Systemic antibiotic therapy in periodontics

Periodontology 2000

Volumn 10, Issue 1, 1996, Pages 45-78

  Van Winkelhoff, Arie Jan ^a   Rams, Thomas E ^a   Slots, Jørgen ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; DRUG COMBINATION; GRAM NEGATIVE INFECTION; HUMAN; MICROBIOLOGY; OPPORTUNISTIC INFECTION; PERIODONTITIS; REVIEW; SUPERINFECTION;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; DRUG THERAPY, COMBINATION; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; OPPORTUNISTIC INFECTIONS; PERIODONTITIS; PERIODONTITIS, JUVENILE; SUPERINFECTION;

EID: 0030072465     PISSN: 09066713     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0757.1996.tb00068.x     Document Type: Article

References (246)

1. Abu-Fanas SH, Drucker DB, Hull PS. Amoxicillin with clavulanic acid and tetracycline in periodontal therapy. J Dent Res 1991: 19: 97-99.
2. Abu-Fanas SH, Drucker DB, Hull PS, Reeder JC, Ganguli LA. Identification and susceptibility to seven antimicrobial agents of 61 gram-negative anaerobic rods for periodontal pockets. J Periodont Res 1991: 19: 46-50.
3. Aitken S, Birek P, Kulkarni GV, Lee W, McCulloch CAG. Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high risk patients. J Periodontol 1992: 63: 87-92.
4. Alaluusua S, Asikainen S, Lai CH. Intrafamilial transmission of Actinobacillus actinomycetemcomitans. J Periodontol 1991: 62: 207-210.
5. Alaluusua S, Saarela M, Jousimies-Somer H, Asikainen S. Ribotyping shows intrafamilial similarity in Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 1993: 8: 225-229.
6. Ali RW, Lie T, Skaug N. Early effects of periodontal therapy on the detection frequency of four putative periodontal pathogens in adults. J Periodontol 1992: 63: 540-547.
7. Anwar H, Dasgupta MK, Costerton JW. Testing the susceptibility of bacteria in biofilms to antibacterial agents. Antimicrob Agents Chemother 1990: 34: 2043-2046.
8. Anwar H, Strap JL, Costerton JW. Establishment of aging biofilms: possible mechanism of bacterial resistance to antibiotic therapy. Antimicrob Agents Chemother 1992: 36: 1347-1351.
9. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol (in press).
10. Asikainen S. The efficacy of nitroimidazoles on moderate or deep periodontal pockets. J Dent Res 1989: 68: 411, abstr 1839.
11. Asikainen S, Jousimies-Somer H, Kanervo A, Saxén L. The immediate efficacy of adjunctive doxycycline in treatment of localized juvenile periodontitis. Arch Oral Biol 1990: 35: 231S-234S.
12. Bain CA, Beagrie GS, Bourgoin J, Delorme F, Holthuis A, Landry RE, Roy S, Schuller P, Singer O, Turnbull R. The effects of spiramycin and/or scaling on advanced periodontitis in humans. Can Dent Assoc J 1994: 60: 209-217.
13. Baker PJ, Evans RT, Coburn RA, Genco RJ. Tetracycline and its derivates strongly bind to and are released from the tooth surface in active form. J Periodontol 1983: 54: 580-585.
14. Baker PJ, Slots J, Genco RJ, Evans RT. Minimal inhibitory concentrations of various antimicrobial agents for human oral anaerobic bacteria. Antimicrob Agents Chemother 1983: 24: 420-424.
15. Bergström J, Preber H. Tobacco use as a risk factor. J Periodontol 1994: 65: 545-550.
16. Björnvatn K, Skaug N, Selvig KA. Tetracycline impregnated enamel and dentin: duration of antimicrobial capacity. Scand J Dent Res 1985: 93: 192-197.
17. Bodinka A, Schmidt H, Henkel B, Flemmig TF, Klaiber B, Karch H. Polymerase chain reaction for the identification of Porphyromomas gingivalis collagenase genes. Oral Microbiol Immunol 1994: 9: 161-165.
18. Bragd L, Dahlén G, Wikström M, Slots J. The capability of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius to indicate progressive periodontitis; a retrospective study. J Clin Periodontol 1987: 14: 95-99.
19. Bragd L, Wikström M, Slots J. Clinical and microbiological study of "refractory" adult periodontitis. J Dent Res 1985: 64: 234, abstr 538.
20. Chaves E, Ryerson C, Snyder B, Jeffcoat M. Effect of systemic tetracycline therapy on specific bacterial antigens and bone height. J Dent Res 1995: 26: abstr 114.
21. Chen C, Slots J. The current status and future prospects of altering the pathogenic microflora of periodontal disease. Curr Opin Periodontol 1993: 71-77.
22. Chiappinelli JA, Walton RE. Tooth discoloration resulting from long-term tetracycline therapy: a case report. Quintessence Int 1992: 23: 539-541.
23. Chin Quee T, Al-Joburi W, Lautar-Lemay C, Chan ECS, Iugovaz IU, Bourgouin J, Delorme F. Comparison of spiramycin and tetracycline used adjunctively in the treatment of advanced periodontitis. J Antimicrob Chemother 1988: 22: (suppl B): 171-177.
24. Chin Quee T, Chan ECS, Clark C, Lautar-Lemay C, Bergeron MJ, Bourgoin J, Stamm J. The role of adjunctive Rodogyl therapy in the treatment of advanced periodontal disease. A longitudinal clinical and microbiologic study. J Periodontol 1987: 58: 594-601.
25. Christersson LA, Slots J, Rosling B, Genco, RJ. Microbiological and clinical effects of surgical treatment of localized juvenile periodontitis. J Clin Periodontol 1985: 12: 465-176.
26. Christersson LA, van Winkelhoff AJ, Zambon JJ, de Graaff J, Genco RJ. Systemic antibiotic combination therapy in recalcitrant and recurrent localized juvenile periodontitis. J Dent Res 1989: 68: 197, abstr 128.
27. Christersson LA, Wikesjö UME, Albini B, Zambon JJ, Genco RJ. Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis. J Periodontol 1987: 58: 540-545.
28. Christersson LA, Zambon JJ. Suppression of subgingival Actinobacillus actinomycetemcomitans in localized juvenile periodontitis by systemic tetracycline. J Clin Periodontol 1993: 20: 395-401.
29. Christersson LA, Zambon JJ, Wikesjö UME, Rosling BG, Dunford RG, Genco RJ. The effects of systemic tetracycline alone on localized juvenile periodontitis. J Dent Res 1986: 65: 805, abstract 718.
30. Ciancio SG, Mather ML, McMullen JA. An evaluation of minocycline in patients with periodontal disease. J Periodontol 1980: 51: 530-534.
31. Ciancio SG, Slots J, Reynolds HS, Zambon JJ, McKenna JD. The effect of short term administration of minocycline HCl on gingival inflammation and subgingival microflora. J Periodontol 1982: 53: 557-561.
32. Clark DC, Shenker S, Stulginsky P, Schwartz S. Effectiveness of routine periodontal treatment with and without adjunctive metronidazole therapy in mentally retarded adolescents. J Periodontol 1983: 54: 658-665.
33. Collins JG, Offenbacher S, Arnold RR. Effects of a combination therapy to eliminate Porphyromonas gingivalis in refractory periodontitis. J Periodontol 1993: 64: 998-1007.
34. Daikos GL, Lolans VT, Jackson GG. First-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical use. Antimicrob Agents Chemother 1991: 35: 117-123.
35. de Graaff J, van Winkelhoff AJ, Goené RJ. The role of Actinobacillus actinomycetemcomitans in periodontal disease. Infection 1989: 17: 269-271.
36. DiRienzo JM. Probe-specific DNA fingerprinting applied to the epidemiology of periodontal bacteria and disease activity of periodontitis. In: Hamada S, Holt SC, McGhee, ed. Periodontal disease: pathogens and host immune responses. Tokyo: Quintessence Publ Co., 1991: 379-392.
37. DiRienzo JM, Slots J, Sixou M, Sol MA, Harmon R, McKay TL. Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis. Infect Immun 1994: 62: 3058-3065.
38. Dougherty MA, Slots J. Periodontal diseases in young individuals. J Calif Dent Assoc 1993: 21 (January): 55-69.
39. Eisenberg L, Suchow R, Coles RS. The effects of metronidazole administration on clinical and microbiological parameters. Clin Prev Dent 1991: 12: 28-34.
40. Fiehn N-E, Westergaard J. Recurrent periodontitis: effect of doxycycline on the subgingival microflora. J Dent Res 1989: 68: 916, abstr 400.
41. Flynn MJ, Slots J. Beta-hemolytic streptococci in advanced periodontitis. Oral Microbiol Immunol 1993: 8: 295-297.
42. Freeman E, Ellen RP, Thompson G. Gingival fluid concentrations and side effects of minocycline: a comparison of two dose regimes. J Periodontol 1992: 63: 13-18.
43. Genco RJ, Cianciola LJ, Rosling B. Treatment of localized juvenile periodontitis. J Dent Res 1981: 60, 527, abstr 872.
44. Genco RJ, Mergenhagen SE. Summary of a workshop on leukocyte function in bacterial disease with an emphasis on periodontal disease. J Infect Dis 1979: 139: 604-612.
45. Genco RJ, Zambon JJ, Christersson LA. Use and interpretation of microbiological assays in periodontal diseases. Oral Microbiol Immunol 1986: 1: 73-79.
46. Giedrys-Leeper E, Selipsky H, Williams BL. Effects of short-term administration of metronidazole on the subgingival microflora. J Clin Periodontol 1985: 12: 797-814.
47. Gill CJ, Pallasch TJ. Clindamycin-associated pseudomembranous colitis: a potentially fatal adverse drug reaction. J Am Dent Assoc 1981: 102: 507-509.
48. Goené RJ, Winkel EG, Abbas F, Rodenburg JP, van Winkelhoff AJ, de Graaff J. Microbiology in diagnosis and treatment of severe periodontitis. A report of four cases. J Periodontol 1990: 61: 61-64.
49. Golub, LM, Lee HM, Lehrer G, Nemitroff A, McNamara TF, Kaplan R, Ramamurthy NS. Minocycline reduces gingival collagenolytic activity during diabetes. J Periodont Res 1983: 18: 516-526.
50. Goodson JM. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994: 5: 142-168.
51. Gordon JM, Walker CB. Current status of systemic antibiotic usage in destructive periodontal disease. J Periodontol 1993: 64: 760-771.
52. Gordon JM, Walker CB, Hovliaris C, Socransky SS. Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. J Periodontol 1990: 61: 686-691.
53. Gordon JM, Walker CB, Lamster I, West T, Socransky SS, Seiger M, Fasciano R. Efficacy of clindamycin hydrochloride in refractory periodontitis - 12 months results. J Periodontol 1985: 56 (suppl): 75-80.
54. Green LW, Tryon WW, Marks B, Huryn J. Periodontal disease as a function of life events stress. J Hum Stress 1986: 32-36.
55. Greenwald G, Moffett L, Offenbacher S, Van Dyke TE. Treatment of juvenile periodontitis with subgingival tetracycline fibers or flap surgery. J Dent Res 1985: 64: 200, abstr 234.
56. Grossi SG, Zambon JJ, Norderyd OM, Genco RJ. Microbiological risk indicators for periodontal disease. J Dent Res 1993: 72: 206, abstr 818.
57. Gusberti FA, Syed SA, Lang NP. Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease. J Clin Periodontol 1988: 15, 353-359.
58. Haffajee AD, Dibart S, Kent RL Jr, Socransky SS. Factors associated with different responses to periodontal therapy. J Clin Periodontol 1995: 22: 628-636.
59. Haffajee AD, Dibart S, Kent RL Jr, Socransky SS. Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections. J Clin Periodontol 1995: 22: 618-627.
60. Haffajee AD, Dzink JL, Socransky SS. Effect of modified Widman flap surgery and systemic tetracycline on the subgingival microbiota of periodontal lesions. J Clin Periodontol 1988: 15: 255-262.
61. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal disease. Periodontol 2000 1994: 5: 78-111.
62. Haffajee AD, Socransky SS, Goodson JM. Clinical parameters as predictors of destructive periodontal activity. J Clin Periodontol 1983:10: 257-265.
63. Haffajee AD, Socransky SS, Goodson JM. Subgingival temperature. II. Relation to future periodontal attachment loss. J Clin Periodontol 1992: 19: 409-416.
64. Hafström CA, Wikström MB, Renvert SN, Dahlén G. Effect of treatment on some periodontopathogens and their antibody levels in periodontal abscesses. J Periodontol 1994: 65: 1022-1028.
65. Helldén LB, Listgarten MA, Lindhe J. The effect of tetracycline and/or scaling on human periodontal disease. J Clin Periodontol 1979: 6: 222-230.
66. Helovuo LB. Periodontal superinfections. Thesis. Turku: University of Turku, Finland, 1986: 1-85.
67. Heluovo LB, Hakkarainen K, Paunio K. Changes in the prevalence of subgingival enterics rods, staphylococci and yeasts after treatment with penicillin and erythromycin. Oral Microbiol Immunol 1993: 8: 75-79.
68. Helovuo H, Paunio K. Effects of penicillin and erythromycin on the clinical parameters of the periodontium. J Periodontol 1989: 60: 467-472.
69. Hoffler U, Niederau W, Pulverer G. Susceptibility of Bacterium actinomycetemcomitans to 45 antibiotics. Antimicrob Agents Chemother 1980: 17: 943-946.
70. Hull PS, Abu-Fanas SH, Drucker DB. Evaluation of two antibacterial agents in the management of rapidly progressive periodontitis. J Dent Res 1989: 68: 564, abstr 46.
71. Jakobs MR, Spangler SK, Appelbaum PC. Susceptibility of Bacteroides non-fragilis and fusobacteria to amoxicillin, amoxicillin/clavulanate, ticarcillin, ticarcillin/clavunalate, cefoxitin, imipenem and metronidazole. Eur J Clin Microbiol Infect Dis 1990: 9: 417-421.
72. Jenkins WMM, MacFarlane TW, Gilmour WH, Ramsy I, MacKenzie D. Systemic metronidazole in the treatment of periodontitis. J Clin Periodontol 1989: 16: 443-450
73. Johnson CC, Wendeler M, Levison MD. In vitro susceptibility of oral pigmented Bacteroides species to spectomycin and other selected antimicrobial agents. Antimicrob Agents Chemother 1990: 34: 1597-1599.
74. Joss A, Adler R, Lang NP. Bleeding upon probing. A parameter for monitoring periodontal conditions in clinical practice. J Clin Periodontol 1994:21: 409-414.
75. Jousimies-Somer H, Asikainen S, Suomala P, Summanen P. Activity of metronidazole and its hydroxymetabolite. Oral Microbiol Immunol 1988: 3: 32-34.
76. Joyston-Bechal S, Smales FC, Duckworth R. A follow-up study 3 years after metronidazole therapy for chronic periodontal disease. J Clin Periodontol 1986: 13: 944-949.
77. Joyston-Bechal S, Smales FC, Duckworth R. Effect of metronidazole on chronic periodontal disease in subjects using topically applied chlorhexidine gel. J Clin Periodontol 1984: 11: 53-62.
78. Khatiblou FA. Combination of tetracycline and metronidazole in the treatment and control of refractory periodontitis. Periodont Abstr 1994: 42: 5-8.
79. Kinder SA, Holt SC, Kornman KS. Penicillin resistance in the subgingival microbiota associated with adult periodontitis. J Clin Microbiol 1986: 23: 1127-1133.
80. Kornman KS, Loesche WJ. Effects of estradiol and progesterone on Bacteroides melaninogenicus and Bacteroides gingivalis. Infect Immun 1982: 35: 256-263.
81. Kornman KS, Newman MG, Flemmig T, Alvarado R, Nachnani S. Treatment of refractory periodontitis with metronidazole plus amoxicillin or Augmentin. J Dent Res 1989: 68: 917, abstr 403.
82. Kornman KS, Newman MG, Moore DJ, Singer RE. The influence of supragingival plaque control on clinical and microbial outcomes following the use of antibiotics for the treatment of periodontitis. J Periodontol 1994: 65: 848-854.
83. Kornman KS, Robertson PB. Clinical and microbiological evaluation of therapy for juvenile periodontitis. J Periodontol 1985: 56: 443-446.
84. Kritchevsky B, Séguin P. The unity of spirochetoses in the mouth. Dent Cosmos 1924: 66: 511-520.
85. Kulkarni GV Lee WK, Aitken S, Birek P, McCulloch CAG. A randomised placebo-controlled trial of doxycycline: effects on the microflora of recurrent periodontitis lesions in high risk patients. J Periodontol 1991: 62: 197-202.
86. Kunihira DM, Caine FA, Palcanis KG, Best AM, Ranney RR. A clinical trial of phenoxymethyl penicillin for adjunctive treatment of juvenile periodontitis. J Periodontol 1985: 56: 352-358.
87. Lacroix JM, Mayrand D. The effect of subminimal inhibitory concentrations of antimicrobial agents on three bacterial mixtures. Oral Microbiol Immunol 1989: 4: 82-88.
88. Lang NP, Adler R, Joss A, Nyman S. Absence of bleeding on probing - an indicator of periodontal stability. J Clin Periodontol 1990: 17: 714-721.
89. Lekovic V, Kenney EB, Carranza FA Jr, Endres B. The effect of metronidazole on human periodontal disease. A clinical and bacteriological study. J Periodontol 1983: 54: 476-480.
90. Linden GJ, Mullally BH. Cigarette smoking and periodontal destruction in young adults. J Periodontol 1994: 65: 718-723.
91. Lindhe J. Treatment of localized juvenile periodontitis. In: Genco RJ, Mergenhagen SE, ed. Host-parasite interactions in periodontal diseases. Washington, DC: Am Soc Microbiol, 1981: 382-394.
92. Lindhe J, Liljenberg B, Adielson B. Effect of long term tetracycline therapy on human periodontal disease. J Clin Periodontol 1983: 10: 590-601.
93. Lindhe J, Liljenberg B, Adielson B, Borjesson I. Use of metronidazole as a probe in the study of human periodontal disease. J Clin Periodontol 1983: 10: 100-112.
94. Listgarten MA, Lindhe J, Helldén L. Effect of tetracycline and/or scaling on human periodontal disease. Clinical, microbiological, and histopathological observations. J Clin Periodontol 1978: 5: 246-271.
95. Loesche WJ. Chemotherapy of dental plaque infections. Oral Sci Rev 1976: 9: 63-105.
96. Loesche WJ, Bretz WA, Lopatin D, Stoll J, Rau CF, Hillenburg KC, Killoy WJ, Drisko CL, Williams R, Weber HP, Clark WB, Magnusson I, Walker CB. Multi-center clinical evaluation of a chairside method for detecting certain periodontopathic bacteria in periodontal disease. J Periodontol 1990: 61: 189-196.
97. Loesche WJ, Giordano JR. Metronidazole in periodontitis. V. Debridement should precede medication. Compendium 1994: 15: 1198-1218.
98. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis. III. Reduced need for surgery. J Clin Periodontol 1992: 19: 103-112.
99. Loesche WJ, Grossman N, Giordano J. Metronidazole in periodontitis. IV. The effect of patient compliance on treatment parameters. J Clin Periodontol 1993: 20: 96-104.
100. Loesche WJ, Schmidt E, Smith BA, Caffesse R, Stoll J. Metronidazole therapy for periodontitis. J Periodontol 1987: 22: 224-226.
101. Loesche WJ, Schmidt E, Smith BA, Morrison EC, Caffesse R, Hujoel P. Metronidazole in periodontitis. II. Effects upon treatment needs. J Periodontol 1991: 62: 247-257.
102. Loesche WJ, Syed SA, Morrison EC, Kerry GA, Higgins T, Stoll J. Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks. J Periodontol 1984: 55: 325-335.
103. Loesche WJ, Syed SA, Schmidt E, Morrison EC. Bacterial profiles of subgingival plaques in periodontitis. J Periodontol 1985: 56: 447-456.
104. Loos BG, Mayrand D, Genco RJ, Dickenson DP. Genetic heterogeneity of Porphyromonas (Bacteroides) gingivalis by genomic DNA fingerprinting. J Dent Res 1990: 69: 1488-1493.
105. Loos BG, van Winkelhoff AJ, Dunford RG, Genco RJ, de Graaff J, Dickenson DP, Dyer DW. A statistical approach to the ecology of Porphyromonas gingivalis. J Dent Res 1992: 71: 353-358.
106. Lorian V, ed. Antibiotics in laboratory medicine. 2nd edn. Baltimore: Williams & Wilkins, 1986.
107. Lotufo RFM, Flynn J, Chen C, Slots J. Molecular detection of Bacteroides forsythus in human periodontitis. Oral Microbiol Immunol 1994: 9: 161-165.
108. Low SB, Magnusson I, Clark WB, Walker CB, Marks RG. Changes in attachment level in subjects with progressive "refractory" periodontitis. J Dent Res 1988: 67: 157, abstr 357.
109. Lundström A, Johansson LA, Hamp SE. Effect of combined systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease. J Clin Periodontol 1984: 11: 321-330.
110. Magnusson I, Clark WB, Low SB, Marunaik J, Marks RG, Walker CB. Effect of non-surgical periodontal therapy combined with adjunctive antibiotics in subjects with "refractory" periodontal disease. I. Clinical results. J Clin Periodontol 1989: 16: 647-653.
111. Magnusson I, Clark WB, McArthur WP, Walker CB, Marks RG, Low SB. Treatment of subjects with refractory periodontal disease. J Dent Res 1992: 71: 757, abstr 1933.
112. Magnusson I, Low SB, McArthur WP, Marks RG, Walker CB, Maruniak J, Taylor M, Padgett P, Jung J, Clark WB. Treatment of subjects with refractory periodontal disease. J Clin Periodontol 1994: 21: 628-637.
113. Mahmood MM, Dolby AE. The value of systemically administered metronidazole in the modified Widman flap procedure. J Periodontol 1987: 58: 147-152.
114. Mandell RL, Socransky SS. Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis. J Periodontol 1988: 59: 373-379.
115. Mandell RL, Tripodi LS, Savitt E, Goodson JM, Socransky SS. The effect of treatment on Actinobadllus actinomycetemcomitans in localized juvenile periodontitis J Periodontol 1986: 57: 94-99.
116. Manor A, Lebendiger M, Shiffer A, Tovel H. Bacterial invasion of periodontal tissues in advanced periodontitis in humans. J Periodontol 1984: 55, 567-573.
117. Mashimo PA, Yamamoto Y, Slots J, Park B, Genco RJ. The periodontal microflora of juvenile diabetics. Culture, immunofluorescence, and serum antibody studies. J Periodontol 1983: 54: 420-430.
118. Matisko M, Bissada N. Short-term systemic administration of Augmentin and doxycycline in the treatment of recurrent progressive periodontitis. J Dent Res 1992: 71: 319, abstr 1711.
119. Mattout P, Moskov BS, Fourel J. Repair potential in localized juvenile periodontitis. A case in point. J Periodontol 1990: 61: 653-660.
120. McCulloch CAG, Birek P, Aitken S, Lee W. Efficacy of doxycycline in prevention of recurrent periodontitis. J Dent Res 1989: 68: 916, abstr 401.
121. McCulloch CAG, Birek P, Overall C, Aitken S, Lee W, Kulkarni G. Randomised controlled trial of doxycycline in prevention of recurent periodontitis in high risk patients: antimicrobial activity and collagenase inhibition. J Clin Periodontol 1990: 17: 616-622.
122. Ménard C, Mouton C. Clonal diversity of the taxon Porphyromonas gingivalis assessed by random amplified polymorphic DNA fingerprinting. Infect Immun 1995: 63: 2522-2531.
123. Mills WH, Thompson GW, Boagrie GS. Clinical evaluation of spiramycin and erythromycin in control of periodontal disease. J Clin Periodontol 1979: 6: 308-316.
124. Minah GE, Peterson DE, Overholser CD, DePaola LG, Suzuki JB. Oral succession of gram-negative bacilli in myelosuppressed cancer patients. J Clin Microbiol 1986: 24: 210-213.
125. Mishkin D, Javed T, Wood G, Engler W. Effect of topically applied tetracycline on microflora of juvenile periodontitis. J Dent Res 1985: 64: 305, abstr 1172.
126. Möller ÅJR. Microbiological examination of root canals and periapical tissues of human teeth. Odontol Tidskr 1966: 74 (suppl): 1-380.
127. Mombelli A, Gusberti FA, Lang NP. Treatment of recurrent periodontal disease by root planing and ornidazole (Tiberal). Clinical and microbiological findings. J Clin Periodontol 1989: 16: 38-45.
128. Mombelli A, Lang NP. Antimicrobial treatment of peri-implant infections. Clin Oral Impl Res 1992: 3: 162-167.
129. Mombelli A, McNabb H, Lang NP. Black-pigmented gram-negative bacteria in periodontal disease. II. Screening strategies for detection of P. gingivalis. J Periodont Res 1991: 26: 308-313.
130. Moore WEC, Moore LVH. The bacteria of periodontal diseases. Periodontol 2000 1994: 5: 66-77.
131. Moskov BS. Repair of an extensive periodontal defect after tetracycline administration. J Periodontol 1986: 57: 29-34.
132. Müller HP, Eickholz P, Heinecke A, Pohl S, Müller RF, Lange DE. Simultaneous isolation of Actinobacillus actinomycetemcomitans from subgingival and extracrevicular locations of the mouth. J Clin Periodontol 1995: 22: 413-419.
133. Müller HP, Lange DE, Müller RF. Failure of adjunctive minocycline-HCl to eliminate oral Actinobacillus actinomycetemcomitans. J Clin Periodontol 1993: 20: 498-504.
134. Müller HP, Lange DE, Müller RF. Konzentrierung von A. actinomycetemcomitans in subgingival Plaque nach kurzristiger Minocyclin-Therapie. Dtsch Zahnärztl Z 1990: 45: 462-465.
135. Müller HP, Müller RF, Lange DE. Die Reduction von A. actinomycetemcomitans bei der profunden Parodontitis. Dtsch Zahnärztl Z 1989: 44: 293-297.
136. Murayama Y, Kurihara H, Nagai A, Dompkowski D, Van Dyke TE. Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. Periodontol 2000 1994: 6: 116-124.
137. Murray PA. Periodontal diseases in patients infected by human immunodeficiency virus. Periodontol 2000 1994: 6: 50-67.
138. Nagy E, Földes J. Inactivation of metronidazole by Enterococcus faecalis. J Antimicrob Chemother 1991: 27: 63-70.
139. Nagy E, Heizmann WR, Werner H. Effect of daptomycin, metronidazole and mezlocillin combinations on mixed bacterial cultures involving facultative and anaerobic bacteria. Scand J Infect Dis 1991: 23: 239-245.
140. Nakagawa T, Yamada S, Oosuka Y, Saito A, Hosaka Y, Ishikawa T, Okuda K. Clinical and microbiological study of local minocycline delivery (Periocline) following scaling and root planing in recurrent periodontal pockets. Bull Tokyo Dent Coll 1991: 32: 63-70.
141. Newman MG, Kornman KS, Flemmig TF, Nachnani S, Alvarado R. Treatment of refractory periodontitis with Augmentin. J Dent Res 1989: 68: 917, abstr 404.
142. Novak MJ, Poison AM, Adair SM. Tetracycline therapy in patients with early juvenile periodontitis. J Periodontol 1988: 59: 366-372.
143. Novak MN, Stamatelakys C, Adair SM. Resolution of early lesions of juvenile periodontitis with tetracycline therapy alone: long-term observations of 4 cases. J Periodontol 1991: 62: 628-633.
144. Nowzari H, Matian F, Slots J. Periodontal pathogens on polytetrafluoroethylene membrane for guided tissue regeneration inhibit healing. J Clin Periodontol 1995: 22: 469-474.
145. Nowzari H, Slots J. Microorganisms on polytetrafluoroethylene barrier membranes for guided tissue regeneration. J Clin Periodontol 1994: 21: 203-210.
146. Ohta Y, Okuda K, Takazoe I. Microbiological and clinical effects of systemic antibiotic administration in advanced periodontitis. Bull Tokyo Dent Coll 1986: 27: 139-148.
147. Overholser CD, Peterson DE, Williams LT, Schimff SC. Periodontal infection in patients with acute nonlymphocytic leukemia. Prevalence of acute exacerbations. Arch Intern Med 1982: 142: 551-554.
148. Page RC, Schroeder HE. Periodontitis in man and other animals. Basel: Karger, 1981.
149. Pajukanta R, Asikainen S, Forsblom B, Saarela M, Jousimies-Somer H. β-Lactamase production and in vitro antimicrobial susceptibility of Porphyromonas gingivalis. FEMS Immunol Med Microbiol 1993: 6: 241-244.
150. Pajukanta R, Asikainen S, Saarela M, Alaluusua S, Jousimies-Somer H. In vitro antimicrobial susceptibility of different serotypes of Actinobacillus actinomycetemcomitans. Scand J Dent Res 1993: 101: 299-303.
151. Pajukanta R, Asikainen S, Saarela M, Alaluusua S, Jousimies-Somer H. In vitro activity of azithromycin compared with that of erythromycin against Actinobacillus actinomycetemcomitans. Antimicrob Agents Chemother 1992: 36: 1241-1243.
152. Pallasch TJ. Pharmacokinetic principles of antimicrobial therapy. Periodontol 2000 1996: 10: 5-11.
153. Papli R, Lewis JM. Refractory chronic periodontitis: effect of oral tetracycline hydrochloride and root planing. Aust Dent J 1989: 34: 60-68.
154. Paquette DW, Fiorellini JP, Howell TH. Effects of systemic metronidazole on human periodontal disease progression and BANA test results. J Dent Res 1992: 71: 757, abstr 1934.
155. Pavičić MJAMP, van Winkelhoff AJ, de Graaff J. Synergistic effects between amoxicillin, metronidazole and the hydroxymetabolite of metronidazole against Actinobacillus actinomycetemcomitans. Antimicrob Agents Chemother 1991: 35: 961-966.
156. Pavičić MJAMP, van Winkelhoff AJ, de Graaff J. In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations. Antimicrob Agents Chemother 1992 36: 2634-2638.
157. Pavičić MJAMP, van Winkelhoff AJ, Douqué NH, Steures RWR, de Graaff J. Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans associated periodontitis. A 2-year evaluation. J Clin Periodontol 1994: 21: 107-112.
158. Pavičić MJAMP, van Winkelhoff AJ, Pavičić-Temming YAM, de Graaff J. Amoxycillin causes an enhanced uptake of metronidazole in Actinobacillus actinomycetemcomitans: a mechanism of synergism. J Antimicrob Chemother 1994 34: 1047-1050.
159. Pavičić MJAMP, van Winkelhoff AJ, Pavičić-Temming YAM, de Graaff J. Metronidazole susceptibility factors in Actinobacillus actinomycetemcomitans. J Antimicrob Chemother 1995: 35: 263-269.
160. Petit MDA, van Steenbergen TJM, de Graaff J, van der Velden U. Transmission of Actinobacillus actinomycetemcomitans in families of adult periodontitis patients. J Periodont Res 1993: 28: 335-345.
161. Petit MDA, van Steenbergen, TJM, Scholte LHM, van der Velden U, de Graaff J. Epidemiology and transmission of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among children and their family members - a report of 4 surveys. J Clin Periodontol 1993: 20: 641-650.
162. Poulsen K, Theilade E, Lally ET, Demuth DR, Kilian M. Population structure of Actinobacillus actinomycetemcomitans: a framework for studies of disease-associated properties. Microbiology 1994: 140: 2049-2060.
163. Preber H, Bergström J. Cigarette smoking in patients referred for periodontal treatment. Scand J Dent Res 1986: 94: 102-108.
164. Preus HR, Russell DT, Zambon JJ. Transmission of Actinobacillus actinomycetemcomitans in families of adult periodontitis patients. J Dent Res 1992: 71: 606.
165. Prinz H. A contribution to the history of Ementin. Dent Cosmos 1915: 57: 313-315.
166. Rams TE, Babalola OO, Slots J. Subgingival occurrence of enteric rods, yeasts and staphylococci after systemic doxycycline therapy. Oral Microbiol Immunol 1990: 5: 166-168.
167. Rams TE, Feik D, Slots J. Ciprofloxacin/metronidazole treatment of recurrent adult periodontitis. J Dent Res 1992: 71: 319, abstr 1708.
168. Rams TE, Feik D, Slots J. Staphylococci in human periodontal diseases. Oral Microbiol Immunol 1990: 5: 29-32.
169. Rams TE, Feik D, Young V, Hammond BF, Slots J. Enterococci in human periodontitis. Oral Microbiol Immunol 1992: 7: 249-252.
170. Rams TE, Keyes PH. A rational for the management of periodontal diseases: effects of tetracycline on subgingival bacteria. J Am Dent Assoc 1983: 107: 37-41.
171. Rams TE, Keyes PH, Wright WE, Howard SA. Long-term effects of microbiologically modulated periodontal therapy on advanced adult periodontitis. J Am Dent Assoc 1985: 111: 429-441.
172. Rams TE, Listgarten MA, Slots J. Utility of radiographic crestal lamina dura for predicting periodontitis disease-activity. J Clin Periodontol 1994: 21: 571-576.
173. Rams TE, Listgarten MA, Slots J. The utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in adults on maintenance care. J Clin Periodontol (in press).
174. Rams TE, Slots J. The subgingival microflora as a determinant in periodontal disease treatment planning. Probe Can Dent Hyg Assoc J 1990: 24: 89-92.
175. Rams TE, Slots J. Comparison of two pressure-sensitive probes and manual periodontal probe in shallow and deep pockets. Int J Periodontics Restorative Dent 1993: 13: 519-527.
176. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000 1996: 10: 139-159.
177. Rams TE, Slots J. Candida biotypes in human adult periodontitis. Oral Microbiol Immunol 1991: 6: 191-192.
178. Renvert S, Wikström M, Dahlén G, Slots J, Egelberg J. Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans from periodontal pockets. J Clin Periodontol 1990: 17: 345-350.
179. Renvert S, Wikström M, Slots J, Egelberg J. On the inability of root debridement and periodontal surgery to eliminate Actinobacillus actinomycetemcomitans from periodontal pockets. J Clin Periodontol 1990: 17: 351-355.
180. Reynolds MA, Minah GE, Peterson DE, Weibel DS, Williams LT, Overholser DS, DePaola LG, Suzuki JB. Periodontal disease and oral microbial succession during myelosuppressive cancer chemotherapy. J Clin Periodontol 1989: 16: 185-189.
181. Rodenburg JP, van Winkelhoff AJ, Winkel EG, Goené RJ, Abbas F, de Graaff J. Occurrence of Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in progressive periodontal disease in relation to age and treatment history. J Clin Periodontol 1990: 17: 392-399.
182. Rosenberg ES, Torosian JP, Hammond BF, Cutler SA. Routine anaerobic bacterial culture and systemic antibiotic usage in the treatment of adult periodontitis: a 6-year longitudinal study. Int J Periodontics Restorative Dent 1993: 13: 213-243.
183. Saarela M, von Troil-Lindén B, Torrko H, Stucki A-M, Alaluusua S, Jousimies-Somer H, Asikainen S. Transmission of oral bacterial species species between spouses. Oral Microbiol Immunol 1993: 8: 349-354.
184. Salman RA, Dalman DG, Glickman RS, Suder S, Salman L. Minocycline induced pigmentation of the oral cavity. J Oral Med 1985: 40: 154-157.
185. Saxén L, Asikainen S. Metronidazole in the treatment of localized juvenile periodontitis. J Dent Res 1992: 71: 1098, abstr 104.
186. Saxén L, Asikainen S. Metronidazole in the treatment of localized juvenile periodontitis. J Clin Periodontol 1993: 20: 166-171.
187. Saxén L, Asikainen S, Kanervo A, Kari K, Jousimies-Somer H. The long-term efficacy of systemic doxycycline medication in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. Arch Oral Biol 1990: 35: 227S-229S.
188. Schenkein HA, van Dyke TE. Early-onset periodontitis: systemic aspects of etiology and pathogenesis. Periodontol 2000 1994: 6: 7-25.
189. Schroeder KL, Ramamurthy NS, Sczepanek KA. Low-dose doxycycline prevents attachment loss in adult periodontitis. J Dent Res 1992: 71: 758, abstr 1936.
190. Scopp IW, Froum SJ, Sullivan M, Kazandjian G, Wank D, Fine A. Tetracycline: a clinical study to determine its effectiveness as long-term adjuvant. J Periodontol 1980: 51: 328-330.
191. Shifer A, Dany S, Schwarzkopp R, Rubinstein E. Concentrations of tetracycline in human gingival tissue in patients with chronic periodontal disease. J Antimicrob Chemother 1989: 23: 464-465.
192. Slots J. Microflora in the healthy gingival sulcus in man. Scand J Dent Res 1977: 85: 247-254.
193. Slots J, Ashimoto A, Flynn MJ, Li G, Chen C. Detection of putative periodontal pathogens in subgingival specimens by 16S ribosomal DNA amplification with the polymerase chain reaction. Clin Infect Dis 1995: 20 (suppl 2): S304-S307.
194. Slots J, Feik D, Rams TE. Age and sex relationships of superinfecting microorganisms in periodontitis patients. Oral Microbiol Immunol 1990: 5: 305-308.
195. Slots J, Feik D, Rams TE. In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis. Oral Microbiol Immunol 1990: 5: 298-301.
196. Slots J, Genco RJ. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J Dent Res 1984: 63, 412-421.
197. Slots J, Hafström C, Rosling B, Dahlén G. Detection of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis in subgingival smears by the indirect immunofluorescent-antibody technique. J Periodont Res 1985: 20: 613-620.
198. Slots J, Listgarten MA. Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J Clin Periodontol 1988: 15: 85-93.
199. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979: 50: 494-509.
200. Slots J, Rams TE. Antibiotics in periodontal therapy: advantages and disadvantages. J Clin Periodontol 1990: 17: 479-493.
201. Slots J, Rams TE, Feik D, Taveras HD, Gillespie GM. Subgingival microflora of advanced periodontitis in the Domenican Republic. J Periodontol 1991: 62: 543-547.
202. Slots J, Rams TE, Listgarten MA. Yeasts, enteric rods and pseudomonads in the subgingival flora of severe adult periodontitis. Oral Microbiol Immunol 1988: 3: 47-52.
203. Slots J, Reynolds HS, Genco RJ. Actinobacillus actinomycetemcomitans in human periodontal disease: a crosssectional microbiological investigation. Infect Immun 1980: 29: 1013-1020.
204. Slots J, Rosling BG. Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline. J Clin Periodontol 1983: 10: 465-486.
205. Slots J, van Winkelhoff AJ. Antimicrobial therapy in periodontics. J Cal Dent Assoc 1993: 21 (November): 51-56.
206. Smith SR, Foyle RM, Daniels J, Joyston-Bechal S, Smales FC. Azithromycin in the treatment of periodontitis. J Dent Res 1995: 74: 481, abstr 645.
207. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000 1994: 5: 7-25.
208. Socransky SS, Haffajee AD, Dzink JL. Relationship of subgingival microbial complexes to clinical features at the sampled sites. J Clin Periodontol 1988: 15: 440-444.
209. Socransky SS, Haffajee AD, Dzink JL, Hillman JD. Associations between microbial species in subgingival plaque samples. Oral Microbiol Immunol 1988: 3: 1-7.
210. Söder PO, Frithiof L, Wikner S, Wouters FR, Nedlich V, Söder B, Rubin B. The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis. J Periodontol 1990: 61: 281-288.
211. Söder PO, Frithiof L, Wikner S, Wouters FR, Nedlich V, Söder B, Rubin B. The effects of metronidazole in treatment of young adults with severe periodontitis. J Dent Res 1989: 68: 710, abstr 86.
212. Sterry KA, Langeroudi M, Dolby AE. Metronidazole as an adjunct to periodontal therapy with subgingival curettage. Br Dent J 1985: 158: 176-178.
213. Syed SA, Loesche WJ. Survival of human dental plaque flora in various transport media. J Appl Microbiol 1972: 24: 638-644.
214. Sznajder N, Piovano S, Bernat MI, Flores L, Macchi R, Carraro JJ. Effect of spiramycin on human periodontal disease. J Periodont Res 1987: 22 255-258.
215. Topoll HH, Lange DE, Müller RF. Multiple periodontal abscesses after systemic antibiotic therapy. J Clin Periodontol 1990: 17: 268-272.
216. Trieger N, Mark L, McKitrick J, Fiorillo J, Van Horn K, Motyl M. Clindamycin v. tetracycline in the surgical treatment of advanced periodontitis: a double blind study with applicability for implant salvage. Int J Oral Implantol 1991: 7: 31-38.
217. van Steenbergen TJM, Bosch-Tijhof CJ, van Winkelhoff AJ, Gmür R, de Graaff J. Comparison of six typing methods for Actinobacillus actinomycetemcomitans. J Clin Microbiol 1994: 32: 2769-2774.
218. van Steenbergen TJM, Colloms SD, Hermans PWM, de Graaff J, Plasterk RHA. Genomic DNA fingerprinting by restriction fragment end labeling (RFEL). Proc Natl Acad Sci U S A 1995: 92: 5572-5576.
219. van Steenbergen TJM, Petit MDA, Scholte LHM, van der Velden U, de Graaff J. Transmission of Porphyromonas gingivalis between spouses. J Clin Periodontol 1993: 20: 340-345.
220. van Steenbergen TJM, Petit MDA, Tijhof CJ, van Winkelhoff AJ, van der Velden U, de Graaff J. Survival in transport media of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in human subgingival samples. Oral Microbiol Immunol 1993: 8: 370-374.
221. van Winkelhoff AJ, Abbas F, Pavičić MJAMP, de Graaff J. Chronic conjunctivitis caused by oral anaerobes and effectively treated with systemic metronidazole plus amoxicillin. J Clin Microbiol 1991: 29: 723-725.
222. van Winkelhoff AJ, de Graaff J. Microbiology in the management of destructive periodontal disease. J Clin Periodontol 1991: 18: 406-410.
223. van Winkelhoff AJ, Overbeek BP, Pavičić MJAMP, van den Bergh JPA, Ernst JPMG, de Graaff J. Long standing bacteremia caused by oral Actinobacillus actinomycetemcomitans in a patient with a pacemaker. Clin Infect Dis 1993: 14: 216-218.
224. van Winkelhoff AJ, Rodenburg JP, Goené RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus afnoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989: 16: 128-131.
225. van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans associated periodontitis. J Periodontol 1992: 63: 52-57.
226. van Winkelhoff AJ, van der Velden U, Clement M, de Graaff J. Intra-oral distribution of black-pigmented Bacteroides species in periodontitis. Oral Microbiol Immunol 1988: 3: 83-85.
227. van Winkelhoff AJ, van der Velden U, de Graaff J. Microbial succession in recolonizing deep periodontal pockets after a single course of supra-and subgingival debridement. J Clin Periodontol 1987: 15: 116-122.
228. van Winkelhoff AJ, van der Velden U, Winkel EG, de Graaff J. Black-pigmented Bacteroides and motile organisms on oral mucosal surfaces in individuals with and without periodontal breakdown. J Periodont Res 1986: 21, 434-139.
229. van Winkelhoff AJ, Winkel EG, Slots J. Microbiology in diagnosis and treatment planning in periodontics. J Parodontol Implantol 1994: 13: 439-450.
230. von Troil-Lindén B, Torkko H, Alaluusua S, Wolf J, Jousimies-Somer H, Asikainen S. Periodontal findings in spouses. A clinical, radiographic and microbiological study. J Clin Periodontol 1995: 22: 93-99.
231. Walker CB. Antimicrobial agents and chemotherapy. In: Slots J, Taubman M, ed. Contemporary oral microbiology and immunology. St. Louis: Mosby Yearbook, 1992: 242-264.
232. Walker CB. Selected antimicrobial agents: mechanisms of action, side effects and drug interactions. Periodontol 2000 1996 10: 12-28.
233. Walker CB, Bueno L, Cohen S. Characterization and properties of beta-lactamases produced by periodontal bacteria. J Dent Res 1986: 65: 226, abstr 513.
234. Walker CB, Gordon JM. The effect of clindamycin on the microbiota associated with refractory periodontitis. J Periodontol 1990: 61: 692-698.
235. Walker CB, Gordon JM, Magnusson I, Clark WB. A role for antibiotics in the treatment of refractory periodontitis. J Periodontol 1993: 64: 772-781.
236. Walker CB, Gordon JM, Socransky SS. Antibiotic susceptibility testing of subgingival plaque samples. J Clin Periodontol 1983: 10: 422-432.
237. Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM. Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents. J Periodontol 1985: 56 (suppl): 67-74.
238. Walker CB, Tyler KZ, Low SB, King CJ. Penicillin-degrading enzymes in sites associated with adult periodontitis. Oral Microbiol Immunol 1989: 2: 129-131.
239. Walsh MM, Buchanan SA, Hoover C, Newbrun E, Taggert EJ, Armitage GC, Robertson PB. Clinical and microbiological effects of single-dose metronidazole or scaling and root planing in the treatment of adult periodontitis. J Clin Periodontol 1986: 13: 151-157.
240. Watts T, Palmer R, Floyd P. Metronidzole: a double blind trial in untreated human periodontol disease. J Clin Periodontol 1986: 13: 939-943.
241. Wennström J, Dahlén G, Svensson J, Nyman S. Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius: predictors of attachment loss? Oral Microbiol Immunol 1987: 2: 158-163.
242. Westergaard J, Fiehn NE. Efficacy of doxycycline treatment on recurrent periodontitis. 2 years observations. J Dent Res 1991: 70: 836, abstr 97.
243. Zambon JJ, Christersson LA, Slots J. Actinobacillus actinomycetemcomitans in human periodontal disease: prevalence in patient groups and distribution of biotypes and serotypes within families. J Periodontol 1983: 54: 707-711.
244. Zambon JJ, Reynolds HS, Chen P, Genco RJ. Rapid identification of periodontal pathogens in subgingival dental plaque. Comparison of indirect immunofluorescence microscopy with bacterial culture for detection of Bacteroides gingivalis. J Periodontol 1985:56: 32-40.
245. Zambon JJ, Reynolds HS, Slots J. Black-pigmented Bacteroides spp. in the human oral cavity. Infect Immun 1981: 32: 198-203.
246. Zhanel GG, Hoban DJ, Harding GKM. The postantibiotic effect: a review of in vitro and in vivo data. DICP Ann Pharmacother 1991: 25: 155-163.