Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism

International Journal of Oncology

Volumn 44, Issue 3, 2014, Pages 830-837

  Ghoneum, Mamdooh ^a   Gimzewski, James ^b  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Caspase; Hl60 AR cells; Lactobacillus kefiri

Indexed keywords

ANTILEUKEMIC AGENT; CASPASE 3; KEFIR; PROBIOTIC AGENT; PROBIOTICS FERMENTATION TECHNOLOGY KEFIR GRAIN PRODUCT; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FERMENTATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTOBACILLUS; LACTOBACILLUS KEFIRI; LEUKEMIA CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CULTURED MILK PRODUCTS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84896716352     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2258     Document Type: Article

References (53)

1. Metchinkoff E and Metchinkoff II: The Prolongation of Life: Optimistic Studies. Putnam, New York, NY, pp109-132, 1908.
2. Shiby VK and Mishra HN: Fermented milks and milk products as functional foods - a review. Crit Rev Food Sci Nutr 53: 482-496, 2013.
3. Ahmed Z, Wang Y, Ahmad A, Khan ST, Nisa M, Ahmad H and Afreen A: Kefir and health: a contemporary perspective. Crit Rev Food Sci Nutr 53: 422-434, 2013.
4. Bianchi-Salvadori B: Intestinal microflora: the role of yoghurt in the equilibrium of the gut ecosystem. Int J Immunother 11 (Suppl): 9-18, 1986.
5. Kanmani P, Satish Kumar R, Yuvaraj N, Paari KA, Pattukumar V and Arul V: Probiotics and its functionally valuable products - a review. Crit Rev Food Sci Nutr 53: 641-658, 2013.
6. Marco ML, Pavan S and Kleerebezem M: Towards understanding molecular modes of probiotic action. Cur Opin Biotechnol 17: 204-210, 2006.
7. Metchnikoff E: Sur le flore du corps humain (On the flora of the Human body). Manch Lit Philos Soc 45: 1-38, 1901.
8. Bergonzelli GE, Blum S, Brussow H and Corthesy-Theulaz I: Probiotics as a treatment strategy for gastrointestinal diseases? Digestion 72: 57-68, 2005.
9. Pala V, Sieri S, Berrino F, Vineis P, Sacerdote C, Palli D, Masala G, Panico S, Mattiello A, Tumino R, Giurdanella MC, Agnoli C, Grioni S and Krogh V: Yogurt consumption and risk of colorectal cancer in the Italian European prospective investigation into cancer and nutrition cohort. Int J Cancer 129: 2712-2719, 2011.
10. Goldin BR, Gualtieri LJ and Moore RP: The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer 25: 197-204, 1996.
11. Shackelford LD, Rao DR, Chawan CB and Pulasani SR: Effect of feeding fermented milk on the incidence of chemically induced colon tumors in rats. Nutr Cancer 5: 159-164, 1983.
12. Bogdanov IG, Dalev PG, Gurevich LA, Kolosov MN and Malkova VP: Antitumor effect of glycopeptides from the cell wall of Lactobacillus bulgaricus . Biull Eksp Biol Med 84: 709-712, 1977.
13. Biffi A, Coradini D, Larsen R, Riva L and Di Fronzo G: Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line. Nutr Cancer 28: 93-99, 1997.
14. Van't Veer P, Dekker JM, Lamars JWJ, Kok FJ and Schouten EG: Consumption of fermented milk products and breast cancer: a case-control study in The Netherlands. Cancer Res 49: 4020-4023, 1989.
15. Van't Veer P, van Leer EM, Rietdijk A, Kok FJ, Schouten EG, Hermus RJ and Sturmans F: Combination of dietary factors in relation to breast-cancer occurrence. Int J Cancer 47: 649-653, 1991.
16. Le MG, Moulton LH, Hill C and Kramer A: Consumption of dairy products and alcohol in a case control study of breast cancer. J Natl Cancer Inst 77: 633-636, 1986.
17. Cramer DW, Harlow BL, Willett W, Welch WR, Bell DA, Scully RE, Ng WG and Knapp RC: Galactose consumption and metabolism in relation to the risk of ovarian cancer. Lancet 2: 66-71, 1989.
18. Iyer C, Kosters A, Sethi G, Kunnumakkara AB, Aggarwal BB and Versalovic J: Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cell Microbiol 10: 1442-1452, 2008.
19. Chiu YH, Hsieh YJ, Liao KW and Peng KC: Preferential promotion of apoptosis of monocytes by Lactobacillus casei rhamnosus soluble factors. Clin Nutr 29: 131-140, 2010.
20. Hertzler SR and Clancy SM: Kefir improves lactose digestion and tolerance in adults with lactose maldigestion. J Am Diet Assoc 103: 582-587, 2003:
21. Maeda H, Zhu X, Omura K, Suzuki S and Kitamura S: Effects of an exopolysaccharide (kefiran) on lipids, blood pressure, blood glucose, and constipation. Biofactors 22: 197-200, 2004.
22. Suzuki K, Tani H, Yabumoto T, Yabumoto Y and Yoshida Y: Novel fermented milk product and use thereof. US Patent No. US 20110123640 A1. May 2011.
23. Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT and Gimzewski JK: Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano 4: 1921-1926, 2010.
24. Palmeira A, Sousa E, Vasconcelos MH and Pinto MM: Three decades of P-gp inhibitors: skimming through several generations and scaffolds. Curr Med Chem 19: 1946-2025, 2012.
25. Binkhathlan Z and Lavasanifar A: P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives. Curr Cancer Drug Targets 13: 326-346, 2013.
26. Gollapudi S, Singh H and Gupta S: Effect of 12-deoxyphorbol 13-phenylacetate on daunorubicin resistance and calcium-independent protein-kinase-C isozymes in drug-sensitive murine leukemia p388 cells. Int J Oncol 4: 849-851, 1994.
27. Gollapudi S, Kim CH, Tran BN, Sangha S and Gupta S: Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells. Cancer Chemother Pharmacol 40: 150-158, 1997.
28. Lai BB, Chen BA, Cheng J, Gao F, Xu WL, Ding JH, Gao C, Sun XC, Li GH, Chen WJ, Liu LJ, Li XM and Wang XM: Daunorubicin-loaded magnetic nanoparticles of Fe(3)O(4) greatly enhance the responses of multidrug-resistant K562 leukemic cells in a nude mouse xenograft model to chemotherapy. Zhongguo Shi Yan Xue Ye Xue Za Zhi 17: 345-351, 2009.
29. Cheng J, Wang J, Chen B, Xia G, Cai X, Liu R, Ren Y, Bao W and Wang X: A promising strategy for overcoming MDR in tumor by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin. Int J Nanomedicine 6: 2123-2131, 2011.
30. Tavan E, Cayuela C, Antoine JM, Trugnan G, Chaugier C and Cassand P: Effects of dairy products on heterocyclic aromatic amine induced rat colon carcinogenesis. Carcinogenesis 23: 477-483, 2002.
31. Lidbeck A, Nord CE, Gustafsson JA and Rafter J: Lactobacilli, anticarcinogenic activities and human intestinal microflora. Eur J Cancer Prev 1: 341-353, 1992.
32. Link-Amster H, Rochat F, Saudan KY, Mignot O and Aeschlimann JM: Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intakes. FEMS Immunol Med Microbiol 10: 55-64, 1994.
33. Tsai YT, Cheng PC and Pan TM: The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl Microbiol Biotechnol 96: 853-862, 2012.
34. Hong WS, Chen YP and Chen MJ: The antiallergic effect of kefir Lactobacilli. J Food Sci 75: H244-H253, 2010.
35. Perdigon G, de Moreno de LA, Valdez J and Rachid M: Role of yoghurt in the prevention of colon cancer. Eur J Clin Nutr 56 (Suppl 3): S65-S68, 2002.
36. Altonsy MO, Andrews SC and Tuohy KM: Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: mediation by the mitochondrial pathway. Int J Food Microbiol 137: 190-203, 2010.
37. 2+ and the ratio of Bax and Bcl-2. Int J Oncol 33: 533-539, 2008.
38. Guo D, Wu C, Li J, et al: Synergistic effect of functionalized nickel nanoparticles and Quercetin on inhibition of the SMMC-7721 cells proliferation. Nanoscale Res Lett 4: 1395-1402, 2009.
39. Ghoneum A, Sharma S and Gimzewski J: Nano-hole induction by nanodiamond and nanoplatinum liquid, DPV576, reverses multidrug resistance in human myeloid leukemia (HL60/AR). Int J Nanomed 8: 2567-2573, 2013.
40. Vandenberghe J, Verheyen A, Lauwers S and Geboes K: Spontaneous adenocarcinoma of the ascending colon in Wistar rats: the intracytoplasmic presence of a Campylobacter-like bacterium. J Comp Pathol 95: 45-55, 1985.
41. Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H and Gill G: Phagocytosis of candida albicans by lymphatic tumour cells in vitro. Acta Histochem 105: 127-133, 2003.
42. Ghoneum M and Gollapudi S: Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro. Cancer Detect Prev 28: 17-26, 2004.
43. Ghoneum M, Hamilton J, Brown J and Gollapudi S: Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res 25: 981-989, 2005.
44. Ghoneum M, Salem F, Shum SS, Perry L and Gill G: In situ lymphophagocytosis by nonlymphoreticular neoplasms. Nat Immun Cell Growth Regul 6: 77-87, 1987.
45. Ghoneum M, Salem F, Allen H and Gill G: Phagocytosis of autologous lymphocytes by cervical preneoplastic and neoplastic cells. Nat Immun Cell Growth Regul 7: 239-248, 1988.
46. Singhal N, Handa U, Bansal C and Mohan H: Neutrophil phagocytosis by tumor cells - a cytological study. Diagn Cytopathol 39: 553-555, 2011.
47. Overholtzer M, Mailleux AA, Mouneimne G, et al: A non-apoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 131: 966-979, 2007.
48. Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D and Korolenko TA: Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer? Neoplasma 55: 387-393, 2008.
49. Cattaruzza S, Nicolosi PA and Perris R: Proteoglycans in the control of tumor growth and metastasis formation. Connect Tissue Res 49: 225-229, 2008.
50. Oh JY, Baek YM, Kim SW, Hwang HJ, Hwang HS, Lee SH and Yun JW: Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala. J Microbiol Biotechnol 18: 512-519, 2008.
51. Lai K, Elsas LJ and Wierenga KJ: Galactose toxicity in animals. IUBMB Life 61: 1063-1074, 2009.
52. Davit-Spraul A, Pourci ML, Soni T and Lemonnier A: Metabolic effects of galactose on human HepG2 hepatoblastoma cells. Metabolism 43: 945-952, 1994.
53. Paitos Co., Ltd. Yokohama, Kanagawa, Japan. Increase the good bacteria held by nature, ideal AH21 is a functional food, consider preventive medicine and food. http://www.bio-j.net/ken00.html. Accessed June 14, 2013.