Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: A clinical and microbiologic study

Quintessence International

Volumn 39, Issue 2, 2008, Pages e33-e39

  Akincibay, Hakan ^a   Örsal, Sibel Ö ^a   Şengün, Dilek ^a   Tözüm, Tolga F ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Aggressive periodontitis; Amoxicillin; Doxycycline; Metronidazole; Therapeutic use

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; DOXYCYCLINE; METRONIDAZOLE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMBINATION; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; MALE; MICROBIOLOGY; MICROCAPSULE; ORAL DRUG ADMINISTRATION; PERIODONTAL DISEASE; PERIODONTICS; PERIODONTITIS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CAPSULES; DENTAL PLAQUE; DENTAL PLAQUE INDEX; DENTAL SCALING; DOXYCYCLINE; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; METRONIDAZOLE; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; ROOT PLANING;

EID: 49849106679     PISSN: 00336572     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Listgarten MA, Loomer PM.Microbial identification in the management of periodontal diseases. A systematic review.Ann Periodontol 2003;8:182-192.
2. Christersson LA, Emrich LJ, Dundorf RG, Genco RJ. Analysis of data from clinical studies of localized juvenile periodontitis. J Clin Periodontol 1986;13:476-480.
3. Genco RJ, Christersson LA, Zambon JJ.Juvenile periodontitis. Int Dent J 1986;36:168-176.
4. Clark RA, Page RC, Wilde G. Defective neutrophil chemotaxis in juvenile periodontitis. Infect Immun 1977;18:694-700.
5. Liljenberg B, Lindhe J. Juvenile periodontitis: Some microbiological, histopathological and clinical characteristics. J Clin Periodontol 1980;7:48-61.
6. Zambon JJ, Reynolds HS, Slots J. Black-pigmented Bacteroides spp in the human oral cavity. Infect Immun 1981;32:198-203.
7. Kolenbrander PE, Andersen RN. Cell to cell interactions of capnocytophaga and bacteroides species with other oral bacteria and their potential role in development of plaque. J Periodont Res 1984;19:564-569.
8. Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. J Periodontol 1976;45:1-18.
9. Mandell RL, Tripodi LSE, Goodson JM, Socransky SS. The effect of treatment on Actinobacillus actinomycetemcomitans in localized juvenile periodontitis. J Periodontol 1986;57:94-99.
10. Moore WEC, Holdeman LV, Cato EP, et al. Comparative bacteriology of juvenile periodontitis. Infect Immun 1985;48:507-519.
11. Slots J. The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976;84:1-10.
12. Tözüm TF, Berker E, Akincibay H, et al. Tetraploid/ diploid mosaicism with generalized aggressive periodontitis. J Periodontol 2005;76:1567-1571.
13. Cacchillo DA, Walters JD. Effect of ciprofloxacin on killing of Actinobacillus actinomycetemcomitans by polymorphonuclear leukocytes. Antimicrob Agents Chemother 2002;46:1980-1984.
14. Smith JA. Neutrophils, host defense, and inflammation:A double-edged sword. J Leukoc Biol 1994;56:672-686.
15. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111.
16. Haake SK, Nisengard RJ, Newman MG, Miyasaki KT. Microbial interactions with the host in periodontal diseases. In: Newman MG, Takei HH, Carranza FA (eds). Clinical Periodontology. Philadelphia:Saunders, 2002:132-152.
17. Christersson LA, Albini B, Zambon JJ, Wikesjo UM, Genco RJ.Tissue localization of Actinobacillus actinomycetemcomitans in human periodontitis. I. Light, immunofluorescence and electron microscopic studies. J Periodontol 1987;58:529-539.
18. Haffajee AD, Dzink JL, Socransky SS. Effect of modified Widman flap surgery and systemic tetracycline on the subgingival microbiota of periodontal lesions. J Clin Periodontol 1988;15:255-262.
19. Tözüm TF, Yildirim A,Çağlayan F, Dinçel A, Bozkurt A. Serum and gingival crevicular fluid levels of ciprofloxacin in patients with periodontitis. J Am Dent Assoc 2004;135:1728-1732.
20. Lindhe J, Liljenberg B, Adielson B, Borjesson I.Effect of long-term tetracycline therapy on human periodontal disease. J Clin Periodontol 1983;10:590-601.
21. Lindhe J, Liljenberg B, Adielson B, Borjesson I. Use of metronidazole as a probe in the study of human periodontal disease. J Clin Periodontol 1983;10:100-112.
22. van Winkelhoff AJ, van Steenberger TJM, de Graff J. The role of black-pigmented bacteroides in human oral infections. J Clin Periodontol 1988;15:145-155.
23. van Winkelhoff AJ, Rodenburg JP, Goene RJ, et al. Metronidazole plus amoxicillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989;16:128-131.
24. Arie J, van Winkelhoff AJ, Carolien J, Graff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans associated periodontitis. J Periodontol 1992;63:52-57.
25. Gargiulo AW, Wentz FM, Orban B. Dimensions and relations of dentogingival junction in humans. J Periodontol 1961;32:261-267.
26. Silness J, Löe H.Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition.Acta Odontol Scand 1964;22:121-135.
27. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalance and severity. Acta Odontol Scand 1963;21:533-551.
28. Slots J, Zambon JJ, Rosling BG, et al. Actinobacillus actinomycetemcomitans in human periodontal disease. Association, serology, leucotoxicity and treatment. J Periodont Res 1982;17:447-448.
29. Lavanchy DL, Bickel M, Baehni PC. The effect of plaque control after scaling and root planing on the subgingival microflora in human periodontitis. J Clin Periodontol 1987;14:295-299.
30. Adriaens PA, De Boever JA, Loesche WJ. Bacterial invasion in root cementum and radicular dentin of periodontally diseased teeth in humans. A reservoir of periodontopathic bacteria. J Periodontol 1988;59:222-230.
31. van Winkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontol 2000 1996;10:45-78.
32. Christersson LA, Slots J, Rosling BG, Genco RJ.Microbiological and clinical effects of surgical treatment of localized juvenile periodontitis. J Clin Periodontol 1985;12:465-467.
33. Jenkins WM, Mac Farlane TW, Gilmour WH, Ramsay I, McKenzie D. Systemic metronidazole in the treatment of periodontitis. J Clin Periodontol 1989;16:443-450.
34. Kornman KS, Robertson PB. Clinical and microbiological evaluation of therapy for juvenile periodontitis. J Periodontol 1985;56:443-446.
35. Novak MJ, Polson AM, Adair SM. Tetracycline treatment in patients with early juvenile periodontitis. J Periodontol 1988;59:366-372.
36. Müller HP, Lange DE, Müller RF. A 2-year study of adjunctive minocycline-HCl in Actinobacillus actinomycetemcomitans associated periodontitis. J Periodontol 1993;64:509-519.
37. Asikainen S. Occurrence of Actinobacillus actinomycetemcomitans and spirochetes in relation to age in localized juvenile periodontitis. J Periodontol 1986;57:537-541.
38. Mandell RL, Socransky SS.Microbiological and clinical effects of surgery plus doxycycline on juvenile periodontitis. J Periodontol 1988;59:373-379.