Loss-of-function mutation in myostatin reduces tumor necrosis factor a production and protects liver against obesity-induced insulin resistance

Diabetes

Volumn 58, Issue 5, 2009, Pages 1133-1143

  Wilkes, Jason J ^a   Lloyd, David J ^b   Gekakis, Nick ^a,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; MYOSTATIN; TUMOR NECROSIS FACTOR ALPHA; CD36 ANTIGEN; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FATTY LIVER; FEMALE; GENE EXPRESSION; GENE MUTATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HISTOPATHOLOGY; HOMEOSTASIS; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LIVER PROTECTION; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFECT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG ANTAGONISM; FAT INTAKE; GENETICS; GLUCOSE CLAMP TECHNIQUE; HETEROZYGOTE; HOMOZYGOTE; LIVER; METABOLIC SYNDROME X; METABOLISM; MOUSE MUTANT; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; ANTIGENS, CD36; BLOOD GLUCOSE; DIETARY FATS; DNA PRIMERS; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HETEROZYGOTE; HOMOZYGOTE; INSULIN RESISTANCE; LIVER; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE, SKELETAL; MUTATION; MYOSTATIN; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65549149871     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0245     Document Type: Article

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