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Volumn 114, Issue 4, 2014, Pages 735-742

Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle

Author keywords

Concentric contraction; Mammalian target of rapamycin; Muscle protein synthesis; Whey hydrolysate

Indexed keywords

EIF4EBP1 PROTEIN, HUMAN; ESSENTIAL AMINO ACID; MILK PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE B; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; WHEY PROTEIN;

EID: 84896491100     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-013-2812-7     Document Type: Article
Times cited : (28)

References (45)
  • 1
    • 78149304854 scopus 로고    scopus 로고
    • Muscle full effect after oral protein: Time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling
    • 10.3945/ajcn.2010.29819 1:CAS:528:DC%2BC3cXhsVWgt7bO 20844073 10.3945/ajcn.2010.29819
    • Atherton PJ, Etheridge T, Watt PW, Wilkinson D, Selby A, Rankin D, Smith K, Rennie MJ (2010) Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr 92(5):1080-1088. doi: 10.3945/ajcn.2010.29819
    • (2010) Am J Clin Nutr , vol.92 , Issue.5 , pp. 1080-1088
    • Atherton, P.J.1    Etheridge, T.2    Watt, P.W.3    Wilkinson, D.4    Selby, A.5    Rankin, D.6    Smith, K.7    Rennie, M.J.8
  • 2
    • 0028914883 scopus 로고
    • Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans
    • 1:CAS:528:DyaK2MXkslKiu7g%3D 7900797
    • Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR (1995) Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol 268(3 Pt 1):E514-E520
    • (1995) Am J Physiol , vol.268 , Issue.3 PART 1
    • Biolo, G.1    Maggi, S.P.2    Williams, B.D.3    Tipton, K.D.4    Wolfe, R.R.5
  • 3
    • 0030859081 scopus 로고    scopus 로고
    • An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
    • 1:CAS:528:DyaK2sXlt1Srsb4%3D 9252488
    • Biolo G, Tipton KD, Klein S, Wolfe RR (1997) An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol 273(1 Pt 1):E122-E129
    • (1997) Am J Physiol , vol.273 , Issue.1 PART 1
    • Biolo, G.1    Tipton, K.D.2    Klein, S.3    Wolfe, R.R.4
  • 4
    • 0031435501 scopus 로고    scopus 로고
    • Slow and fast dietary proteins differently modulate postprandial protein accretion
    • 1:CAS:528:DyaK1cXis1yrtQ%3D%3D 25140 9405716 10.1073/pnas.94.26.14930
    • Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL, Beaufrere B (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 94(26):14930-14935
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.26 , pp. 14930-14935
    • Boirie, Y.1    Dangin, M.2    Gachon, P.3    Vasson, M.P.4    Maubois, J.L.5    Beaufrere, B.6
  • 5
    • 2942733632 scopus 로고    scopus 로고
    • Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling
    • 10.1079/PNS2004355 1:CAS:528:DC%2BD2cXms12msbY%3D 15294054 10.1079/PNS2004355
    • Bolster DR, Jefferson LS, Kimball SR (2004) Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proc Nutr Soc 63(2):351-356. doi: 10.1079/PNS2004355
    • (2004) Proc Nutr Soc , vol.63 , Issue.2 , pp. 351-356
    • Bolster, D.R.1    Jefferson, L.S.2    Kimball, S.R.3
  • 6
    • 0036785628 scopus 로고    scopus 로고
    • Essential amino acids and muscle protein recovery from resistance exercise
    • 10.1152/ajpendo.00466.2001 1:CAS:528:DC%2BD38XotV2rurg%3D 12217881
    • Borsheim E, Tipton KD, Wolf SE, Wolfe RR (2002) Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 283(4):E648-E657. doi: 10.1152/ajpendo.00466.2001
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , Issue.4
    • Borsheim, E.1    Tipton, K.D.2    Wolf, S.E.3    Wolfe, R.R.4
  • 7
    • 77955761684 scopus 로고    scopus 로고
    • Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men
    • 10.1113/jphysiol.2010.192856 1:CAS:528:DC%2BC3cXhtFWmsrjJ 2956949 20581041 10.1113/jphysiol.2010.192856
    • Burd NA, Holwerda AM, Selby KC, West DW, Staples AW, Cain NE, Cashaback JG, Potvin JR, Baker SK, Phillips SM (2010a) Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J Physiol 588(Pt 16):3119-3130. doi: 10.1113/jphysiol.2010.192856
    • (2010) J Physiol , vol.588 , Issue.PART 16 , pp. 3119-3130
    • Burd, N.A.1    Holwerda, A.M.2    Selby, K.C.3    West, D.W.4    Staples, A.W.5    Cain, N.E.6    Cashaback, J.G.7    Potvin, J.R.8    Baker, S.K.9    Phillips, S.M.10
  • 8
    • 77957805350 scopus 로고    scopus 로고
    • Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men
    • 10.1371/journal.pone.0012033 2918506 20711498 10.1371/journal.pone. 0012033
    • Burd NA, West DW, Staples AW, Atherton PJ, Baker JM, Moore DR, Holwerda AM, Parise G, Rennie MJ, Baker SK, Phillips SM (2010b) Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One 5(8):e12033. doi: 10.1371/journal.pone.0012033
    • (2010) PLoS One , vol.5 , Issue.8 , pp. 12033
    • Burd, N.A.1    West, D.W.2    Staples, A.W.3    Atherton, P.J.4    Baker, J.M.5    Moore, D.R.6    Holwerda, A.M.7    Parise, G.8    Rennie, M.J.9    Baker, S.K.10    Phillips, S.M.11
  • 9
    • 30744439347 scopus 로고    scopus 로고
    • Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans
    • 10.1096/fj.05-4809fje 1:CAS:528:DC%2BD28XjsFarsg%3D%3D 16267123
    • Coffey VG, Zhong Z, Shield A, Canny BJ, Chibalin AV, Zierath JR, Hawley JA (2006) Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. Faseb J 20(1):190-192. doi: 10.1096/fj.05-4809fje
    • (2006) Faseb J , vol.20 , Issue.1 , pp. 190-192
    • Coffey, V.G.1    Zhong, Z.2    Shield, A.3    Canny, B.J.4    Chibalin, A.V.5    Zierath, J.R.6    Hawley, J.A.7
  • 11
    • 79955486262 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
    • 10.3945/jn.111.139485 1:CAS:528:DC%2BC3MXltlCqtbs%3D 3077888 21430254 10.3945/jn.111.139485
    • Dickinson JM, Fry CS, Drummond MJ, Gundermann DM, Walker DK, Glynn EL, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB (2011) Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. J Nutr 141(5):856-862. doi: 10.3945/jn.111.139485
    • (2011) J Nutr , vol.141 , Issue.5 , pp. 856-862
    • Dickinson, J.M.1    Fry, C.S.2    Drummond, M.J.3    Gundermann, D.M.4    Walker, D.K.5    Glynn, E.L.6    Timmerman, K.L.7    Dhanani, S.8    Volpi, E.9    Rasmussen, B.B.10
  • 12
    • 84861840965 scopus 로고    scopus 로고
    • Leucine and mTORC1: A complex relationship
    • 10.1152/ajpendo.00525.2011 1:CAS:528:DC%2BC38XhtVGlsr7L 22354780 10.1152/ajpendo.00525.2011
    • Dodd KM, Tee AR (2012) Leucine and mTORC1: a complex relationship. Am J Physiol Endocrinol Metab 302(11):E1329-E1342. doi: 10.1152/ajpendo.00525.2011
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , Issue.11
    • Dodd, K.M.1    Tee, A.R.2
  • 13
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • 10.1113/jphysiol.2006.113175 1:CAS:528:DC%2BD28XhtFGqt7rK 1890364 16873412 10.1113/jphysiol.2006.113175
    • Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB (2006) Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576(Pt 2):613-624. doi: 10.1113/jphysiol.2006.113175
    • (2006) J Physiol , vol.576 , Issue.PART 2 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 14
    • 38949126221 scopus 로고    scopus 로고
    • Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    • 10.1152/ajpendo.00582.2007 1:CAS:528:DC%2BD1cXit1yktbc%3D 2706121 18056791 10.1152/ajpendo.00582.2007
    • Dreyer HC, Drummond MJ, Pennings B, Fujita S, Glynn EL, Chinkes DL, Dhanani S, Volpi E, Rasmussen BB (2008) Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab 294(2):E392-E400. doi: 10.1152/ajpendo.00582.2007
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , Issue.2
    • Dreyer, H.C.1    Drummond, M.J.2    Pennings, B.3    Fujita, S.4    Glynn, E.L.5    Chinkes, D.L.6    Dhanani, S.7    Volpi, E.8    Rasmussen, B.B.9
  • 15
    • 66149097065 scopus 로고    scopus 로고
    • Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
    • 10.1152/japplphysiol.91397.2008 1:CAS:528:DC%2BD1MXltVyhtLw%3D 2698645 19150856 10.1152/japplphysiol.91397.2008
    • Drummond MJ, Dreyer HC, Fry CS, Glynn EL, Rasmussen BB (2009a) Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol 106(4):1374-1384. doi: 10.1152/japplphysiol.91397.2008
    • (2009) J Appl Physiol , vol.106 , Issue.4 , pp. 1374-1384
    • Drummond, M.J.1    Dreyer, H.C.2    Fry, C.S.3    Glynn, E.L.4    Rasmussen, B.B.5
  • 16
    • 63849130621 scopus 로고    scopus 로고
    • Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
    • 10.1113/jphysiol.2008.163816 1:CAS:528:DC%2BD1MXos1GjtLw%3D 2678224 19188252 10.1113/jphysiol.2008.163816
    • Drummond MJ, Fry CS, Glynn EL, Dreyer HC, Dhanani S, Timmerman KL, Volpi E, Rasmussen BB (2009b) Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol 587(Pt 7):1535-1546. doi: 10.1113/jphysiol.2008.163816
    • (2009) J Physiol , vol.587 , Issue.PART 7 , pp. 1535-1546
    • Drummond, M.J.1    Fry, C.S.2    Glynn, E.L.3    Dreyer, H.C.4    Dhanani, S.5    Timmerman, K.L.6    Volpi, E.7    Rasmussen, B.B.8
  • 17
    • 77950839133 scopus 로고    scopus 로고
    • An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    • 10.1152/ajpendo.00690.2009 1:CAS:528:DC%2BC3cXmtlWjtrc%3D 2867366 20304764 10.1152/ajpendo.00690.2009
    • Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, Rasmussen BB (2010) An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab 298(5):E1011-E1018. doi: 10.1152/ajpendo.00690.2009
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.5
    • Drummond, M.J.1    Glynn, E.L.2    Fry, C.S.3    Timmerman, K.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 18
    • 33750371417 scopus 로고    scopus 로고
    • Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply
    • 10.1152/ajpendo.00141.2006 1:CAS:528:DC%2BD2sXjvV2q 16835402 10.1152/ajpendo.00141.2006
    • Eliasson J, Elfegoun T, Nilsson J, Kohnke R, Ekblom B, Blomstrand E (2006) Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply. Am J Physiol Endocrinol Metab 291(6):E1197-E1205. doi: 10.1152/ajpendo.00141.2006
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , Issue.6
    • Eliasson, J.1    Elfegoun, T.2    Nilsson, J.3    Kohnke, R.4    Ekblom, B.5    Blomstrand, E.6
  • 19
    • 34147141941 scopus 로고    scopus 로고
    • A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
    • 10.1042/BJ20061881 1:CAS:528:DC%2BD2sXksFOks7g%3D 1828895 17253963 10.1042/BJ20061881
    • Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF (2007) A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 403(1):13-20. doi: 10.1042/BJ20061881
    • (2007) Biochem J , vol.403 , Issue.1 , pp. 13-20
    • Findlay, G.M.1    Yan, L.2    Procter, J.3    Mieulet, V.4    Lamb, R.F.5
  • 20
    • 34447290867 scopus 로고    scopus 로고
    • Nutrient signalling in the regulation of human muscle protein synthesis
    • 10.1113/jphysiol.2007.134593 1:CAS:528:DC%2BD2sXosFCisbs%3D 2075348 17478528 10.1113/jphysiol.2007.134593
    • Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E, Rasmussen BB (2007) Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol 582(Pt 2):813-823. doi: 10.1113/jphysiol. 2007.134593
    • (2007) J Physiol , vol.582 , Issue.PART 2 , pp. 813-823
    • Fujita, S.1    Dreyer, H.C.2    Drummond, M.J.3    Glynn, E.L.4    Cadenas, J.G.5    Yoshizawa, F.6    Volpi, E.7    Rasmussen, B.B.8
  • 21
    • 77955491433 scopus 로고    scopus 로고
    • Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise
    • 10.1152/ajpregu.00077.2010 1:CAS:528:DC%2BC3cXhtVOhu7fN 2928613 20519362 10.1152/ajpregu.00077.2010
    • Glynn EL, Fry CS, Drummond MJ, Dreyer HC, Dhanani S, Volpi E, Rasmussen BB (2010a) Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol 299(2):R533-R540. doi: 10.1152/ajpregu.00077.2010
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , Issue.2
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3    Dreyer, H.C.4    Dhanani, S.5    Volpi, E.6    Rasmussen, B.B.7
  • 22
    • 78149245600 scopus 로고    scopus 로고
    • Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
    • 10.3945/jn.110.127647 1:CAS:528:DC%2BC3cXhtl2nur%2FE 2955876 20844186 10.3945/jn.110.127647
    • Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB (2010b) Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140(11):1970-1976. doi: 10.3945/jn.110.127647
    • (2010) J Nutr , vol.140 , Issue.11 , pp. 1970-1976
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3    Timmerman, K.L.4    Dhanani, S.5    Volpi, E.6    Rasmussen, B.B.7
  • 24
    • 0038045562 scopus 로고    scopus 로고
    • Functional properties of whey, whey components, and essential amino acids: Mechanisms underlying health benefits for active people (review)
    • 1:CAS:528:DC%2BD3sXkvVKisrs%3D 12832028 10.1016/S0955-2863(03)00030-5
    • Ha E, Zemel MB (2003) Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). J Nutr Biochem 14(5):251-258
    • (2003) J Nutr Biochem , vol.14 , Issue.5 , pp. 251-258
    • Ha, E.1    Zemel, M.B.2
  • 25
    • 79960353171 scopus 로고    scopus 로고
    • Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism
    • 10.1113/jphysiol.2011.207175 1:CAS:528:DC%2BC3MXpsl2qurY%3D 3167122 21606113 10.1113/jphysiol.2011.207175
    • Hamdi MM, Mutungi G (2011) Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism. J Physiol 589(Pt 14):3623-3640. doi: 10.1113/jphysiol.2011.207175
    • (2011) J Physiol , vol.589 , Issue.PART 14 , pp. 3623-3640
    • Hamdi, M.M.1    Mutungi, G.2
  • 26
    • 67650733280 scopus 로고    scopus 로고
    • Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression
    • 10.1007/s00726-008-0150-6 1:CAS:528:DC%2BD1MXotVKisr8%3D 18661258 10.1007/s00726-008-0150-6
    • Hulmi JJ, Kovanen V, Selanne H, Kraemer WJ, Hakkinen K, Mero AA (2009) Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids 37(2):297-308. doi: 10.1007/s00726-008-0150-6
    • (2009) Amino Acids , vol.37 , Issue.2 , pp. 297-308
    • Hulmi, J.J.1    Kovanen, V.2    Selanne, H.3    Kraemer, W.J.4    Hakkinen, K.5    Mero, A.A.6
  • 27
    • 79956137343 scopus 로고    scopus 로고
    • Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle
    • 10.1007/s12576-010-0130-y 1:CAS:528:DC%2BC3MXktFajsrg%3D 21222186 10.1007/s12576-010-0130-y
    • Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T, Katamoto S (2011) Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. J Physiol Sci 61(2):131-140. doi: 10.1007/s12576-010-0130-y
    • (2011) J Physiol Sci , vol.61 , Issue.2 , pp. 131-140
    • Kakigi, R.1    Naito, H.2    Ogura, Y.3    Kobayashi, H.4    Saga, N.5    Ichinoseki-Sekine, N.6    Yoshihara, T.7    Katamoto, S.8
  • 28
    • 0036720367 scopus 로고    scopus 로고
    • Invited review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
    • 10.1152/japplphysiol.00221.2002 1:CAS:528:DC%2BD38Xnt1art7k%3D 12183515
    • Kimball SR, Farrell PA, Jefferson LS (2002) Invited review: role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol 93(3):1168-1180. doi: 10.1152/japplphysiol.00221.2002
    • (2002) J Appl Physiol , vol.93 , Issue.3 , pp. 1168-1180
    • Kimball, S.R.1    Farrell, P.A.2    Jefferson, L.S.3
  • 29
    • 33744939435 scopus 로고    scopus 로고
    • Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers
    • 10.1152/ajpendo.00530.2005 1:CAS:528:DC%2BD28XlvVeju7c%3D 16434552 10.1152/ajpendo.00530.2005
    • Koopman R, Zorenc AH, Gransier RJ, Cameron-Smith D, van Loon LJ (2006) Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers. Am J Physiol Endocrinol Metab 290(6):E1245-E1252. doi: 10.1152/ajpendo.00530.2005
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.6
    • Koopman, R.1    Zorenc, A.H.2    Gransier, R.J.3    Cameron-Smith, D.4    Van Loon, L.J.5
  • 30
    • 58149307453 scopus 로고    scopus 로고
    • Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men
    • 10.1113/jphysiol.2008.164483 1:CAS:528:DC%2BD1MXhtVKlsLs%3D 2670034 19001042 10.1113/jphysiol.2008.164483
    • Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, Williams J, Smith K, Seynnes O, Hiscock N, Rennie MJ (2009) Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 587(Pt 1):211-217. doi: 10.1113/jphysiol.2008.164483
    • (2009) J Physiol , vol.587 , Issue.PART 1 , pp. 211-217
    • Kumar, V.1    Selby, A.2    Rankin, D.3    Patel, R.4    Atherton, P.5    Hildebrandt, W.6    Williams, J.7    Smith, K.8    Seynnes, O.9    Hiscock, N.10    Rennie, M.J.11
  • 31
    • 39149112227 scopus 로고    scopus 로고
    • Changes in markers of muscle damage of middle-aged and young men following eccentric exercise of the elbow flexors
    • 10.1016/j.jsams.2006.11.004 17350334 10.1016/j.jsams.2006.11.004
    • Lavender AP, Nosaka K (2008) Changes in markers of muscle damage of middle-aged and young men following eccentric exercise of the elbow flexors. J Sci Med Sport 11(2):124-131. doi: 10.1016/j.jsams.2006.11.004
    • (2008) J Sci Med Sport , vol.11 , Issue.2 , pp. 124-131
    • Lavender, A.P.1    Nosaka, K.2
  • 32
    • 38349043742 scopus 로고    scopus 로고
    • Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle
    • 10.1152/ajpendo.00504.2007 1:CAS:528:DC%2BD1cXhtVWrsrY%3D 17971512 10.1152/ajpendo.00504.2007
    • Mascher H, Tannerstedt J, Brink-Elfegoun T, Ekblom B, Gustafsson T, Blomstrand E (2008) Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle. Am J Physiol Endocrinol Metab 294(1):E43-E51. doi: 10.1152/ajpendo.00504.2007
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , Issue.1
    • Mascher, H.1    Tannerstedt, J.2    Brink-Elfegoun, T.3    Ekblom, B.4    Gustafsson, T.5    Blomstrand, E.6
  • 33
    • 0037372193 scopus 로고    scopus 로고
    • Independent and combined effects of amino acids and glucose after resistance exercise
    • 10.1249/01.MSS.0000053910.63105.45 1:CAS:528:DC%2BD3sXislaqu74%3D 12618575 10.1249/01.MSS.0000053910.63105.45
    • Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR (2003) Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci Sports Exerc 35(3):449-455. doi: 10.1249/01.MSS.0000053910.63105.45
    • (2003) Med Sci Sports Exerc , vol.35 , Issue.3 , pp. 449-455
    • Miller, S.L.1    Tipton, K.D.2    Chinkes, D.L.3    Wolf, S.E.4    Wolfe, R.R.5
  • 34
    • 58149389265 scopus 로고    scopus 로고
    • Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men
    • 10.3945/ajcn.2008.26401 1:CAS:528:DC%2BD1MXnsFKnsA%3D%3D 19056590 10.3945/ajcn.2008.26401
    • Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM (2009) Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 89(1):161-168. doi: 10.3945/ajcn.2008.26401
    • (2009) Am J Clin Nutr , vol.89 , Issue.1 , pp. 161-168
    • Moore, D.R.1    Robinson, M.J.2    Fry, J.L.3    Tang, J.E.4    Glover, E.I.5    Wilkinson, S.B.6    Prior, T.7    Tarnopolsky, M.A.8    Phillips, S.M.9
  • 35
    • 0035055777 scopus 로고    scopus 로고
    • Intracellular signaling specificity in skeletal muscle in response to different modes of exercise
    • 1:CAS:528:DC%2BD3MXjsFert7c%3D 11299288
    • Nader GA, Esser KA (2001) Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. J Appl Physiol 90(5):1936-1942
    • (2001) J Appl Physiol , vol.90 , Issue.5 , pp. 1936-1942
    • Nader, G.A.1    Esser, K.A.2
  • 36
    • 0026476465 scopus 로고
    • Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans
    • 1:CAS:528:DyaK3sXjs1Cksw%3D%3D 1443126
    • Nair KS, Schwartz RG, Welle S (1992) Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans. Am J Physiol 263(5 Pt 1):E928-E934
    • (1992) Am J Physiol , vol.263 , Issue.5 PART 1
    • Nair, K.S.1    Schwartz, R.G.2    Welle, S.3
  • 37
    • 79955412532 scopus 로고    scopus 로고
    • Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men
    • 10.3945/ajcn.110.008102 1:CAS:528:DC%2BC3MXltlCqsb8%3D 21367943 10.3945/ajcn.110.008102
    • Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ (2011) Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 93(5):997-1005. doi: 10.3945/ajcn.110.008102
    • (2011) Am J Clin Nutr , vol.93 , Issue.5 , pp. 997-1005
    • Pennings, B.1    Boirie, Y.2    Senden, J.M.3    Gijsen, A.P.4    Kuipers, H.5    Van Loon, L.J.6
  • 38
    • 0030822785 scopus 로고    scopus 로고
    • Mixed muscle protein synthesis and breakdown after resistance exercise in humans
    • 1:CAS:528:DyaK2sXlt1SrsLk%3D 9252485
    • Phillips SM, Tipton KD, Aarsland A, Wolf SE, Wolfe RR (1997) Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol 273(1 Pt 1):E99-E107
    • (1997) Am J Physiol , vol.273 , Issue.1 PART 1
    • Phillips, S.M.1    Tipton, K.D.2    Aarsland, A.3    Wolf, S.E.4    Wolfe, R.R.5
  • 40
    • 45849105156 scopus 로고    scopus 로고
    • The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • 10.1126/science.1157535 1:CAS:528:DC%2BD1cXntVWqsr4%3D 2475333 18497260 10.1126/science.1157535
    • Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM (2008) The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320(5882):1496-1501. doi: 10.1126/science.1157535
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 41
    • 69749123362 scopus 로고    scopus 로고
    • Ingestion of whey hydrolysate, casein, or soy protein isolate: Effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
    • 10.1152/japplphysiol.00076.2009 1:CAS:528:DC%2BD1MXhtFKnurvN 19589961 10.1152/japplphysiol.00076.2009
    • Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM (2009) Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol 107(3):987-992. doi: 10.1152/japplphysiol.00076.2009
    • (2009) J Appl Physiol , vol.107 , Issue.3 , pp. 987-992
    • Tang, J.E.1    Moore, D.R.2    Kujbida, G.W.3    Tarnopolsky, M.A.4    Phillips, S.M.5
  • 42
    • 66149154339 scopus 로고    scopus 로고
    • Maximal lengthening contractions induce different signaling responses in the type i and type II fibers of human skeletal muscle
    • 10.1152/japplphysiol.91243.2008 1:CAS:528:DC%2BD1MXltVyhtLg%3D 19112158 10.1152/japplphysiol.91243.2008
    • Tannerstedt J, Apro W, Blomstrand E (2009) Maximal lengthening contractions induce different signaling responses in the type I and type II fibers of human skeletal muscle. J Appl Physiol 106(4):1412-1418. doi: 10.1152/japplphysiol.91243.2008
    • (2009) J Appl Physiol , vol.106 , Issue.4 , pp. 1412-1418
    • Tannerstedt, J.1    Apro, W.2    Blomstrand, E.3
  • 43
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • 10.1152/physiol.00024.2006 1:CAS:528:DC%2BD28XhtFKqu7jM 10.1152/physiol.00024.2006
    • Wang X, Proud CG (2006) The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21:362-369. doi: 10.1152/physiol.00024.2006
    • (2006) Physiology (Bethesda) , vol.21 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 44
    • 48549107440 scopus 로고    scopus 로고
    • Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle
    • 10.1113/jphysiol.2008.153916 1:CAS:528:DC%2BD1cXhtVCltLfL 2538832 18556367 10.1113/jphysiol.2008.153916
    • Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA, Rennie MJ (2008) Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586(Pt 15):3701-3717. doi: 10.1113/jphysiol.2008.153916
    • (2008) J Physiol , vol.586 , Issue.PART 15 , pp. 3701-3717
    • Wilkinson, S.B.1    Phillips, S.M.2    Atherton, P.J.3    Patel, R.4    Yarasheski, K.E.5    Tarnopolsky, M.A.6    Rennie, M.J.7
  • 45
    • 84870043638 scopus 로고    scopus 로고
    • Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men
    • 10.1017/S0007114511007422 1:CAS:528:DC%2BC38Xhslaiu77F 22313809 10.1017/S0007114511007422
    • Yang Y, Breen L, Burd NA, Hector AJ, Churchward-Venne TA, Josse AR, Tarnopolsky MA, Phillips SM (2012) Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr 108(10):1780-1788. doi: 10.1017/S0007114511007422
    • (2012) Br J Nutr , vol.108 , Issue.10 , pp. 1780-1788
    • Yang, Y.1    Breen, L.2    Burd, N.A.3    Hector, A.J.4    Churchward-Venne, T.A.5    Josse, A.R.6    Tarnopolsky, M.A.7    Phillips, S.M.8


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