Expression of carbonic anhydrase IX in NSCLC and its relationship with VEGF and Ki67 expression

Chinese Journal of Lung Cancer

Volumn 13, Issue 9, 2010, Pages 861-866

  Zhao, Xiangfei ^a   Liu, Xiaoqing ^a   Guo, Wanfeng ^a   Li, Xiaobing ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

CAIX; Hypoxia; Ki67; Lung neoplasms; VEGF

Indexed keywords

CARBONATE DEHYDRATASE IX; KI 67 ANTIGEN; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER STAGING; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; LUNG PSEUDOTUMOR; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PNEUMONIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SMOKING; TISSUE DIFFERENTIATION; TREATMENT RESPONSE; WEIGHT REDUCTION;

ADULT; AGED; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MIDDLE AGED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78049377333     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2010.09.05     Document Type: Article

References (15)

1. Barnea G, Silvennoinen O, Shaanan B, et al. Identification of a calbonic anhydrase-like domain in the extracellular region of RFTP gamma defines a new subfamily of receptor tyrosine phosphatases. Mol Cell Biol, 1993, 13(3): 1497-1506. (Pubitemid 23068087)
2. Pastorekova S, Pastorek J. Cancer-related carbonicanhydrase isozymes and their inhibition [A]. Supuran CT. Carbonic anhydrase. Its Inhibitors and activators [M]. RocaRaton, FL: CRC Press, 2004. 255-281.
3. Swinson DE, Cox G, O'Byrne KJ, et al. Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer. Br J Cancer, 2004, 91(7): 1301-1307.
4. Simi L, Venturini G, Malentacchi F, et al. Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer. Lung Cancer, 2006, 52(1): 59-66. (Pubitemid 43340200)
5. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res, 2001, 61(21): 7992-7998. (Pubitemid 33049392)
6. 99mTc-HL91 hypoxic scintigr aphy for lung cancer. J SUN Yat-sen Univ (Med Sci), 2007, 28(2): 205-208, 213.
7. Le QJ, Chen E, Salim A, et al. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res, 2006, 12(5): 1507-1514.
8. Kim SJ, Rabbani ZN, Dewhirst MW, et al. Expression of HIF-1 alpha, CAIX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer, 2005, 49(3): 325-335.
9. Raghunand N, Mahoney BP, Gillies RJ, et al. Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol, 2003, 66(7): 1219-1229.
10. Koukourakis MI, Bentzen SM, Giatromanolaki A, et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol, 2006, 24(5): 727-735. (Pubitemid 46622039)
11. Said HM, Hagemann C, Staab A, et al. Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1 alpha in human glioma in vitro and in vivo. Radiother Oncol, 2007, 83(3): 398-405. (Pubitemid 46907985)
12. Kaluzova M, Pastorekova S, Svastova E, et al. Characterization of the MN/CA 9 promoter proximal region: a. role for specificity protein (SP) and activator protein 1 (AP1) factor. Biochem J, 2001, 359(Pt3): 669-677. (Pubitemid 33063392)
13. Generali D, Fox SB, Berruti A, et al. Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer. Endocr Relat Cancer, 2006, 13(3): 921-930. (Pubitemid 44763267)
14. Bui MH, Visapaa H, Seligron D, et al. Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. J Urol, 2004, 171(6Pt1): 2461-2466. (Pubitemid 38625515)
15. Kim SJ, Rabbani ZN, Vollmer RT, et al. Carbonic anhydrase IX in early-stage non-small cell lung cancer. Clin Cancer Res, 2004, 10(23): 7925-7933. (Pubitemid 39587532)