Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 3, 2010, Pages 314-317

  Yamaguchi, Hiroaki ^a,b   Sugie, Misa ^b   Okada, Masahiro ^b   Mikkaichi, Tsuyoshi ^b   Toyohara, Takafumi ^b   Abe, Takaaki ^b   Goto, Junichi ^a   Hishinuma, Takanori ^b   Shimada, Miki ^a,b   Mano, Nariyasu ^a,b  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Digoxin; Estrone 3 sulfate; Mutual inhibition; OATP4C1; Recognition site

Indexed keywords

BROMSULFOPHTHALEIN; CHENODEOXYCHOLIC ACID; CYCLOSPORIN; DIGOXIN; ESTRONE SULFATE; LIOTHYRONINE; ORGANIC ANION TRANSPORTER 4; ORGANIC ANION TRANSPORTER 4C1; UNCLASSIFIED DRUG; ESTRONE; ORGANIC ANION TRANSPORTER; OUABAIN; SLCO4C1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG UPTAKE; GENE OVEREXPRESSION; HORMONE TRANSPORT; IC 50; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; CELL LINE; CYTOLOGY; DOG; DRUG EFFECTS; EPITHELIUM CELL; HUMAN; KIDNEY; METABOLISM; PHARMACOKINETICS; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CELL LINE; CHENODEOXYCHOLIC ACID; CYCLOSPORINE; DIGOXIN; DOGS; EPITHELIAL CELLS; ESTRONE; HUMANS; KIDNEY; ORGANIC ANION TRANSPORTERS; OUABAIN; PHARMACOKINETICS; SULFOBROMOPHTHALEIN; TRIIODOTHYRONINE;

EID: 77954289040     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.25.314     Document Type: Article

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