Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 6, 2014, Pages 1873-1882

  Sitaram, ^a   Celik, Gulsah ^b   Khloya, Poonam ^a   Vullo, Daniela ^c   Supuran, Claudiu T ^c   Sharma, Pawan K ^a  

^a KURUKSHETRA UNIVERSITY   (India)

^b BALIKESIR UNIVERSITY   (Turkey)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Acetazolamide; Benzenesulfonamide; Carbonic anhydrase isoforms I, II, IX, XII; Triazoles

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 4 (3 PHENYL 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL)BENZENESULFONAMIDE; 4 (6 PHENYL 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 3 YL)BENZENESULFONAMIDE; 4 (6 PHENYL[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL)BENZENESULFONAMIDE; 4 [3 (4 AMINOSULFONYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 BROMOPHENYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 CHLOROPHENYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 FLUOROPHENYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 METHOXYPHENYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 METHYLPHENYL) 5 THIOXO 1,5 DIHYDRO 4H 1,2,4 TRIAZOL 4 YL]BENZENESULFONAMIDE; 4 [6 (4 BROMOPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 BROMOPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; 4 [6 (4 CHLOROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 CHLOROPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; 4 [6 (4 FLUOROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 FLUOROPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; 4 [6 (4 METHOXYPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 METHOXYPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; 4 [6 (4 METHYLPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 METHYLPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; 4 [6 (4 NITROPHENYL) 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZIN 3 YL]BENZENESULFONAMIDE; 4 [6 (4 NITROPHENYL)[1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]BENZENESULFONAMIDE; ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; UNCLASSIFIED DRUG; 1,2,4-TRIAZOLE; BENZENESULFONAMIDE; CARBONATE DEHYDRATASE; ISOENZYME; SULFONAMIDE; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFRARED SPECTROMETRY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES;

EID: 84896703515     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.01.055     Document Type: Article

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