Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7654-7670

  Bonala, Sabeera ^a   Lokireddy, Sudarsanareddy ^a,b,d   McFarlane, Craig ^b   Patnam, Sreekanth ^a   Sharma, Mridula ^c   Kambadur, Ravi ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CARBOHYDRATES; GLUCOSE; INSULIN; NUTRITION; ONCOLOGY; PROTEINS;

ELEMENT-BINDING PROTEINS; HIGH-FAT DIET; INSULIN RECEPTOR SUBSTRATE-1; INSULIN RESISTANCE; MOLECULAR ANALYSIS; OVER-EXPRESSION; STEROL REGULATORY ELEMENT-BINDING PROTEINS; TYPE-2 DIABETES;

LOADING;

CARBOHYDRATE BINDING PROTEIN; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN; CASITAS B LINEAGE LYMPHOMA B; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MYOSTATIN; PROTEOME; SMAD3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; FOOD COMPOSITION; GLUCOSE INTAKE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIPID DIET; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

CBLB; DIABETES; HIGH FAT DIET; HIGH GLUCOSE; INSULIN RESISTANCE; IRS1; MYOSTATIN; SIGNALING; SKELETAL MUSCLE; SKELETAL MUSCLE METABOLISM;

ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET; DIETARY FATS; GENE EXPRESSION REGULATION; GLUCOSE; HEP G2 CELLS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LENTIVIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MYOSTATIN; NUCLEAR PROTEINS; PALMITATES; PROTO-ONCOGENE PROTEINS C-CBL; SMAD3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 84896292655     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.529925     Document Type: Article

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