C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3ε

Human Molecular Genetics

Volumn 15, Issue 19, 2006, Pages 2888-2902

  Choe, Chi Un ^a   Schulze Bahr, Eric ^b   Neu, Axel ^a   Xu, Jun ^c   Zhu, Zheng I ^c   Sauter, Kathrin ^a   Bähring, Robert ^a   Priori, Silvia ^d   Guicheney, Pascale ^e,f   Mönnig, Gerold ^b   Neapolitano, Carlo ^d   Heidemann, Jan ^b   Clancy, Colleen E ^c   Pongs, Olaf ^a   Isbrandt, Dirk ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d IRCCS   (Italy)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCINE; MUTANT PROTEIN; POTASSIUM CHANNEL HERG; PROTEIN 14 3 3; VALINE;

ADRENERGIC STIMULATION; ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; FAMILY STUDY; GENE DISRUPTION; GENETIC IDENTIFICATION; GENETIC REGULATION; HEART MUSCLE CELL; HETEROZYGOSITY; HUMAN; HYPERPOLARIZATION; LONG QT SYNDROME; MUSCLE ACTION POTENTIAL; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; WHOLE CELL; WILD TYPE;

EID: 33749001960     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl230     Document Type: Article

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