Osteocalcin increase after bariatric surgery predicts androgen recovery in hypogonadal obese males

International Journal of Obesity

Volumn 38, Issue 3, 2014, Pages 357-363

  Samavat, J ^a   Facchiano, E ^b   Cantini, G ^a   Di Franco, A ^a   Alpigiano, G ^b   Poli, G ^a   Seghieri, G ^c   Lucchese, M ^b   Forti, G ^a   Luconi, M ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

^c General Hospital   (Italy)

Author keywords

bariatric surgery; bone and testis; free testosterone; male obesity; osteocalcin; prospective longitudinal study

Indexed keywords

ANDROGEN; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; OSTEOCALCIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ANDROGEN BLOOD LEVEL; ANDROGEN SYNTHESIS; ANTHROPOMETRIC PARAMETERS; ARTICLE; BARIATRIC SURGERY; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CONVALESCENCE; DECARBOXYLATION; GROUPS BY AGE; HOSPITAL ADMISSION; HUMAN; HYPOGONADISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORBID OBESITY; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ROUX Y ANASTOMOSIS; STOMACH BYPASS; COMPLICATION; LONGITUDINAL STUDY; METABOLISM; OBESITY, MORBID; PROSPECTIVE STUDY; REMISSION; TREATMENT OUTCOME;

ADULT; ANDROGENS; BODY MASS INDEX; FOLLICLE STIMULATING HORMONE; GASTRIC BYPASS; HUMANS; HYPOGONADISM; LONGITUDINAL STUDIES; LUTEINIZING HORMONE; MALE; OBESITY, MORBID; OSTEOCALCIN; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REMISSION INDUCTION; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; TREATMENT OUTCOME;

EID: 84896317018     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.228     Document Type: Article

References (46)

1. Khosla S, Melton 3rd LJ, Atkinson EJ, O?Fallon WM. Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 2001; 86: 3555-3561
2. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 2007; 130: 811-823
3. Manolagas SC, Kousteni S, Jilka RL. Sex steroids and bone. Recent Prog Horm Res 2002; 57: 385-409
4. Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE et al. Endocrine regulation of male fertility by the skeleton. Cell 2011; 144: 796-809
5. Smith LB, Saunders PT. The skeleton: The new controller of male fertility? Cell 2011; 144: 642-643
6. Kirmani S, Atkinson EJ, Melton 3rd LJ, Riggs BL, Amin S, Khosla S. Relationship of testosterone and osteocalcin levels during growth. J Bone Miner Res 2011; 26: 2212-2216
7. Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe JS et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-Testis axis. J Clin Invest 2013; 123: 2421-2433
8. Yang B, Sun H, Wan Y, Wang H, Qin W, Yang L et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl 2012; 35: 783-792
9. Bolland MJ, Grey A, Horne AM, Reid IR. Testosterone levels following decreases in serum osteocalcin. Calcif Tissue Int 2013; 93: 133-136
10. Hannemann A, Breer S, Wallaschofski H, Nauck M, Baumeister SE, Barvencik F et al. Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders. Andrology 2013; 1: 469-474
11. Liao M, Guo X, Yu X, Pang G, Zhang S, Li J et al. Role of metabolic factors in the association between osteocalcin and testosterone in Chinese men. J Clin Endocrinol Metab 2013; 98: 3463-3469
12. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007; 130: 456-469
13. Fernaíndez-Real JM, Izquierdo M, Ortega F, Gorostiaga E, Goímez-Ambrosi J Moreno-Navarrete JM et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab 2009; 94: 237-245
14. Saleem U, Mosley Jr TH, Kullo IJ. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 2010; 30: 1474-1478
15. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Beilby JP et al. Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. Eur J Endocrinol 2010; 63: 265-272
16. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B. Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 2009; 94: 827-832
17. Alfadda AA, Masood A, Shaik SA, Dekhil H, Goran M. Association between osteocalcin, metabolic syndrome, and cardiovascular risk factors: Role of total and undercarboxylated osteocalcin in patients with type 2 diabetes. Int J Endocrinol 2013; 2013: 197519
18. Foresta C, Strapazzon G, De Toni L, Gianesello L, Calcagno A, Pilon C et al. Evidence for osteocalcin production by adipose tissue and its role in human metabolism. J Clin Endocrinol Metab 2010; 95: 3502-3506
19. Kanazawa I, Tanaka K, Ogawa N, Yamauchi M, Yamaguchi T, Sugimoto T. Undercarboxylated osteocalcin is positively associated with free testosterone in male patients with type 2 diabetes mellitus. Osteoporos Int 2013; 24: 1115-1119
20. Hammoud A, Gibson M, Hunt SC, Adams TD, Carrell DT, Kolotkin RL et al. Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men. J Clin Endocrinol Metab 2009; 94: 1329-1332
21. Luconi M, Samavat J, Seghieri G, Iannuzzi G, Lucchese M, Rotella C et al. Determinants of testosterone recovery after bariatric surgery: Is it only a matter of reduction of body mass index? Fertil Steril 2013; 99: 1872-1879
22. Pellitero S, Olaizola I, Alastrue A, Martiínez E, Granada ML, Balibrea JM et al. Hypogonadotropic hypogonadism in morbidly obese males is reversed after bariatric surgery. Obes Surg 2012; 22: 1835-1842
23. Facchiano E, Scaringi S, Veltri M, Samavat J, Maggi M, Forti G et al. Age as a predictive factor of testosterone improvement in male patients after bariatric surgery: Preliminary results of a monocentric prospective study. Obes Surg 2013; 23: 167-172
24. Corona G, Rastrelli G, Monami M, Saad F, Luconi M, Lucchese M et al. Body weight loss reverts obesity-Associated hypogonadotropic hypogonadism: A systematic review and meta-Analysis. Eur J Endocrinol 2013; 168: 829-843
25. Coates PS, Fernstrom JD, Fernstrom MH, Schauer PR, Greenspan SL. Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass. J Clin Endocrinol Metab 2004; 89: 1061-1065
26. Bruno C, Fulford AD, Potts JR, McClintock R, Jones R, Cacucci BM et al. Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: Correlation with the reduction in leptin. J Clin Endocrinol Metab 2010; 95: 159-166
27. Fernaíndez-Real JM, Ortega F, Goí mez-Ambrosi J, Salvador J, Frühbeck G, Ricart W. Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss. Osteoporos Int 2010; 21: 2101-2107
28. Huhtaniemi IT, Tajar A, Lee DM, O?Neill TW, Finn JD, Bartfai G et al. EMAS Group. Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men. Eur J Endocrinol 2012; 66: 983-991
29. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-3672
30. Bhasin S, Pencina M, Jasuja GK, Travison TG, Coviello A, Orwoll E et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab 2011; 96: 2430-2439
31. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-Type mice. Proc Natl Acad Sci USA 2008; 105: 5266-5270
32. Kim SH, Lee JW, Im JA, Hwang HJ. Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men. Clin Chim Acta 2010; 411: 2054-2057
33. Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res 2005; 309: 99-109
34. Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005; 331: 520-526
35. Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B et al. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 2013; 17: 901-915
36. Karsenty G. Convergence between bone and energy homeostases: Leptin regulation of bone mass. Cell Metab 2006; 4: 341-348
37. Maser RE, James Lenhard M, Balagopal PB, Kolm P, Peters MB. Effects of surgically induced weight loss by Roux-en-Y gastric bypass on osteocalcin. Surg Obes Relat Dis 2013; 9: 950-955
38. Suh HS, Hwang IC, Lee KS, Kim KK. Relationships between serum osteocalcin leptin and the effect of weight loss by pharmacological treatment in healthy nonsmoking Korean obese adults. Clin Chim Acta 2013; 418: 17-21
39. Andersson DP, Wahrenberg H, Toft E, Qvisth V, Lö fgren P, Hertel K et al. Waist circumference to assess reversal of insulin resistance following weight reduction after bariatric surgery: Cohort and cross-sectional studies. Int J Obes (Lond) 2014; 38: 438-443
40. Maser RE, Lenhard MJ, Peters MB, Irgau I, Wynn GM. Effects of surgically induced weight loss by Roux-en-Y gastric bypass on cardiovascular autonomic nerve function. Surg Obes Relat Dis 2013; 9: 221-226
41. Corona G, Monami M, Rastrelli G, Aversa A, Tishova Y, Saad F et al. Testosterone and metabolic syndrome: A meta-Analysis study. J Sex Med 2011; 8: 272-283
42. Foresta C, Strapazzon G, De Toni L, Gianesello L, Bruttocao A, Scarda A et al. Androgens modulate osteocalcin release by human visceral adipose tissue. Clin Endocrinol (Oxf) 2011; 75: 64-69
43. Strapazzon G, De Toni L, Foresta C. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 2011; 22: 1643-1644
44. Laughlin GA, Ix JH, Cummins K, Allison MA, Daniels LB. Extremes of an aromatase index predict increased 25-year risk of cardiovascular mortality in older women. Clin Endocrinol 2012; 77: 391-398
45. Sinha N, Shieh A, Stein EM, Strain G, Schulman A, Pomp A et al. Increased PTH and 1.25(OH)(2)D levels associated with increased markers of bone turnover following bariatric surgery. Obesity (Silver Spring) 2011; 19: 2388-2393
46. Guney E, Kisakol G, Ozgen G, Yilmaz C, Yilmaz R, Kabalak T. Effect of weight loss on bone metabolism: Comparison of vertical banded gastroplasty and medical intervention. Obes Surg 2003; 13: 383-388