In vitro metabolism of the alkaloid piplartine by rat liver microsomes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 95, Issue , 2014, Pages 113-120

  Marques, Lucas Maciel Mauriz ^a   da Silva Junior, Eduardo Afonso ^a   Gouvea, Dayana Rubio ^a   Vessecchi, Ricardo ^a   Pupo, MÔnica Tallarico ^a   Lopes, Norberto Peporine ^a   Kato, Massuo Jorge ^a   De Oliveira, Anderson Rodrigo Moraes ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Enzymatic kinetics; In vitro metabolism; Microsomes; Piplartine; Sigmoidal profile

Indexed keywords

5,6 DIHYDRO 1 [1 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 2 PROPENYL] 2(1H) PYRIDINONE; ACETONITRILE; ALKALOID; CYTOCHROME P450; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; PIPERIDONE DERIVATIVE; PIPLARTINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIMIT OF QUANTITATION; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION STUDY; ANIMAL; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; TANDEM MASS SPECTROMETRY; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; MALE; MICROSOMES, LIVER; PIPERIDONES; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84896463457     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.02.020     Document Type: Article

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