Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker

Journal of Biological Regulators and Homeostatic Agents

Volumn 13, Issue 1, 1999, Pages 54-61

  Funaro, A ^a   Malavasi, F ^a  

^a Biologia e Biochimica   (Italy)

Author keywords

Ectoenzyme; Human CD38; Surface receptor; Transmembrane signaling

Indexed keywords

CALCIUM; CD38 ANTIGEN; CELL ADHESION MOLECULE; CELL ENZYME; CELL MARKER; CELL SURFACE RECEPTOR; HYALURONIC ACID; LIGAND; MEMBRANE ENZYME; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CELL MEMBRANE; CELL SURFACE; CELL SURVIVAL; COENZYME; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; HEMATOPOIETIC SYSTEM; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKOCYTE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; SIGNAL TRANSDUCTION;

EID: 0033303239     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (121)

1. Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T cell lineage
2. Expression cloning of a cDNA encoding a novel murine B cell activation marker
3. Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homolog to human CD38) from islet of Langherans
4. BP-3 alloantigen. A cell surface glycoprotein that marks early B lineage cells in mice
5. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase
6. Cloning of a cDNA encoding rat bone marrow stromal cell antigen (BST-1) from the islets of Langherans
7. Structure and function of eukaryotic mono-ADP-ribosyl transferases
8. Similarities in aminoacid sequence of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38
9. Human CD38: A glycoprotein in search of a function
10. Characterization of a murine monoclonal antibody specific for human early lymphohemopoietic cells
11. Immunotyping of blasts in human bone marrow
12. Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10
13. CD38: A multilineage cell activation molecule with a split personality
14. Ligation of CD38 suppresses human B lymphopoiesis
15. Expression of surface markers after B lymphocyte activation
16. Human CD38: A versatile leukocyte marker with emerging clinical perspectives
17. Expression of cyclic ADP-ribose-synthesizing CD38 molecule on human platelet membranes
18. + glycohydolase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes
19. Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-α
20. Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues
21. High expression of a CD3 8-like molecule in normal prostatic epithelium and its differential loss in benign and malignant disease
22. A molecule on the cell surface of murine B lymphocytes mediating activation and protection from apoptosis via calcium channels
23. Murine CD38: An immunoregulatory ectoenzyme
24. Reticular cells in peripheral lymphoid tissues express the phosphatidylinositol-linked BP-3 antigen
25. BST-1 a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth
26. + cells in the rat
27. Defects in the structure and expression of the genes for the T cell Marker Rt6 in NZW and (NZBxNZW)F1 mice
28. CD38 molecule: Structural and biochemical analysis on human T lymphocytes, thymocytes and plasma cells
29. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with unusual discontinuous pattern of expression during lymphocyte differentiation
30. Post-translational modification of CD38 into a high molecular weight form modulates its catalytic functions
31. Identification and characterization of an active soluble form of human CD38 in normal and pathological fluids
32. Characterization of a CD38-like 78-Kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia
33. Human CD38, a cell surface protein with multiple functions
34. + glycohydrolase to a functional domain in the carboxyl terminus
35. Cell surface antigen CD38 identified as ectoenzyme of NAD glycohydrolase has hyaluronate-binding activity
36. Essential cysteine residees for cyclic ADP-ribose synthesis and hydrolysis by CD38
37. The murine BP-3 gene encodes a relative of the CD38/NAD glycohydrolase family
38. Crystal structure of Aplysia ADP ribosyl cyclase, a homomolgue of the bifunctional ectoenzyme CD38
39. Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells
40. Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15
41. Molecular cloning of CD38
42. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): Organization, nucleotide sequence and alternative splicing
43. +-converting enzymes. Extensive structural homology with the genes for murine BST-1 and Aplysian ADP-ribosyl cyclase
44. The structure of Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme
45. The metamorphosis of a molecule: From soluble enzyme to the leukocyte receptor CD38
46. Mice deficient for the ecto-nicotinamide dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses
47. Genomic structure of human BST-1
48. + lymphocytes. Role of the human CD38 molecule
49. Human CD38 ligand: A 120-kDa protein predominantly expressed by endothelial cells
50. Human CD38 (ADP-ribosyl cyclase) is a counter receptor of CD31, an Ig superfamily member
51. Lymphocyte adhesion to endothelium
52. CD38 binding to human myeloid cells is mediated by mouse and human CD31
53. CD38 functions are regulated through an internalization step
54. Role of CD38 and its ligand in the regulation of MHC non-restricted cytotoxic T cells
55. 1 glycohydrolase
56. Cyclic ADP-ribose: Metabolism and calcium mobilizing function
57. Purification and characterization of a molluscan egg-specific NADase, a second messenger enzyme
58. Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells
59. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38
60. ADP-ribosyl cyclase and CD38
61. +-dependent internalization of the transmembrane glycoprotein CD38 in human Namalva B cells
62. +-dependent internalization of recombinant CD38 in CHO cells
63. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation
64. CD38 ligation induces discrete cytokine mRNA expression in human cultured lymphocytes
65. Secretion of IFN- γ, IL-6, granulocyte-macrophage colony-stimulating factor and IL-10 cytokines after activation of human purified T lymphocytes upon CD38 ligation
66. CD38 Panel report
67. Functional associations of CD38 with CD3 on T cell membrane
68. CD38 is functionally dependent of TCR/CD3 complex in human T cells
69. CD3 8 ligation results in activation of the Raf-MAP kinase and CD3-ξ/ZAP-70 signaling pathways in Jurkat T lymphocytes
70. Signaling through murine CD38 is impaired in antigen receptor unresponsive B cells
71. Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression
72. CD38: A new paradigm in lymphocyte activation and signal transduction
73. Role of human CD38 in B cell activation and proliferation
74. CD38-mediated growth suppression of B-cells progenitors requires activation of phosphatidylinositol 3-kinase and involves its association with the protein product of the c-cbl proto-oncogene
75. A role for BP-3/BST-1 antigen in early T cell development
76. Nurse-like cells from bone marrow and synovium of patient with rheumatoid arthritis promote survival and enhance function of human B cells
77. CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells
78. CD38-mediated signaling events in murine pro-B cells expressing human CD38 with or without its cytoplasmic domain
79. CD38 signal transduction in human B cell precursors: Rapid induction of tyrosine phosphorylation on phospholipase C-γ and phosphatidylinositol 3-kinase
80. CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase
81. Tyrosine phosphorylation of c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells
82. CD38 ligation induces tyrosine phosphorylation of Bruton Tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: Synergistic effect with IL-5
83. IL-S induces isotype switch recombination in mouse CD38-activated sIgD-positive lymphocytes
84. The mechanism of interleukin-4-induced down-regulation of human B cells
85. Human CD38 is associated to distinct molecules which mediate transmembrane signaling in different lineages
86. Rapid induction of the CD38 molecule on myeloid leukemia cells by all-trans retinoic acid
87. Retinoid-mediated signaling pathways in CD38 antigen expression in myeloid leukemia cells
88. Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines
89. Protein-tyrosine phosphorylation by CD38 monoclonal antibodies is mediated through stimulation of the FcγII receptors in human myeloid cell lines
90. Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells
91. Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP-ribose
92. The lymphocyte antigen CD38 acts as a nicotinamide adenin dinucleotide glycohydrolase in human T lymphocytes
93. Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP
94. ADP-ribosyl cyclase and CD38 catalyze the synthesis of calcium mobilizing metabolite from NADP
95. Self-aggregation of purified membrane erythrocyte CD38 induces extensive decrease of its ADP-ribosyl cyclase activity
96. The CD38/cyclic ADP-ribose system: A topological paradox
97. +-dependent internalization of the transmembrane glycoprotein CD38 in human Namalva B cells
98. + transport across cell membrane
99. CD38 unresponsiveness of Xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction
100. Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells: Enhanced insulin secretion in CD38-expressing transgenic mice
101. CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADR-ribose
102. Two novel members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxin
103. CD38-mediated ribosylation of protein
104. Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADP ribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins
105. Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody
106. Anti-B4-blocked ricin: A phase I trial of 7-day continuous infusion in patients with B neoplasm
107. Anti-CD38-blocked ricin: An immunotoxin for the treatment of multiple myeloma
108. Systemic therapy with 3BIT, a triple combination cocktail of anti-CD19, -CD22, and -CD38-saporin immunotoxins, is curative of human B-cell lymphoma in severe combined immunodeficient mice
109. CD38 expression distinguishes two groups of B cells-chronic lymphocytic leukemias with different response to anti-IgM antibodies and propensity to apoptosis
110. Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: Evidence of CD8 cell immaturity
111. + T cell levels: Results of 6 years follow-up
112. + cytotoxic T cells express CD38 and HLA-DR antigens
113. + T cells predict the decline of CD4 T cells in HIV-1 infected patients
114. + T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency
115. Potential role of membrane CD38 in protection against cell death induced by HIV-1
116. Neuronal localization of CD38 antigen in human brain
117. Immunoreactivity in Alzheimer's neurofibrillary tangles
118. Cyclic ADP-ribose in insulin secretion from pancreatic β cells
119. The CD38-cyclic ADP-ribose signaling system in insulin secretion: Molecular basis and clinical implications
120. 2+]i, and insulin secretion
121. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis