Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical peptides

FEBS Letters

Volumn 403, Issue 2, 1997, Pages 208-212

  Dathe, Margitta ^a   Wieprecht, Torsten ^a   Nikolenko, Heike ^a   Handel, Liselotte ^a   Maloy, W Lee ^b   MacDonald, Dorothy L ^b   Beyermann, Michael ^a   Bienert, Michael ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b Genaera Corporation   (United States)

Author keywords

Antimicrobial peptide; Haemolysis; Hydrophobic moment; Hydrophobicity; Magainin

Indexed keywords

ANTIINFECTIVE AGENT; PEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; GRAM-POSITIVE BACTERIA; HEMOLYSIS; MOLECULAR SEQUENCE DATA; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

NEGIBACTERIA; POSIBACTERIA;

EID: 0031059377     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00055-0     Document Type: Article

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