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Volumn 18, Issue 8, 2007, Pages 533-540

l-Carnitine attenuates oxidative stress in hypertensive rats

Author keywords

Antioxidant enzymes; l Carnitine; Nitric oxide; Oxidative stress; SHR

Indexed keywords

ANTIOXIDANT; CARNITINE; CATALASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

EID: 34447282257     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2006.10.004     Document Type: Article
Times cited : (54)

References (46)
  • 1
    • 4444257541 scopus 로고    scopus 로고
    • Reactive oxygen species in hypertension; an update
    • Lassegue B., and Griendling K.K. Reactive oxygen species in hypertension; an update. Am J Hypertens 17 (2004) 852-860
    • (2004) Am J Hypertens , vol.17 , pp. 852-860
    • Lassegue, B.1    Griendling, K.K.2
  • 2
    • 0033566797 scopus 로고    scopus 로고
    • Nitric oxide and coronary endothelial dysfunction in humans
    • Drexler H. Nitric oxide and coronary endothelial dysfunction in humans. Cardiovasc Res 43 (1999) 572-579
    • (1999) Cardiovasc Res , vol.43 , pp. 572-579
    • Drexler, H.1
  • 3
    • 0034255053 scopus 로고    scopus 로고
    • Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity
    • Lembo G., Vecchione C., Izzo R., Fratta L., Fontana D., Marino G., et al. Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity. Circulation 102 (2000) 552-557
    • (2000) Circulation , vol.102 , pp. 552-557
    • Lembo, G.1    Vecchione, C.2    Izzo, R.3    Fratta, L.4    Fontana, D.5    Marino, G.6
  • 4
    • 0035076005 scopus 로고    scopus 로고
    • Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats
    • Wu R., Millette E., Wu L., and de Champlain J. Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. J Hypertens 19 (2001) 741-748
    • (2001) J Hypertens , vol.19 , pp. 741-748
    • Wu, R.1    Millette, E.2    Wu, L.3    de Champlain, J.4
  • 5
    • 0142122214 scopus 로고    scopus 로고
    • Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation
    • Ulker S., McMaster D., McKeown P.P., and Bayraktutan U. Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation. Cardiovasc Res 59 (2003) 488-500
    • (2003) Cardiovasc Res , vol.59 , pp. 488-500
    • Ulker, S.1    McMaster, D.2    McKeown, P.P.3    Bayraktutan, U.4
  • 6
    • 0032780507 scopus 로고    scopus 로고
    • Role for NADPH/NADH oxidase in the modulation of vascular tone
    • Munzel T., Hink U., Heitzer T., and Meinertz T. Role for NADPH/NADH oxidase in the modulation of vascular tone. Ann N Y Acad Sci 874 (1999) 386-400
    • (1999) Ann N Y Acad Sci , vol.874 , pp. 386-400
    • Munzel, T.1    Hink, U.2    Heitzer, T.3    Meinertz, T.4
  • 8
    • 0034993163 scopus 로고    scopus 로고
    • Antioxidant status of the hypertrophic heart of Dahl hypertensive rat as a model for evaluation of antioxidants
    • Somova L.I., Nadar A., Gregory M., and Khan N. Antioxidant status of the hypertrophic heart of Dahl hypertensive rat as a model for evaluation of antioxidants. Methods Find Exp Clin Pharmacol 23 (2001) 5-12
    • (2001) Methods Find Exp Clin Pharmacol , vol.23 , pp. 5-12
    • Somova, L.I.1    Nadar, A.2    Gregory, M.3    Khan, N.4
  • 10
    • 0347927335 scopus 로고    scopus 로고
    • Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production
    • Midaoui A.E., Elimadi A., Wu L., Haddad P.S., and de Champlain J. Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production. Am J Hypertens 16 (2003) 173-179
    • (2003) Am J Hypertens , vol.16 , pp. 173-179
    • Midaoui, A.E.1    Elimadi, A.2    Wu, L.3    Haddad, P.S.4    de Champlain, J.5
  • 11
    • 0031926961 scopus 로고    scopus 로고
    • Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide
    • Schnackenberg C.G., Welch W.J., and Wilcox C.S. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 32 (1998) 59-64
    • (1998) Hypertension , vol.32 , pp. 59-64
    • Schnackenberg, C.G.1    Welch, W.J.2    Wilcox, C.S.3
  • 12
    • 0032956654 scopus 로고    scopus 로고
    • Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha
    • Schnackenberg C.G., and Wilcox C.S. Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha. Hypertension 33 (1999) 424-428
    • (1999) Hypertension , vol.33 , pp. 424-428
    • Schnackenberg, C.G.1    Wilcox, C.S.2
  • 13
    • 0035460097 scopus 로고    scopus 로고
    • Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR
    • Chen X., Touyz R.M., Park J.B., and Schiffrin E.L. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 38 (2001) 606-611
    • (2001) Hypertension , vol.38 , pp. 606-611
    • Chen, X.1    Touyz, R.M.2    Park, J.B.3    Schiffrin, E.L.4
  • 14
    • 0032189158 scopus 로고    scopus 로고
    • Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats
    • Kalaiselvi T., and Panneerselvam C. Effect of l-carnitine on the status of lipid peroxidation and antioxidants in aging rats. J Nutr Biochem 9 (1998) 575-581
    • (1998) J Nutr Biochem , vol.9 , pp. 575-581
    • Kalaiselvi, T.1    Panneerselvam, C.2
  • 15
    • 0034769470 scopus 로고    scopus 로고
    • Carnitine as a free radical scavenger in aging
    • Arockia P., Rani J., and Panneerselvam C. Carnitine as a free radical scavenger in aging. Exp Gerontol 36 (2001) 1713-1726
    • (2001) Exp Gerontol , vol.36 , pp. 1713-1726
    • Arockia, P.1    Rani, J.2    Panneerselvam, C.3
  • 16
    • 0024553760 scopus 로고
    • Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol
    • Sushamakumari S., Jayadeep A., Kumar J.S., and Menon V.P. Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol. Indian J Exp Biol 27 (1989) 134-137
    • (1989) Indian J Exp Biol , vol.27 , pp. 134-137
    • Sushamakumari, S.1    Jayadeep, A.2    Kumar, J.S.3    Menon, V.P.4
  • 17
    • 0022539574 scopus 로고
    • Aging and arteriosclerosis: I. Development of myointimal hyperplasia after endothelial injury
    • Hariri R.J., Alonso D.R., Hajjar D.P., Coletti D., and Weksler M.E. Aging and arteriosclerosis: I. Development of myointimal hyperplasia after endothelial injury. J Exp Med 164 (1986) 1171-1178
    • (1986) J Exp Med , vol.164 , pp. 1171-1178
    • Hariri, R.J.1    Alonso, D.R.2    Hajjar, D.P.3    Coletti, D.4    Weksler, M.E.5
  • 18
    • 0034994973 scopus 로고    scopus 로고
    • Protective role of l-carnitine on liver and heart lipid peroxidation in atherosclerotic rats
    • Dayanandan A., Kumar P., and Panneerselvam C. Protective role of l-carnitine on liver and heart lipid peroxidation in atherosclerotic rats. J Nutr Biochem 12 (2001) 254-257
    • (2001) J Nutr Biochem , vol.12 , pp. 254-257
    • Dayanandan, A.1    Kumar, P.2    Panneerselvam, C.3
  • 19
    • 0034834828 scopus 로고    scopus 로고
    • l-Carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits
    • Sayed-Ahmed M.M., Khattab M.M., Gad M.Z., and Mostafa N. l-Carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits. Pharmacol Res 44 (2001) 235-242
    • (2001) Pharmacol Res , vol.44 , pp. 235-242
    • Sayed-Ahmed, M.M.1    Khattab, M.M.2    Gad, M.Z.3    Mostafa, N.4
  • 20
    • 23744493081 scopus 로고    scopus 로고
    • l-Carnitine and propionyl-l-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products
    • Bueno R., Alvarez d.S., Perez-Guerrero C., Gomez-Amores L., Vazquez C.M., and Herrera M.D. l-Carnitine and propionyl-l-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci 77 (2005) 2082-2097
    • (2005) Life Sci , vol.77 , pp. 2082-2097
    • Bueno, R.1    Alvarez, d.S.2    Perez-Guerrero, C.3    Gomez-Amores, L.4    Vazquez, C.M.5    Herrera, M.D.6
  • 21
    • 0345451570 scopus 로고    scopus 로고
    • The effect of chronic l-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats
    • Rauchova H., Dobesova Z., Drahota Z., Zicha J., and Kunes J. The effect of chronic l-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats. Eur J Pharmacol 342 (1998) 235-239
    • (1998) Eur J Pharmacol , vol.342 , pp. 235-239
    • Rauchova, H.1    Dobesova, Z.2    Drahota, Z.3    Zicha, J.4    Kunes, J.5
  • 22
    • 0030063942 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled trial of l-carnitine in suspected acute myocardial infarction
    • Singh R.B., Niaz M.A., Agarwal P., Beegum R., Rastogi S.S., and Sachan D.S. A randomised, double-blind, placebo-controlled trial of l-carnitine in suspected acute myocardial infarction. Postgrad Med J 72 (1996) 45-50
    • (1996) Postgrad Med J , vol.72 , pp. 45-50
    • Singh, R.B.1    Niaz, M.A.2    Agarwal, P.3    Beegum, R.4    Rastogi, S.S.5    Sachan, D.S.6
  • 24
    • 0017067418 scopus 로고
    • Glutathione peroxidase activity in selenium-deficient rat liver
    • Lawrence R.A., and Burk R.F. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71 (1976) 952-958
    • (1976) Biochem Biophys Res Commun , vol.71 , pp. 952-958
    • Lawrence, R.A.1    Burk, R.F.2
  • 25
    • 0016808562 scopus 로고
    • Purification and characterization of the flavoenzyme glutathione reductase from rat liver
    • Carlberg I., and Mannervik B. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 250 (1975) 5475-5480
    • (1975) J Biol Chem , vol.250 , pp. 5475-5480
    • Carlberg, I.1    Mannervik, B.2
  • 26
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord J.M., and Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244 (1969) 6049-6055
    • (1969) J Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 27
    • 41049100518 scopus 로고
    • A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase
    • Beers Jr. R.F., and Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195 (1952) 133-140
    • (1952) J Biol Chem , vol.195 , pp. 133-140
    • Beers Jr., R.F.1    Sizer, I.W.2
  • 28
    • 0025127633 scopus 로고
    • Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal
    • Esterbauer H., and Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186 (1990) 407-421
    • (1990) Methods Enzymol , vol.186 , pp. 407-421
    • Esterbauer, H.1    Cheeseman, K.H.2
  • 29
    • 0027509770 scopus 로고
    • A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates
    • Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., and Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 84 (1993) 407-412
    • (1993) Clin Sci (Lond) , vol.84 , pp. 407-412
    • Miller, N.J.1    Rice-Evans, C.2    Davies, M.J.3    Gopinathan, V.4    Milner, A.5
  • 30
    • 0031424178 scopus 로고    scopus 로고
    • Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and s-nitrosothiols
    • Marzinzig M., Nussler A.K., Stadler J., Marzinzig E., Barthlen W., Nussler Jr. N.C., et al. Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and s-nitrosothiols. Nitric Oxide 1 (1997) 177-189
    • (1997) Nitric Oxide , vol.1 , pp. 177-189
    • Marzinzig, M.1    Nussler, A.K.2    Stadler, J.3    Marzinzig, E.4    Barthlen, W.5    Nussler Jr., N.C.6
  • 31
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 33
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 34
    • 0029055276 scopus 로고
    • In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography
    • Suzuki H., Swei A., Zweifach B.W., and Schmid-Schonbein G.W. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography. Hypertension 25 (1995) 1083-1089
    • (1995) Hypertension , vol.25 , pp. 1083-1089
    • Suzuki, H.1    Swei, A.2    Zweifach, B.W.3    Schmid-Schonbein, G.W.4
  • 35
    • 22144457461 scopus 로고    scopus 로고
    • Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids
    • Tsikas D. Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Radic Res 39 (2005) 797-815
    • (2005) Free Radic Res , vol.39 , pp. 797-815
    • Tsikas, D.1
  • 36
    • 0026669086 scopus 로고
    • A comparative study on defense systems for lipid peroxidation by free radicals in spontaneously hypertensive and normotensive rat myocardium
    • Ito H., Torii M., and Suzuki T. A comparative study on defense systems for lipid peroxidation by free radicals in spontaneously hypertensive and normotensive rat myocardium. Comp Biochem Physiol B 103 (1992) 37-40
    • (1992) Comp Biochem Physiol B , vol.103 , pp. 37-40
    • Ito, H.1    Torii, M.2    Suzuki, T.3
  • 37
    • 0031750501 scopus 로고    scopus 로고
    • Plasma and lipoprotein lipid composition and hepatic antioxidant status in spontaneously hypertensive (SHR) and normotensive (WKY) rats
    • Kitts D.D., Yuan Y.V., and Godin D.V. Plasma and lipoprotein lipid composition and hepatic antioxidant status in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Can J Physiol Pharmacol 76 (1998) 202-209
    • (1998) Can J Physiol Pharmacol , vol.76 , pp. 202-209
    • Kitts, D.D.1    Yuan, Y.V.2    Godin, D.V.3
  • 38
    • 0032430308 scopus 로고    scopus 로고
    • Effect of alpha-tocopherol on lipid peroxidation and total antioxidant status in spontaneously hypertensive rats
    • Newaz M.A., and Nawal N.N. Effect of alpha-tocopherol on lipid peroxidation and total antioxidant status in spontaneously hypertensive rats. Am J Hypertens 11 (1998) 1480-1485
    • (1998) Am J Hypertens , vol.11 , pp. 1480-1485
    • Newaz, M.A.1    Nawal, N.N.2
  • 39
    • 0033669975 scopus 로고    scopus 로고
    • Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats
    • Vaziri N.D., Ni Z., Oveisi F., and Trnavsky-Hobbs D.L. Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats. Hypertension 36 (2000) 957-964
    • (2000) Hypertension , vol.36 , pp. 957-964
    • Vaziri, N.D.1    Ni, Z.2    Oveisi, F.3    Trnavsky-Hobbs, D.L.4
  • 40
    • 0035317895 scopus 로고    scopus 로고
    • Prospects for the use of antioxidant therapy in hypertension
    • Digiesi V., Lenuzza M., and Digiesi G. Prospects for the use of antioxidant therapy in hypertension. Ann Ital Med Int 16 (2001) 93-100
    • (2001) Ann Ital Med Int , vol.16 , pp. 93-100
    • Digiesi, V.1    Lenuzza, M.2    Digiesi, G.3
  • 41
    • 33644618872 scopus 로고    scopus 로고
    • Antioxidant activity of propionyl-l-carnitine in liver and heart of spontaneously hypertensive rats
    • Gomez-Amores L., Mate A., Revilla E., Santa-Maria C., and Vazquez C.M. Antioxidant activity of propionyl-l-carnitine in liver and heart of spontaneously hypertensive rats. Life Sci 78 (2006) 1945-1952
    • (2006) Life Sci , vol.78 , pp. 1945-1952
    • Gomez-Amores, L.1    Mate, A.2    Revilla, E.3    Santa-Maria, C.4    Vazquez, C.M.5
  • 43
    • 0028279693 scopus 로고
    • l-Carnitine adjuvant therapy in essential hypertension
    • Digiesi V., Cantini F., Bisi G., Guarino G., and Brodbeck B. l-Carnitine adjuvant therapy in essential hypertension. Clin Ter 144 (1994) 391-395
    • (1994) Clin Ter , vol.144 , pp. 391-395
    • Digiesi, V.1    Cantini, F.2    Bisi, G.3    Guarino, G.4    Brodbeck, B.5
  • 44
    • 0031015288 scopus 로고    scopus 로고
    • Griendling, p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats
    • Fukui T., Ishizaka N., Rajagopalan S., Laursen J.B., Capers Q., Taylor W.R., et al. Griendling, p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res 80 (1997) 45-51
    • (1997) Circ Res , vol.80 , pp. 45-51
    • Fukui, T.1    Ishizaka, N.2    Rajagopalan, S.3    Laursen, J.B.4    Capers, Q.5    Taylor, W.R.6
  • 45
    • 0029661428 scopus 로고    scopus 로고
    • p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells
    • Ushio-Fukai M., Zafari A.M., Fukui T., Ishizaka N., and Griendling K.K. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271 (1996) 23317-23321
    • (1996) J Biol Chem , vol.271 , pp. 23317-23321
    • Ushio-Fukai, M.1    Zafari, A.M.2    Fukui, T.3    Ishizaka, N.4    Griendling, K.K.5
  • 46
    • 0036791717 scopus 로고    scopus 로고
    • Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    • Virdis A., Neves M.F., Amiri F., Viel E., Touyz R.M., and Schiffrin E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 40 (2002) 504-510
    • (2002) Hypertension , vol.40 , pp. 504-510
    • Virdis, A.1    Neves, M.F.2    Amiri, F.3    Viel, E.4    Touyz, R.M.5    Schiffrin, E.L.6


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