Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Schlichter, Lyanne C ^a,b   Jiang, Jiahua ^a   Wang, John ^a,b   Newell, Evan W ^a,b,d   Tsui, Florence W L ^a,c   Lam, Doris ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c AMGEN INC   (United States)

^d AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC NUCLEOTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL HEAG; POTASSIUM CHANNEL HERG; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNORECEPTOR TYROSINE BASED INHIBITION MOTIF; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; CYCLIC AMP; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PYRAZOLES; PYRIMIDINES; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84896502350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090024     Document Type: Article

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