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Volumn 44, Issue 3, 2014, Pages 761-768

Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53

Author keywords

c jun N terminal kinase; Heme oxygenase 1; Murine double minute 2 protein; Nutlin 3; Tumor suppressor protein p53

Indexed keywords

HO 1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUTLIN 3; PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84896696089     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2227     Document Type: Article
Times cited : (9)

References (36)
  • 3
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1: 639-649, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 4
    • 0033533612 scopus 로고    scopus 로고
    • 14-3-3s is required to prevent mitotic catastrophe after DNA damage
    • Chan TA, Hermeking H, Lengauer C, Kinzler KW and Vogelstein B: 14-3-3s is required to prevent mitotic catastrophe after DNA damage. Nature 401: 616-620, 1999.
    • (1999) Nature , vol.401 , pp. 616-620
    • Chan, T.A.1    Hermeking, H.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 5
    • 12144286529 scopus 로고    scopus 로고
    • Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
    • Cohen HY, Lavu S, Bitterman KJ, et al: Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 13: 627-638, 2004.
    • (2004) Mol Cell , vol.13 , pp. 627-638
    • Cohen, H.Y.1    Lavu, S.2    Bitterman, K.J.3
  • 6
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, Heinrichs S, Xu D, et al: Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-653, 2005.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3
  • 7
    • 28944447430 scopus 로고    scopus 로고
    • PIDD mediates NF-kappaB activation in response to DNA damage
    • Janssens S, Tinel A, Lippens S and Tschopp J: PIDD mediates NF-kappaB activation in response to DNA damage. Cell 123: 1079-1092, 2005.
    • (2005) Cell , vol.123 , pp. 1079-1092
    • Janssens, S.1    Tinel, A.2    Lippens, S.3    Tschopp, J.4
  • 8
    • 0035901496 scopus 로고    scopus 로고
    • p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
    • Fang L, Li G, Liu G, Lee SW and Aaronson SA: p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J 20: 1931-1939, 2001.
    • (2001) EMBO J , vol.20 , pp. 1931-1939
    • Fang, L.1    Li, G.2    Liu, G.3    Lee, S.W.4    Aaronson, S.A.5
  • 9
    • 0344837350 scopus 로고    scopus 로고
    • p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop
    • Ongusaha PP, Kim JI, Fang L, et al: p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J 22: 1289-1301, 2003.
    • (2003) EMBO J , vol.22 , pp. 1289-1301
    • Ongusaha, P.P.1    Kim, J.I.2    Fang, L.3
  • 10
    • 84873055344 scopus 로고    scopus 로고
    • MDM2, MDMX and p53 in oncogenesis and cancer therapy
    • Wade M, Li YC and Wahl GM: MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 13: 83-96, 2013.
    • (2013) Nat Rev Cancer , vol.13 , pp. 83-96
    • Wade, M.1    Li, Y.C.2    Wahl, G.M.3
  • 11
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al: In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-848, 2004.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 12
    • 33746646758 scopus 로고    scopus 로고
    • Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
    • Kojima K, Konopleva M, McQueen T, O'Brien S, Plunkett W and Andreeff M: Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription- dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108: 993-1000, 2006.
    • (2006) Blood , vol.108 , pp. 993-1000
    • Kojima, K.1    Konopleva, M.2    McQueen, T.3    O'Brien, S.4    Plunkett, W.5    Andreeff, M.6
  • 13
    • 33845901313 scopus 로고    scopus 로고
    • MDM2 inhibitors for cancer therapy
    • Vassilev LT: MDM2 inhibitors for cancer therapy. Trends Mol Med 13: 23-31, 2007.
    • (2007) Trends Mol Med , vol.13 , pp. 23-31
    • Vassilev, L.T.1
  • 14
    • 32444449180 scopus 로고    scopus 로고
    • Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
    • Tovar C, Rosinski J, Filipovic Z, et al: Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci USA 103: 1888-1893, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1888-1893
    • Tovar, C.1    Rosinski, J.2    Filipovic, Z.3
  • 15
    • 60649103811 scopus 로고    scopus 로고
    • MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
    • Enge M, Bao W, Hedstrom E, Jackson SP, Moumen A and Selivanova G: MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 15: 171-183, 2009.
    • (2009) Cancer Cell , vol.15 , pp. 171-183
    • Enge, M.1    Bao, W.2    Hedstrom, E.3    Jackson, S.P.4    Moumen, A.5    Selivanova, G.6
  • 16
    • 68049131458 scopus 로고    scopus 로고
    • HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA
    • Rinaldo C, Prodosmo A, Siepi F, et al: HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. Cancer Res 69: 6241-6248, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6241-6248
    • Rinaldo, C.1    Prodosmo, A.2    Siepi, F.3
  • 17
    • 84873679971 scopus 로고    scopus 로고
    • ERK1/2 activation mediated by the nutlin3-induced mitochondrial translocation of p53
    • Lee SY, Shin SJ and Kim HS: ERK1/2 activation mediated by the nutlin3-induced mitochondrial translocation of p53. Int J Oncol 42: 1027-1035, 2013.
    • (2013) Int J Oncol , vol.42 , pp. 1027-1035
    • Lee, S.Y.1    Shin, S.J.2    Kim, H.S.3
  • 18
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • Ryter SW, Alam J and Choi AM: Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86: 583-650, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 19
    • 79952038728 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
    • Yang JD, Nakamura I and Roberts LR: The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin Cancer Biol 21: 35-43, 2011.
    • (2011) Semin Cancer Biol , vol.21 , pp. 35-43
    • Yang, J.D.1    Nakamura, I.2    Roberts, L.R.3
  • 20
    • 79952276580 scopus 로고    scopus 로고
    • Heme oxygenase-1 in tumor biology and therapy
    • Was H, Dulak J and Jozkowicz A: Heme oxygenase-1 in tumor biology and therapy. Curr Drug Targets 11: 1551-1570, 2010.
    • (2010) Curr Drug Targets , vol.11 , pp. 1551-1570
    • Was, H.1    Dulak, J.2    Jozkowicz, A.3
  • 21
    • 21044452445 scopus 로고    scopus 로고
    • Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
    • Berberat PO, Dambrauskas Z, Gulbinas A, et al: Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clin Cancer Res 11: 3790-3798, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 3790-3798
    • Berberat, P.O.1    Dambrauskas, Z.2    Gulbinas, A.3
  • 22
    • 43549095276 scopus 로고    scopus 로고
    • HO-1 underlies resistance of AML cells to TNF-induced apoptosis
    • Rushworth SA and MacEwan DJ: HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111: 3793-3801, 2008.
    • (2008) Blood , vol.111 , pp. 3793-3801
    • Rushworth, S.A.1    MacEwan, D.J.2
  • 23
    • 57149114933 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells
    • Guan J, Wu X, Arons E and Christou H: The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. J Cell Biochem 105: 1298-1306, 2008.
    • (2008) J Cell Biochem , vol.105 , pp. 1298-1306
    • Guan, J.1    Wu, X.2    Arons, E.3    Christou, H.4
  • 24
    • 33846924300 scopus 로고    scopus 로고
    • How many transcription factors does it take to turn on the heme oxygenase-1 gene?
    • Alam J and Cook JL: How many transcription factors does it take to turn on the heme oxygenase-1 gene? Am J Respir Cell Mol Biol 36: 166-174, 2007.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 166-174
    • Alam, J.1    Cook, J.L.2
  • 25
    • 80455164743 scopus 로고    scopus 로고
    • p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1
    • Nam SY and Sabapathy K: p53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1. Oncogene 30: 4476-4486, 2011.
    • (2011) Oncogene , vol.30 , pp. 4476-4486
    • Nam, S.Y.1    Sabapathy, K.2
  • 26
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108, 2008.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 27
    • 84860529329 scopus 로고    scopus 로고
    • Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
    • Jang JY, Kim MK, Jeon YK, Joung YK, Park KD and Kim CW: Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells. Exp Mol Med 44: 251-259, 2012.
    • (2012) Exp Mol Med , vol.44 , pp. 251-259
    • Jang, J.Y.1    Kim, M.K.2    Jeon, Y.K.3    Joung, Y.K.4    Park, K.D.5    Kim, C.W.6
  • 28
    • 38949199337 scopus 로고    scopus 로고
    • HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
    • Lau LM, Nugent JK, Zhao X and Irwin MS: HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function. Oncogene 27: 997-1003, 2008.
    • (2008) Oncogene , vol.27 , pp. 997-1003
    • Lau, L.M.1    Nugent, J.K.2    Zhao, X.3    Irwin, M.S.4
  • 29
    • 18144382261 scopus 로고    scopus 로고
    • p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
    • Zhao Y, Chaiswing L, Velez JM, et al: p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res 65: 3745-3750, 2005.
    • (2005) Cancer Res , vol.65 , pp. 3745-3750
    • Zhao, Y.1    Chaiswing, L.2    Velez, J.M.3
  • 30
    • 0037349289 scopus 로고    scopus 로고
    • p53 has a direct apoptogenic role at the mitochondria
    • Mihara M, Erster S, Zaika A, et al: p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590, 2003.
    • (2003) Mol Cell , vol.11 , pp. 577-590
    • Mihara, M.1    Erster, S.2    Zaika, A.3
  • 31
    • 46749115781 scopus 로고    scopus 로고
    • Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model
    • Palacios G, Crawford HC, Vaseva A and Moll UM: Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. Cell Cycle 7: 2584-2590, 2008.
    • (2008) Cell Cycle , vol.7 , pp. 2584-2590
    • Palacios, G.1    Crawford, H.C.2    Vaseva, A.3    Moll, U.M.4
  • 32
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME and George DL: Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6: 443-450, 2004.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 33
    • 84862675016 scopus 로고    scopus 로고
    • p53 opens the mitochondrial permeability transition pore to trigger necrosis
    • Vaseva AV, Marchenko ND, Ji K, Tsirka SE, Holzmann S and Moll UM: p53 opens the mitochondrial permeability transition pore to trigger necrosis. Cell 149: 1536-1548, 2012.
    • (2012) Cell , vol.149 , pp. 1536-1548
    • Vaseva, A.V.1    Marchenko, N.D.2    Ji, K.3    Tsirka, S.E.4    Holzmann, S.5    Moll, U.M.6
  • 34
    • 66749128074 scopus 로고    scopus 로고
    • The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells
    • Vaseva AV, Marchenko ND and Moll UM: The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle 8: 1711-1719, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 1711-1719
    • Vaseva, A.V.1    Marchenko, N.D.2    Moll, U.M.3
  • 36
    • 36549089750 scopus 로고    scopus 로고
    • Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas
    • Moreno CS, Matyunina L, Dickerson EB, et al: Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas. PLoS One 2: e441, 2007.
    • (2007) PLoS One , vol.2
    • Moreno, C.S.1    Matyunina, L.2    Dickerson, E.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.