Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages

Toxicological Sciences

Volumn 138, Issue 2, 2014, Pages 412-424

  Schroeter, Jeffry D ^a   Campbell, Jerry ^b   Kimbell, Julia S ^c   Conolly, Rory B ^d   Clewell, Harvey J ^b   Andersen, Melvin E ^b  

^a APPLIED RESEARCH ASSOCIATES   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Computational fluid dynamics; Endogenous; Formaldehyde; Nasal; Pharmacokinetics

Indexed keywords

FORMALDEHYDE;

ABSORPTION; ARTICLE; CANCER RISK; CARCINOGEN DNA INTERACTION; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; COMPUTATIONAL FLUID DYNAMICS; DESORPTION; DOSIMETRY; EXPERIMENTAL MODEL; EXPOSURE; HUMAN; INHALATION; MEASUREMENT ACCURACY; NONHUMAN; NOSE; NOSE AIRFLOW; NOSE MUCOSA; PARTICLE SIZE; PREDICTION; PROTEIN CROSS LINKING; PROTEIN DNA BINDING; RAT; RESPIRATORY TRACT MUCOSA; RHESUS MONKEY; RISK ASSESSMENT; SIMULATION; SPECIES DIFFERENCE; SURFACE PROPERTY; TOXICOKINETICS;

COMPUTATIONAL FLUID DYNAMICS; ENDOGENOUS; FORMALDEHYDE; NASAL; PHARMACOKINETICS;

ANIMALS; CARCINOGENS; COMPUTATIONAL BIOLOGY; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; HUMANS; INHALATION EXPOSURE; MACACA MULATTA; MODELS, ANATOMIC; MODELS, BIOLOGICAL; NASAL CAVITY; NASAL MUCOSA; PREDICTIVE VALUE OF TESTS; RATS; RATS, INBRED F344; SPECIES SPECIFICITY;

EID: 84896470730     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft333     Document Type: Article

References (44)

1. Agency for Toxic Substances and Disease Registry (ATSDR). (1999). Toxicological Profile for Formaldehyde. U.S. Department of Health and Human Services, Atlanta, GA.
2. Andersen, M. E., Clewell, H. J., Bermudez, E., Dodd, D. E., Willson, G. A., Campbell, J. L., and Thomas, R. S. (2010). Formaldehyde: Integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. Toxicol. Sci. 118, 716-731.
3. Asgharian, B., Price, O. T., Schroeter, J. D., Kimbell, J. S., and Singal, M. (2012). A lung dosimetrymodel of vapor uptake and tissue disposition. Inhal. Toxicol. 24, 182-193.
4. Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P. (1997). Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13, 407-484.
5. Casanova, M., Deyo, D. F., and Heck, H. D. (1989). Covalent binding of inhaled formaldehyde to DNA in the nasal mucosa of Fischer 344 rats: Analysis of formaldehyde and DNA by high-performance liquid chromatography and provisional pharmacokinetic interpretation. Fundam. Appl. Toxicol. 12, 397-417.
6. Casanova, M., Heck, H. D., Everitt, J. I., Harrington, W. W., and Popp, J. A. (1988). Formaldehyde concentrations in the blood of rhesus monkeys after inhalation exposure. Food Chem. Toxicol. 26, 715-716.
7. Casanova, M., Morgan, K. T., Gross, E. A., Moss, O. R., and Heck, H. d'A. (1994). DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam. Appl. Toxicol. 23, 525-536.
8. Casanova, M., Morgan, K. T., Steinhagen, W. H., Everitt, J. I., Popp, J. A., and Heck, H. d'A. (1991). Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam. Appl. Toxicol. 17, 409-428.
9. Conolly, R. B., Kimbell, J. S., Janszen, D., Schlosser, P. M., Kalisak, D., Preston, J., and Miller, F. J. (2003). Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol. Sci. 75, 432-447.
10. Conolly, R. B., Kimbell, J. S., Janszen, D., Schlosser, P. M., Kalisak, D., Preston, J., and Miller, F. J. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologicallymotivated computational modeling of a combined rodent and human dataset. Toxicol. Sci. 82, 279-296.
11. Conolly, R. B., Lilly, P. D., and Kimbell, J. S. (2000). Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein crosslinks in Fischer 344 rats, rhesus monkeys, and humans. Environ. Health Perspect. 108(Suppl. 5), 919-924.
12. Corley, R. A., Kabilan, S., Kuprat, A. P., Carson, J. P., Minard, K. R., Jacob, R. E., Timchalk, C., Glenny, R., Pipavath, S., and Cox, T. et al. (2012). Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol. Sci. 128, 500-516.
13. 2]-formaldehyde exposures in rats. Chem. Res. Toxicol. 26, 1421-1423.
14. Franks, S. J. (2005).Amathematical model for the absorption and metabolism of formaldehyde vapour by humans. Toxicol. Appl. Pharmacol. 206, 309-320.
15. Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. (1998). Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152, 211-231.
16. Garcia, G. J. M., Schroeter, J. D., Segal, R. A., Stanek, J., Foureman, G. L., and Kimbell, J. S. (2009).Dosimetry of nasal uptake ofwater-soluble and reactive gases: A first study of interhuman variability. Inhal. Toxicol. 21, 607-618.
17. Heck, H. D., Casanova-Schmitz, M., Dodd, P. B., Schachter, E. N., Witek, T. J., and Tosun, T. (1985). Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. Am. Ind. Hyg. Assoc. J. 46, 1-3.
18. Heck, H. d'A., White, E. L., and Casanova-Schmitz, M. (1982). Determination of formaldehyde in biological tissues by gas chromatography/mass spectrometry. Biomed. Mass Spectrom. 9, 347-353.
19. Hernandez, O., Rhomberg, L., Hogan, K., Siegel-Scott, C., Lai, D., Grindstaff, G., Henry, M., and Cotruvo, J. A. (1994). Risk assessment of formaldehyde. J. Hazard. Mater. 39, 161-172.
20. Keller, D. A., Heck, H. d'A., Randall, H. W., and Morgan, K. T. (1990). Histochemical localization of formaldehyde dehydrogenase in the rat. Toxicol. Appl. Pharmacol. 106, 311-326.
21. Kepler, G. M., Richardson, R. B., Morgan, K. T., and Kimbell, J. S. (1998). Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey. Toxicol. Appl. Pharmacol. 150, 1-11.
22. Kerns, W. D., Pavkov, K. L., Donofrio, D. J., Gralla, E. J., and Swenberg, J. A. (1983). Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 43, 4382-4392.
23. Kimbell, J. S., Asgharian, B., and Schroeter, J. D. (2010). An updated, threedimensional dosimetry model for uptake of inhaled soluble vapors in the human respiratory tract. Abstract 868. Toxicologist CD-Offic. J. Soc. Toxicol., 114.
24. Kimbell, J. S., Godo, M. N., Gross, E. A., Joyner, D. R., Richardson, R. B., and Morgan, K. T. (1997). Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol. Appl. Pharmacol. 145, 388-398.
25. Kimbell, J. S., Overton, J. H., Subramaniam, R. P., Schlosser, P. M., Morgan, K. T., Conolly, R. B., and Miller, F. J. (2001a). Dosimetry modeling of inhaled formaldehyde: Binning nasal flux predictions for quantitative risk assessment. Toxicol. Sci. 64, 111-121.
26. Kimbell, J. S., Subramaniam, R. P., Gross, E. A., Schlosser, P. M., and Morgan, K. T. (2001b).Dosimetrymodeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol. Sci. 64, 100-110.
27. Lang, J. (1989). Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses. Thieme Medical, New York, NY.
28. 2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem. Res. Toxicol. 24, 159-161.
29. 2-formaldehyde inhalation exposure. Chem. Res. Toxicol. 24, 162-164.
30. Monticello, T.M., Miller, F. J., andMorgan, K. T. (1991). Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde. Toxicol. Appl. Pharmacol. 111, 409-421.
31. Monticello, T. M., Morgan, K. T., Everitt, J. I., and Popp, J. A. (1989). Effects of formaldehyde gas on the respiratory tract of rhesus monkeys: Pathology and cell proliferation. Am. J. Pathol. 134, 515-527.
32. Monticello, T. M., Swenberg, J. A., Gross, E. A., Leininger, J. R., Kimbell, J. S., Seilkop, S., Starr, T. B., Gibson, J. E., and Morgan, K. T. (1996). Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells. Cancer Res. 56, 1012-1022.
33. Morgan, K. T., Kimbell, J. S., Monticello, T. M., Patra, A. L., and Fleishman, A. (1991). Studies of inspiratory airflow patterns in the nasal passages of the F-344 rat and rhesus monkey using nasal molds: Relevance to formaldehyde toxicity. Toxicol. Appl. Pharmacol. 110, 223-240.
34. Morris, J. B., Hassett, D. N., and Blanchard, K. T. (1993). A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors. Toxicol. Appl. Pharmacol. 123, 120-129.
35. Moser, B., Bodrogi, F., Eibl, G., Lechner, M., Rieder, J., and Lirk, P. (2005). Mass spectrometric profile of exhaled breath-field study by PRT-MS. Respir. Physiol. Neurobiol. 145, 295-300.
36. National Research Council (NRC). (2011). Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde. The National Academies Press, Washington, DC.
37. Patterson, D. L., Gross, E. A., Bogdanffy,M. S., andMorgan, K. T. (1986). Retention of formaldehyde gas by the nasal passages of F-344 rats. Toxicologist 6, 55.
38. Riess, U., Tegtbur, U., Fauck, C., Fuhrmann, F., Markewitz, D., and Salthammer, T. (2010). Experimental setup and analytical methods for the noninvasive determination of volatile organic compounds, formaldehyde and NOx in exhaled human breath. Anal. Chim. Acta 669, 53-62.
39. Salthammer, T., Mentese, S., and Marutzky, R. (2010). Formaldehyde in the indoor environment. Chem. Rev. 110, 2536-2572.
40. Schroeter, J. D., Kimbell, J. S., Andersen,M. E., and Dorman, D. C. (2006). Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol. Sci. 94, 359-367.
41. Schroeter, J. D., Kimbell, J. S., Gross, E. A., Willson, G. A., Dorman, D. C., Tan, Y. M., and Clewell, H. J., III (2008). Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein. Inhal. Toxicol. 20, 227-243.
42. Subramaniam, R. P., Richardson, R. B., Morgan, K. T., Guilmette, R. A., and Kimbell, J. S. (1998). Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol. 10, 91-120.
43. Teeguarden, J. G., Bogdanffy, M. S., Covington, T. R., Tan, C., and Jarabek, A. M. (2008). A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. Inhal. Toxicol. 20, 375-390.
44. Wang, T. S., Pysanenko, A., Dryahina, K., Spanel, P., and Smith, D. (2008). Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity. J. Breath Res. 2, 1-13.