Letters to the editor

Journal of Periodontology

Volumn 85, Issue 3, 2014, Pages 374-384

  Preus, Hans R ^a   Scheie, Anne Aamdal ^a   Baelum, Vibeke ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; METRONIDAZOLE;

AGGRESSIVE PERIODONTITIS; CHRONIC PERIODONTITIS; HUMAN; PREVENTIVE DENTISTRY;

AGGRESSIVE PERIODONTITIS; AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CHRONIC PERIODONTITIS; DENTAL SCALING; HUMANS; METRONIDAZOLE; ROOT PLANING;

EID: 84896519993     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2014.130379     Document Type: Letter

References (81)

1. Zandbergen D, Slot DE, Cobb CM, Van der Weijden FA. The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: A systematic review. J Periodontol 2013;84:332-351.
2. Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: A systematic review and meta-Analysis. J Periodontol 2012;83:731-743.
3. Sgolastra F, Gatto R, Petrucci A, Monaco A. Effectiveness of systemic amoxicillin/metronidazole as adjunct therapy to scaling and root planing in the treatment of chronic periodontitis: A systematic review and metaanalysis. J Periodontol 2012;83:1257-1269.
4. Becker W, Becker BE, Caffesse R, et al. A longitudinal study comparing scaling, osseous surgery, and modified Widman procedures: Results after 5 years. J Periodontol 2001;72:1675-1684.
5. Cobb CM. Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing. J Clin Periodontol 2002;29 (Suppl. 2):6-16.
6. Pawlowski AP, Chen A, Hacker BM, Mancl LA, Page RC, Roberts FA. Clinical effects of scaling and root planing on untreated teeth. J Clin Periodontol 2005;32:21-28.
7. Brochut PF, Marin I, Baehni P, Mombelli A. Predictive value of clinical and microbiological parameters for the treatment outcome of scaling and root planing. J Clin Periodontol 2005;32:695-701.
8. RosalemW, Rescala B, Teles RP, Fischer RG, Gustafsson A, Figueredo CM. Effect of non-surgical treatment on chronic and aggressive periodontitis: Clinical, immunologic, and microbiologic findings. J Periodontol 2011;82: 979-989.
9. Walker CB, Gordon JM, Magnusson I, Clark WB. A role for antibiotics in the treatment of refractory periodontitis. J Periodontol 1993;64(Suppl. 8):772-781.
10. Lang NP, Joss A, Orsanic T, Gusberti FA, Siegrist BE. Bleeding on probing, a predictor for the progression of periodontal disease? J Clin Periodontol 1986;13:590-596.
11. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003;8:115-181.
12. Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S.A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002;29(Suppl. 3): 136-159.
13. Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontol 2000 2002;28:106-176.
14. Slots J. Systemic antibiotics in periodontics. J Periodontol 2003;74:1415-1422.
15. Mombelli A. Heresy? Treatment of chronic periodontitis with systemic antibiotics only. J Clin Periodontol 2006; 33:661-662.
16. Aimetti M, Romano F, Guzzi N, Carnevale G. Fullmouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: A randomized placebo-controlled trial. J Clin Periodontol 2012;39: 284-294.
17. Silva MP, Feres M, Sirotto TAO, et al. Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2011;38:828-837.
18. Yek EC, Cintan S, Topcuoglu N, Kulekci G, Issever H, Kantarci A. Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. J Periodontol 2010;81:964-974.
19. Mombelli A, Cionca N, Almaglouth A. Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery? Periodontol 2000 2011;55: 205-216.
20. Bittner J, Munteanu V. Potentiating action of combining metronidazole and penicillin against C. perfringens in vitro. In: Finegold S, McFadzean JA, Roe FJC, eds. Metronidazole: Proceedings of the International Metronidazole Conference (Quebec, Canada, May 26-28, 1976). Amsterdam: Excerpta Medica; 1977:293-298.
21. Van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxicillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989; 16:128-131.
22. Socransky SS, Haffajee AD. Periodontal microbial ecology. Microbiology of periodontal diseases. Periodontol 2000 2005;38:135-187.
23. World Health Organization. The Evolving Threat of Antimicrobial Resistance: Options for Action. Geneva, Switzerland: World Health Organization; 2012.
24. Bronzwaer S, Lönnroth A, Haigh R. The European community strategy against antimicrobial resistance. Euro Surveill 2004;9:441.
25. European Center for Disease Prevention and Control. Strategies for Disease-Specific Programs: 2010-2013. Stockholm: European Center for Disease Prevention and Control; 2010.
26. Jorgensen MG, Slots J. Responsible use of antimicrobials in periodontics. J Calif Dent Assoc 2000;28: 185-193.
27. Veloo AC, Seme K, Raangs E, et al. Antibiotic susceptibility profiles of oral pathogens. Int J Antimicrob Agents 2012;40:450-454.
28. Van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996;10:45-78.
29. Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG. Epidemiology and reporting characteristics of systematic reviews. PLoS Med 2007;4:e78.
30. Lundh A, Knijnenburg SL, Jorgensen AW, van Dalen EC, Kremer LC. Quality of systematic reviews in pediatric oncology-A systematic review. Cancer Treat Rev 2009;35:645-652.
31. Baderstein A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. II. J Clin Periodontol 1984;11:63-76.
32. Claffey N, Loos B, Gantes B, Martin M, Heins P, Egelberg J. The relative effects of therapy and periodontal disease on loss of probing attachment after root debridement. J Clin Periodontol 1988;17:108-114.
33. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part I. J Periodontol 1989;60:664-674.
34. Goodson JM, Haffajee AD, Socransky SS, et al. Control of periodontal infections: A randomized controlled trial. I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 2012;39:526-536.
35. Valenza G, Veihelmann S, Peplies J, et al. Microbial changes in periodontitis successfully treated with mechanical plaque removal and systemic amoxicillin and metronidazole. Int J Med Microbiol 2009;299:427-438.
36. Giannopoulou C, Andersen E, Brochut P, Plagnat D, Mombelli A. Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: Biologic response. J Periodontol 2006;77: 707-713.
37. Mombelli A, Brochut P, Plagnat D, Casagni F, Giannopoulou C. Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: Clinical effects. J Clin Periodontol 2005;32:225-230.
38. Ehmke B, Moter A, Beikler T, Milian E, Flemmig TF. Adjunctive antimicrobial therapy of periodontitis: Long-term effects on disease progression and oral colonization. J Periodontol 2005;76:749-759.
39. Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol 1998;25:354-362.
40. Walker C, Karpinia K. Rationale for use of antibiotics in periodontics. J Periodontol 2002;73:1188-1196.
41. Aimetti M, Romano F, Guzzi N, Carnevale G. Fullmouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: A randomized placebo-controlled trial. J Clin Periodontol 2012;39: 284-294.
42. Preus HR, Gunleiksrud TM, Sandvik L, Gjermo P, Baelum V. A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. J Periodontol 2013;84:1075-1086.
43. Flemmig TF, Milian E, Karch H, Klaiber B. Differential treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. J Clin Periodontol 1998;25:380-387.
44. Müller HP, Heinecke A, Borneff M, Kiencke C, Knopf A, Pohl S. Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. J Periodontal Res 1998;33:49-58.
45. Winkel EG, van Winkelhoff AJ, van der Velden U. Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy. J Clin Periodontol 1998;25:857-864.
46. Van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans- associated periodontitis. J Periodontol 1992;63:52-57.
47. Page RC, Eke PI. Case definitions for use in populationbased surveillance of periodontitis. J Periodontol 2007; 78:1387-1399.
48. Tonetti MS, Claffey N; European Workshop in Periodontology group C. Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group C consensus report of the 5th European Workshop in Periodontology. J Clin Periodontol 2005;32(Suppl. 6):210-213.
49. Wærhaug J. Healing of the dento-epithelial junction following subgingival plaque control. II: As observed on extracted teeth. J Periodontol 1978;49:119-134.
50. Marsh PD, Moter A, Devine DA. Dental plaque biofilms: Communities, conflict and control. Periodontol 2000 2011;55:16-35.
51. Quirynen M, Bollen CML, Vandekerckhove BNA, Dekeyser C, Papaioannou W, Eyssen H. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: Short-term clinical and microbiological observations. J Dent Res 1995;74:1459-1467.
52. Teughels W, Dekeyser C, Van Essche M, Quirynen M. One-stage, full-mouth disinfection: Fiction or reality? Periodontol 2000 2009;50:39-51.
53. Apatzidou DA, Kinane DF. Quadrant root planing versus same-day full-mouth root planing. I. Clinical findings. J Clin Periodontol 2004;31:132-140.
54. Apatzidou DA, Riggio CF, Kinane DF. Quadrant root planing versus same-day full-mouth root planing. II. Microbiological findings. J Clin Periodontol 2004;31: 141-148.
55. Bollen C M, Mongardini C, Papaioannou W, Van Steenberghe D, Quirynen M. The effect of a one-stage full-mouth disinfection on different intra-oral niches. Clinical and microbiological observations. J Clin Periodontol 1998;25:56-66.
56. Amid R, Tabeie MB, Kadkhodazadeh M, Mehdizadeh AR, Youssefi N. Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: A comparative in vivo study. Drug Metab Drug Interact 2012;27:113-118.
57. Pähkla ER, Koppel T, Saag M, Pähkla R. Metronidazole concentrations in plasma, saliva, and periodontal pockets in patients with periodontitis. J Clin Periodontol 2005;32:163-166.
58. Egelberg J. Periodontics, the Scientific Way: Synopses of Human Clinical Studies, 3rd ed. Malmö, Sweden: OdontoScience; 1999:184.
59. Xajigeorgiou C, Sakellari D, Slini T, Baka A, Konstantinidis A. Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. J Clin Periodontol 2006;33:254-264.
60. Mestnik MJ, Feres M, Figueiredo LC, Duarte PM, Lira EAG, Faveri M. Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. J Clin Periodontol 2010;37:353-365.
61. Varela VM, Heller D, Silva-Senem MX, Torres MC, Colombo AP, Feres-Filho EJ. Systemic antimicrobials adjunctive to a repeated mechanical and antiseptic therapy for aggressive periodontitis: A 6-month randomized controlled trial. J Periodontol 2011;82:1121-1130.
62. Baltacioglu E, Aslan M, Sarac Ö, Saybak A, Yuva P. Analysis of clinical results of systemic antimicrobials combined with non-surgical periodontal treatment for generalized aggressive periodontitis. J Can Dent Assoc 2011;77:b97.
63. Guerrero A, Griffiths GS, Nibali L, et al. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2005;32:1096-1107.
64. Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in treatment of smokers with chronic periodontitis: A randomized placebocontrolled study. J Clin Periodontol 2008;35:885-896.
65. Winkel EG, van Winkelhoff AJ, Timmerman MF, van der Velden U, Van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 2001;28:296-305.
66. Oliveira APL, Faveri M, Gursky LC, et al. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol 2012;39:295-302.
67. Mestnik MJ, Feres M, Figueiredo LC, et al. The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis. A 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2012;39:955-961.
68. Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr., Goncalves RB, Casati MZ. The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 2012;83:988-998.
69. Rodrigues AS, Lourencxão DS, Lima Neto LG, et al. Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. J Periodontol 2012;83:744-752.
70. Heller D, Varela VM, Silva-Senem MX, Torres MC, Feres-Filho EJ, Colombo AP. Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: A 6-month RCT. J Clin Periodontol 2011;38:355-364.
71. Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis. J Periodontol 2010; 81:15-23.
72. Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and metronidazole as an adjunct to fullmouth scaling and root planing of chronic periodontitis. J Periodontol 2009;80:364-371.
73. Ribeiro Edel P, Bittencourt S, Zanin IC, et al. Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis. J Periodontol 2009;80:1254-1264.
74. Akincibay H,Örsal SÖ, SengünD, TözümTF. Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: A clinical and microbiological study. Quintessence Int 2008;39(2):e33-e39.
75. Johnson JD, Chen R, Lenton PA, Zhang G, Hinrichs JE, Rudney JD. Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis. J Periodontol 2008;79:2305-2312.
76. Machtei EE, Younis MN. The use of 2 antibiotic regimens in aggressive periodontitis: Comparison of changes in clinical parameters and gingival crevicular fluid biomarkers. Quintessence Int 2008;39:811-819.
77. Kaner D, Christian C, Dietrich T, Bernimoulin J-P, Kleber B-M, Friedman A. Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. J Periodontol 2007;78:1201-1208.
78. Moeintaghavi A, Talebi-Ardakani MR, Haerian-Ardakani A, et al. Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: A randomized, placebo-controlled clinical trial. J Contemp Dent Pract 2007;8:51-59.
79. Moreira RM, Feres-Filho EJ. Comparison between fullmouth scaling and root planing and quadrant-wise basic therapy of aggressive periodontitis. Six-month clinical results. J Periodontol 2007;78:1683-1688.
80. Guerrero A, Echeverria JJ, Tonetti MS. Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: A pilot retrospective study. J Clin Periodontol 2007;34:897-902.
81. Ehmke B, Beikler T, Haubitz I, Karch H, Flemmig TF. Multifactorial assessment of predictors for prevention of periodontal disease progression. Clin Oral Investig 2003;7:217-221.