Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

Molecular Microbiology

Volumn 91, Issue 6, 2014, Pages 1106-1119

  Song, Taeksun ^a   Park, Yumi ^a   Shamputa, Isdore Chola ^b   Seo, Sunghwa ^a   Lee, Sun Young ^a   Jeon, Han Seung ^a   Choi, Hongjo ^a   Lee, Myungsun ^a   Glynne, Richard J ^c   Barnes, S Whitney ^c   Walker, John R ^c   Batalov, Serge ^c   Yusim, Karina ^d   Feng, Shihai ^d   Tung, Chang Shung ^d   Theiler, James ^d   Via, Laura E ^b   Boshoff, Helena I M ^b   Murakami, Katsuhiko S ^e   Korber, Bette ^d   Barry, Clifton E ^a,b   Cho, Sang Nae ^a,f   more..

^a International Tuberculosis Research Center   (South Korea)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

^f Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

RIFAMPICIN; RNA POLYMERASE;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM ISOLATE; BETA CHAIN; BIOACCUMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE FITNESS; RPOA GENE; RPOB GENE; RPOC GENE;

MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; MUTATION, MISSENSE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN;

EID: 84896711307     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12520     Document Type: Article

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