The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial

Journal of Clinical Periodontology

Volumn 39, Issue 10, 2012, Pages 955-961

  Mestnik, Maria J ^a   Feres, Magda ^a   Figueiredo, Luciene C ^a   Soares, Geisla ^a   Teles, Ricardo P ^b   Fermiano, Daiane ^a   Duarte, Poliana M ^a   Faveri, Marcelo ^a  

^a GUARULHOS UNIVERSITY   (Brazil)

^b FORSYTH INSTITUTE   (United States)

Author keywords

Amoxicillin; generalized aggressive periodontitis; metronidazole; periodontal disease; periodontal treatment; scaling and root planing

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; METRONIDAZOLE;

ADULT; AGGRESSIVE PERIODONTITIS; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; FEMALE; HUMAN; LONGITUDINAL STUDY; MALE; METHODOLOGY; MULTIMODALITY CANCER THERAPY; PERIODONTAL DISEASE; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AGGRESSIVE PERIODONTITIS; AMOXICILLIN; ANTI-INFECTIVE AGENTS; COMBINED MODALITY THERAPY; DENTAL SCALING; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; METRONIDAZOLE; PERIODONTAL ATTACHMENT LOSS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84866108516     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2012.01932.x     Document Type: Article

References (26)

1. Aimetti, M., Romano, F., Guzzi, N., &, Carnevale, G., (2012) Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. Journal of Clinical Periodontology 39, 284-294.
2. Armitage, G. C., (1999) Development of a classification and conditions. Annals of Periodontology 4, 1-6.
3. Baltacioǧlu, E., Aslan, M., Saraç, Ö., Saybak, A., &, Yuva, P., (2011) Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study. Journal of Canadian Dental Association 77, b97.
4. Berglundh, T., Krok, L., Liljenberg, B., Westfelt, E., Serino, G., &, Lindhe, J., (1998) The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. Journal of Clinical Periodontology 25, 354-362.
5. Cionca, N., Giannopoulou, C., Ugolotti, G., &, Mombelli, A., (2010) Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/metronidazole in chronic periodontitis. Journal of Periodontology 81, 15-23.
6. Goodson, J. M., Haffajee, A. D., Socransky, S. S., Kent, R., Teles, R., Hasturk, H., Bogren, A., Van Dyke, T., Wennstrom, J., &, Lindhe, L., (2012) Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. Journal of Clinical Periodontology 39, 526-536.
7. Guerrero, A., Griffiths, G. S., Nibali, L., Suvan, J., Moles, D. R., Laurell, L., &, Tonetti, M. S., (2005) Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. Journal of Clinical Periodontology 32, 1096-1107.
8. Kaner, D., Bernimoulin, J. P., Hopfenmuller, W., Kleber, B. M., &, Friedmann, A., (2007) Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. Journal of Clinical Periodontology 34, 880-891.
9. Kinney, J. S., Morelli, T., Braun, T., Ramseier, C. A., Herr, A. E., Sugai, J. V., Shelburne, C. E., Rayburn, L. A., Singh, A. K., &, Giannobile, W. V., (2011) Saliva/pathogen biomarker signatures and periodontal disease progression. Journal of Dental Research 90, 752-758.
10. Lang, N. P., &, Tonetti, M. S., (2003) Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health & Preventive Dentistry 1, 7-16.
11. de Lima Oliveira, A. P., de Faveri, M., Gursky, L. C., Mestnik, M. J., Feres, M., Haffajee, A. D., Socransky, S. S., &, Teles, R. P., (2012) Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. Journal of Clinical Periodontology 39, 295-302.
12. Machtei, E. E., &, Younis, M. N., (2008) The use of 2 antibiotic regimens in aggressive periodontitis: comparison of changes in clinical parameters and gingival crevicular fluid biomarkers. Quintessence International 39, 811-819.
13. Matarazzo, F., Figueiredo, L. C., Cruz, S. E., Faveri, M., &, Feres, M., (2008) Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo-controlled study. Journal of Clinical Periodontology 35, 885-896.
14. Matuliene, G., Pjetursson, B. E., Salvi, G. E., Schmidlin, K., Brägger, U., Zwahlen, M., &, Lang, N. P., (2008) Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. Journal of Clinical Periodontology 35, 685-695.
15. Matuliene, G., Studer, R., Lang, N. P., Schmidlin, K., Pjetursson, B. E., Salvi, G. E., Brägger, U., &, Zwahlen, M., (2010) Significance of periodontal risk assessment in the recurrence of periodontitis and tooth loss. Journal of Clinical Periodontology 37, 191-199.
16. Mestnik, M. J., Feres, M., Figueiredo, L. C., Duarte, P. M., Lira, E. A., &, Faveri, M., (2010) Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. Journal of Clinical Periodontology 37, 353-365.
17. Pavicić, M. J., van Winkelhoff, A. J., &, de Graaff, J., (1992) In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations. Antimicrobial Agents and Chemotherapy 36, 2634-2638.
18. Pavicić, M. J., van Winkelhoff, A. J., Pavicić-Temming, Y. A., &, de Graaff, J., (1994) Amoxycillin causes an enhanced uptake of metronidazole in Actinobacillus actinomycetemcomitans: a mechanism of synergy. Journal of Antimicrobial Chemotherapy 34, 1047-1050.
19. Renvert, S., &, Persson, G. R., (2002) A systematic review on the use of residual probing depth, bleeding on probing and furcation status following initial periodontal therapy to predict further attachment and tooth loss. Journal of Clinical Periodontology 29 (Suppl. 3), 82-89.
20. Silva, M. P., Feres, M., Sirotto, T. A., Soares, G. M., Mendes, J. A., Faveri, M., &, Figueiredo, L. C., (2011) Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial. Journal of Clinical Periodontology 38, 828-837.
21. Teles, R. P., Patel, M., Socransky, S. S., &, Haffajee, A. D., (2008) Disease progression in periodontally healthy and maintenance subjects. Journal of Periodontology 79, 784-794.
22. Varela, V. M., Heller, D., Silva-Senem, M. X., Torres, M. C., Colombo, A. P., &, Feres-Filho, E. J., (2011) Systemic antimicrobials adjunctive to a repeated mechanical and antiseptic therapy for aggressive periodontitis: a 6-month randomized controlled trial. Journal of Periodontology 82, 1121-1130.
23. Winkel, E. G., van Winkelhoff, A. J., Timmerman, M. F., van der Velden, U., &, van der Weijden, G. A., (2001) Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo controlled study. Journal of Clinical Periodontology 28, 296-305.
24. van Winkelhoff, A. J., Rodenburg, J. P., Goene', R. J., Abbas, F., Winkel, E. G., &, de Graaff, J., (1989) Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. Journal of Clinical Periodontology 16, 128-131.
25. Xajigeorgiou, C., Sakellari, D., Slini, T., Baka, A., &, Konstantinidis, A., (2006) Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. Journal of Clinical Periodontology 33, 254-264.
26. Yek, E. C., Cintan, S., Topcuoglu, N., Kulekci, G., Issever, H., &, Kantarci, A., (2010) Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. Journal of Periodontology 81, 964-974.