Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Urbanelli, Lorena ^a   Magini, Alessandro ^a,b   Ercolani, Luisa ^c   Sagini, Krizia ^a   Polchi, Alice ^a   Tancini, Brunella ^a   Brozzi, Alessandro ^a   Armeni, Tatiana ^c   Principato, Giovanni ^c   Emiliani, Carla ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; H RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; BETA GALACTOSIDASE; HRAS PROTEIN, HUMAN; LUCIFERASE; MESSENGER RNA; PROTEIN P21; SMALL INTERFERING RNA; TFEB PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; BINDING AFFINITY; BINDING SITE; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LYSOSOME; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; ONCOGENE H RAS; PROMOTER REGION; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL AGING; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; DERMIS; ENZYMOLOGY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA-GALACTOSIDASE; BETA-N-ACETYLHEXOSAMINIDASES; BLOTTING, WESTERN; CELL AGING; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DERMIS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LUCIFERASES; LYSOSOMES; MUTATION; PROTO-ONCOGENE PROTEINS P21(RAS); RAF KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84896091755     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089485     Document Type: Article

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