Complement components as potential therapeutic targets for asthma treatment

Respiratory Medicine

Volumn 108, Issue 4, 2014, Pages 543-549

  Khan, Mohammad Afzal ^a   Nicolls, Mark R ^b   Surguladze, Besiki ^c   Saadoun, Ismail ^a  

^a UNIVERSITY OF SHARJAH   (United Arab Emirates)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Innovative Bio Medical Technologies Ltd   (Canada)

Author keywords

Anaphylatoxins; Asthma; Complement mediated injury

Indexed keywords

COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; ANTIASTHMATIC AGENT; COMPLEMENT; COMPLEMENT INHIBITOR;

ASTHMA; CELL INTERACTION; HUMAN; IMMUNOCOMPETENT CELL; MEDIATOR; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; RESPIRATORY TRACT INJURY; REVIEW; BIOSYNTHESIS; IMMUNOLOGY; INNATE IMMUNITY; MOLECULARLY TARGETED THERAPY; PROCEDURES;

ANTI-ASTHMATIC AGENTS; ASTHMA; COMPLEMENT C3A; COMPLEMENT C5A; COMPLEMENT INACTIVATING AGENTS; COMPLEMENT SYSTEM PROTEINS; HUMANS; IMMUNITY, INNATE; MOLECULAR TARGETED THERAPY;

EID: 84896095600     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2014.01.005     Document Type: Review

References (72)

1. R. Pawankar, G.W. Canonica, S.T. Holgate, and R.F. Lockey Allergic diseases and asthma: a major global health concern Curr Opin Allergy Clin Immunol 12 2012 39 41
2. N. Krug, V.J. Erpenbeck, K. Balke, J. Petschallies, T. Tschernig, J.M. Hohlfeld, and H. Fabel Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gammadelta T cells in people with asthma after segmental allergen challenge Am J Respir Cell Mol Biol 25 2001 125 131
3. N. Krug, T. Tschernig, V.J. Erpenbeck, J.M. Hohlfeld, and J. Kohl Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma Am J Respir Crit Care Med 164 2001 1841 1843
4. M.A. Khan Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis Multidiscip Respir Med 8 2013 11
5. X. Zhang, I. Schmudde, Y. Laumonnier, M.K. Pandey, J.R. Clark, P. Konig, N.P. Gerard, C. Gerard, M. Wills-Karp, and J. Kohl A critical role for C5L2 in the pathogenesis of experimental allergic asthma J Immunol 185 2010 6741 6752
6. K. Takeda, J.M. Thurman, S. Tomlinson, M. Okamoto, Y. Shiraishi, V.P. Ferreira, C. Cortes, M.K. Pangburn, V.M. Holers, and E.W. Gelfand The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation J Immunol 188 2012 661 667
7. K. Maruo, T. Akaike, T. Ono, T. Okamoto, and H. Maeda Generation of anaphylatoxins through proteolytic processing of C3 and C5 by house dust mite protease J Allergy Clin Immunol 100 1997 253 260
8. J. Kohl Self, non-self, and danger: a complementary view Adv Exp Med Biol 586 2006 71 94
9. J. Kohl, and M. Wills-Karp A dual role for complement in allergic asthma Curr Opin Pharmacol 7 2007 283 289
10. X. Zhang, and J. Kohl A complex role for complement in allergic asthma Expert Rev Clin Immunol 6 2010 269 277
11. J. Kohl, and M. Wills-Karp Complement regulates inhalation tolerance at the dendritic cell/T cell interface Mol Immunol 44 2007 44 56
12. D.M. Walters, P.N. Breysse, B. Schofield, and M. Wills-Karp Complement factor 3 mediates particulate matter-induced airway hyperresponsiveness Am J Respir Cell Mol Biol 27 2002 413 418
13. M. Wills-Karp Complement activation pathways: a bridge between innate and adaptive immune responses in asthma Proc Am Thorac Soc 4 2007 247 251
14. R.F. Guo, and P.A. Ward Role of C5a in inflammatory responses Annu Rev Immunol 23 2005 821 852
15. A.A. Humbles, B. Lu, C.A. Nilsson, C. Lilly, E. Israel, Y. Fujiwara, N.P. Gerard, and C. Gerard A role for the C3a anaphylatoxin receptor in the effector phase of asthma Nature 406 2000 998 1001
16. X. Zhang, I.P. Lewkowich, G. Kohl, J.R. Clark, M. Wills-Karp, and J. Kohl A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells J Immunol 182 2009 5123 5130
17. M.A. Khan, C. Maasch, A. Vater, S. Klussmann, J. Morser, L.L. Leung, C. Atkinson, S. Tomlinson, P.S. Heeger, and M.R. Nicolls Targeting complement component 5a promotes vascular integrity and limits airway remodeling Proc Natl Acad Sci U S A 110 2013 6061 6066
18. M.A. Khan, and M.R. Nicolls Complement-mediated microvascular injury leads to chronic rejection Adv Exp Med Biol 734 2013 233 246
19. S.M. Drouin, D.B. Corry, J. Kildsgaard, and R.A. Wetsel Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy J Immunol 167 2001 4141 4145
20. H. Ali, and R.A. Panettieri Jr. Anaphylatoxin C3a receptors in asthma Respir Res 6 2005 19
21. S. Mizuno, L. Farkas, A. Al Husseini, D. Farkas, J. Gomez-Arroyo, D. Kraskauskas, M.R. Nicolls, C.D. Cool, H.J. Bogaard, and N.F. Voelkel Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization Am J Respir Cell Mol Biol 47 2012 679 687
22. S.T. Holgate Innate and adaptive immune responses in asthma Nat Med 18 2012 673 683
23. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am J Respir Crit Care Med 161 2000 1720 1745
24. M.A. Khan, X. Jiang, G. Dhillon, J. Beilke, V.M. Holers, C. Atkinson, S. Tomlinson, and M.R. Nicolls CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants Circ Res 109 2011 1290 1301
25. A. Soruri, S. Kim, Z. Kiafard, and J. Zwirner Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody Immunol Lett 88 2003 47 52
26. A. Soruri, J. Riggert, T. Schlott, Z. Kiafard, C. Dettmer, and J. Zwirner Anaphylatoxin C5a induces monocyte recruitment and differentiation into dendritic cells by TNF-alpha and prostaglandin E2-dependent mechanisms J Immunol 171 2003 2631 2636
27. S.M. Drouin, J. Kildsgaard, J. Haviland, J. Zabner, H.P. Jia, P.B. McCray Jr., B.F. Tack, and R.A. Wetsel Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma J Immunol 166 2001 2025 2032
28. A. Fayyazi, R. Sandau, L.Q. Duong, O. Gotze, H.J. Radzun, S. Schweyer, A. Soruri, and J. Zwirner C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells Am J Pathol 154 1999 495 501
29. J. Zwirner, A. Fayyazi, and O. Gotze Expression of the anaphylatoxin C5a receptor in non-myeloid cells Mol Immunol 36 1999 877 884
30. J. Zwirner, O. Gotze, G. Begemann, A. Kapp, K. Kirchhoff, and T. Werfel Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies Immunology 97 1999 166 172
31. K. Hasegawa, M. Tamari, C. Shao, M. Shimizu, N. Takahashi, X.Q. Mao, A. Yamasaki, F. Kamada, S. Doi, and H. Fujiwara et al. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma Hum Genet 115 2004 295 301
32. S.M. Drouin, D.B. Corry, T.J. Hollman, J. Kildsgaard, and R.A. Wetsel Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy J Immunol 169 2002 5926 5933
33. S.M. Drouin, M. Sinha, G. Sfyroera, J.D. Lambris, and R.A. Wetsel A protective role for the fifth complement component (c5) in allergic airway disease Am J Respir Crit Care Med 173 2006 852 857
34. J. Kohl Drug evaluation: the C5a receptor antagonist PMX-53 Curr Opin Mol Ther 8 2006 529 538
35. D. Ricklin, G. Hajishengallis, K. Yang, and J.D. Lambris Complement: a key system for immune surveillance and homeostasis Nat Immunol 11 2010 785 797
36. A.N. Babu, T. Murakawa, J.M. Thurman, E.J. Miller, P.M. Henson, M.R. Zamora, N.F. Voelkel, and M.R. Nicolls Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis J Clin Invest 117 2007 3774 3785
37. S. Ulrich, M.R. Nicolls, L. Taraseviciene, R. Speich, and N. Voelkel Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension Respiration 75 2008 272 280
38. A. Conroy, L. Serghides, C. Finney, S.O. Owino, S. Kumar, D.C. Gowda, W.C. Liles, J.M. Moore, and K.C. Kain C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria PLoS ONE 4 2009 e4953
39. G.A. Melendi, S.J. Hoffman, R.A. Karron, P.M. Irusta, F.R. Laham, A. Humbles, B. Schofield, C.H. Pan, R. Rabold, and B. Thumar et al. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression J Virol 81 2007 991 999
40. P. Henson Complementing asthma Nat Immunol 1 2000 190 192
41. J.W. Park, C. Taube, A. Joetham, K. Takeda, T. Kodama, A. Dakhama, G. McConville, C.B. Allen, G. Sfyroera, and L.D. Shultz et al. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure Am J Respir Crit Care Med 169 2004 726 732
42. C. Taube, Y.H. Rha, K. Takeda, J.W. Park, A. Joetham, A. Balhorn, A. Dakhama, P.C. Giclas, V.M. Holers, and E.W. Gelfand Inhibition of complement activation decreases airway inflammation and hyperresponsiveness Am J Respir Crit Care Med 168 2003 1333 1341
43. S.P. Hogan, H.F. Rosenberg, R. Moqbel, S. Phipps, P.S. Foster, P. Lacy, A.B. Kay, and M.E. Rothenberg Eosinophils: biological properties and role in health and disease Clin Exp Allergy 38 2008 709 750
44. O. Levy Innate immunity of the newborn: basic mechanisms and clinical correlates Nat Rev Immunol 7 2007 379 390
45. S.C. Makrides Therapeutic inhibition of the complement system Pharmacol Rev 50 1998 59 87
46. I. Kawikova, V. Paliwal, M. Szczepanik, A. Itakura, M. Fukui, R.A. Campos, G.P. Geba, R.J. Homer, B.P. Iliopoulou, and J.S. Pober et al. Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma Immunology 113 2004 234 245
47. S. Lajoie, I.P. Lewkowich, Y. Suzuki, J.R. Clark, A.A. Sproles, K. Dienger, A.L. Budelsky, and M. Wills-Karp Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma Nat Immunol 11 2010 928 935
48. N. Mizutani, H. Goshima, T. Nabe, and S. Yoshino Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice J Immunol 188 2012 5694 5705
49. H. Qu, D. Ricklin, and J.D. Lambris Recent developments in low molecular weight complement inhibitors Mol Immunol 47 2009 185 195
50. P.J. Barnes, K.F. Chung, and C.P. Page Inflammatory mediators of asthma: an update Pharmacol Rev 50 1998 515 596
51. P.J. Barnes, and S. Lim Inhibitory cytokines in asthma Mol Med Today 4 1998 452 458
52. Y.H. Wang, K.S. Voo, B. Liu, C.Y. Chen, B. Uygungil, W. Spoede, J.A. Bernstein, D.P. Huston, and Y.J. Liu A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma J Exp Med 207 2010 2479 2491
53. E.R. Walsh, and A. August Eosinophils and allergic airway disease: there is more to the story Trends Immunol 31 2010 39 44
54. E.R. Walsh, K. Stokes, and A. August The role of eosinophils in allergic airway inflammation Discov Med 9 2010 357 362
55. C.A. Janeway Jr. How the immune system protects the host from infection Microbes Infect 3 2001 1167 1171
56. C.A. Janeway Jr. How the immune system works to protect the host from infection: a personal view Proc Natl Acad Sci U S A 98 2001 7461 7468
57. M.M. Markiewski, and J.D. Lambris The role of complement in inflammatory diseases from behind the scenes into the spotlight Am J Pathol 171 2007 715 727
58. N.P. Stimler, W.E. Brocklehurst, C.M. Bloor, and T.E. Hugli Complement anaphylatoxin C5a stimulates release of SRS-A-like activity from guinea-pig lung fragments J Pharm Pharmacol 32 1980 804
59. N.P. Stimler, T.E. Hugli, and C.M. Bloor Pulmonary injury induced by C3a and C5a anaphylatoxins Am J Pathol 100 1980 327 348
60. Z. Marom, J. Shelhamer, M. Berger, M. Frank, and M. Kaliner Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro J Exp Med 161 1985 657 668
61. Z. Marom, J.H. Shelhamer, and M. Kaliner Human monocyte-derived mucus secretagogue J Clin Invest 75 1985 191 198
62. S. Konno, and S. Tsurufuji Inability of rat anaphylatoxin to induce histamine release in rats Jpn J Pharmacol 38 1985 185 193
63. S. Konno, and S. Tsurufuji Inhibitory effect of a novel anticomplementary agent, K-76COONa, on the release of histamine induced by zymosan and compound 48/80 Jpn J Pharmacol 38 1985 116 119
64. W.A. Schumacher, J.C. Fantone, S.E. Kunkel, R.C. Webb, and B.R. Lucchesi The anaphylatoxins C3a and C5a are vasodilators in the canine coronary vasculature in vitro and in vivo Agents Actions 34 1991 345 349
65. N. Shushakova, J. Skokowa, J. Schulman, U. Baumann, J. Zwirner, R.E. Schmidt, and J.E. Gessner C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease J Clin Invest 110 2002 1823 1830
66. E.B. Thangam, R.T. Venkatesha, A.K. Zaidi, K.L. Jordan-Sciutto, D.A. Goncharov, V.P. Krymskaya, Y. Amrani, R.A. Panettieri Jr., and H. Ali Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact FASEB J 19 2005 798 800
67. B.N. Lambrecht An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization J Clin Invest 116 2006 628 632
68. N.W. Lukacs, M.M. Glovsky, and P.A. Ward Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity Am J Physiol Lung Cell Mol Physiol 280 2001 L512 L518
69. M.M. Glovsky, P.A. Ward, and K.J. Johnson Complement determinations in human disease Ann Allergy Asthma Immunol 93 2004 513 522 quiz 523-5, 605
70. K.R. Kalli, P. Hsu, and D.T. Fearon Therapeutic uses of recombinant complement protein inhibitors Springer Semin Immunopathol 15 1994 417 431
71. M. Fridkis-Hareli, M. Storek, I. Mazsaroff, A.M. Risitano, A.S. Lundberg, C.J. Horvath, and V.M. Holers Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases Blood 118 2011 4705 4713
72. S.T. Holgate, R. Djukanovic, T. Casale, and J. Bousquet Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy Clin Exp Allergy 35 2005 408 416