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Volumn 190, Issue 3, 2014, Pages 276-282

A pilot study on potential plasma hypoxia markers in the radiotherapy of non-small cell lung cancer: Osteopontin, carbonicanhydrase IX and vascular endothelial growth factor

Author keywords

Biological markers; Hemoglobin; Overall survival; Prognostic factors; Vascular endothelial growth factor

Indexed keywords

CARBONATE DEHYDRATASE IX; CISPLATIN; NAVELBINE; OSTEOPONTIN; VASCULOTROPIN;

EID: 84896385809     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-013-0484-1     Document Type: Article
Times cited : (41)

References (53)
  • 1
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • Höckel M, Vaupel P (2001) Biological consequences of tumor hypoxia. Semin Oncol 28:6-41
    • (2001) Semin Oncol , vol.28 , pp. 6-41
    • Höckel, M.1    Vaupel, P.2
  • 2
    • 84862695530 scopus 로고    scopus 로고
    • Acute versus chronic hypoxia in tumors
    • Bayer C, Vaupel P (2012) Acute versus chronic hypoxia in tumors. Strahlenther Onkol 188:616-627
    • (2012) Strahlenther Onkol , vol.188 , pp. 616-627
    • Bayer, C.1    Vaupel, P.2
  • 3
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • DOI 10.1007/s10555-007-9055-1, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • Vaupel P, Mayer A (2007) Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26:225-239 (Pubitemid 47101660)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 4
    • 79960290731 scopus 로고    scopus 로고
    • Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control
    • Zips D, Böke S, Kroeber T et al (2011) Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control. Strahlenther Onkol 187:306-310
    • (2011) Strahlenther Onkol , vol.187 , pp. 306-310
    • Zips, D.1    Böke, S.2    Kroeber, T.3
  • 5
    • 0034743861 scopus 로고    scopus 로고
    • Oxygenation status of malignant tumors: Pathogenesis of hypoxia and significance for tumor therapy
    • Vaupel P, Kelleher DK, Höckel M (2001) Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy. Semin Oncol 28:29-35 (Pubitemid 32522235)
    • (2001) Seminars in Oncology , vol.28 , Issue.2 SUPPL. 8 , pp. 29-35
    • Vaupel, P.1    Kelleher, D.K.2    Hockel, M.3
  • 6
    • 84892243658 scopus 로고    scopus 로고
    • Osteopontin - An indicator of tumor hypoxia and treatment resistance
    • Vordermark D (ed) Nova Publishers, New York
    • Ostheimer C, Vordermark D (2013) Osteopontin - an indicator of tumor hypoxia and treatment resistance. In: Vordermark D (ed) Hypoxia: causes, types and management. Nova Publishers, New York
    • (2013) Hypoxia: Causes, Types and Management
    • Ostheimer, C.1    Vordermark, D.2
  • 7
    • 0344667645 scopus 로고    scopus 로고
    • Endogenous Markers of Tumor Hypoxia: Predictors of Clinical Radiation Resistance?
    • DOI 10.1007/s00066-003-1150-9
    • Vordermark D, Brown JM (2003) Endogenous markers of tumor hypoxia predictors of clinical radiation resistance? Strahlenther Onkol 179:801-811 (Pubitemid 37509467)
    • (2003) Strahlentherapie und Onkologie , vol.179 , Issue.12 , pp. 801-811
    • Vordermark, D.1    Brown, J.M.2
  • 8
    • 34548446807 scopus 로고    scopus 로고
    • Identification and targeting hypoxia in head and neck cancer - A brief overview of current approaches
    • Le QT (2007) Identification and targeting hypoxia in head and neck cancer - a brief overview of current approaches. Int J Radiat Oncol Biol Phys 69:S56-S58
    • (2007) Int J Radiat Oncol Biol Phys , vol.69
    • Le, Q.T.1
  • 9
    • 39449090004 scopus 로고    scopus 로고
    • Detection and specific targeting of hypoxic regions within solid tumors: Current preclinical and clinical strategies
    • DOI 10.2174/092986708783497391
    • Bache M, Kappler M, Said HM et al (2008) Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies. Curr Med Chem 15:322-338 (Pubitemid 351266939)
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.4 , pp. 322-338
    • Bache, M.1    Kappler, M.2    Said, H.M.3    Staab, A.4    Vordermark, D.5
  • 10
    • 84892251873 scopus 로고    scopus 로고
    • Visualization and treatment of the HIF-1-active microenvironments in tumors: Drug design and application of oxygen-dependent degradable probes for molecular imaging of HIF-1-active microenvironments
    • Vordermark D (ed) 1st edn. Nova Publishers, New York
    • Masahi U, Hideo S (2013) Visualization and treatment of the HIF-1-active microenvironments in tumors: drug design and application of oxygen-dependent degradable probes for molecular imaging of HIF-1-active microenvironments. In: Vordermark D (ed) Hypoxia: causes, types and management, 1st edn. Nova Publishers, New York, pp 221-235
    • (2013) Hypoxia: Causes, Types and Management , pp. 221-235
    • Masahi, U.1    Hideo, S.2
  • 11
    • 84862667418 scopus 로고    scopus 로고
    • Basal HIF-1α expression levels are not predictive of radiosensitivity of human cancer cell lines
    • Schilling D, Bayer C, Emmerich K et al (2012) Basal HIF-1α expression levels are not predictive of radiosensitivity of human cancer cell lines. Strahlenther Onkol 188:353-358
    • (2012) Strahlenther Onkol , vol.188 , pp. 353-358
    • Schilling, D.1    Bayer, C.2    Emmerich, K.3
  • 14
    • 77952888155 scopus 로고    scopus 로고
    • High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer
    • Ilie M, Mazure NM, Hofman V et al (2010) High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer. Br J Cancer 25:1627-1635
    • (2010) Br J Cancer , vol.25 , pp. 1627-1635
    • Ilie, M.1    Mazure, N.M.2    Hofman, V.3
  • 15
    • 34250193203 scopus 로고    scopus 로고
    • Tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of hypoxic markers. A review
    • DOI 10.1002/hed.20543
    • Hoogsteen IJ, Marres HA, Bussink J et al (2007) Tumor microenvironment in head and neck squamous cell carcinoma: predictive value and clinical relevance of hypoxic markers. A review. Head Neck 29:591-604 (Pubitemid 47324777)
    • (2007) Head and Neck , vol.29 , Issue.6 , pp. 591-604
    • Hoogsteen, I.J.1    Marres, H.A.M.2    Bussink, J.3    Van Der, K.A.J.4    Kaanders, J.H.A.M.5
  • 16
    • 26944478634 scopus 로고    scopus 로고
    • Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer
    • DOI 10.1038/sj.onc.1208800, PII 1208800
    • Zhu Y, Denhardt DT, Cao H et al (2005) Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene 24:6555-6563 (Pubitemid 41486638)
    • (2005) Oncogene , vol.24 , Issue.43 , pp. 6555-6563
    • Zhu, Y.1    Denhardt, D.T.2    Cao, H.3    Sutphin, P.D.4    Koong, A.C.5    Giaccia, A.J.6    Le, Q.-T.7
  • 17
    • 33645079888 scopus 로고    scopus 로고
    • An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • Le QT, Chen E, Salim A et al (2006) An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res 12:1507-1514
    • (2006) Clin Cancer Res , vol.12 , pp. 1507-1514
    • Le, Q.T.1    Chen, E.2    Salim, A.3
  • 18
    • 26444467146 scopus 로고    scopus 로고
    • Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: Results from the DAHANCA 5 randomised double-blind placebo-controlled trial
    • DOI 10.1016/S1470-2045(05)70292-8, PII S1470204505702928
    • Overgaard J, Eriksen JG, Nordsmark M et al (2005) Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol 6:757-764 (Pubitemid 41430716)
    • (2005) Lancet Oncology , vol.6 , Issue.10 , pp. 757-764
    • Overgaard, J.1    Eriksen, J.G.2    Nordsmark, M.3    Alsner, J.4    Horsman, M.R.5
  • 19
    • 54249152439 scopus 로고    scopus 로고
    • SWOG: Lower osteopontin plasma levels are associated with superior outcomes in advanced nonsmall-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003
    • Mack PC, Redman MW, Chansky K et al (2008) SWOG: Lower osteopontin plasma levels are associated with superior outcomes in advanced nonsmall-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003. J Clin Oncol 26:4771-4776
    • (2008) J Clin Oncol , vol.26 , pp. 4771-4776
    • Mack, P.C.1    Redman, M.W.2    Chansky, K.3
  • 20
    • 77949890243 scopus 로고    scopus 로고
    • Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer
    • Blasberg JD, Pass HI, Goparaju CM et al (2010) Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer. J Clin Oncol 28:936-941
    • (2010) J Clin Oncol , vol.28 , pp. 936-941
    • Blasberg, J.D.1    Pass, H.I.2    Goparaju, C.M.3
  • 21
    • 84899409082 scopus 로고    scopus 로고
    • Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF-1α-mediated VEGF-dependent angiogenesis
    • doi:10.1038/onc.2013.171
    • Raja R, Kale S, Thorat D et al (2013) Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF-1α-mediated VEGF-dependent angiogenesis. Oncogene doi:10.1038/onc.2013.171
    • (2013) Oncogene
    • Raja, R.1    Kale, S.2    Thorat, D.3
  • 23
    • 52949107240 scopus 로고    scopus 로고
    • Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy
    • Solberg TD, Nearman J, Mullins J et al (2008) Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy. Int J Radiat Oncol Biol Phys 72:918-926
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 918-926
    • Solberg, T.D.1    Nearman, J.2    Mullins, J.3
  • 24
    • 78049377333 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX in NSCLC and its relationship with VEGF and Ki67 expression
    • Zhao X, Liu X, Guo W et al (2010) Expression of carbonic anhydrase IX in NSCLC and its relationship with VEGF and Ki67 expression. Chin J Cancer 13:881-866
    • (2010) Chin J Cancer , vol.13 , pp. 881-1866
    • Zhao, X.1    Liu, X.2    Guo, W.3
  • 27
    • 68949158602 scopus 로고    scopus 로고
    • Plasma osteopontin levels in patients with head and neck cancer undergoing chemoradiotherapy
    • Snitcovsky I, Leitão GM, Pasini FS et al (2009) Plasma osteopontin levels in patients with head and neck cancer undergoing chemoradiotherapy. Arch Otolaryngol Head Neck Surg 135:807-811
    • (2009) Arch Otolaryngol Head Neck Surg , vol.135 , pp. 807-811
    • Snitcovsky, I.1    Leitão, G.M.2    Pasini, F.S.3
  • 28
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9:539-549
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 29
    • 84867951231 scopus 로고    scopus 로고
    • Prognostic value of HIF-1α expression during fractionated irradiation
    • Helbig L, Yaromina A, Sriramareddy SN et al (2012) Prognostic value of HIF-1α expression during fractionated irradiation. Strahlenther Onkol 188:1031-1037
    • (2012) Strahlenther Onkol , vol.188 , pp. 1031-1037
    • Helbig, L.1    Yaromina, A.2    Sriramareddy, S.N.3
  • 31
    • 33751162608 scopus 로고    scopus 로고
    • Immunohistochemical detection of osteopontin in advanced head and neck cancer: Prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1-alpha-related markers, and hemoglobin levels
    • Bache M, Reddemann R, Said HM et al (2006) Immunohistochemical detection of osteopontin in advanced head and neck cancer: prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1-alpha-related markers, and hemoglobin levels. Int J Radiat Oncol Biol Phys 66:1481-1487
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1481-1487
    • Bache, M.1    Reddemann, R.2    Said, H.M.3
  • 34
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumors: Role of hypoxia and anemia
    • DOI 10.1385/MO:18:4:243
    • Vaupel P, Thews O, Hoeckel M (2001) Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 18:243-259 (Pubitemid 34044509)
    • (2001) Medical Oncology , vol.18 , Issue.4 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 35
    • 34548047714 scopus 로고    scopus 로고
    • Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2007.04.005, PII S0169500207002218
    • Chang YS, Kim HJ, Chang J (2007) Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer. Lung Cancer 57:373-380 (Pubitemid 47285428)
    • (2007) Lung Cancer , vol.57 , Issue.3 , pp. 373-380
    • Chang, Y.S.1    Kim, H.J.2    Chang, J.3    Ahn, C.M.4    Kim, S.K.5    Kim, S.K.6
  • 36
    • 81255128868 scopus 로고    scopus 로고
    • Osteopontin as a marker of weight loss in lung cancer
    • Karadag F, Gulen ST, Karul AB et al (2011) Osteopontin as a marker of weight loss in lung cancer. Scand J Clin Lab Invest 71:690-694
    • (2011) Scand J Clin Lab Invest , vol.71 , pp. 690-694
    • Karadag, F.1    Gulen, S.T.2    Karul, A.B.3
  • 37
    • 77952307612 scopus 로고    scopus 로고
    • Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients
    • Bache M, Kappler M, Wichman H et al (2010) Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients. BMC Cancer 10:132-140
    • (2010) BMC Cancer , vol.10 , pp. 132-140
    • Bache, M.1    Kappler, M.2    Wichman, H.3
  • 38
    • 84876141390 scopus 로고    scopus 로고
    • GTV differentially impacts locoregional control of non small-cell lung cancer (NSCLC) after different fractionation schedules: Subgroup analysis of the prospective randomized CHARTWELL trial
    • Soliman M, Yaromina A, Appold S et al (2013) GTV differentially impacts locoregional control of non small-cell lung cancer (NSCLC) after different fractionation schedules: Subgroup analysis of the prospective randomized CHARTWELL trial. Radiother Oncol 106:299-304
    • (2013) Radiother Oncol , vol.106 , pp. 299-304
    • Soliman, M.1    Yaromina, A.2    Appold, S.3
  • 39
    • 84876137567 scopus 로고    scopus 로고
    • The complex relationship between lung tumor volume and survival in patients with non small-cell lung cancer treated by definite radiotherapy: A prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05)
    • Ball DL, Fisher RJ, Burmeister BH et al (2013) The complex relationship between lung tumor volume and survival in patients with non small-cell lung cancer treated by definite radiotherapy: a prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05). Radiother Oncol 106:305-311
    • (2013) Radiother Oncol , vol.106 , pp. 305-311
    • Ball, D.L.1    Fisher, R.J.2    Burmeister, B.H.3
  • 40
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • DOI 10.1016/j.lungcan.2005.09.005, PII S0169500205004988
    • Bremnes RM, Camps C, Sirera R (2006) Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 51:143-158 (Pubitemid 43144358)
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 143-158
    • Bremnes, R.M.1    Camps, C.2    Sirera, R.3
  • 41
    • 84876920511 scopus 로고    scopus 로고
    • Serum level of osteopontin as a prognostic factor in patients who underwent surgical resection for non-small cell lung cancer
    • Takenaka M, Hanagiri T, Shinohara S et al (2012) Serum level of osteopontin as a prognostic factor in patients who underwent surgical resection for non-small cell lung cancer. Clin Lung Cancer 31:S1525-S7304
    • (2012) Clin Lung Cancer , vol.31
    • Takenaka, M.1    Hanagiri, T.2    Shinohara, S.3
  • 42
    • 0042847064 scopus 로고    scopus 로고
    • Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
    • DOI 10.1038/sj.bjc.6600936
    • Potter CP, Harris AL (2003) Diagnostic, prognostic and therapeutic of carbonic anhydrases in cancer. Br J Cancer 89:2-7 (Pubitemid 36897927)
    • (2003) British Journal of Cancer , vol.89 , Issue.1 , pp. 2-7
    • Potter, C.P.S.1    Harris, A.L.2
  • 43
    • 84934436127 scopus 로고    scopus 로고
    • Endogenous hypoxia markers: Case not proven!
    • Mayer A, Höckel M, Vaupel P (2008) Endogenous hypoxia markers: case not proven! Adv Exp Med Biol 614:127-136
    • (2008) Adv Exp Med Biol , vol.614 , pp. 127-136
    • Mayer, A.1    Höckel, M.2    Vaupel, P.3
  • 44
    • 81855174717 scopus 로고    scopus 로고
    • The cancer biomarker osteopontin: Combination with other markers
    • Weber GF (2011) The cancer biomarker osteopontin: combination with other markers. Cancer Genomics Proteomics 8:263-288
    • (2011) Cancer Genomics Proteomics , vol.8 , pp. 263-288
    • Weber, G.F.1
  • 45
    • 26844468059 scopus 로고    scopus 로고
    • The prognostic value of the hypoxia markers CA IX and GLUT I and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy ± chemotherapy
    • De Schutter H, Landuyt W, Verbeken E et al (2005) The prognostic value of the hypoxia markers CA IX and GLUT I and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy ± chemotherapy. BMC Cancer 5:42-53
    • (2005) BMC Cancer , vol.5 , pp. 42-53
    • De Schutter, H.1    Landuyt, W.2    Verbeken, E.3
  • 46
    • 77953463905 scopus 로고    scopus 로고
    • Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer
    • Byers LA, Holsinger FC, Kies MS et al (2010) Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer. Mol Cancer Ther 9:1755-1763
    • (2010) Mol Cancer Ther , vol.9 , pp. 1755-1763
    • Byers, L.A.1    Holsinger, F.C.2    Kies, M.S.3
  • 47
    • 70449509857 scopus 로고    scopus 로고
    • Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human suqmous cell carcinoma (hSCC) xenografts
    • Yaromina A, Quennet V, Zips D et al (2009) Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human suqmous cell carcinoma (hSCC) xenografts. Int J Radiat Biol 85:971-980
    • (2009) Int J Radiat Biol , vol.85 , pp. 971-980
    • Yaromina, A.1    Quennet, V.2    Zips, D.3
  • 48
    • 84868360868 scopus 로고    scopus 로고
    • Exploratory prospective trial of hypoxia-specific PET-imaging during radiochemotherapy in patients with locally advanced head-and-neack cancer
    • Zips D, Zöphel K, Abolmaali N et al (2012) Exploratory prospective trial of hypoxia-specific PET-imaging during radiochemotherapy in patients with locally advanced head-and-neack cancer. Radiother Oncol 105:21-28
    • (2012) Radiother Oncol , vol.105 , pp. 21-28
    • Zips, D.1    Zöphel, K.2    Abolmaali, N.3
  • 49
    • 84884563512 scopus 로고    scopus 로고
    • Correlation between tumor oxygenation and (18) F-fluoromisonidazole PET data simulated based on microvessel images
    • Mönnich D, Troost EG, Kaanders JH et al (2013) Correlation between tumor oxygenation and (18) F-fluoromisonidazole PET data simulated based on microvessel images. Acta Oncol 52:1308-1313
    • (2013) Acta Oncol , vol.52 , pp. 1308-1313
    • Mönnich, D.1    Troost, E.G.2    Kaanders, J.H.3
  • 50
    • 84874050988 scopus 로고    scopus 로고
    • Hypoxia-related molecules HIF-1á, CA9, and osteopontin. Predictors of survival in patients with high-grade glioma
    • Erpolat, Gocun PO, Akmansu M et al (2013) Hypoxia-related molecules HIF-1á, CA9, and osteopontin. Predictors of survival in patients with high-grade glioma. Strahlenther Onkol 189:147-154
    • (2013) Strahlenther Onkol , vol.189 , pp. 147-154
    • Erpolat1    Gocun, P.O.2    Akmansu, M.3
  • 51
    • 80052810391 scopus 로고    scopus 로고
    • Development and validation of a prognostic model using blood biomarker information for prediction of survival of non-small-cell lung cancer patients treated with combined chemotherapy and radiation or radiotherapy alone (NCT00181519, NCT00573040, and NCT00572325)
    • Dehing-Oberije C, Aerts H, Yu S et al (2011) Development and validation of a prognostic model using blood biomarker information for prediction of survival of non-small-cell lung cancer patients treated with combined chemotherapy and radiation or radiotherapy alone (NCT00181519, NCT00573040, and NCT00572325). Int J Radiat Oncol Biol Phys 81:360-368
    • (2011) Int J Radiat Oncol Biol Phys , vol.81 , pp. 360-368
    • Dehing-Oberije, C.1    Aerts, H.2    Yu, S.3
  • 52
    • 79955741602 scopus 로고    scopus 로고
    • Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro
    • Staab A, Fleischer M, Loeffler J et al (2011) Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlenther Onkol 187:252-259
    • (2011) Strahlenther Onkol , vol.187 , pp. 252-259
    • Staab, A.1    Fleischer, M.2    Loeffler, J.3
  • 53
    • 77955097923 scopus 로고    scopus 로고
    • Hypoxia-specific targets in cancer therapy: Role of splice variants
    • Vordermark D (2010) Hypoxia-specific targets in cancer therapy: role of splice variants. BMC Med 12:1741-7015
    • (2010) BMC Med , vol.12 , pp. 1741-7015
    • Vordermark, D.1


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