Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function

Journal of Biological Chemistry

Volumn 274, Issue 47, 1999, Pages 33388-33392

  Seth, Pankaj ^a   Wu, Xiang ^a   Huang, Wei ^a   Leibach, Frederick H ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; CARRIER PROTEIN; CATION; SODIUM ION;

ARTICLE; CARNITINE DEFICIENCY; CATION TRANSPORT; CHEMICAL REACTION KINETICS; CHIMERA; GENETIC DISORDER; HUMAN; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; RAT;

ANIMALS; CARNITINE; CARRIER PROTEINS; CATIONS; HELA CELLS; HUMANS; ION TRANSPORT; KINETICS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; ORGANIC CATION TRANSPORT PROTEINS; RATS; TETRAETHYLAMMONIUM COMPOUNDS; TYROSINE;

EID: 0033585084     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.47.33388     Document Type: Article

References (21)

1. Koepsell, H., Gorboulev, V., and Arndt, P. (1999) J. Membr. Biol. 167, 103-117
2. Wu, X., Prasad, P. D., Leibach, F. H., and Ganapathy, V. (1998) Biochem. Biophys. Res. Commun. 246, 589-595
3. Tamai, I., Ohashi, R., Nezu, J., Yabuuchi, H., Oku, A., Shimane, M., Sai, Y., and Tsuji, A. (1998) J. Biol. Chem. 273, 20378-20382
4. Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J., and Ganapathy, V. (1999) J. Pharmacol. Exp. Ther. 290, 1482-1492
5. Bieber, L. L., (1988) Annu. Rev. Biochem. 57, 261-283
6. Kerner, J., and Hoppel, C. (1998) Annu. Rev. Nutr. 18, 179-206
7. Rebouche, C. J., and Mack, D. L. (1984) Arch. Biochem. Biophys. 236, 393-402
8. Steiger, B., O'Neill, B., and Krahenbuhl, S. (1995) Biochem. J. 309, 643-647
9. Hamilton, J. W., Li, B. U. K, Shug, A., and Olsen, W. A. (1986) Gastroenterology 91, 10-16
10. Roque, A. S., Prasad, P. D., Bhatia, J. S., Leibach, F. H., and Ganapathy, V. (1996) Biochim. Biophys. Acta 1282, 274-282
11. Prasad, P. D., Huang, W., Ramamoorthy, S., Carter, A. L., Leibach, F. H., and Ganapathy, V. (1996) Biochim. Biophys. Acta 1284, 109-117
12. Wang, Y., Ye, J., Ganapathy, V., and Longo, N. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2356-2360
13. Tang, N., Ganapathy, V., Wu, X, Hui, J., Seth, P., Yuen, P., Fok, T., and Hjelm, N. (1999) Hum. Mol. Genet. 8, 655-660
14. Nezu, J., Tamai, I., Oku, A., Ohashi, R., Yabuuchi, H., Hashimoto, N., Nikaido, H., Sai, Y., Koizumi, A., Shoji, Y., Takada, G., Matsuishi, T., Yoshino, M., Kato, H., Ohura, T., Tsujimoto, G., Hayakawa, J., Shimane, M., and Tsuji, A. (1999) Nat. Genet. 21, 91-94
15. Lamhonwah, A. M., and Tein, I. (1998) Biochem. Biophys. Res. Commun. 252, 396-401
16. Lu, K, Nishimori, H., Nakamura, Y., Shima, K., and Kuwajima, M. (1998) Biochem. Biophys. Res. Commun. 252, 590-594
17. Koizumi, T., Nikaido, H., Hayakawa, J., Nonomura, A., and Yoneda, T. (1988) Lab. Anim. 22, 83-87
18. Wright, E. M., and Peerce, B. E. (1984) J. Biol. Chem. 259, 14993-14996
19. Peerce, B. E., and Wright, E. M. (1985) J. Biol. Chem. 260, 6026-6031
20. Kulanthaivel, P., Leibach, F. H., Mahesh, V. B., and Ganapathy, V. (1989) Biochim. Biophys. Acta 985, 139-146
21. Ganapathy, V., Kulanthaivel, P., Tiruppathi, C., Mahesh, V. B., and Leibach, F. H. (1989) J. Pharmacol. Exp. Ther. 251, 9-15