Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

Nature Genetics

Volumn 44, Issue 1, 2012, Pages 106-110

  Comas, Iñaki ^a,h   Borrell, Sonia ^b,c   Roetzer, Andreas ^d   Rose, Graham ^a   Malla, Bijaya ^b,c   Kato Maeda, Midori ^e   Galagan, James ^f,g   Niemann, Stefan ^d   Gagneux, Sebastien ^b,c  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d RESEARCH CENTER BORSTEL   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g BOSTON UNIVERSITY   (United States)

^h Centre for Public Health Research   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ISONIAZID; RIFAMPICIN; RNA POLYMERASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; COMPENSATORY MUTATION; CONTROLLED STUDY; GENE MUTATION; GENOME ANALYSIS; MOLECULAR EVOLUTION; MULTIDRUG RESISTANT TUBERCULOSIS; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULOSIS;

DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS, MULTIDRUG-RESISTANT;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84555209977     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1038     Document Type: Article

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