Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

Cellular Signalling

Volumn 26, Issue 5, 2014, Pages 1040-1047

  Ohotski, Jan ^a   Rosen, Hugh ^c   Bittman, Robert ^b   Pyne, Susan ^a   Pyne, Nigel J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cancer; Growth; Nuclear signaling; Sphingosine 1 phosphate; Sphingosine 1 phosphate receptors; Sphingosine kinase

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN TYROSINE KINASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 4; SPHINGOSINE KINASE 2; TYROSINE; UNCLASSIFIED DRUG; PROTEIN KINASE P60; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1;

ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL; CANCER GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITOR COMPLEX; GENE OVEREXPRESSION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; UPREGULATION; BREAST CANCER; BREAST CANCER CELL LINE; CELL LYSATE; DENSITOMETRY; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CANCER; GROWTH; NUCLEAR SIGNALING; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE 1-PHOSPHATE RECEPTORS; SPHINGOSINE KINASE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; RECEPTORS, ESTROGEN; RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHINGOSINE; SRC-FAMILY KINASES; THIAZOLES; TYROSINE;

EID: 84896356313     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.01.023     Document Type: Article

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