Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: Clinical effects

Journal of Clinical Periodontology

Volumn 32, Issue 3, 2005, Pages 225-230

  Mombelli, A ^a   Brochut, P ^a   Plagnat, D ^a   Casagni, F ^a   Giannopoulou, C ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Amoxicillin; Chronic periodontitis; Enamel matrix proteins; Metronidazole; Non surgical periodontal treatment

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; MATRIX PROTEIN; METRONIDAZOLE; PLACEBO;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE REGENERATION; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DENTITION; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HUMAN; LONGITUDINAL STUDY; MULTIMODALITY CANCER THERAPY; PERIODONTAL DISEASE; PERIODONTITIS; PERIODONTIUM; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; PREVENTIVE DENTISTRY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; REDUCTION;

ADULT; AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BONE DENSITY; CHRONIC DISEASE; COMBINED MODALITY THERAPY; DENTAL ENAMEL PROTEINS; DENTAL SCALING; HUMANS; LONGITUDINAL STUDIES; METRONIDAZOLE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PERIODONTITIS; PLACEBOS; PORPHYROMONAS GINGIVALIS; ROOT PLANING;

EID: 16244390818     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2005.00664.x     Document Type: Article

References (28)

1. Arweiler, N. B., Auschill, T. M., Donos, N. & Sculean, A. (2002) Antibacterial effect of an enamel matrix protein derivative on in vivo dental biofilm vitality. Clinical Oral Investigations 6, 205-209.
2. Blomlöf, J. P. S., Blomlöf, L. B. & Lindskog, S. F. (1996) Smear removal and collagen exposure after non-surgical root-planning followed by etching with EDTA gel preparation. Journal of Clinical Periodontology 67, 841-845.
3. Blomlöf, J. & Lindskog, S. (1995) Root surface texture and cell colonization after different etching modalities. European Journal of Oral Sciences 103, 17-24.
4. Caffesse, R. G., Sweeney, P. L. & Smith, B. A. (1986) Scaling and root planing with and without periodontal flap surgery. Journal of Clinical Periodontology 13, 205-210.
5. Dix, K., Watanabe, S. M., McArdle, S., Lee, D. I., Randolph, C., Moncla, B. & Schwartz, D. E. (1990) Species-specific oligodeoxynucleotide probes for the identification of periodontal bacteria. Journal of Clinical Microbiology 28, 319-323.
6. Dornier, C., Dorsaz-Brossa, L., Thévenaz, P., Casagni, F., Brochut, P., Mombelli, A. & Vallée, J. P. (2004) Geometric alignment and chromatic calibration of serial radiographic images. Dentomaxillofacial Radiology 33, 220-225.
7. Dubrez, B., Jacot-Descombes, S. & Cimasoni, G. (1995) Reliability of a paralleling instrument for dental radiographs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 80, 358-364.
8. Graf, J. M., Mounir, A., Payot, P. & Cimasoni, G. (1988) A simple paralleling instrument for superimposing radiographs of the molar regions. Oral Surgery, Oral Medicine, and Oral Pathology 66, 502-506.
9. Gutierrez, M. A., Mellonig, J. T. & Cochran, D. L. (2003) Evaluation of enamel matrix derivative as an adjunct to non-surgical periodontal therapy. Journal of Clinical Periodontology 30, 739-745.
10. Hammarstrom, L., Heijl, L. & Gestrelius, S. (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology 24, 669-677.
11. Heijl, L. (1997) Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. Journal of Clinical Periodontology 24, 693-696.
12. Heijl, L., Heden, G., Svardstrom, G. & Ostgren, A. (1997) Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. Journal of Clinical Periodontology 24, 705-714.
13. Herrera, D., Sanz, M., Jepsen, S., Needleman, I. & Roldán, S. (2002) A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. Journal of Clinical Periodontology 29, Suppl. 3, 136-159.
14. Löe, H. & Silness, J. (1963) Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica 21, 533-551.
15. Mellonig, J. T. (1999) Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. International Journal of Periodontics and Restorative Dentistry 19, 8-19.
16. Mombelli, A., Gmür, R., Gobbi, C. & Lang, N. P. (1994) Actinobacillus actinomycetemcomitans in adult periodontitis. I. Topographic distribution before and after treatment. Journal of Periodontology 65, 820-826.
17. Mombelli, A., Schmid, B., Rutar, A. & Lang, N. P. (2000) Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia/ nigrescens, and Actinobacillus actino-mycetem-comitans after mechanical therapy of periodontal disease. Journal of Periodontology 71, 14-21.
18. Renvert, S., Wikstrom, M., Dahlen, G., Slots, J. & Egelberg, J. (1990) Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis from periodontal pockets. Journal of Clinical Periodontology 17, 345-350.
19. Rooney, J., Wade, W. G., Sprague, S. V., Newcombe, R. G. & Addy, M. (2002) Adjunctive effects to non-surgical therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. Journal of Clinical Periodontology 29, 342-350.
20. Sculean, A., Auschill, T. M., Donos, N., Brecx, M. & Arweiler, N. B. (2001) Effect of an enamel matrix protein derivative (Emdogain) on ex vivo dental plaque vitality. Journal of Clinical Periodontology 28, 1074-1078.
21. Sculean, A., Donos, N., Windisch, P., Brecx, M., Gera, I., Reich, E. & Karring, T. (1999a) Healing of human intrabony defects following treatment with enamel matrix proteins or guided tissue regeneration. Journal of Periodontal Research 34, 310-322.
22. Sculean, A., Reich, E., Chiantella, G. C. & Brecx, M. (1999b) Treatment of intrabony periodontal defects with an enamel matrix protein derivative (Emdogain): a report of 32 cases. International Journal of Periodontics and Restorative Dentistry 19, 157-163.
23. Silness, J. & Löe, H. (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 22, 121-135.
24. Spahr, A., Lyngstadaas, S. P., Boeckh, C., Andersson, C., Podbielski, A. & Haller, B. (2002) Effect of the enamel matrix derivative Emdogain on the growth of periodontal pathogens in vitro. Journal of Clinical Periodontology 29, 62-72.
25. Tonetti, M. S., Lang, N. P., Cortellini, P., Suvan, J. E., Adriaens, P., Dubravec, D., Fonzar, A., Fourmousis, I., Mayfield, L., Rossi, R., Silvestri, M., Tiedemann, C., Topoll, H., Vangsted, T. & Wallkamm, B. (2002) Enamel matrix proteins in the regenerative therapy of deep intrabony defects. Journal of Clinical Periodontology 29, 317-325.
26. van der Weijden, G. A. & Timmerman, F. A. (2002) A systematic review on the clinical efficacy of subgingival debridement in the treatment of chronic periodontitis. Journal of Clinical Periodontology 29, 55-71.
27. Waerhaug, J. (1978) Healing of the dentoepithelial junction following subgingival plaque control. As observed on extracted teeth. Journal of Periodontology 49, 119-134.
28. Yukna, R. A. & Mellonig, J. T. (2000) Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series. Journal of Periodontology 71, 752-759.