Engineering antimicrobial peptides with improved antimicrobial and hemolytic activities

Journal of Chemical Information and Modeling

Volumn 53, Issue 12, 2013, Pages 3280-3296

  Zhao, Jun ^a   Zhao, Chao ^a   Liang, Guizhao ^a,b   Zhang, Mingzhen ^a   Zheng, Jie ^a  

^a The University of Akron   (United States)

^b CHONGQING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOACTIVITY; BLOOD; CELLS; FREE ENERGY; HEALTH RISKS; LIPID BILAYERS; MOLECULAR DYNAMICS;

ADAPTIVE BIASING FORCES; AMINO ACID SUBSTITUTION; ANTI-MICROBIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL INNER MEMBRANES; COARSE-GRAINED MOLECULAR DYNAMICS; COOPERATIVE INTERACTIONS; POTENTIAL OF MEAN FORCE;

PEPTIDES;

1 PALMITOYL 2 OLEOYLGLYCERO 3 PHOSPHOGLYCEROL; 1 PALMITOYL 2 OLEOYLPHOSPHATIDYLETHANOLAMINE; 1-PALMITOYL-2-OLEOYLGLYCERO-3-PHOSPHOGLYCEROL; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLETHANOLAMINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; ANTIMICROBIAL CATIONIC PEPTIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; DIFFUSION; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HEMOLYSIS; HUMAN; LIPID BILAYER; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; MOLECULAR GENETICS; MOLECULAR MIMICRY; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; SYNTHESIS; THERMODYNAMICS; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DIFFUSION; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPID BILAYERS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLGLYCEROLS; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; THERMODYNAMICS;

EID: 84896510367     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci400477e     Document Type: Article

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