P53 promotes cellular survival in a context-dependent manner by directly inducing the expression of haeme-oxygenase-1

Oncogene

Volumn 30, Issue 44, 2011, Pages 4476-4486

  Nam, S Y ^a   Sabapathy, K ^a,b,c  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

haeme oxygenease 1; hydrogen peroxide; p53; survival

Indexed keywords

ANTIOXIDANT; BILIRUBIN; CISPLATIN; ETOPOSIDE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; PROTEIN MDM2; PROTEIN P21; PROTEIN P73;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME METABOLISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLORECTAL NEOPLASMS; EMBRYONIC STEM CELLS; ENZYME INDUCTION; GENES, P53; HEME OXYGENASE-1; HUMANS; HYDROGEN PEROXIDE; MICE;

EID: 80455164743     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.150     Document Type: Article

References (37)

1. Batista LF, Roos WP, Christmann M, Menck CF, Kaina B. (2007). Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer Res 67: 11886-11895.
2. Brooks CL, Gu W. (2010). New insights into p53 activation. Cell Res 20: 614-621.
3. Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP. (2009). Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer 9: 862-873.
4. Burdelya LG, Komarova EA, Hill JE, Browder T, Tararova ND, Mavrakis L et al. (2006). Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangio-genic effects of chemotherapy and radiotherapy in mice. Cancer Res 66: 9356-9361. (Pubitemid 44623629)
5. Buzek J, Latonen L, Kurki S, Peltonen K, Laiho M. (2002). Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277. Nucleic Acids Res 30: 2340-2348. (Pubitemid 34618984)
6. Chen-Roetling J, Benvenisti-Zarom L, Regan RF. (2005). Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury. J Neurosci Res 82: 802-810. (Pubitemid 41746493)
7. Choi AM, Alam J. (1996). Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 15: 9-19. (Pubitemid 126439851)
8. Fang J, Akaike T, Maeda H. (2004). Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis 9: 27-35. (Pubitemid 38270426)
9. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK et al. (1999). Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1: 152-157. (Pubitemid 129656019)
10. Foresti R, Clark JE, Green CJ, Motterlini R. (1997). Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions. J Biol Chem 272: 18411-18417. (Pubitemid 27306435)
11. Gozzelino R, Jeney V, Soares MP. (2010). Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50: 323-354.
12. Gudkov AV, Komarova EA. (2010). Pathologies associated with the p53 response. Cold Spring Harb Perspect Biol 2: a001180.
13. Helton ES, Chen X. (2007). p53 modulation of the DNA damage response. J Cell Biochem 100: 883-896.
14. Hermisson M, Klumpp A, Wick W, Wischhusen J, Nagel G, Roos W et al. (2006). O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem 96: 766-776.
15. Hu W, Feng Z, Teresky AK, Levine AJ. (2007). p53 regulates maternal reproduction through LIF. Nature 450: 721-724. (Pubitemid 350207678)
16. Janicke RU, Sohn D, Schulze-Osthoff K. (2008). The dark side of a tumor suppressor: antiapoptotic p53. Cell Death Differ 15: 959-976. (Pubitemid 351712601)
17. Jozkowicz A, Was H, Dulak J. (2007). Heme oxygenase-1 in tumors: is it a false friend? Antioxid Redox Signal 9: 2099-2117. (Pubitemid 350059009)
18. Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR et al. (2004). Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastrointestinal syndrome in mice. Oncogene 23: 3265-3271. (Pubitemid 38669816)
19. Lackinger D, Kaina B. (2000). Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mutat Res 457: 113-123.
20. Laptenko O, Prives C. (2006). Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 13: 951-961.
21. Lassus P, Ferlin M, Piette J, Hibner U. (1996). Anti-apoptotic activity of low levels of wild-type p53. EMBO J 15: 4566-4573. (Pubitemid 26294575)
22. Lee MK, Hande MP, Sabapathy K. (2005). Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation-and stress-induced p53-dependent apoptosis. J Cell Sci 118: 819-829. (Pubitemid 40372589)
23. Levine AJ, Oren M. (2009). The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9: 749-758.
24. Motterlini R, Foresti R, Bassi R, Calabrese V, Clark JE, Green CJ. (2000). Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols. J Biol Chem 275: 13613-13620. (Pubitemid 30257429)
25. Motterlini R, Green CJ, Foresti R. (2002). Regulation of heme oxygenase-1 by redox signals involving nitric oxide. Antioxid Redox Signal 4: 615-624. (Pubitemid 35001445)
26. Meiller A, Alvarez S, Drane P, Lallemand C, Blanchard B, Tovey M et al. (2007). p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated-mice identification of haeme-oxygenase 1 as a direct p53 target gene. Nucleic Acids Res 35: 6924-6934. (Pubitemid 350201811)
27. Persons DL, Yazlovitskaya EM, Pelling JC. (2000). Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J Biol Chem 275: 35778-35785.
28. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AM. (2000). Heme oxygenase-1 inhibits TNF-alpha-induced apoptosis in cultured fibroblasts. Am J Physiol Lung Cell Mol Physiol 278: L312-L319. (Pubitemid 30131216)
29. Roepke M, Diestel A, Bajbouj K, Walluscheck D, Schonfeld P, Roessner A et al. (2007). Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther 6: 160-169. (Pubitemid 46641618)
30. Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF et al. (2007). Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 26: 186-197. (Pubitemid 46095730)
31. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. (2004). Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15: 713-725. (Pubitemid 39194902)
32. Sur S, Pagliarini R, Bunz F, Rago C, Diaz Jr LA, Kinzler KW et al. (2009). A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc Natl Acad Sci USA 106: 3964-3969.
33. Vikhanskaya F, Toh WH, Dulloo I, Wu Q, Boominathan L, Ng HH et al. (2007). p73 supports cellular growth through c-Jun-dependent AP-1 transactivation. Nat Cell Biol 9: 698-705.
34. Vikhanskaya F, Vignati S, Beccaglia P, Ottoboni C, Russo P, D'Incalci M et al. (1998). Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis. Exp Cell Res 241: 96-101. (Pubitemid 28366583)
35. Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. (1999). Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 96: 14517-14522. (Pubitemid 30000682)
36. Zhang Y, Lu N, Gao Z. (2009). Hemin-H2O2-NO2(-) induced protein oxidation and tyrosine nitration are different from those of SIN-1: a study on glutamate dehydrogenase nitrative/oxidative modification. Int J Biochem Cell Biol 41: 907-915.
37. Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y. (2009). Tumour suppression by p53: the importance of apoptosis and cellular senescence. J Pathol 219: 3-15.