The human Δ1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression

Journal of Biological Chemistry

Volumn 272, Issue 2, 1997, Pages 705-708

  Li, Xiaodong ^a   Xu, Jia ^a   Li, Min ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALFRED P SLOAN FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; OLIGOMER; POTASSIUM; POTASSIUM CHANNEL; PROTEIN SUBUNIT; CATION TRANSPORT PROTEIN; DNA BINDING PROTEIN; ERG PROTEIN, HUMAN; ERG1 POTASSIUM CHANNEL; KCNH2 PROTEIN, HUMAN; KCNH6 PROTEIN, HUMAN; POTASSIUM CHANNEL HERG; TRANSACTIVATOR PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 7; CROSS LINKING; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHILICITY; LONG QT SYNDROME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SUDDEN DEATH; VOLTAGE CLAMP; GENETICS; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION;

CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LONG QT SYNDROME; MUTAGENESIS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; TRANS-ACTIVATORS;

EID: 0030614462     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.2.705     Document Type: Article

References (25)

1. Warmke, J. W., and Ganetzky, B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3438-3842
2. Warmke, J., Drysdale, R., and Ganetzky, B. (1991) Science 252, 1560-1562
3. Drysdale, R., Warmke, J., Kreber, R., and Ganetzky, B. (1991) Genetics 127, 497-505
4. Trudeau, M. C., Warmke, J. W., Ganetzky, B., and Robertson, G. A. (1995) Science 269, 92-95
5. Smith, P. L., Baukrowwitz, T., and Yellen, G. (1996) Nature 379, 833-836
6. Jan, L. Y., and Jan, Y. N. (1994) Nature 371, 119-122
7. Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D., and Keating, M. T. (1995) Cell 80, 795-803
8. Sanguinetti, M. C., Jiang, C., Curran, M. E., and Keating, M. T. (1995) Cell 81, 299-307
9. Sanguinetti, M. C., Curran, M. E., Spector, P. S., and Keating, M. T. (1995) Proc. Natl. Acad. Sci. U. S. A. 93, 2208-2212
10. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
11. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (1993) Current Protocols in Molecular Biology, Greene Publishing Associates and John Wiley & Sons, New York
12. Li, M., Jan, Y. N., and Jan, L. Y. (1992) Science 257, 1225-1230
13. Jurman, M. E., Boland, L. M., Liu, Y., and Yellen, G. (1994) Biotechniques 17, 876-881
14. Yu, W. F., Xu, J., and Li, M. (1996) Neuron 16, 441-453
15. Hamill, O. P., Marty, A., Nehre, E., Sakmann, B., and Sigworth, F. J. (1981) Pflügers Arch. 391, 85-100
16. Barry, P. H. (1994) J. Neurosci. Methods 51, 107-116
17. Xu, J., Yu, W., Jan, Y. N., Jan, L. Y., and Li, M. (1995) J. Biol. Chem. 270, 24761-24768.
18. Li, M., Unwin, N., Stauffer, K. A., Jan, Y. N., and Jan, L. Y. (1994) Curr. Biol. 4, 110-115
19. MacKinnon, R. (1991) Nature 350, 232-235
20. Yang, J., Jan, Y. N., and Jan, L. Y. (1995) Neuron 15, 1441-1447
21. Yu, X. M., and Hall, Z. W. (1991) Nature 352, 64-67
22. Tu, L., Santarelli, V., and Deutsch, C. (1995) Biophys. J. 68, 147-156
23. Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., and Nakanishi, S. (1991) Nature 354, 31-37
24. Nakanishi, S. (1992) Science 258, 597-603
25. Hollmann, M., and Heinemann, S. (1994) Annu. Rev. Neurosci. 17, 31-108