Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-κB and MAPK signalling

Cellular Microbiology

Volumn 10, Issue 7, 2008, Pages 1442-1452

  Iyer, Chandra ^a   Kosters, Astrid ^b   Sethi, Gautam ^c   Kunnumakkara, Ajaikumar B ^c   Aggarwal, Bharat B ^c   Versalovic, James ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; ESTERASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROBIOTIC AGENT; PROTEIN BCL 2; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LACTOBACILLUS REUTERI; MYELOID LEUKEMIA; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REPORTER GENE; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; I-KAPPA B PROTEINS; LACTOBACILLUS REUTERI; LEUKEMIA, MYELOID; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS; UBIQUITIN;

LACTOBACILLUS REUTERI;

EID: 45249084814     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01137.x     Document Type: Article

References (55)

1. Adams, J.M., and Cory, S. (2007) Bcl-2-regulated apoptosis: Mechanism and therapeutic potential. Curr Opin Immunol 26: 1324-1337.
2. Aggarwal, B.B. (2003) Signalling pathways of the TNF superfamily: A double-edged sword. Nat Rev Immunol 3: 745-756.
3. Ahn, K.S., Sethi, G., and Aggarwal, B.B. (2007) Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: Role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol 178: 2507-2516.
4. Alao, J.P. (2007) The regulation of cyclin D1 degradation: Roles in cancer development and the potential for therapeutic invention. Mol Cancer 6: 24.
5. Aso, Y., Akaza, H., Kotake, T., Tsukamoto, T., Imai, K., and Naito, S. (1995) Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group. Eur Urol 27: 104-109.
6. Biffi, A., Coradini, D., Larsen, R., Riva, L., and Di Fronzo, G. (1997) Antiproliferative effect of fermented milk on the growth of a human breast cancer cell line. Nutr Cancer 28: 93-99.
7. Carol, M., Borruel, N., Antolin, M., Llopis, M., Casellas, F., Guarner, F., and Malagelada, J.R. (2006) Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease. J Leukoc Biol 79: 917-922.
8. Chaturvedi, M.M., Mukhopadhyay, A., and Aggarwal, B.B. (2000) Assay for redox-sensitive transcription factor. Methods Enzymol 319: 585-602.
9. Chen, Z., Hagler, J., Palombella, V.J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev 9: 1586-1597.
10. De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D.U., Jin, R., Jones, J., et al. (2001) Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature 414: 308-313.
11. Dong, C., Yang, D.D., Tournier, C., Whitmarsh, A.J., Xu, J., Davis, R.J., and Flavell, R.A. (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature 405: 91-94.
12. Efimova, T., Broome, A.M., and Eckert, R.L. (2004) Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol 24: 8167-8183.
13. FAO/WHO (2001) Evaluation of health and nutritional properties of probiotics in food, including powder milk with live lactic acid bacteria. Food and Agricultural Organization of United Nations and World Health Organization Expert Consultation Report. http://www.who.int/ foodsafety/publications/fs_management/en/probiotics.pdf.
14. Fichera, G.A., and Giese, G. (1994) Non-immunologically-mediated cytotoxicity of Lactobacillus casei and its derivative peptidoglycan against tumor cell lines. Cancer Lett 85: 93-103.
15. Friedman, A., and Perrimon, N. (2006) A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature 444: 230-234.
16. Gilliland, S.E., Nelson, C.R., and Maxwell, C. (1985) Assimilation of cholesterol by Lactobacillus acidophilus. Appl Environ Microbiol 49: 377-381.
17. Gray-Schopfer, V., Wellbrock, C., and Marais, R. (2007) Melanoma biology and new targeted therapy. Nature 445: 851-857.
18. Grethe, S., and Porn-Ares, M.I. (2006) p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/ 2 survival pathway in TNF-alpha induced endothelial apoptosis. Cell Signal 18: 531-540.
19. Guarner, F., Bourdet-Sicard, R., Brandtzaeg, P., Gill, H.S., McGuirk, P., van Eden, W., et al. (2006) Mechanisms of disease: The hygiene hypothesis revisited. Nat Clin Pract Gastroenterol Hepatol 3: 275-284.
20. Hayashi, M., and Lee, J.D. (2004) Role of the BMK1/ERK5 signaling pathway: Lessons from knockout mice. J Mol Med 82: 800-808.
21. Hirschowitz, E.A., Hidalgo, G.E., and Doherty, D.E. (2002) Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by adenovirus vector information. Chest 121: 32S.
22. Ichikawa, H., Takada, Y., Shishodia, S., Jayaprakasam, B., Nair, M.G., and Aggarwal, B.B. (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. Mol Cancer Ther 5: 1434-1445.
23. Isolauri, E., Salminen, S., and Ouwehand, A.C. (2004) Microbial-gut interactions in health and disease. Probiotics. Best Pract Res Clin Gastroenterol 18: 299-313.
24. Jachak, S.M. (2007) PGE synthase inhibitors as an alternative to COX-2 inhibitors. Curr Opin Invest Drugs 8: 411-415.
25. Karin, M., and Greten, F.R. (2005) NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759.
26. Kato, I., Endo-Tanaka, K., and Yokokura, T. (1998) Suppressive effects of the oral administration of Lactobacillus casei on type II collagen-induced arthritis in DBA/1 mice. Life Sci 63: 635-644.
27. Kelly, D., Campbell, J.I., King, T.P., Grant, G., Jansson, E.A., Coutts, A.G., et al. (2004) Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol 5: 104-112.
28. Kim, J.Y., Woo, H.J., Kim, Y.S., and Lee, J.H. (2002) Screening for antiproliferative effects of cellular components from lactic acid bacteria against human cancer cell lines. Biotechnol Lett 24: 1431-1436.
29. Kotarski, S.F., and Savage, D.C. (1979) Models for study of the specificity by which indigenous lactobacilli adhere to murine gastric epithelia. Infect Immun 26: 966-975.
30. Kumar, A., Wu, H., Collier-Hyams, L.S., Hansen, J.M., Li, T., Yamoah, K., et al. (2007) Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J 26: 4457-4466.
31. Lim, B.K., Mahendran, R., Lee, Y.K., and Bay, B.H. (2002) Chemopreventive effect of Lactobacillus rhamnosus on growth of a subcutaneously implanted bladder cancer cell line in the mouse. Jpn J Cancer Res 93: 36-41.
32. Lin, A., and Dibling, B. (2002) The true face of JNK activation in apoptosis. Aging Cell 1: 112-116.
33. Ma, D., Forsythe, P., and Bienenstock, J. (2004) Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect Immun 72: 5308-5314.
34. Meloche, S., and Pouyssegur, J. (2007) The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26: 3227-3239.
35. de Moreno de Leblanc, A., Matar, C., Farnworth, E., and Perdigon, G. (2007) Study of immune cells involved in the antitumor effect of kefir in a murine breast cancer model. J Dairy Sci 90: 1920-1928.
36. Nasuhara, Y., Adcock, I.M., Catley, M., Barnes, P.J., and Newton, R. (1999) Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription. J Biol Chem 274: 19965-19972.
37. Neish, A.S., Gewirtz, A.T., Zeng, H., Young, A.N., Hobert, M.E., Karmali, V., et al. (2000) Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 289: 1560-1563.
38. Pena, J.A., Rogers, A.B., Ge, Z., Ng, V., Li, S.Y., Fox, J.G., and Versalovic, J. (2005) Probiotic Lactobacillus spp. diminish Helicobacter hepaticus -induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun 73: 912-920.
39. Perdigon, G., Fuller, R., and Raya, R. (2001) Lactic acid bacteria and their effect on the immune system. Curr Issues Intest Microbiol 2: 27-42.
40. Petrof, E.O., Kojima, K., Ropeleski, M.J., Musch, M.W., Tao, Y., De Simone, C., and Chang, E.B. (2004) Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 127: 1474-1487.
41. Rafter, J. (2003) Probiotics and colon cancer. Best Pract Res Clin Gastroenterol 17: 849-859.
42. Reddy, B.S., and Rivenson, A. (1993) Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen. Cancer Res 53: 3914-3918.
43. Reuter, G. (2001) The Lactobacillus and Bifidobacterium microflora of the human intestine: Composition and succession. Curr Issues Intest Microbiol 2: 43-53.
44. Roberts, P.J., and Der, C.J. (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310.
45. Salminen, S., Bouley, C., Boutron-Ruault, M.C., Cummings, J.H., Franck, A., Gibson, G.R., et al. (1998) Functional food science and gastrointestinal physiology and function. Br J Nutr 80 (Suppl 1): S147 -S171.
46. Sheil, B., McCarthy, J., O'Mahony, L., Bennett, M.W., Ryan, P., Fitzgibbon, J.J., et al. (2004) Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut 53: 694-700.
47. Shishodia, S., and Aggarwal, B.B. (2004) Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem 279: 47148-47158.
48. Smits, H.H., Engering, A., van der Kleij, D., de Jong, E.C., Schipper, K., van Capel, T.M., et al. (2005) Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 115: 1260-1267.
49. Tanaka, N., Kamanaka, M., Enslen, H., Dong, C., Wysk, M., Davis, R.J., and Flavell, R.A. (2002) Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep 3: 785-791.
50. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M., and Lin, A. (2001) Inhibition of JNK activation through NF-kappaB target genes. Nature 414: 313-317.
51. Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M.R., and Lin, A. (2002) The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 22: 8571-8579.
52. Tien, M.T., Girardin, S.E., Regnault, B., Le Bourhis, L., Dillies, M.A., Coppee, J.Y., et al. (2006) Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 176: 1228-1237.
53. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., and Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
54. Yan, F., and Polk, D.B. (2002) Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem 277: 50959-50965.
55. Yan, F., Cao, H., Cover, T.L., Whitehead, R., Washington, M.K., and Polk, D.B. (2007) Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132: 562-575.