Androgens modulate osteocalcin release by human visceral adipose tissue

Clinical Endocrinology

Volumn 75, Issue 1, 2011, Pages 64-69

  Foresta, Carlo ^a   Strapazzon, Giacomo ^a   De Toni, Luca ^a   Gianesello, Lisa ^a   Bruttocao, Andrea ^b   Scarda, Alessandro ^c   Plebani, Mario ^c   Garolla, Andrea ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b INSTITUTE FOR RENEWABLE ENERGY   (Italy)

^c UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ESTRADIOL; FLUTAMIDE; OSTEOCALCIN; SEX HORMONE; ANTIANDROGEN; TESTOSTERONE;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTRADIOL BLOOD LEVEL; EX VIVO STUDY; HORMONE ACTION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTRAABDOMINAL FAT; LIPID STORAGE; LIPOLYSIS; MALE; OBESITY; OMENTUM; PRIORITY JOURNAL; PROTEIN SECRETION; TESTOSTERONE BLOOD LEVEL; BLOOD; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; ANDROGEN ANTAGONISTS; ANDROGENS; DIHYDROTESTOSTERONE; FLUTAMIDE; HUMANS; INTRA-ABDOMINAL FAT; MIDDLE AGED; OSTEOCALCIN; OVERWEIGHT; TESTOSTERONE;

EID: 79958836071     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.03997.x     Document Type: Article

References (33)

1. Pond, C.M., (1992) An evolutionary and functional view of mammalian adipose tissue. Proceedings of the Nutrition Society, 51, 367-377.
2. Pasquali, R., Casimirri, F., Cantobelli, S., et al. (1991) Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism, 40, 101-104.
3. Gapstur, S.M., Gann, P.H., Kopp, P., et al. (2002) Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study. Cancer, Epidemiology, Biomarkers & Prevention, 11, 1041-1047. (Pubitemid 35192655)
4. Seidell, J.C., Björntorp, P., Sjöström, L., et al. (1990) Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism, 39, 897-901. (Pubitemid 20293933)
5. Garaulet, M., Pérez-Llamas, F., Fuente, T., et al. (2000) Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. European Journal of Endocrinology, 143, 657-666.
6. Tsai, E.C., Matsumoto, A.M., Fujimoto, W.Y., et al. (2004) Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care, 27, 861-868. (Pubitemid 38420205)
7. Boyanov, M.A., Boneva, Z., &, Christov, V.G., (2003) Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male, 6, 1-7. (Pubitemid 36606394)
8. Kapoor, D., Goodwin, E., Channer, K.S., et al. (2006) Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. European Journal of Endocrinology, 154, 899-906. (Pubitemid 43997730)
9. MÃ¥rin, P., Holmäng, S., Jönsson, L., et al. (1992) The effects of testosterone treatment on body composition and metabolism in middle-aged and obese men. International Journal of Obesity, 16, 991-997. (Pubitemid 23010023)
10. Caminiti, G., Volterrani, M., &, Iellamo, F., et al. (2009) Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. Journal of American College Cardiology, 54, 919-927.
11. Elbers, J.M., Asscheman, H., Seidell, J.C., et al. (1997) Long-term testosterone administration increases visceral fat in female to male transsexuals. Journal of Clinical Endocrinology and Metabolism, 82, 2044-2047. (Pubitemid 27287559)
12. Elbers, J.M., Giltay, E.J., Teerlink, T., et al. (2003) Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clinical Endocrinology, 58, 562-571. (Pubitemid 36566798)
13. Glazer, G., (1991) Atherogenic effects of anabolic steroids on serum lipid levels. A literature review. Archive of Internal Medicine, 151, 1925-1933.
14. Lee, N.K., Sowa, H., Hinoi, E., et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130, 456-469. (Pubitemid 47208519)
15. Kanazawa, I., Yamaguchi, T., Yamauchi, M., et al. (2010) Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporosis International, 22, 187-194.
16. Foresta, C., Strapazzon, G., De Toni, L., et al. (2010) Evidence for Osteocalcin production by adipose tissue and Its role in human metabolism. Journal Clinical Endocrinology and Metabolism, 95, 3502-3506.
17. Hernandez-Morante, J.J., Milagro, F.I., Lujan, J.A., et al. (2008) Insulin effect on adipose tissue (AT) adiponectin expression is regulated by the insulin resistance status of the patients. Clinical Endocrinology (Oxford), 69, 412-417.
18. Podvinec, M., Kaufmann, M.R., Handschin, C., et al. (2002) NUBIScan, an in Silico approach for prediction of nuclear receptor response elements. Molecular Endocrinology, 16, 1269-1279. (Pubitemid 34621075)
19. Moehren, U., Denayer, S., Podvinec, M., et al. (2008) Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes. Biochemistry Journal 411, 679-686. (Pubitemid 351600752)
20. Claessens, F., Denayer, S., Van Tilborgh, N., et al. (2008) Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nuclear Receptor Signalling, 6, e008.
21. Vermeulen, A., Verdonck, L., &, Kaufman, J.M., (1999) A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism, 84, 3666-3672. (Pubitemid 30645223)
22. Zhu, L., Hou, M., Sun, B., et al. (2010) Testosterone stimulates adipose tissue 11{beta}-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children. Journal of Clinical Endocrinology and Metabolism, 95, 3300-3308.
23. World Health Organization (2000) Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Convention, Geneva, 1999. Tech Rep Series 894. World Health Organization, Geneva.
24. Singh, R., Artaza, J.N., Taylor, W.E., et al. (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology, 147, 141-154. (Pubitemid 43004269)
25. Gupta, V., Bhasin, S., Guo, W., et al. (2008) Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Molecular and Cellular Endocrinology, 296, 32-40.
26. Ramirez, M.E., McMurry, M.P., Wiebke, G.A., et al. (1997) Evidence for sex steroid inhibition of lipoprotein lipase in men: comparison of abdominal and femoral adipose tissue. Metabolism, 46, 179-185. (Pubitemid 27078764)
27. Ferron, M., Hinoi, E., Karsenty, G., et al. (2008) Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proceedings of the National Academy of Sciences of the United States of America, 105, 5266-5270. (Pubitemid 351738545)
28. Kindblom, J.M., Ohlsson, C., Ljunggren, O., et al. (2009) Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. Journal of Bone and Mineral Research, 24, 785-791.
29. Saleem, U., Mosley Jr, T.H., &, Kullo, I.J., (2010) Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arteriosclerosis, Thrombosis and Vascular Biology, 51, 1918-1928.
30. Kim, S.H., Lee, J.W., Im, J.A., et al. (2010) Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men. Clinica Chimica Acta, 411, 2054-2057.
31. Kaufman, J.M., &, Vermeulen, A., (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocrine Review, 26, 833-876. (Pubitemid 41428540)
32. Zitzmann, M., (2009) Testosterone deficiency, insulin resistance and the metabolic syndrome. Nature Review in Endocrinology, 5, 673-681.
33. Dhindsa, S., Miller, M.G., McWhirter, C.L., et al. (2010) Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33, 1186-1192. Erratum in: Diabetes Care, 2010, 33, 1911.