Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H

European Journal of Medicinal Chemistry

Volumn 77, Issue , 2014, Pages 231-242

  Raghav, Neera ^a   Singh, Mamta ^a  

^a KURUKSHETRA UNIVERSITY   (India)

Author keywords

4 Amino 1,2,4 triazoles; Acyl hydrazides; Cathepsin B inhibitors; Cathepsin H inhibitors; Endogenous proteolysis

Indexed keywords

2 CHLOROBENZOHYDRAZIDE; 3 (2' HYDROXY 3' METHYLPHENYL) 5 (2 HYDROXY 3' METHYLPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (2' METHYLPHENYL) 5 (2' METHYLPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (3 AMINOPHENYL) 5 (3 AMINOPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (3 NITROPHENYL) 5 (3 NITROPHENYL) 4-AMINO 1,2,4 TRIAZOLE; 3 (3' METHYLPHENYL) 5 (3' METHYLPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (4 CHLOROPHENYL) 5 (4' CHLOROPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (4' METHYLPHENYL) 5 (4' METHYLPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3 (4' NITROPHENYL) 5 (4' 3 NITROPHENYL) 4 AMINO 1,2,4 TRIAZOLE; 3,5 DIPHENYL 4 AMINO 1,2,4 TRIAZOLE; 4 HYDROXYBENZOHYDRAZIDE; 4 METHOXYBENZOHYDRAZIDE; CATHEPSIN B; CATHEPSIN H; CELL PROTEIN; CYSTEINE PROTEINASE; HYDRAZIDE DERIVATIVE; PHENYLACETYL HYDRAZINE; PROTEINASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; HYDRAZINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; INFRARED SPECTROMETRY; LIVER HOMOGENATE; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR WEIGHT; PH; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; GOAT; LIVER; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CATHEPSIN B; CATHEPSIN H; DOSE-RESPONSE RELATIONSHIP, DRUG; GOATS; HYDRAZINES; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84896507475     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.007     Document Type: Article

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