Association between Serum Osteocalcin and Markers of Metabolic Phenotype

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 3, 2009, Pages 827-832

  Pittas, Anastassios G ^a,b,c   Harris, Susan S ^a,b   Eliades, Myrto ^a,b   Stark, Paul ^a,b   Dawson Hughes, Bess ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; C REACTIVE PROTEIN; CALCIUM; INSULIN; INTERLEUKIN 6; OSTEOCALCIN; PLACEBO; VITAMIN D;

AGED; ARTICLE; BODY FAT; BODY MASS; DIABETES MELLITUS; DIET SUPPLEMENTATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; OBESITY; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANIMALIA;

EID: 62349099001     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1422     Document Type: Article

References (37)

1. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Slien J, Vinson C, Rueger JM, Karsenty G 2000 Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100:197-207
2. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G 2005 Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-520
3. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G 2004 Serum leptin level is a regulator of bone mass, Proc Natl Acad Sci USA 101:3258-3263
4. Karsenty G 2006 Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 4:341-348
5. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-469
6. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE 1997 Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670-676
7. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
8. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M 2000 Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-63
9. Garcia-Estevez DA, Araujo-Vilar D, Fiestr as-Janeiro G, Saavedra-Gonzalez A, Cabezas-Cerrato J 2003 Comparison of several insulin sensitivity indices derived from basal plasma insulin and glucose levels with minimal model indices. Horm Metab Res 35:13-17
10. Chang AM, Smith MJ, Bloem CJ, Galecki AT, Halter JB, Supiano MA 2006 Limitation of the homeostasis model assessment to predict insulin resistance and β-cell dysfunction in older people. J Clin Endocrinol Metab 91:629-634
11. Pittas AG, Joseph NA, Greenberg AS 2004 Adipocytokines and insulin resistance. J Clin Endocrinol Metab 89:447-452
12. Ridker PM, Buring JE, Cook NR, Rifai N 2003 C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 107:391-397
13. Johnson J, Dawson-Hughes B 1991 Precision and stability of dual-energy x-ray absorptiometry measurements. Calcif Tissue Int 49:174-178
14. Washburn RA, Smith KW, Jette AM, Janney CA 1993 The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol 46:153-162
15. Ferron M, Hinoi E, Karsenty G, Ducy P 2008 Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266-5270
16. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B 2007 The effects of calcium and vitaminD supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care 30:980-986
17. Franke S, Siggelkow H, Wolf G, Hein G 2007 Advanced glycation endproducts influence the m RNA expression of RAGE, RANKL and various osteoblastic genes in human osteoblasts. Arch Physiol Biochem 113:154-161
18. Fujii H, Hamada Y, Fukagawa M 2008 Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats. Bone 42:372-379
19. Lee NK, Karsenty G 2008 Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab 19:161-166
20. Martin TJ 2007 A skeleton key to metabolism. Nat Med 13:1021-1023
21. Akin O, Gol K, Akturk M, Erkaya S 2003 Evaluation of bone turnover in postmenopausal patients with type 2 diabetes mellitus using biochemical markers and bone mineral density measurements. Gynecol Endocrinol 17:19-29
22. Achemlal L, Tellal S, Rkiouak F, Nouijai A, Bezza A, Derouiche el M, Ghafir D, El Alaghraoui A 2005 Bone metabolism in male patients with type 2 diabetes. Clin Rheumatol 24:493-496
23. Rosato MT, Schneider SH, Shapses SA 1998 Bone turnover and insulin-like growth factor I levels increase after improved glycemic control in noninsulindependent diabetes mellitus. Calcif Tissue Int 63:107-111
24. Pietschmann P, Schemthaner G, Woloszczuk W 1988 Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 31:892-895
25. Dobnig H, Piswanger-Solkner JC, Roth M, Obermayer-Pietsch B, Tiran A, Strele A, Maier E, Maritschnegg P, Sieberer C, Fahrleitner-Pammer A 2006 Type 2 diabetes mellitus in nursing home patients: effects on bone turnover, bone mass, and fracture risk. J Clin Endocrinol Metab 91:3355-3363
26. Gerdhem P, Isaksson A, Akesson K, Obrant KJ 2005 Increased bone density and decreased bone turnover, but no evident alteration of fracture susceptibility in elderly women with diabetes mellitus. Osteoporos Int 16:1506-1512
27. Bouillon R, Bex M, Van Herck E, Laureys J, Dooms L, Lesaffre E, Ravussin E 1995 Influence of age, sex, and insulin on osteoblast function: osteoblast dysfunction in diabetes mellitus. J Clin Endocrinol Metab 80:1194-1202
28. elMiedany YM, el Gaafary S, el Baddini MA 1999 Osteoporosis in older adults with non-insulin-dependent diabetes mellitus: is it sex related? Clin Exp Rheumatol 17:561-567
29. Wittrant Y, Gorin Y, Woodruff K, Horn D, Abboud HE, Mohan S, Abboud-Werner SL 2008 High D(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Bone 42:1122-1130
30. Berberoglu Z, Gursoy A, Bayraktar N, Yazici AC, Bascil Tutuncu N, Guvener Demirag N 2007 Rosiglitazone decreases serum bone-specific alkaline phosphatase activity in postmenopausal diabetic women. J Clin Endocrinol Metab 92:3523-3530
31. Nimptsch K, Hailer S, Rohrmann S, Gedrich K, Wolfram G, Linseisen J 2007 Determinants and correlates of serum undercarboxylated osteocalcin. Ann Nutr Metab 51:563-570
32. Murshed M, Schinke T, McKee MD, Karsenty G 2004 Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165:625-630
33. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G 1996 Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452
34. Price PA 1989 Gla-containing proteins of bone. Connect Tissue Res 21:51-57; discussion 57-60
35. Hauschka PV, Wians Jr FH 1989 Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone. Anat Rec 224:180-188
36. Hauschka PV, Lian JB, Cole DE, Gundberg CM 1989 Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69: 990-1047
37. Vestri HS, Lara-Castro C, Moellering DR, Gunberg CM, Garvey WT 2008 Osteocalcin is not just for bones: effects on adipocytes and role in human metabolism. Diabetes 57:A29