Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-β-glucosidase mutant that causes Gaucher disease

Protein Engineering, Design and Selection

Volumn 24, Issue 10, 2011, Pages 773-775

  Offman, Marc N ^a   Krol, Marcin ^b   Rost, Burkhard ^a   Silman, Israel ^c   Sussman, Joel L ^c   Futerman, Anthony H ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Gaucher disease; GCase; molecular dynamics; N370S

Indexed keywords

ACTIVE SITE; CATALYTIC RESIDUE; GAUCHER DISEASE; GCASE; GLUCOSIDASE; HYDROGEN BONDING NETWORK; MOLECULAR-DYNAMICS MODEL; N370S; X-RAY STRUCTURE;

HYDROGEN BONDS; X RAY CRYSTALLOGRAPHY;

MOLECULAR DYNAMICS;

BETA GLUCOSIDASE; N370S ACID BETA GLUCOSIDASE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; ENZYME CONFORMATION; ENZYME STRUCTURE; GAUCHER DISEASE; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; MUTATION;

EID: 80052690225     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr032     Document Type: Article

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