Improved detection of host cell proteins (HCPs) in a mammalian cell-derived antibody drug using liquid chromatography/mass spectrometry in conjunction with an HCP-enrichment strategy

Rapid Communications in Mass Spectrometry

Volumn 28, Issue 8, 2014, Pages 855-860

  Thompson, Jenny Heidbrink ^a   Chung, Wai Keen ^a   Zhu, Min ^a   Tie, Liu ^a   Lu, Yali ^a,b   Aboulaich, Nabila ^a   Strouse, Robert ^a   Mo, Wenjun ^a  

^a MEDIMMUNE   (United States)

^b NOVAVAX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL DETECTION; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MAMMALS; MONOCLONAL ANTIBODIES; RECOMBINANT PROTEINS; SPECTROMETRY;

ANTIBODY DRUGS; BIOPHARMACEUTICAL PRODUCTS; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST CELL PROTEIN; IS PROCESS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MAMMALIAN CELLS; MONOCLONAL ANTIBODY DRUGS; PROCESS-RELATED IMPURITIES; QUALITATIVE INFORMATION;

CYTOLOGY;

MONOCLONAL ANTIBODY; PEPTIDE FRAGMENT; PROTEIN; RECOMBINANT PROTEIN; TRYPSIN;

ANIMAL; ARTICLE; CHEMISTRY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; MICE; PEPTIDE FRAGMENTS; PROTEINS; RECOMBINANT PROTEINS; TRYPSIN;

EID: 84896136825     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.6854     Document Type: Article

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