick F, De Franco AL. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP associated proteins. J Immunol 1993;150:377-386.
49. Diegel ML, Rankin BM, Bolen JB, Dubois PM, Kiener PA. Cross-linking of Fcg receptor to surface immunoglobulin on B cells provides an inhibitory signal that closes the plasma membrane calcium channel. J Biol Chem 1994;269:11409-11416.
50. Vuica M, Desidero S, Schneck JP. Differential effects of B cell receptor and B cell receptor-FcgRIIB1 engagement on docking of csk to GTPase-activating protein (GAP)-associated p62. J Exp Med 1997;186:259-267.
51. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994;76:263-274.
52. Crabtree GR, Clipstone NA. Signal transmission between the plasma membrane and the nucleus of T lymphocytes. Annu Rev Biochem 1994;63:1045-1083.
53. Choi MSK, Brines RD, Holman MJ, Klaus GGB. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1994;1:179-187.
54. Venkataraman L, Francis DA, Wang Z, Liu J, Rothstein TL, Sen R. Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity 1994;1:189-196.
55. Francis DA, Karras JG, Ke XY, Sen R, Rothstein TL. Induction of the transcription factors NF-kB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int Immunol 1995;7:151-161.
56. Kindler V, Matthes T, Jeannin P, Zubler RH. Interleukin-2 secretion by human B lymphocytes occurs as a late event and requires additional stimulation after CD40 cross-linking. Eur J Immunol 1995;25:1239-1243.
57. Heinzel FP, Sadick MS, Mutha S, Locksley RM. Production of interferon-gamma, interleukin-2, interleukin-4 and interleukin-10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 1991;88:7011-7015.
58. Kim K-M, Alber G, Weiser P, Reth M. Differential signaling through the Ig-α and Ig-β components of the B cell antigen receptor. Eur J Immunol 1993;23:911-916.
59. Galione A, White A, Willmott N, Turner M, Potter BVL, Watson SP. cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature 1993;365:456-459.
60. 2+ release induced by cyclic ADP-ribose. Trends Cell Biol 1994;4:431-436.
61. Shaw AC, Mitchell RN, Weaver YK, Campos-Torres J, Abbas AK, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell 1990;63:381-392.
62. Blum JH, Stevens TL, DeFranco AL. Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction. J Biol Chem 1993;268:27236-27245.
63. Lund FE, Muller-Steffner HM, Yu N, Stout CD, Schuber F, Howard M. CD38 signaling is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose. (Submitted)
64. Hellmich MR, Strumwasser F. Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul 1991;2:193-202.
65. Lee HC, Aarhus R. ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium mobilizing metabolite. Cell Regul 1991;2:203-209.
66. Sitsapesan R, McGarry SJ, Williams AJ. Cyclic ADP-ribose, the ryanodine receptor and Ca2+ release. Trends Pharmacol Sci 1995;16:386-391.
67. 2+ channel. Nature 1993;354:76-78.
68. Muller-Steffner HM, Augustin A, Schuber F. Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase. J Biol Chem 1996;271:23967-23972.
69. Kim H, Jacobson EL, Jacobson MK. Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases. Science 1993;261:1330-1333.
70. Kukimoto I, et al. Stimulation of ADP-ribosyl cyclase activity of the cell surface antigen CD38 by zinc ions resulting from inhibition of its NAD+ glycohydrolase activity. Eur J Biochem 1996;239:177-182.
71. Graeff RM, Walseth TF, Fryxell K, Branton WD, Lee HC. Enzymatic synthesis and characterization of cyclic GDP-ribose. J Biol Chem 1994;269:30260-30267.
72. Aarhus R, Graeff RM, Dickey DM, Walseth TF, Lee HC. ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium mobilizing metabolite from NADP. J Biol Chem 1995;270:30327-30333.
73. De Flora A, et al. CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium mobilizing activity of cyclic ADP-ribose. J Biol Chem 1997;272:12945-12951.
74. Tohgo A, et al. Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase. J Biol Chem 1997;272:3879-3882.
75. Guida L, Franco L, Zocchi E, De Flora A. Structural role of disulphide bridges in the cyclic ADP-ribose related bifunctional ectoenzyme CD38. FEBS Lett 1995;368:481-484.
76. Tohgo A, et al. Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. J Biol Chem 1994;269:28555-28557.
77. Grimaldi JC, et al. CD38-mediated ribosylation of proteins. J Immunol 1995;155:811-817.
78. Sprang SR. G protein mechanisms: insights from structural analysis. Annu Rev Biochem 1997;66:639-678.
79. Cockayne D, et al. Mice deficient for the ecto-NAD+ glycohydrolase CD38 exhibit altered humoral immune responses. (Submitted)
80. Price SR, Pekala PH. Pyridine nucleotide-linked glycohydrolases. In: Dolphin D, Poulson R, Avramovic D, eds. Pyridine Nucleotide Coenzymes: Chemical, Biochemical, and Medical Aspects. Vol 2B. New York: John Wiley & Sons, Inc. 1987. p. 513-548.
81. Berthelier B, Tixier J-M, Muller-Steffner H, Schuber F, Deterre P. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J 1997 (In press).
82. Mond JJ, Lees A, Snapper CM. T cell independent antigens type-2. Annu Rev Immunol 1995;13:655-692.