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Volumn 144, Issue 4, 2014, Pages 475-483

Bitter gourd inhibits the development of obesity-associated fatty liver in C57BL/6 mice fed a high-fat diet

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; DYNAMIN I; INTERLEUKIN 6; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; MOMORDICA CHARANTIA EXTRACT; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

EID: 84896458830     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.187450     Document Type: Article
Times cited : (45)

References (42)
  • 1
    • 56949097660 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease in China
    • Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol. 2009;50:204-10.
    • (2009) J Hepatol. , vol.50 , pp. 204-210
    • Fan, J.G.1    Farrell, G.C.2
  • 3
    • 0034253772 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with hyperlipidemia and obesity
    • Sharabi Y, Eldad A. Nonalcoholic fatty liver disease is associated with hyperlipidemia and obesity. Am J Med. 2000;109:171.
    • (2000) Am J Med. , vol.109 , pp. 171
    • Sharabi, Y.1    Eldad, A.2
  • 4
    • 84862209977 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in children now: lifestyle changes and pharmacologic treatments
    • Alisi A, Nobili V. Non-alcoholic fatty liver disease in children now: lifestyle changes and pharmacologic treatments. Nutrition. 2012;28: 722-6.
    • (2012) Nutrition. , vol.28 , pp. 722-726
    • Alisi, A.1    Nobili, V.2
  • 6
    • 84882265143 scopus 로고    scopus 로고
    • Obesity notches up fatty liver
    • Czech MP. Obesity notches up fatty liver. Nat Med. 2013;19:969-71.
    • (2013) Nat Med. , vol.19 , pp. 969-971
    • Czech, M.P.1
  • 7
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: master regulators of lipid homeostasis
    • Eberlé D, Hegarty B, Bossard P, Ferre P, Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie. 2004;86: 839-48.
    • (2004) Biochimie. , vol.86 , pp. 839-848
    • Eberlé, D.1    Hegarty, B.2    Bossard, P.3    Ferre, P.4    Foufelle, F.5
  • 10
    • 34249792393 scopus 로고    scopus 로고
    • Role of mitochondria in non-alcoholic fatty liver disease
    • Pessayre D. Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2007;22 Suppl 1:S20-7.
    • (2007) J Gastroenterol Hepatol. , vol.22 , Issue.SUPPL. 1
    • Pessayre, D.1
  • 13
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, Mikus CR, Laye MJ, Laughlin MH, Booth FW, et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010;52:727-36.
    • (2010) J Hepatol. , vol.52 , pp. 727-736
    • Rector, R.S.1    Thyfault, J.P.2    Uptergrove, G.M.3    Morris, E.M.4    Naples, S.P.5    Borengasser, S.J.6    Mikus, C.R.7    Laye, M.J.8    Laughlin, M.H.9    Booth, F.W.10
  • 14
    • 1542631889 scopus 로고    scopus 로고
    • Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents
    • Platel K, Srinivasan K. Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycaemic agents. Nahrung. 1997; 41:68-74.
    • (1997) Nahrung. , vol.41 , pp. 68-74
    • Platel, K.1    Srinivasan, K.2
  • 15
    • 33746386763 scopus 로고    scopus 로고
    • Bitter gourd (Momordica Charantia): a dietary approach to hyperglycemia
    • Krawinkel MB, Keding GB. Bitter gourd (Momordica Charantia): a dietary approach to hyperglycemia. Nutr Rev. 2006;64:331-7.
    • (2006) Nutr Rev. , vol.64 , pp. 331-337
    • Krawinkel, M.B.1    Keding, G.B.2
  • 16
    • 78650032735 scopus 로고    scopus 로고
    • Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice
    • Klomann SD, Mueller AS, Pallauf J, Krawinkel MB. Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice. Br J Nutr. 2010;104:1613-20.
    • (2010) Br J Nutr. , vol.104 , pp. 1613-1620
    • Klomann, S.D.1    Mueller, A.S.2    Pallauf, J.3    Krawinkel, M.B.4
  • 17
    • 20044383440 scopus 로고    scopus 로고
    • Antioxidant properties of Momordica Charantia (bitter gourd) seeds on streptozotocin induced diabetic rats
    • Sathishsekar D, Subramanian S. Antioxidant properties of Momordica Charantia (bitter gourd) seeds on streptozotocin induced diabetic rats. Asia Pac J Clin Nutr. 2005;14:153-8.
    • (2005) Asia Pac J Clin Nutr. , vol.14 , pp. 153-158
    • Sathishsekar, D.1    Subramanian, S.2
  • 18
    • 8144224399 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats
    • Babu PS, Stanely Mainzen Prince P. Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J Pharm Pharmacol. 2004;56: 1435-42.
    • (2004) J Pharm Pharmacol. , vol.56 , pp. 1435-1442
    • Babu, P.S.1    Stanely Mainzen Prince, P.2
  • 19
    • 79955464109 scopus 로고    scopus 로고
    • Wild bitter gourd extract up-regulates mRNA expression of PPARalpha, PPARgamma and their target genes in C57BL/6J mice
    • Chao CY, Yin MC, Huang CJ. Wild bitter gourd extract up-regulates mRNA expression of PPARalpha, PPARgamma and their target genes in C57BL/6J mice. J Ethnopharmacol. 2011;135:156-61.
    • (2011) J Ethnopharmacol. , vol.135 , pp. 156-161
    • Chao, C.Y.1    Yin, M.C.2    Huang, C.J.3
  • 20
    • 40449117390 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats
    • Sridhar MG, Vinayagamoorthi R, Arul Suyambunathan V, Bobby Z, Selvaraj N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr. 2008;99:806-12.
    • (2008) Br J Nutr. , vol.99 , pp. 806-812
    • Sridhar, M.G.1    Vinayagamoorthi, R.2    Arul Suyambunathan, V.3    Bobby, Z.4    Selvaraj, N.5
  • 21
    • 77449115593 scopus 로고    scopus 로고
    • Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients
    • Sun L, Shen W, Liu Z, Guan S, Liu J, Ding S. Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients. Life Sci. 2010;86:39-44.
    • (2010) Life Sci. , vol.86 , pp. 39-44
    • Sun, L.1    Shen, W.2    Liu, Z.3    Guan, S.4    Liu, J.5    Ding, S.6
  • 23
    • 33745132417 scopus 로고    scopus 로고
    • Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria
    • Sun L, Luo C, Long HA, Wei DZ, Liu HK. Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion. 2006;6:136-42.
    • (2006) Mitochondrion. , vol.6 , pp. 136-142
    • Sun, L.1    Luo, C.2    Long, H.A.3    Wei, D.Z.4    Liu, H.K.5
  • 25
    • 0000138314 scopus 로고    scopus 로고
    • Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)
    • Raman A, Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine. 1996;2: 349-62.
    • (1996) Phytomedicine. , vol.2 , pp. 349-362
    • Raman, A.1    Lau, C.2
  • 26
    • 2942538292 scopus 로고    scopus 로고
    • Pharmacological actions and potential uses of Momordica charantia: a review
    • Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol. 2004;93:123-32.
    • (2004) J Ethnopharmacol. , vol.93 , pp. 123-132
    • Grover, J.K.1    Yadav, S.P.2
  • 27
    • 0019842946 scopus 로고
    • Hypoglycemic activity of polypeptide-p from a plant source
    • Khanna P, Jain SC, Panagariya A, Dixit VP. Hypoglycemic activity of polypeptide-p from a plant source. J Nat Prod. 1981;44:648-55.
    • (1981) J Nat Prod. , vol.44 , pp. 648-655
    • Khanna, P.1    Jain, S.C.2    Panagariya, A.3    Dixit, V.P.4
  • 28
    • 74949111350 scopus 로고    scopus 로고
    • Antidiabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review
    • Leung L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson S. Antidiabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review. Br J Nutr. 2009;102:1703-8.
    • (2009) Br J Nutr. , vol.102 , pp. 1703-1708
    • Leung, L.1    Birtwhistle, R.2    Kotecha, J.3    Hannah, S.4    Cuthbertson, S.5
  • 29
    • 47849123027 scopus 로고    scopus 로고
    • Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet
    • Shih CC, Lin CH, Lin WL. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract. 2008;81:134-43.
    • (2008) Diabetes Res Clin Pract. , vol.81 , pp. 134-143
    • Shih, C.C.1    Lin, C.H.2    Lin, W.L.3
  • 30
    • 51749119492 scopus 로고    scopus 로고
    • Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions
    • Nerurkar PV, Lee YK, Motosue M, Adeli K, Nerurkar VR. Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions. Br J Nutr. 2008;100:751-9.
    • (2008) Br J Nutr. , vol.100 , pp. 751-759
    • Nerurkar, P.V.1    Lee, Y.K.2    Motosue, M.3    Adeli, K.4    Nerurkar, V.R.5
  • 31
    • 80053362207 scopus 로고    scopus 로고
    • Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice
    • Wang ZQ, Zhang XH, Yu Y, Poulev A, Ribnicky D, Floyd ZE, Cefalu WT. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem. 2011;22:1064-73.
    • (2011) J Nutr Biochem. , vol.22 , pp. 1064-1073
    • Wang, Z.Q.1    Zhang, X.H.2    Yu, Y.3    Poulev, A.4    Ribnicky, D.5    Floyd, Z.E.6    Cefalu, W.T.7
  • 32
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006; 444:860-7.
    • (2006) Nature. , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 33
    • 84884176199 scopus 로고    scopus 로고
    • Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
    • Asrih M, Jornayvaz FR. Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance. J Endocrinol. 2013;218:R25-36.
    • (2013) J Endocrinol. , vol.218
    • Asrih, M.1    Jornayvaz, F.R.2
  • 34
    • 0037205433 scopus 로고    scopus 로고
    • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
    • Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, et al. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem. 2002;277:19353-7.
    • (2002) J Biol Chem. , vol.277 , pp. 19353-19357
    • Yahagi, N.1    Shimano, H.2    Hasty, A.H.3    Matsuzaka, T.4    Ide, T.5    Yoshikawa, T.6    Amemiya-Kudo, M.7    Tomita, S.8    Okazaki, H.9    Tamura, Y.10
  • 35
    • 33749253713 scopus 로고    scopus 로고
    • Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    • Ji C, Chan C, Kaplowitz N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006;45:717-24.
    • (2006) J Hepatol. , vol.45 , pp. 717-724
    • Ji, C.1    Chan, C.2    Kaplowitz, N.3
  • 36
    • 0032570828 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase
    • Lawler JF Jr, Yin M, Diehl AM, Roberts E, Chatterjee S. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem. 1998;273:5053-9.
    • (1998) J Biol Chem. , vol.273 , pp. 5053-5059
    • Lawler, J.F.1    Yin, M.2    Diehl, A.M.3    Roberts, E.4    Chatterjee, S.5
  • 37
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol-and obesity-induced fatty liver diseases
    • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol-and obesity-induced fatty liver diseases. Free Radic Biol Med. 2008;44:1259-72.
    • (2008) Free Radic Biol Med. , vol.44 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4    Bailey, S.M.5
  • 38
    • 65249179642 scopus 로고    scopus 로고
    • Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats
    • Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009;13:701-11.
    • (2009) J Cell Mol Med. , vol.13 , pp. 701-711
    • Hao, J.1    Shen, W.2    Tian, C.3    Liu, Z.4    Ren, J.5    Luo, C.6    Long, J.7    Sharman, E.8    Liu, J.9
  • 39
    • 30844433781 scopus 로고    scopus 로고
    • Mitochondrial function, energy expenditure, aging and insulin resistance
    • Spec NO 2
    • Ritz P, Berrut G. Mitochondrial function, energy expenditure, aging and insulin resistance. Diabetes Metab. 2005;31 Spec No 2:5S67-73.
    • (2005) Diabetes Metab. , vol.31
    • Ritz, P.1    Berrut, G.2
  • 40
    • 30044450727 scopus 로고    scopus 로고
    • Improving metabolism by increasing energy expenditure
    • discussion, 5
    • Auwerx J. Improving metabolism by increasing energy expenditure. Nat Med. 2006;12:44-5; discussion, 5.
    • (2006) Nat Med. , vol.12 , pp. 44-45
    • Auwerx, J.1
  • 41
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 2013;17:491-506.
    • (2013) Cell Metab. , vol.17 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.