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Volumn 9, Issue 2, 2014, Pages

Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CARNITINE; CARNITINE TRANSPORTER 1; CARNITINE TRANSPORTER 2; MESSENGER RNA; SODIUM ION;

EID: 84896511491     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090339     Document Type: Article
Times cited : (6)

References (44)
  • 1
    • 0035527564 scopus 로고    scopus 로고
    • Genetic factors in hypertension - What is known and what does it mean?
    • DOI 10.1080/080370501753400575
    • Melander O (2001) Genetic factors in hypertension-what is known and what does it mean? Blood Press 10: 254-270. (Pubitemid 34083352)
    • (2001) Blood Pressure , vol.10 , Issue.5-6 , pp. 254-270
    • Melander, O.1
  • 3
    • 53749084068 scopus 로고    scopus 로고
    • Carnitine in metabolic disease: Potential for pharmacological intervention
    • Arduini A, Bonomini M, Savica V, Amato A, Zammit V (2008) Carnitine in metabolic disease: potential for pharmacological intervention. Pharmacol Ther 120: 149-156.
    • (2008) Pharmacol Ther , vol.120 , pp. 149-156
    • Arduini, A.1    Bonomini, M.2    Savica, V.3    Amato, A.4    Zammit, V.5
  • 4
    • 70349241849 scopus 로고    scopus 로고
    • Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: Effects of acetyl-L-carnitine therapy
    • Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, et al. (2009) Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. Hypertension 54: 567-574.
    • (2009) Hypertension , vol.54 , pp. 567-574
    • Ruggenenti, P.1    Cattaneo, D.2    Loriga, G.3    Ledda, F.4    Motterlini, N.5
  • 5
    • 36849055496 scopus 로고    scopus 로고
    • Increase in nitric oxide and reductions in blood pressure, protein kinase C β II and oxidative stress by L-carnitine: A study in the fructose-fed hypertensive rat
    • DOI 10.1080/10641960701743998, PII 787915219
    • Rajasekar P, Palanisamy N, Anuradha CV (2007) Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by Lcarnitine: a study in the fructose-fed hypertensive rat. Clin Exp Hypertens 29: 517-530. (Pubitemid 350223251)
    • (2007) Clinical and Experimental Hypertension , vol.29 , Issue.8 , pp. 517-530
    • Rajasekar, P.1    Palanisamy, N.2    Anuradha, C.V.3
  • 6
    • 77955146114 scopus 로고    scopus 로고
    • OCTN2 is associated with carnitine transport capacity of rat skeletal muscles
    • Furuichi Y, Sugiura T, Kato Y, Shimada Y, Masuda K (2010) OCTN2 is associated with carnitine transport capacity of rat skeletal muscles. Acta Physiol 200: 57-64.
    • (2010) Acta Physiol , vol.200 , pp. 57-64
    • Furuichi, Y.1    Sugiura, T.2    Kato, Y.3    Shimada, Y.4    Masuda, K.5
  • 7
    • 1042288659 scopus 로고    scopus 로고
    • A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets
    • DOI 10.1016/S0306-9877(03)00232-9
    • McCarty MF (2004) A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets. Med Hypotheses 62: 62-71. (Pubitemid 38200007)
    • (2004) Medical Hypotheses , vol.62 , Issue.1 , pp. 62-71
    • McCarty, M.F.1
  • 8
    • 54249163313 scopus 로고    scopus 로고
    • The role of inflammatory markers in the cardioprotective effect of Lcarnitine in L-NAME-induced hypertension
    • Miguel-Carrasco JL, Mate A, Monserrat MT, Arias JL, Aramburu O, et al. (2008) The role of inflammatory markers in the cardioprotective effect of Lcarnitine in L-NAME-induced hypertension. Am J Hypertens 21: 1231-1237.
    • (2008) Am J Hypertens , vol.21 , pp. 1231-1237
    • Miguel-Carrasco, J.L.1    Mate, A.2    Monserrat, M.T.3    Arias, J.L.4    Aramburu, O.5
  • 10
    • 84880286881 scopus 로고    scopus 로고
    • L-Carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow
    • Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, et al. (2013) L-Carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res 74: 39-47.
    • (2013) Pediatr Res , vol.74 , pp. 39-47
    • Sharma, S.1    Aramburo, A.2    Rafikov, R.3    Sun, X.4    Kumar, S.5
  • 11
    • 55249096765 scopus 로고    scopus 로고
    • Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults
    • Volek JS, Judelson DA, Silvestre R, Yamamoto LM, Spiering BA, et al. (2008) Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol 102: 1413-1417.
    • (2008) Am J Cardiol , vol.102 , pp. 1413-1417
    • Volek, J.S.1    Judelson, D.A.2    Silvestre, R.3    Yamamoto, L.M.4    Spiering, B.A.5
  • 12
    • 84872688669 scopus 로고    scopus 로고
    • Pharmacological and pathophysiological roles of carnitine/ organic cation transporters (OCTNs: SLC22A4, SLC22A5 and SLC22A21)
    • Tamai I (2013) Pharmacological and pathophysiological roles of carnitine/ organic cation transporters (OCTNs: SLC22A4, SLC22A5 and SLC22A21). Biopharm Drug Dispos 34: 29-44.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 29-44
    • Tamai, I.1
  • 15
    • 80053474357 scopus 로고    scopus 로고
    • Synthesis, transport and mechanism of a type i prodrug: L-carnitine ester of prednisolone
    • Mo JX, Shi SJ, Zhang Q, Gong T, Sun X, et al. (2011) Synthesis, transport and mechanism of a type I prodrug: L-carnitine ester of prednisolone. Mol Pharm 8: 1629-1640.
    • (2011) Mol Pharm , vol.8 , pp. 1629-1640
    • Mo, J.X.1    Shi, S.J.2    Zhang, Q.3    Gong, T.4    Sun, X.5
  • 18
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • DOI 10.1074/jbc.273.32.20378
    • Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, et al. (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273: 20378-20382. (Pubitemid 28377603)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.-I.3    Yabuuchi, H.4    Oku, A.5    Shimane, M.6    Sai, Y.7    Tsujit, A.8
  • 19
    • 0033585084 scopus 로고    scopus 로고
    • Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function
    • Seth P, Wu X, Huang W, Leibach FH, Ganapathy V (1999) Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function. J Biol Chem 274: 33388-33392. (Pubitemid 129511642)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.47 , pp. 33388-33392
    • Seth, P.1    Wu, X.2    Huang, W.3    Leibach, F.H.4    Ganapathy, V.5
  • 23
    • 84898480007 scopus 로고    scopus 로고
    • Functional expression of organic cation/ carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model
    • doi: 10.2133/dmpk.DMPK-13-RG-058
    • Okura T, Kato S, Deguchi Y (2013) Functional expression of organic cation/ carnitine transporter 2 (OCTN2/SLC22A5) in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model. Drug Metab Pharmacokinet. doi: 10.2133/dmpk.DMPK-13-RG-058.
    • (2013) Drug Metab Pharmacokinet
    • Okura, T.1    Kato, S.2    Deguchi, Y.3
  • 25
    • 23744493081 scopus 로고    scopus 로고
    • L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: Different participation of NO and COX-products
    • DOI 10.1016/j.lfs.2005.01.035, PII S0024320505004376
    • Bueno R, Alvarez de Sotomayor M, Perez-Guerrero C, Gomez-Amores L, Vazquez CM, et al. (2005) L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci 77: 2082-2097. (Pubitemid 41140450)
    • (2005) Life Sciences , vol.77 , Issue.17 , pp. 2082-2097
    • Bueno, R.1    Alvarez De Sotomayor, M.2    Perez-Guerrero, C.3    Gomez-Amores, L.4    Vazquez, C.M.5    Herrera, M.D.6
  • 26
    • 84874666148 scopus 로고    scopus 로고
    • L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-c expression
    • Zambrano S, Blanca AJ, Ruiz-Armenta MV, Miguel-Carrasco JL, Arévalo M, et al. (2013) L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-c expression. Biochem Pharmacol 85: 937-944.
    • (2013) Biochem Pharmacol , vol.85 , pp. 937-944
    • Zambrano, S.1    Blanca, A.J.2    Ruiz-Armenta, M.V.3    Miguel-Carrasco, J.L.4    Arévalo, M.5
  • 27
    • 0025190263 scopus 로고
    • Rat aortic smooth muscle cells in culture express kallikrein, kinogen, and bradykininase activity
    • Oza NB, Schwartz JH, Goud HD, Levinsky NG (1990) Rat aortic smooth muscle cells in culture express kallikrein, kininogen, and bradykininase activity. J Clin Invest 85: 597-600. (Pubitemid 20070072)
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.2 , pp. 597-600
    • Oza, N.B.1    Schwartz, J.H.2    Goud, H.D.3    Levinsky, N.G.4
  • 28
    • 84864231326 scopus 로고    scopus 로고
    • Insulin-increased L-arginine transport requires A2A adenosine receptors activation in human umbilical vein endothelium
    • Guzmán-Gutiérrez E, Westermeier F, Salomón C, González M, Pardo F, et al. (2012) Insulin-increased L-arginine transport requires A2A adenosine receptors activation in human umbilical vein endothelium. PLoS One 7: e41705.
    • (2012) PLoS One , vol.7
    • Guzmán-Gutiérrez, E.1    Westermeier, F.2    Salomón, C.3    González, M.4    Pardo, F.5
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT Method. Methods 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 84869854776 scopus 로고    scopus 로고
    • PPARc agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes
    • Kanakasabai S, Pestereva E, Chearwae W, Gupta SK, Ansari S, et al. (2012) PPARc agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. PLoS One 7: e50500.
    • (2012) PLoS One , vol.7
    • Kanakasabai, S.1    Pestereva, E.2    Chearwae, W.3    Gupta, S.K.4    Ansari, S.5
  • 31
    • 84872356625 scopus 로고    scopus 로고
    • Lcarnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: The SABPA study
    • Mels CM, Schutte AE, Erasmus E, Huisman HW, Schutte R, et al. (2013) Lcarnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study. Lipids 48: 63-73.
    • (2013) Lipids , vol.48 , pp. 63-73
    • Mels, C.M.1    Schutte, A.E.2    Erasmus, E.3    Huisman, H.W.4    Schutte, R.5
  • 32
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • DOI 10.1016/S0014-5793(97)01441-5, PII S0014579397014415
    • Tamai I, Yabuuchi H, Nezu J, et al. (1997) Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419: 107-111. (Pubitemid 28011227)
    • (1997) FEBS Letters , vol.419 , Issue.1 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.-I.3    Sai, Y.4    Oku, A.5    Shimane, M.6    Tsuji, A.7
  • 34
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • DOI 10.1007/s11095-007-9254-z
    • Koepsell H, Lips K, Volk C (2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24: 1227-1251. (Pubitemid 46876495)
    • (2007) Pharmaceutical Research , vol.24 , Issue.7 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 35
    • 84875181483 scopus 로고    scopus 로고
    • The SLC22 family with transporters of organic cations, anions and zwitterions
    • Koepsell H (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 34: 413-435.
    • (2013) Mol Aspects Med , vol.34 , pp. 413-435
    • Koepsell, H.1
  • 36
    • 0031916983 scopus 로고    scopus 로고
    • Transporters for cationic amino acids in animal cells: Discovery, structure, and function
    • Devés R, Boyd CA (1998) Transporters for cationic amino acids in animal cells: discovery, structure, and function. Physiol Rev 78: 487-545. (Pubitemid 28182902)
    • (1998) Physiological Reviews , vol.78 , Issue.2 , pp. 487-545
    • Deves, R.1    Boyd, C.A.R.2
  • 37
    • 0037207473 scopus 로고    scopus 로고
    • Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells
    • Mann GE, Yudilevich DL, Sobrevia L (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83: 183-252. (Pubitemid 36459881)
    • (2003) Physiological Reviews , vol.83 , Issue.1 , pp. 183-252
    • Mann, G.E.1    Yudilevich, D.L.2    Sobrevia, L.3
  • 38
    • 48849091224 scopus 로고    scopus 로고
    • Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart
    • Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, et al. (2008) Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart. Drug Metab Pharmacokinet 23: 207-215.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 207-215
    • Iwata, D.1    Kato, Y.2    Wakayama, T.3    Sai, Y.4    Kubo, Y.5
  • 40
    • 33645310407 scopus 로고    scopus 로고
    • Uptake of cardiovascular drugs into the human heart: Expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5)
    • Grube M, Meyer zu Schwabedissen HE, Präger D, Haney J, Möritz KU, et al. (2006) Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5). Circulation 113: 1114-1122.
    • (2006) Circulation , vol.113 , pp. 1114-1122
    • Grube, M.1    Meyer Zu Schwabedissen, H.E.2    Präger, D.3    Haney, J.4    Möritz, K.U.5
  • 41
    • 0022104089 scopus 로고
    • Altered carnitine metabolism in spontaneously hypertensive rats
    • Foster KA, O'Rourke B, Reibel DK (1985) Altered carnitine metabolism in spontaneously hypertensive rats. Am J Physiol 249: 183-186.
    • (1985) Am J Physiol , vol.249 , pp. 183-186
    • Foster, K.A.1    O'rourke, B.2    Reibel, D.K.3
  • 43
    • 0032577202 scopus 로고    scopus 로고
    • CDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • DOI 10.1006/bbrc.1998.8669
    • Wu X, Prasad PD, Leibach FH, Ganapathy V (1998) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246: 589-595. (Pubitemid 28420901)
    • (1998) Biochemical and Biophysical Research Communications , vol.246 , Issue.3 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 44
    • 84870827215 scopus 로고    scopus 로고
    • Potential role of sodium-proton exchangers in the low concentration arsenic trioxideincreased intracellular pH and cell proliferation
    • Aravena C, Beltrán AR, Cornejo M, Torres V, Díaz ES, et al. (2012) Potential role of sodium-proton exchangers in the low concentration arsenic trioxideincreased intracellular pH and cell proliferation. PLoS One 7: e51451.
    • (2012) PLoS One , vol.7
    • Aravena, C.1    Beltrán, A.R.2    Cornejo, M.3    Torres, V.4    Díaz, E.S.5


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