Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

Gene

Volumn 539, Issue 2, 2014, Pages 190-197

  Gong, Qiuming ^a   Stump, Matthew R ^a   Zhou, Zhengfeng ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Arrhythmia; KCNH2; Long QT syndrome; Patch clamp; Potassium channels

Indexed keywords

CRE RECOMBINASE; MESSENGER RNA; MORPHOLINO OLIGONUCLEOTIDE; POTASSIUM CHANNEL HERG; RECOMBINASE;

ARTICLE; CELL STRAIN HEK293; CODON; CONTROLLED STUDY; EXON; FRAMESHIFT MUTATION; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HUMAN; INTRON; LONG QT SYNDROME 2; LOXP SITE; NONSENSE MEDIATED MRNA DECAY; PATCH CLAMP TECHNIQUE; PREMATURE TERMINATION CODON; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY; RNA DEGRADATION; RNA INTERFERENCE;

ARRHYTHMIA; KCNH2; LONG QT SYNDROME; PATCH-CLAMP; POTASSIUM CHANNELS;

CODON, NONSENSE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LONG QT SYNDROME; MORPHOLINOS; MUTATION; NONSENSE MEDIATED MRNA DECAY; PATCH-CLAMP TECHNIQUES; RNA, SMALL INTERFERING;

EID: 84896702134     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2014.02.012     Document Type: Article

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