Evidence for osteocalcin production by adipose tissue and its role in human metabolism

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 7, 2010, Pages 3502-3506

  Foresta, Carlo ^a   Strapazzon, Giacomo ^a   De Toni, Luca ^a   Gianesello, Lisa ^a   Calcagno, Alessandra ^a   Pilon, Catia ^a   Plebani, Mario ^b   Vettor, Roberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATED OSTEOCALCIN; MESSENGER RNA; OSTEOCALCIN; UNCLASSIFIED DRUG; UNDERCARBOXYLATED OSTEOCALCIN;

ADIPOGENESIS; ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CARBOXYLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLISM; OBESITY; OMENTUM; OUTPATIENT DEPARTMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; WORLD HEALTH ORGANIZATION; CELL CULTURE; GENETICS; NONPARAMETRIC TEST; PHYSIOLOGY;

ADIPOGENESIS; ADIPOSE TISSUE; BODY MASS INDEX; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OBESITY; OSTEOCALCIN; OVERWEIGHT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 77954890773     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2557     Document Type: Article

References (25)

1. Catalán V, Gómez-Ambrosi J, Rodríguez A, Salvador J, Frühbeck G 2009 Adipokines in the treatment of diabetes mellitus and obesity. Expert Opin Pharmacother 10:239-254
2. Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD 2009 Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab 94:3387-3393
3. Ho JS, Cannaday JJ, Barlow CE, Willis B, Haskell WL, FitzGerald SJ 2009 Comparative relation of general, central, and visceral adiposity measures for coronary artery calcium in subjects without previous coronary events. Am J Cardiol 104:943-946
4. Confavreux CB, Levine RL, Karsenty G 2009 A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol Cell Endocrinol 310:21-29
5. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-469 (Pubitemid 47208519)
6. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G 1996 Increased bone formation in osteocalcin-deficient mice. Nature 382: 448-452 (Pubitemid 26264860)
7. Mauro LJ, Olmsted EA, Skrobacz BM, Mourey RJ, Davis AR, Dixon JE 1994 Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. J Biol Chem 269:30659-30667
8. Ferron M, Hinoi E, Karsenty G, Ducy P 2008 Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266-5270 (Pubitemid 351738545)
9. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D 2009 Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 24:785-791
10. Pagano C, Pilon C, Calcagno A, Urbanet R, Rossato M, Milan G, Bianchi K, Rizzuto R, Bernante P, Federspil G, Vettor R 2007 The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms. J Clin Endocrinol Metab 92:4810-4819 (Pubitemid 350223464)
11. Ferlin A, Pepe A, Facciolli A, Gianesello L, Foresta C 2010 Relaxin stimulates osteoclast differentiation and activation. Bone 46:504-513
12. World Health Organization 2000 Obesity: preventing and managing the global epidemic. Report of a WHO convention, Geneva, 1999. Tech Rep Series 894. Geneva: World Health Organization
13. Hernandez-Morante JJ, Milagro FI, Lujan JA, Martinez JA, Zamora S, Garaulet M 2008 Insulin effect on adipose tissue (AT) adiponectin expression is regulated by the insulin resistance status of the patients. Clin Endocrinol (Oxf) 69:412-417
14. Hajer GR, van Haeften TW, Visseren FL 2008 Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959-2971
15. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
16. Luo XH, Zhao LL, Yuan LQ, Wang M, Xie H, Liao EY 2009 Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification. J Bone Miner Res 24: 1461-1468
17. Zeadin M, Butcher M, Werstuck G, Khan M, Yee CK, Shaughnessy SG 2009 Effect of leptin on vascular calcification in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 29:2069-2075
18. Gössl M, Mödder UI, Atkinson EJ, Lerman A, Khosla S 2008 Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol 52:1314-1325
19. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T 2009 Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:3031-3037
20. Reinehr T, Roth CL 12 January 2010 A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes (Lond) 10.1038/ijo.2009.282
21. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers Jr MG, Chua Jr SC, Kim JK, Kaestner KH, Karsenty G 2008 The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183:1235-1242
22. Warshaw AL, Lee KH, Napier TW, Fournier PO, Duchainey D, Axelrod L 1985 Depression of serum calcium by incerased plasma free fatty acids in the rat: a mechanism for hypocalcemia in acute pancreatitis. Gastroenterology 89:814-820
23. Ahlstrom M, Pekkinen M, Riehle U, Lamberg-Allardt C 2008 Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells. Bone 42: 483-490
24. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH 2002 Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: 4279-4295 (Pubitemid 35471185)
25. Aguiari P, Leo S, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R 2008 High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci USA 105:1226-1231 (Pubitemid 351397035)