-
2
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
DOI 10.1038/nrm2395, PII NRM2395
-
Riley T, Sontag E, Chen P and Levine A: Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9: 402-412, 2008. (Pubitemid 351574202)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.5
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
3
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
DOI 10.1016/S0014-5793(97)01480-4, PII S0014579397014804
-
Honda R, Tanaka H and Yasuda H: Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420: 25-27, 1997. (Pubitemid 28037193)
-
(1997)
FEBS Letters
, vol.420
, Issue.1
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
4
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
DOI 10.1038/362857a0
-
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW and Vogelstein B: Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53. Nature 362: 857-860, 1993. (Pubitemid 23132165)
-
(1993)
Nature
, vol.362
, Issue.6423
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
5
-
-
84857443702
-
The p53 network: Cellular and systemic DNA damage responses in aging and cancer
-
Reinhardt HC and Schumacher B: The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet 28: 128-136, 2012.
-
(2012)
Trends Genet
, vol.28
, pp. 128-136
-
-
Reinhardt, H.C.1
Schumacher, B.2
-
6
-
-
79251470793
-
Therapy-related myeloid neoplasms: Pathobiology and clinical characteristics
-
Sill H, Olipitz W, Zebisch A, Schulz E and Wölfler A: Therapy-related myeloid neoplasms: pathobiology and clinical characteristics. Br J Pharmacol 162: 792-805, 2011.
-
(2011)
Br J Pharmacol
, vol.162
, pp. 792-805
-
-
Sill, H.1
Olipitz, W.2
Zebisch, A.3
Schulz, E.4
Wölfler, A.5
-
7
-
-
84863230431
-
Second malignant neoplasms and cardiovascular disease following radiotherapy
-
Travis LB, Ng AK, Allan JM, et al: Second malignant neoplasms and cardiovascular disease following radiotherapy. J Natl Cancer Inst 104: 357-370, 2012.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 357-370
-
-
Travis, L.B.1
Ng, A.K.2
Allan, J.M.3
-
8
-
-
53049108040
-
Targeting the MDM2-p53 interaction for cancer therapy
-
Shangary S and Wang S: Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res 14: 5318-5324, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5318-5324
-
-
Shangary, S.1
Wang, S.2
-
9
-
-
77952550955
-
Small-molecule inhibitors of MDM2 as new anticancer therapeutics
-
Dickens MP, Fitzgerald R and Fischer PM: Small-molecule inhibitors of MDM2 as new anticancer therapeutics. Semin Cancer Biol 20: 10-18, 2010.
-
(2010)
Semin Cancer Biol
, vol.20
, pp. 10-18
-
-
Dickens, M.P.1
Fitzgerald, R.2
Fischer, P.M.3
-
10
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
DOI 10.1126/science.1092472
-
Vassilev LT, Vu BT, Graves B, et al: In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-848, 2004. (Pubitemid 38174664)
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
11
-
-
79953655080
-
Recent advances in the therapeutic perspectives of nutlin-3
-
Secchiero P, Bosco R, Celeghini C and Zauli G: Recent advances in the therapeutic perspectives of nutlin-3. Curr Pharm Des 17: 569-577, 2011.
-
(2011)
Curr Pharm des
, vol.17
, pp. 569-577
-
-
Secchiero, P.1
Bosco, R.2
Celeghini, C.3
Zauli, G.4
-
12
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
-
DOI 10.1073/pnas.0507493103
-
Tovar C, Rosinski J, Filipovic Z, et al: Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci USA 103: 1888-1893, 2006. (Pubitemid 43228788)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.6
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
Myklebost, O.11
Heimbrook, D.C.12
Vassilev, L.T.13
-
13
-
-
29944447632
-
Tumor suppression and normal aging in mice with constitutively high p53 activity
-
DOI 10.1101/gad.1378506
-
Mendrysa SM, O'Leary KA, McElwee MK, et al: Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev 20: 16-21, 2006. (Pubitemid 43042663)
-
(2006)
Genes and Development
, vol.20
, Issue.1
, pp. 16-21
-
-
Mendrysa, S.M.1
O'Leary, K.A.2
McElwee, M.K.3
Michalowski, J.4
Eisenman, R.N.5
Powell, D.A.6
Perry, M.E.7
-
14
-
-
65949119310
-
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
-
Mebratu Y and Tesfaigzi Y: How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle 8: 1168-1175, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 1168-1175
-
-
Mebratu, Y.1
Tesfaigzi, Y.2
-
15
-
-
34547209343
-
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
-
DOI 10.1016/j.bbamcr.2006.10.001, PII S0167488906003156
-
McCubrey JA, Steelman LS, Chappell WH, et al: Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773: 1263-1284, 2007. (Pubitemid 47125967)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1263-1284
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Wong, E.W.T.5
Chang, F.6
Lehmann, B.7
Terrian, D.M.8
Milella, M.9
Tafuri, A.10
Stivala, F.11
Libra, M.12
Basecke, J.13
Evangelisti, C.14
Martelli, A.M.15
Franklin, R.A.16
-
16
-
-
0034680896
-
Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin
-
Persons DL, Yazlovitskaya EM and Pelling JC: Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J Biol Chem 275: 35778-35785, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 35778-35785
-
-
Persons, D.L.1
Yazlovitskaya, E.M.2
Pelling, J.C.3
-
17
-
-
0035931854
-
p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling
-
DOI 10.1038/sj.onc.1204156
-
Sablina AA, Chumakov PM, Levine AJ and Kopnin BP: p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene 20: 899-909, 2001. (Pubitemid 32207107)
-
(2001)
Oncogene
, vol.20
, Issue.8
, pp. 899-909
-
-
Sablina, A.A.1
Chumakov, P.M.2
Levine, A.J.3
Kopnin, B.P.4
-
18
-
-
0035866404
-
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
-
She QB, Bode AM, Ma WY, Chen NY and Dong Z: Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 61: 1604-1610, 2001. (Pubitemid 34292594)
-
(2001)
Cancer Research
, vol.61
, Issue.4
, pp. 1604-1610
-
-
She, Q.-B.1
Bode, A.M.2
Ma, W.-Y.3
Chen, N.-Y.4
Dong, Z.5
-
19
-
-
42749090537
-
MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylation
-
Lin T, Mak NK and Yang MS: MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxicology 247: 145-153, 2008.
-
(2008)
Toxicology
, vol.247
, pp. 145-153
-
-
Lin, T.1
Mak, N.K.2
Yang, M.S.3
-
20
-
-
0034682469
-
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
-
DOI 10.1073/pnas.150024397
-
Lee SW, Fang L, Igarashi M, Ouchi T, Lu KP and Aaronson SA: Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc Natl Acad Sci USA 97: 8302-8305, 2000. (Pubitemid 30639667)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.15
, pp. 8302-8305
-
-
Lee, S.W.1
Fang, L.2
Igarashi, M.3
Ouchi, T.4
Lu, K.P.5
Aaronson, S.A.6
-
21
-
-
0035901496
-
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
-
DOI 10.1093/emboj/20.8.1931
-
Fang L, Li G, Liu G, Lee SW and Aaronson SA: p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J 20: 1931-1939, 2001. (Pubitemid 32397395)
-
(2001)
EMBO Journal
, vol.20
, Issue.8
, pp. 1931-1939
-
-
Fang, L.1
Li, G.2
Liu, G.3
Lee, S.W.4
Aaronson, S.A.5
-
22
-
-
0344837350
-
p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop
-
DOI 10.1093/emboj/cdg129
-
Ongusaha PP, Kim JI, Fang L, et al: p53 induction and activation of DDR1 kinase counteracts p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J 22: 1289-1301, 2003. (Pubitemid 36362693)
-
(2003)
EMBO Journal
, vol.22
, Issue.6
, pp. 1289-1301
-
-
Ongusaha, P.P.1
Kim, J.-I.2
Fang, L.3
Wong, T.W.4
Yancopoulos, G.D.5
Aaronson, S.A.6
Lee, S.W.7
-
23
-
-
0037417281
-
PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
-
DOI 10.1038/nature01519
-
Yin Y, Liu YX, Jin YJ, Hall EJ and Barrett JC: PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422: 527-531, 2003. (Pubitemid 36433648)
-
(2003)
Nature
, vol.422
, Issue.6931
, pp. 527-531
-
-
Yin, Y.1
Llu, Y.-X.2
Jin, Y.J.3
Hall, E.J.4
Barrett, J.C.5
-
24
-
-
0041836252
-
Dual-specificity phospha tase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53
-
DOI 10.1038/sj.onc.1206845
-
Ueda K, Arakawa H and Nakamura Y: Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene 22: 5586-5591, 2003. (Pubitemid 37102694)
-
(2003)
Oncogene
, vol.22
, Issue.36
, pp. 5586-5591
-
-
Ueda, K.1
Arakawa, H.2
Nakamura, Y.3
-
25
-
-
0142039878
-
The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation
-
DOI 10.1074/jbc.M307149200
-
Li M, Zhou JY, Ge Y, Matherly LH and Wu GS: The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem 278: 41059-41068, 2003. (Pubitemid 37280929)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.42
, pp. 41059-41068
-
-
Li, M.1
Zhou, J.-Y.2
Ge, Y.3
Matherly, L.H.4
Wu, G.S.5
-
26
-
-
34248177222
-
Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells
-
DOI 10.1158/0008-5472.CAN-06-2712
-
Kojima K, Konopleva M, Samudio IJ, Ruvolo V and Andreeff M: Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. Cancer Res 67: 3210-3219, 2007. (Pubitemid 46724859)
-
(2007)
Cancer Research
, vol.67
, Issue.7
, pp. 3210-3219
-
-
Kojima, K.1
Konopleva, M.2
Samudio, I.J.3
Ruvolo, V.4
Andreeff, M.5
-
27
-
-
77950212489
-
Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim
-
Zhang W, Konopleva M, Burks JK, et al: Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res 70: 2424-2434, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 2424-2434
-
-
Zhang, W.1
Konopleva, M.2
Burks, J.K.3
-
28
-
-
44949231424
-
T method
-
DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
-
Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108, 2008. (Pubitemid 351818697)
-
(2008)
Nature Protocols
, vol.3
, Issue.6
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
29
-
-
84860529329
-
Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
-
Jang JY, Kim MK, Jeon YK, et al: Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells. Exp Mol Med 44: 251-259, 2012.
-
(2012)
Exp Mol Med
, vol.44
, pp. 251-259
-
-
Jang, J.Y.1
Kim, M.K.2
Jeon, Y.K.3
-
30
-
-
77952236403
-
Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells
-
Sauer L, Gitenay D, Vo C and Baron VT: Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells. Oncogene 29: 2628-2637, 2010.
-
(2010)
Oncogene
, vol.29
, pp. 2628-2637
-
-
Sauer, L.1
Gitenay, D.2
Vo, C.3
Baron, V.T.4
-
31
-
-
33750909999
-
Reactive oxygen species-induced activation of the MAP kinase signaling pathways
-
DOI 10.1089/ars.2006.8.1775
-
McCubrey JA, Lahair MM and Franklin RA: Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 8: 1775-1789, 2006. (Pubitemid 44726351)
-
(2006)
Antioxidants and Redox Signaling
, vol.8
, Issue.9-10
, pp. 1775-1789
-
-
McCubrey, J.A.1
LaHair, M.M.2
Franklin, R.A.3
-
32
-
-
84863839992
-
Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway
-
Liu CM, Sun YZ, Sun JM, Ma JQ and Cheng C: Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway. Biochim Biophys Acta 1820: 1693-1703, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1820
, pp. 1693-1703
-
-
Liu, C.M.1
Sun, Y.Z.2
Sun, J.M.3
Ma, J.Q.4
Cheng, C.5
-
34
-
-
0035910385
-
Hypoxia death stimulus induces translocation of p53 protein to mitochondria - Detection by immunofluorescence on whole cells
-
DOI 10.1016/S0014-5793(00)02368-1, PII S0014579300023681
-
Sansome C, Zaika A, Marchenko ND and Moll UM: Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett 488: 110-115, 2001. (Pubitemid 32103581)
-
(2001)
FEBS Letters
, vol.488
, Issue.3
, pp. 110-115
-
-
Sansome, C.1
Zaika, A.2
Marchenko, N.D.3
Moll, U.M.4
-
35
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
DOI 10.1016/S1097-2765(03)00050-9
-
Mihara M, Erster S, Zaika A, et al: p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-590, 2003. (Pubitemid 36385115)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
Petrenko, O.4
Chittenden, T.5
Pancoska, P.6
Moll, U.M.7
-
36
-
-
33749845328
-
Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo
-
DOI 10.1038/sj.onc.1209641, PII 1209641
-
Palacios G and Moll UM: Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo. Oncogene 25: 6133-6139, 2006. (Pubitemid 44562412)
-
(2006)
Oncogene
, vol.25
, Issue.45
, pp. 6133-6139
-
-
Palacios, G.1
Moll, U.M.2
-
37
-
-
27544490654
-
Mitochondrially targeted p53 has tumor suppressor activities in vivo
-
DOI 10.1158/0008-5472.CAN-05-1084
-
Talos F, Petrenko O, Mena P and Moll UM: Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res 65: 9971-9981, 2005. (Pubitemid 41541478)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9971-9981
-
-
Talos, F.1
Petrenko, O.2
Mena, P.3
Moll, U.M.4
-
38
-
-
66749128074
-
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells
-
Vaseva AV, Marchenko ND and Moll UM: The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle 8: 1711-1719, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 1711-1719
-
-
Vaseva, A.V.1
Marchenko, N.D.2
Moll, U.M.3
-
39
-
-
18144382261
-
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
-
DOI 10.1158/0008-5472.CAN-04-3835
-
Zhao Y, Chaiswing L, Velez JM, et al: p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res 65: 3745-3750, 2005. (Pubitemid 40616352)
-
(2005)
Cancer Research
, vol.65
, Issue.9
, pp. 3745-3750
-
-
Zhao, Y.1
Chaiswing, L.2
Velez, J.M.3
Batinic-Haberle, I.4
Colburn, N.H.5
Oberley, T.D.6
St. Clair, D.K.7
-
40
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
-
DOI 10.1038/nchembio809, PII NCHEMBIO809
-
Strom E, Sathe S, Komarov PG, et al: Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2: 474-479, 2006. (Pubitemid 44266309)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.9
, pp. 474-479
-
-
Strom, E.1
Sathe, S.2
Komarov, P.G.3
Chernova, O.B.4
Pavlovska, I.5
Shyshynova, I.6
Bosykh, D.A.7
Burdelya, L.G.8
Macklis, R.M.9
Skaliter, R.10
Komarova, E.A.11
Gudkov, A.V.12
|