Fasudil mesylate protects PC12 cells from oxidative stress injury via the bax-mediated pathway

Cellular and Molecular Neurobiology

Volumn 31, Issue 2, 2011, Pages 243-250

  Li, Qin ^a,b   Liu, Dong ^a   Huang, Xianju ^a   Guo, Lianjun ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Fasudil mesylate; Oxidative stress; Rho kinase; ROS

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; FASUDIL MESYLATE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DAMAGE; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; IN VITRO STUDY; NEUROPROTECTION; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STAINING; UPREGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CYTOPROTECTION; GENE EXPRESSION REGULATION, NEOPLASTIC; HYDROGEN PEROXIDE; INTRACELLULAR SPACE; MESYLATES; OXIDATIVE STRESS; PC12 CELLS; PROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

RATTUS;

EID: 79959744812     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-010-9614-9     Document Type: Article

References (32)

1. Bailey SR, Mitra S, Flavahan S, Flavahan NA (2005) Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol 289:H243-H250 (Pubitemid 40934106)
2. Burlacu A (2003) Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7:249-257
3. Chandra J, Samali A, Orrenius S (2000) Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29:323-333
4. Crack PJ, Taylor JM (2005) Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 38:1433-1444 (Pubitemid 40693828)
5. Davis W Jr, Ronai Z, Tew KD (2001) Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther 296:1-6 (Pubitemid 32015053)
6. Del Re DP, Miyamoto S, Brown JH (2007) RhoA/Rho kinase upregulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem 282:8069-8078 (Pubitemid 47093605)
7. Ding J, Yu JZ, Li QY, Wang X, Lu CZ, Xiao BG (2009) Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF. Brain Behav Immun 23(8):1083-1088
8. Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310-318
9. Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420:629-635 (Pubitemid 36764489)
10. Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, Ichiki T, Takahashi S, Takeshita A (2003) Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. Circ Res 93:767-775 (Pubitemid 37288672)
11. Hu W, Xie J, Zhao J, Xu Y, Yang S, Ni W (2009) Involvement of bcl-2 family in apoptosis and signal pathways induced by cigarette smoke extract in the human airway smooth muscle cells. DNA Cell Biol 28:13-22
12. Huang L, He Z, Guo L, Wang H (2007) Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of Rho-kinase. Cell Mol Neurobiol 28:757-768 (Pubitemid 351905062)
13. Huang L, Li Q, Li H, He Z, Cheng Z, Chen J, Guo L (2009a) Inhibition of intracellular Ca2? release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons. Eur J Pharmacol 602:238-244
14. Huang X, Li Q, Li H, Guo L (2009b) Neuroprotective and antioxidative properties of Cactus Polysaccharides in vivo and in vitro. Cell Mol Neurobiol 29(8):1211-1221
15. Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thébaud B, Michelakis ED, Archer SL (2007) Oxygen activates the rho/rho-kinase pathway and induces Rhob and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species. Circulation 115(13):1777-1788 (Pubitemid 46648615)
16. Li Q, Huang L, Liu D, Wang W, Chen W, Guo L (2007) Effects of Ethanesulfonic fasudil on cerebral vasospasm in dogs. Chin J Hosp Pharm 27:746-749
17. Li Q, Huang XJ, He W, Ding J, Jia JT, Fu G, Wang HX, Guo LJ (2009) Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats. Cell Mol Neurobiol 29:169-180
18. Ma R, Xiong N, Huang C, Tang Q, Hu B, Xiang J, Li G (2009) Erythropoietin protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Neuropharmacology 56:1027-1034
19. Mehta SL, Manhas N, Raghubir R (2007) Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 54:34-66 (Pubitemid 46498164)
20. Mueller BK, Mack H, Teusch N (2005) Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 4:387-398 (Pubitemid 40704122)
21. Riento K, Ridley AJ (2003) Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4:446-456 (Pubitemid 36648590)
22. Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T, Moskowitz MA, Liao JK (2005) Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36:2251-2257 (Pubitemid 41429255)
23. Satoh S, Kobayashi T, Hitomi A, Ikegaki I, Suzuki Y, Shibuya M, Yoshida J, Asano T (1999) Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction. Jpn J Pharmacol 80:41-48 (Pubitemid 29271512)
24. Satoh S, Toshima Y, Hitomi A, Ikegaki I, Seto M, Asano T (2008) Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. Brain Res 1193:102-108
25. Satoh SI, Hitomi A, Ikegaki I, Kawasaki K, Nakazono O, Iwasaki M, Mohri M, Asano T (2010) Amelioration of endothelial damage/ dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage. Brain Res Bull 81(1):191-195
26. Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J (2009) Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia 57:898-907
27. Sugawara T, Fujimura M, Noshita N, Kim GW, Saito A, Hayashi T, Narasimhan P, Maier CM, Chan PH (2004) Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1:17-25 (Pubitemid 46589339)
28. Takada Y, Yonezawa A, Kume T, Katsuki H, Kaneko S, Sugimoto H, Akaike A (2003) Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J Pharmacol Exp Ther 306:772-777 (Pubitemid 36886179)
29. Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, Wu WN, Dong LD, Chen JG (2009) Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med 47:229-240
30. Wu Y, Shang Y, Sun S, Liu R (2007) Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells. Eur J Pharmacol 564:47-56 (Pubitemid 46946850)
31. Yamashita K, Kotani Y, Nakajima Y, Shimazawa M, Yoshimura S, Nakashima S, Iwama T, Hara H (2007) Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons. Brain Res 1154:215-224 (Pubitemid 46856349)
32. Yano K, Kawasaki K, Hattori T, Tawara S, Toshima Y, Ikegaki I, Sasaki Y, Satoh S, Asano T, Seto M (2008) Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction. Eur J Pharmacol 594:77-83