Systemic antibiotics in the treatment of periodontal disease

Periodontology 2000

Volumn 28, Issue 1, 2002, Pages 106-176

  Slots, Joørgen ^a   Ting, Miriam ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; ANTIBIOTIC RESISTANCE; DRUG EFFECT; DRUG INTERACTION; HUMAN; ORAL DRUG ADMINISTRATION; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; REVIEW;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; DRUG INTERACTIONS; DRUG RESISTANCE, BACTERIAL; HUMANS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS;

EID: 0036367090     PISSN: 09066713     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0757.2002.280106.x     Document Type: Article

References (147)

1. Abu Fanas SH, Drucker DB, Hull PS. Amoxycillin with clavulanic acid and tetracycline in periodontal therapy. J Dent 1991: 19: 97-99.
2. Adriaens PA, De Boever JA, Loesche WJ. Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans. A reservoir of periodontopathic bacteria. J Periodontol 1988: 59: 222-230.
3. Aitken S, Birek P, Kulkarni GV, Lee WL, McCulloch CA. Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients. J Periodontol 1992: 63: 87-92.
4. Al-Joburi W, Quee TC, Lautar C, lugovaz I, Bourgouin J, Delorme F, Chan EC. Effects of adjunctive treatment of periodontitis with tetracycline and spiramycin. J Periodontol 1989: 60: 533-539.
5. Asikainen S, Lai CH, Alaluusua S, Slots J. Distribution of Actinobacillus actinomycetemcomitans serotypes in periodontal health and disease. Oral Microbiol Immunol 1991: 6: 115-118.
6. Atilla G, Balcan M, Bicakci N, Kazandi A. The effect of non-surgical periodontal and adjunctive minocycline-HCL treatments on the activity of salivary proteases. J Periodontol 1996: 67: 1-6.
7. Bain CA, Beagrie GS, Bourgoin J, Delorme F, Holthuis A, Landry RG, Roy S, Schuller P, Singer D, Turnbull R. The effects of spiramycin and/or scaling on advanced periodontitis in humans. J Can Dent Assoc 1994: 60: 209, 212-227-127.
8. Barbosa FCB, Mayer MPA, Saba-Chujfi E, Cai S. Subgingival occurrence and antimicrobial susceptibility of enteric rods and pseudomonads from Brazilian periodontitis patients. Oral Microbiol Immunol 2001: 16: 306-310.
9. Barone A, Sbordone L, Ramaglia L, Ciaglia RN. Microbiotica associated with refractory periodontitis. Prevalence and antibiotic susceptibility. Minerva Stomatol 1999: 48: 191-201.
10. Bedeschi G, Beltrame M, Baldin C, Confente G, Guerra L, Fostini R. Pharmacokinetics of a new oral antibacterial agent, ofloxacin, in dentistry and oral surgery. Int J Clin Pharmacol Ther Toxicol 1988: 26: 162-164.
11. Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol 1998: 25: 354-362.
12. Blandizzi C, Malizia T, Lupetti A, Pesce D, Gabriele M, Giuca MR, Campa M, Del Tacca M, Senesi S. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol 1999: 70: 960-966.
13. Britt MR, Pohlod DJ. Serum and crevicular fluid concentrations after a single oral dose of metronidazole. J Periodontol 1986: 57: 104-107.
14. Buchmann R, Müller RF, Heinecke A, Lange DE. Actinobacillus actinomycetemcomitans in destructive periodontal disease. Three-year follow-up results. J Periodontol 2000: 71: 444-453.
15. Chen C, Slots J. The current status and future prospects of altering the pathogenic microflora of periodontal disease. Curr Opin Periodontol 1993: 71-77.
16. Christersson LA, Albini B, Zambon JJ, Wikesjö UM, Genco RJ. Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis. I. Light, immunofluorescence and electron microscopic studies. J Periodontol 1987: 58: 529-539.
17. Ciancio SG, Mather ML, McMullen JA. An evaluation of minocycline in patients with periodontal disease. J Periodontol 1980: 51: 530-534.
18. Clark CD, Shenker S, Stulginski P, Schwartz S. Effectiveness of routine periodontal treatment with and without adjunctive metronidazole therapy in a sample of mentally retarded adolescents. J Periodontol 1983: 54: 658-665.
19. Collins JG, Offenbacher S, Arnold RR. Effects of a combination therapy to eliminate Porphyromonas gingivalis in refractory periodontitis. J Periodontol 1993: 64: 998-1007.
20. Conway TB, Beck FM, Walters JD. Gingival fluid ciprofloxacin levels at healthy and inflamed human periodontal sites. J Periodontol 2000: 71: 1448-1452.
21. Dahlén G. Role of suspected periodontopathogens in microbiological monitoring of periodontitis. Adv Dent Res 1993: 7: 163-174.
22. Dahlén G. Microbiology and treatment of dental abscesses and periodontal-endodontic lesions. Periodontol 2000 2002: 28: 206-239.
23. Del Tacca M, Danesi R, Bernardini N, Ducci M, Zolfino I, Senesi S, Panattoni E, Gabriele M, Marcucci M, Lazzarini A et al. Roxithromycin penetration into gingiva and alveolar bone of odontoiatric patients. Chemotherapy 1990: 36: 332-336.
24. Dzink JL, Gibbons RJ, Childs WC 3rd, Socransky SS. The predominant cultivable microbiota of crevicular epithelial cells. Oral Microbiol Immunol 1989: 4: 1-5.
25. Duckworth R, Waterhouse JP, Britton DE, Nuki K, Sheiham A, Winter R, Blake GC. Acute ulcerative gingivitis. A double-blind controlled clinical trial of metronidazole. Br Dent J 1966: 120: 599-602.
26. Edlund C, Hedberg M, Nord CE. Antimicrobial treatment of periodontal diseases disturbs the human ecology: a review. J Chemother 1996: 8: 331-341.
27. Edwardsson S, Bing M, Axtelius B, Lindberg B, Söderfeldt B, Attström R. The microbiota of periodontal pockets with different depths in therapy-resistant periodontitis. J Clin Periodontol 1999: 26: 143-152.
28. Eickholz P, Kugel B, Pohl S, Naher H, Staehle HJ. Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome. J Periodontol 2001: 72: 542-549.
29. Elter JR, Lawrence HP, Offenbacher S, Beck JD. Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. J Periodontal Res 1997: 32: 487-496.
30. Feres M, Haffajee AD, Goncalves C, Allard KA, Som S, Smith C, Goodson JM, Socransky SS. Systemic doxycycline administration in the treatment of periodontal infections. I. Effect on the subgingival microbiota. J Clin Periodontol 1999: 26: 775-783.
31. Feres M, Haffajee AD, Goncalves C, Allard KA, Som S, Smith C, Goodson JM, Socransky SS. Systemic doxycycline administration in the treatment of periodontal infections. II. Effect on antibiotic resistance of subgingival species. J Clin Periodontol 1999: 26: 784-792.
32. Fine DH. Microbial identification and antibiotic sensitivity testing, an aid for patients refractory to periodontal therapy. A report of 3 cases. J Clin Periodontol 1994: 21: 98-106.
33. Fives-Taylor PM, Meyer DH, Mintz KP, Brissette C. Virulence factors of Actinobacillus actinomycetemcomitans. Periodontol 2000 1999: 20: 136-167.
34. Flemmig TF, Milián E, Karch H, Klaiber B. Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. J Clin Periodontol 1998: 25: 380-387.
35. Flemmig TF, Milián E, Kopp C, Karch H, Klaiber B. Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats. J Clin Periodontol 1998: 25: 1-10.
36. Flynn MJ, Slots J. Beta-hemolytic streptococci in advanced periodontitis. Oral Microbiol Immunol 1993: 8: 295-297.
37. Giuliana G, Ammatuna P, Pizzo G, Capone F, D'Angelo M. Occurrence of invading bacteria in radicular dentin of periodontally diseased teeth: microbiological findings. J Clin Periodontol 1997: 24: 478-485.
38. Gordon J, Walker C, Holviaras C, Socransky S. Efficacy of clindamycin hydrochloride in refractory periodontitis: 24-month results. J Periodontol 1990: 61: 686-691.
39. Gordon J, Walker C, Lamster I, West T, Socransky S, Seiger M, Fasciano R. Efficacy of clindamycin hydrochloride in refractory periodontitis. 12-months results. J Periodontol 1985: 56: S75-S80.
40. Gusberti FA, Syed SA, Lang NP. Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease. J Clin Periodontol 1988: 15: 353-359.
41. Haffajee AD, Socransky SS, Dibart S, Kent RL Jr. Response to periodontal therapy in patients with high or low levels of P. gingivalis, P. intermedia, P. nigrescens and B. forsythus. J Clin Periodontol 1996: 23: 336-345.
42. Helldén LB, Listgarten MA, Lindhe J. The effect of tetracycline and/or scaling on human periodontal disease. J Clin Periodontol 1979: 6: 222-230.
43. Higashi K, Seike M, Mitani Y, Morisaki K, Hayashi S, Kitamura M, Fujimoto N, Kimura S, Ebisu S, Okada H. Concentration of ofloxacin in human gingival crevicular fluid after oral administration of Tarivid®. J Periodontal Res 1989: 24: 409-411.
44. Ishikawa I, Umeda M, Laosrisin N. Clinical, bacteriological, and immunological examinations and the treatment process of two Papillon-Lefèvre syndrome patients. J Periodontol 1994: 65: 364-371.
45. Jenkins WM, MacFarlane TW, Gilmour WH, Ramsay I, MacKenzie D. Systemic metronidazole in the treatment of periodontitis. J Clin Periodontol 1989: 16: 443-450.
46. Kamma JJ, Nakou M, Mitsis FJ. The clinical and microbiological effects of systemic ornidazole in sites with and without subgingival debridement in early-onset periodontitis patients. J Periodontol 2000: 71: 1862-1873.
47. Kleinfelder JW, Müller RF, Lange DE. Bacterial susceptibility to amoxicillin and potassium clavulanate in advanced periodontitis patients not responding to mechanical therapy. J Clin Periodontol 2000: 27: 846-853.
48. Kleinfelder JW, Müller RF, Lange DE. Fluoroquinolones in the treatment of Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 2000: 71: 202-208.
49. Lamont RJ, Jenkinson HF. Subgingival colonization by Porphyromonas gingivalis. Oral Microbiol Immunol 2000: 15: 341-349.
50. Levy RM, Giannobile WV, Feres M, Haffajee AD, Smith C, Socransky SS. The short-term effect of apically repositioned flap surgery on the composition of the subgingival microbiota. Int J Periodontics Restorative Dent 1999: 19: 555-567.
51. Liew V, Mack G, Tseng P, Cvejic M, Hayden M, Buchanan N. Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis. J Dent Res 1991: 70: 910-912.
52. Lindhe J, Liljenberg B, Adielson B, Adielson B. Long-term tetracycline therapy on human periodontal disease. J Clin Periodontol 1983: 10: 590-601.
53. Lindhe J, Liljenberg B, Adielson B, Börjesson I. Use of metronidazole as a probe in the study of human periodontal disease. J Clin Periodontol 1983: 10: 100-112.
54. Listgarten MA. Monitoring the periodontal microbiota as an adjunct to periodontal therapy: rationale, interpretation of test results and application to patient management. Alpha Omegan 1992: 5: 49-53.
55. Listgarten MA, Lai CH, Young V. Microbial composition and pattern of antibiotic resistance in subgingival microbial samples from patients with refractory periodontitis. J Periodontol 1993: 64: 155-161.
56. Listgarten MA, Lindhe J, Helldén LB. Effect of tetracycline and/or scaling on human periodontal disease: clinical, microbiological and histological observations. J Clin Periodontol 1978: 5: 246-271.
57. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis: reduced need for surgery. J Clin Periodontol 1992: 19: 103-112.
58. Loesche WJ, Giordano J, Soebren S, Hutchinson R, Rau CP, Walsh L, Schork MA. Nonsurgical treatment of patients with periodontal disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996: 81: 533-543.
59. Loesche WJ, Schmidt E, Smith BA, Morrison EC, Caffesse R, Hujoel PP. Effects of metronidazole on periodontal treatment needs. J Periodontol 1991: 62: 247-257.
60. Loesche WJ, Syed SA, Morrison EC, Kerry GA, Higgins T, Stoll J. Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks. J Periodontol 1984: 55: 325-335.
61. Löpez NJ, Gamonal JA. Effects of metronidazole plus amoxicillin in progressive untreated adult periodontitis: results of a single 1-week course after 2 and 4 months. J Periodontol 1998: 69: 1291-1298.
62. López NJ, Gamonal JA, Martinez B. Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study. J Periodontol 2000: 71: 79-89.
63. Lundström Å, Johansson LÅ, Hamp SE. Effect of combined systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease. J Clin Periodontol 1984: 11: 321-330.
64. Malizia T, Tejada MR, Ghelardi E, Senesi S, Gabriele M, Giuca MR, Blandizzi C, Danesi R, Campa M, Del Tacca M. Periodontal tissue disposition of azithromycin. J Periodontol 1997: 68: 1206-1209.
65. Mandell RL, Socransky SS. Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis. J Periodontol 1988: 59: 373-379.
66. Matisko MW, Bissada NE Short-term sequential administration of amoxicillin/clavulanate potassium and doxycycline in the treatment of recurrent/progressive periodontitis. J Periodontol 1993: 64: 553-558.
67. Mombelli A, Nyman S, Bragger U, Wennström J, Lang NP. Clinical and microbiological changes associated with an altered subgingival environment induced by periodontal pocket reduction. J Clin Periodontol 1995: 22: 780-787.
68. Mombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedial nigrescens, and Actinobacillus actinomycetemcomitans after mechanical therapy of periodontal disease. J Periodontol 2000: 71: 14-21.
69. Müller HP, Heinecke A, Borneff M, Kiencke C, Knopf A, Pohl S. Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. J Periodontal Res 1998: 33: 49-58.
70. Müller HP, Heinecke A, Borneff M, Knopf A, Kiencke C, Pohl S. Microbial ecology of Actinobacillus actinomycetemcomitans, Eikenella corrodens and Capnocytophaga spp. in adult periodontitis. J Periodontal Res 1997: 32: 530-542.
71. Müller HP, Heinecke A, Borneff M, Kiencke C, Knopf A, Pohl S. Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. J Periodontal Res 1998: 33: 49-58.
72. Müller HP, Lange DE, Müller RF. A 2-year study of adjunctive minocycline-HCl in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1993: 64: 509-519.
73. Müller HP, Lange DE, Müller RF. Failure of adjunctive minocycline-HCl to eliminate oral Actinobacillus actinomycetemcomitans. J Clin Periodontol 1993: 20: 498-504.
74. Müller HP, Lange DE, Müller RF. Actinobacillus actinomycetemcomitans recovery from extracrevicular locations of the mouth. Oral Microbiol Immunol 1993: 8: 344-348.
75. Naito Y, Gibbons RJ. Attachment of Bacteroides gingivalis to collagenous substrata. J Dent Res 1988: 67: 1075-1080.
76. Ng VW, Bissada NF. Clinical evaluation of systemic doxycycline and ibuprofen administration as an adjunctive treatment for adult periodontitis. J Periodontol 1998: 69: 772-776.
77. Nieminen A, Asikainen S, Torkko H, Kari K, Uitto VJ, Saxén L. Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis. J Clin Periodontol 1996: 23: 572-581.
78. Novak MJ, Stamatelakys C, Adair SM. Resolution of early lesions of juvenile periodontitis with tetracycline therapy alone: long-term observations of 4 cases. J Periodontol 1991: 62: 628-633.
79. Noyan Ü, Yilmaz S, Kuru B, Kadir T, Acar O, Büget E. A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. J Clin Periodontol 1997: 24: 158-165.
80. Olsvik B, Hansen BF, Tenover FC, Olsen I. Tetracycline-resistant micro-organisms recovered from patients with refractory periodontal disease. J Clin Periodontol 1995: 22: 391-396.
81. Pacheco JJ, Coelho C, Salazar F, Contreras A, Slots J, Velazco CH. Treatment of Papillon-Lefevre syndrome periodontitis. J Clin Periodontol (in press).
82. Palmer RM, Matthews JP, Wilson RF. Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. Br Dent J 1998: 184: 548-552.
83. Palmer RM, Matthews JP, Wilson RF. Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. J Clin Periodontol 1999: 26: 158-163.
84. Pappalardo G, Bianchi A, Scire Scappuzzo G, Mirone M, Salomone S. Preliminary pharmacokinetic and clinical evaluation of ofloxacin in dental and oral cavity diseases. Int J Clin Pharmacol Res 1989: 9: 229-232.
85. Pavičić MJAMR van Winkelhoff AJ, Douqué NH, Steures RWR, de Graaff J. Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. J Clin Periodontol 1994: 21: 107-112.
86. Pertuiset JH, Saglie FR, Lofthus J, Rezende M, Sanz M. Recurrent periodontal disease and bacterial presence in the gingiva. J Periodontol 1987: 58: 553-558.
87. Petersilka GJ, Ehmke B, Flemmig TF. Antimicrobial effects of mechanical debridement. Periodontol 2000 2002: 28: 56-71.
88. Preus HR, Lassen J, Aass AM, Ciancio SG. Bacterial resistance following subgingival and systemic administration of minocycline. J Clin Periodontol 1995: 22: 380-384.
89. Quirynen M, De Soete M, Dierickx K, van Steenberghe D. The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy. A review of the literature. J Clin Periodontol 2001: 28: 499-507.
90. Ramberg P, Rosling B, Serino G, Hellström MK, Socransky SS, Lindhe J. The long-term effect of systemic tetracycline used as an adjunct to non-surgical treatment of advanced periodontitis. J Clin Periodontol 2001: 28: 446-452.
91. Rams TE. Availability of laboratory testing services for identification of periodontal pathogens in dental plaque. Clin Prev Dent 1989: 11: 18-21.
92. Rams TE, Babalola OO, Slots J. Subgingival occurrence of enteric rods, yeasts and staphylococci after systemic doxycycline therapy. Oral Microbiol Immunol 1990: 5: 166-168.
93. Rams TE, Feik D, Listgarten MA, Slots J. Peptostreptococcus micros in human periodontitis. Oral Microbiol Immunol 1992: 7: 1-6.
94. Rams TE, Feik D, Slots J. Campylobacter rectus in human periodontitis. Oral Microbiol Immunol 1993: 8: 230-235.
95. Renvert S, Wikström M, Dahlén G, Slots J, Egelberg J. On the inability of root debridement and periodontal surgery to eliminate Actinobacillus actinomycetemcomitans from periodontal pockets. J Clin Periodontol 1990: 17: 351-355.
96. Roberts MC. Antibiotic toxicity, interactions and resistance development. Periodontol 2000 2002: 28: 280-297.
97. Rotzetter PA, Le Liboux A, Pichard E, Cimasoni G. Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. J Clin Periodontol 1994: 21: 595-600.
98. Rudney JD, Chen R, Sedgewick GJ. Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in buccal epithelial cells collected from human subjects. Infect Immun 2001: 69: 2700-2707.
99. Ryan ME, Golub LM. Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy. Periodontol 2000 2000: 24: 226-238.
100. Sakellari D, Goodson JM, Kolokotronis A, Konstantinidis A. Concentration of 3 tetracyclines in plasma, gingival crevice fluid and saliva. J Clin Periodontol 2000: 27: 53-60.
101. Saxén L, Asikainen S. Metronidazole in the treatment of localized juvenile periodontitis. J Clin Periodontol 1993: 20: 166-171.
102. Saxén L, Asikainen S, Kanervo A, Kari K, Jousimies-Somer H. The long-term efficacy of systemic doxycycline medication in the treatment of localized juvenile periodontitis. Arch Oral Biol 1990: 35(suppl): 227S-229S.
103. Sefton AM. Macrolides and changes in the oral flora. Int J Antimicrob Agents 1999: 11(suppl 1): S23-S29; discussion S31-S32.
104. Sefton AM, Maskell JP, Beighton D, Whiley A, Shain H, Foyle D, Smith SR, Smales FC, Williams JD. Azithromycin in the treatment of periodontal disease. Effect on microbial flora. J Clin Periodontol 1996: 23: 998-1003.
105. Serino G, Rosling B, Ramberg P, Hellström MK, Socransky SS, Lindhe J. The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis. J Clin Periodontol 2001: 28: 411-118.
106. Shiloah J, Patters MR, Dean JW 3rd, Bland P, Toledo G. The prevalence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Bacteroides forsythus in humans 1 year after 4 randomized treatment modalities. J Periodontol 1998: 69: 1364-1372.
107. Sigusch B, Beier M, Klinger G, Pfister W, Glockmann E. A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. J Periodontol 2001: 72: 275-283.
108. Slots J. Systemic antibiotics in periodontics (Am Acad Periodontol position paper). J Periodontol 1996: 67: 831-838.
109. Slots J. Primer for antimicrobial periodontal therapy. J Periodontal Res 2000: 35: 108-114. Translated into Spanish: Compendio de terapeutica antimicrobiana periodontal. Acta Dent Int 2000: 1: 295-302.
110. Slots J. Primer for antimicrobial periodontal therapy. J Periodontal Res 2000: 35: 108-114. Translated into Spanish: Compendio de terapeutica antimicrobiana periodontal. Acta Dent Int 2000: 1: 295-302.
111. Slots J, Chen C. The oral microflora and human periodontal disease. In: Tannock GW, ed. Medical importance of the normal microflora. London: Kluwer Academic Publishers, 1999: 101-127.
112. Slots J, Feik D, Rams TE. Prevalence and antimicrobial susceptibility of Enterobacteriaceae, Pseudomonadaceae and Acinetobacter in human periodontitis. Oral Microbiol Immunol 1990: 5: 149-154.
113. Slots J, Feik D, Rams TE. In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis. Oral Microbiol Immunol 1990: 5: 298-301.
114. Slots J, Jorgensen MG. Effective, safe, practical and affordable periodontal antimicrobial therapy: where are we going, and are we there yet? Periodontol 2000 2002: 28: 298-312.
115. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol 1979: 50: 495-509.
116. Slots J, Pallasch TJ. Dentists' role in halting antimicrobial resistance. J Dent Res 1996: 75: 1338-1341.
117. Slots J, Rams TE. Systemic and topical antimicrobial therapy in periodontics. Periodontol 2000 1996: 10: 5-159.
118. Slots J, Rosling B. Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline. J Clin Periodontol 1983: 10: 465-486.
119. Slots J, Ting M. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 1999: 20: 82-121.
120. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002: 28: 12-55.
121. Socransky SS, Haffajee AD, Ximenez-Fyvie LA, Feres M, Mager D. Ecological considerations in the treatment of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis periodontal infections. Periodontol 2000 1999: 20: 341-362.
122. Söder PÖ, Frithiof L, Wikner S, Wouters F, Engström PE, Rubin B, Nedlich U, Söder B. The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. J Periodontol 1990: 61: 281-288.
123. Söder B, Nedlich U, Jin LJ. Longitudinal effect of non-surgical treatment and systemic metronidazole for 1 week in smokers and non-smokers with refractory periodontitis: a 5-year study. J Periodontol 1999: 70: 761-771.
124. Takamatsu N, Yano K, He T, Umeda M, Ishikawa I. Effect of initial periodontal therapy on the frequency of detecting Bacteroides forsythus, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans. J Periodontol 1999: 70: 574-580.
125. Tanner A, Stillman N. Oral and dental infections with anaerobic bacteria: clinical features, predominant pathogens, and treatment. Clin Infect Dis 1993: 16(suppl 4): S304-S309.
126. Tenenbaum H, Jehl F, Gallion C, Dahan M. Amoxicillin and clavulanic acid concentrations in gingival crevicular fluid. J Clin Periodontol 1997: 24: 804-807.
127. Ting M, Slots J. Microbiological diagnostics in periodontics. Compendium Contin Educ Dent 1997: 18: 861-878. Translated into German: Mikrobiologische Testverfahren: Wann, wie, warum? Ästhet Zahnmed 1998: 1: 146-156.
128. Ting M, Slots J. Microbiological diagnostics in periodontics. Compendium Contin Educ Dent 1997: 18: 861-878. Translated into German: Mikrobiologische Testverfahren: Wann, wie, warum? Ästhet Zahnmed 1998: 1: 146-156.
129. Tinoco EM, Beldi MI, Campedelli F, Lana M, Loureiro CA, Bellini HT, Rams TE, Tinoco NM, Gjermo P, Preus HR. Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial. J Periodontol 1998: 69: 1355-1363.
130. Tuan M-C, Nowzari H, Slots J. Clinical and microbiologic study of periodontal surgery by means of apically positioned flaps with and without osseous recontouring. Int J Periodontics Restorative Dent 2000: 20: 469-475. Translated into German: Parodontalchirurgie mit apikalen positioniertem Lappen mit und ohne Osteoplastik: klinische und mikrobiologische Studie. Int J Paradontol Restaurative Zahnheilkd 2000: 20: 453-459.
131. Tuan M-C, Nowzari H, Slots J. Clinical and microbiologic study of periodontal surgery by means of apically positioned flaps with and without osseous recontouring. Int J Periodontics Restorative Dent 2000: 20: 469-475. Translated into German: Parodontalchirurgie mit apikalen positioniertem Lappen mit und ohne Osteoplastik: klinische und mikrobiologische Studie. Int J Paradontol Restaurative Zahnheilkd 2000: 20: 453-459.
132. Van Oosten MA, Notten FJ, Mikx FH. Metronidazole concentrations in human plasma, saliva, and gingival crevice fluid after a single dose. J Dent Res 1986: 65: 1420-1423.
133. van Winkelhoff AJ, Herrera Gonzales D, Winkel EG, Dellemijn-Kippuw N, Vandenbroucke-Grauls CM, Sanz M. Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis. A comparison between the Netherlands and Spain. J Clin Periodontol 2000: 27: 79-86.
134. van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996: 10: 45-78.
135. van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989: 16: 128-131.
136. van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1992: 63: 52-57.
137. van Winkelhoff AJ, Winkel EG, Vandenbroucke-Grauls CMJE. On the dosage of antibiotics in clinical trials. J Clin Periodontol 1999: 26: 764-766.
138. von Troil-Lindén B, Alaluusua S, Wolf J, Jousimies-Somer H, Torppa J, Asikainen S. Periodontitis patient and the spouse: periodontal bacteria before and after treatment. J Clin Periodontol 1997: 24: 893-099.
139. Walker CB. Selected antimicrobial agents: mechanisms of action, side effects and drug interactions. Periodontol 2000 1996: 10: 12-28.
140. Walker CB. The acquisition of antibiotic resistance in the periodontal microflora. Periodontol 2000 1996: 10: 79-08.
141. Walsh MM, Buchanan SA, Hoover CI, Newbrun E, Taggart EJ, Armitage GC, Robertson PB. Clinical and microbiologie effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis. J Clin Periodontol 1986: 13: 151-157.
142. Watts T, Palmer R, Floyd P. Metronidazole: a double-blind trial in untreated human periodontal disease. J Clin Periodontol 1986: 13: 939-943.
143. Winkel EG, van Winkelhoff AJ, Barendregt DS, van der Weijden GA, Timmerman MF, van der Velden U. Clinical and microbiological effects of initial periodontal therapy in conjunction with amoxicillin and clavulanic acid in patients with adult periodontitis. A randomised double-blind, placebo-controlled study. J Clin Periodontol 1999: 26: 461-468.
144. Winkel EG, van Winkelhoff AJ, Timmerman MF, van der Velden U, van der Weijden GA. Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. J Clin Periodontol 2001: 28: 296-305.
145. Winkel EG, van Winkelhoff AJ, Timmerman MF, Vangsted T, van der Velden U. Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. J Clin Periodontol 1997: 24: 573-579.
146. Winkel EG, van Winkelhoff AJ, van der Velden U. Additional clinical and microbiological effects of amoxicillin and metronidazole after initial periodontal therapy. J Clin Periodontol 1998: 25: 857-864.
147. Wright TL, Ellen RP, Lacroix JM, Sinnadurai S, Mittelman MW. Effects of metronidazole on Porphyromonas gingivalis biofilms. J Periodontal Res 1997: 32: 473-477.